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AELRTESAAGARRRNASGESTRVMLMEVAERLFATRGIEAVTLREIQQAAGQSNTSVIRYHFGSRDGLIR ALISYRQASLGADRREMLMSMREQGKEADPRAVVWLLARPLANSIAAGEMFAPFLARLVEDPRARSRYWP DHVDDDWTQEKLEELVDAALQDLPGRIRRGRTFQLYVSLINTLAAAARSGHGLSEAQLHNYVDTWVGMLT APVSYETRALIADDDD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2626 | - | - | 100% (227) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_1916 | - | 6e-99 | 86.63% (202) | transcriptional regulator, TetR family protein, putative |
| M. avium 104 | MAV_0887 | - | 8e-17 | 28.44% (218) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0310 | - | 2e-07 | 34.92% (63) | TetR/ACRR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2416 | - | 7e-14 | 26.70% (221) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0302 | - | 2e-07 | 34.92% (63) | TetR/ACRR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0835c | - | 1e-10 | 39.00% (100) | TetR family transcriptional regulator |
| M. marinum M | MMAR_4764 | - | 6e-16 | 30.16% (189) | hypothetical protein MMAR_4764 |
| M. smegmatis MC2 155 | MSMEG_4858 | - | 3e-17 | 30.09% (226) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2278 | - | 4e-13 | 28.57% (224) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_0335 | - | 3e-16 | 30.16% (189) | hypothetical protein MUL_0335 |
| M. vanbaalenii PYR-1 | Mvan_4236 | - | 4e-14 | 27.60% (221) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2416|M.gilvum_PYR-GCK MQSGATTFLNGTTHLKQSLDLPGVTRFTDRVTTARTVRADRATGTQEAIL
Mvan_4236|M.vanbaalenii_PYR-1 -----MSFLN------QSLDLVGVTGFTEWVTTARTVRADRASSTQEAIL
MSMEG_4858|M.smegmatis_MC2_155 ----MTRFTG----------LVTTASRTASRTAARTARADRATSTQEAIL
MMAR_4764|M.marinum_M -----------------------------MTAVGRAVRGERASSTQEAIL
MUL_0335|M.ulcerans_Agy99 -----------------------------MTAVGRAVRGERASSTQEAIL
TH_2278|M.thermoresistible__bu -----------------------VVQFTEGVTAARTVRADRASSTQEAIL
Mb0310|M.bovis_AF2122/97 ------------------------------MGVPAKKKQQQGERSRESIL
Rv0302|M.tuberculosis_H37Rv ------------------------------MGVPAKKKQQQGERSRESIL
MAV_2626|M.avium_104 -----------------------MAELRTESAAGARRRNASGESTRVMLM
MAB_0835c|M.abscessus_ATCC_199 -----------------------------MTDTSAETTILTEDSTDQRLL
. : ::
Mflv_2416|M.gilvum_PYR-GCK KAAERLYAEHGVFAVSNRQVSEAAGQGNNAAVGYHFGTKADLVRAIEHKH
Mvan_4236|M.vanbaalenii_PYR-1 KAAERLYAEHGVFAVSNRQVSEAAGQGNNAAVGYHFGTKADLVRAIEHKH
MSMEG_4858|M.smegmatis_MC2_155 KAAERLYAEHGVFAVSNRQVSEAAGQGNNAAVGYHFGTKTDLVRAIEHKH
MMAR_4764|M.marinum_M VAAERLFAEHGVFAVSNRQVSEAAGQGNNAAVGYHFGTKTDLVRAIEQKH
MUL_0335|M.ulcerans_Agy99 VAAERLFAEHGVFAVSNRQVSEAAGQGNNAAVGYHFGTKTDLVRAIEQKH
TH_2278|M.thermoresistible__bu KAAERLYAERGMFAVSNRQVSEAAGQGNNAAVGYHFGTKTDLVRAIEQKH
Mb0310|M.bovis_AF2122/97 DATERLMATKGYAATSISDIRDACGLAP-SSIYWHFGSKEGVLAAMMERG
Rv0302|M.tuberculosis_H37Rv DATERLMATKGYAATSISDIRDACGLAP-SSIYWHFGSKEGVLAAMMERG
MAV_2626|M.avium_104 EVAERLFATRGIEAVTLREIQQAAGQSNTSVIRYHFGSRDGLIRALISYR
MAB_0835c|M.abscessus_ATCC_199 NAAERLFAERGVDAVSLRAIMAAAG-TNVASVHYHFGSKERLIEALLDRY
.:*** * :* *.: : *.* : : :***:: :: *:
Mflv_2416|M.gilvum_PYR-GCK RGPIEELREQRVAAIDSS---GDMRDWVAALVCPLTDHLAALGNPTWYAR
Mvan_4236|M.vanbaalenii_PYR-1 RGPIEELREQRVAAIGAS---TDMRDWVAALVCPLTDHLAALGNPTWYAR
MSMEG_4858|M.smegmatis_MC2_155 RGPIEYLREQMIGTVQGS---TDLRDWVGALVRPLTDHLAALGNPTWYAR
MMAR_4764|M.marinum_M RVPVERLREQMVAAAAAKGVAATMRDWVACLVCPLTEHLAVLGNPTWYAR
MUL_0335|M.ulcerans_Agy99 RVPIERLREQMVAAAAAKGAAATMRDWVACLVCPLTEHLAVLGNPTWYAR
TH_2278|M.thermoresistible__bu RVEIERLLEKMVAETGDS---TDLRDWVACLVCSLTEHLHQLGNPTWYAR
Mb0310|M.bovis_AF2122/97 AQRFFAAIPTWDEAHGPVE--QRSERQLTELVSLQSQHPDFLR---LFYL
Rv0302|M.tuberculosis_H37Rv AQRFFAAIPTWDEAHGPVE--QRSERQLTELVSLQSQHPDFLR---LFYL
MAV_2626|M.avium_104 QASLGADRREMLMSMREQGKEADPRAVVWLLARPLAN---SIAAGEMFAP
MAB_0835c|M.abscessus_ATCC_199 LDQIEKRRFALLDVAETAR---TLRAIAEAIVTPLSEIAEEGSTAWLSTL
. . :. ::
Mflv_2416|M.gilvum_PYR-GCK FAAQVMTDPAYHNMIVKDALSSPSLVRVLDGINGCLP-DLPVDVRVERNI
Mvan_4236|M.vanbaalenii_PYR-1 FAAQVMTDPAYHNMIVKDALSSPSLVRVLDGINSCLP-DLPVDVRVERNI
MSMEG_4858|M.smegmatis_MC2_155 FAAQVMTDPAYHNIIVRDALSSPSLVQVIEGMNNCLP-DLPAEIRAERNI
MMAR_4764|M.marinum_M FAAQAMTDPAYHNIIVKDALSSPSLVQVIDGINSCLP-DLPVDVRYERNL
MUL_0335|M.ulcerans_Agy99 FAAQAMTDPAYHNIIVKDALSSPSLVQVIDGINSCLP-DLPVDVRYERNL
TH_2278|M.thermoresistible__bu FAAQALADPAYQKIVVKDALASPALVRVVEGITRCLP-DLPAAVVVERNI
Mb0310|M.bovis_AF2122/97 LSMERSQDPVVAAVVRR--VRNTAIARFRDSITHLLPSDIPPGK---ADL
Rv0302|M.tuberculosis_H37Rv LSMERSQDPAVAAVVRR--VRNTAIARFRDSITHLLPSDIPPGK---ADL
MAV_2626|M.avium_104 FLARLVEDPRARSRYWPDHVDDDWTQEKLEELVDAALQDLPGRIRRGRTF
MAB_0835c|M.abscessus_ATCC_199 GKLLISGHPALIPMSVSFQPQAARLQELILRLR-------PDATLPSIRF
.* . : * :
Mflv_2416|M.gilvum_PYR-GCK MGRNLLMHSCADRERLLAQGSPVPRGSWQSAATGLIDAIIGLWHAPVTER
Mvan_4236|M.vanbaalenii_PYR-1 MGRNLLMHSCADRERLLAQGAPVARPSWQAAATGLIDAIIGLWHAPVTEP
MSMEG_4858|M.smegmatis_MC2_155 MARNLLMHSCAERERALAQGAPVPRSSWQGAASGLIDAIVGLWLAPVTGE
MMAR_4764|M.marinum_M MARNLLMHTCADLERALAAGTSVPRPSWREAATGLIDAITGLWLAPVTAR
MUL_0335|M.ulcerans_Agy99 MARNLLMHTCADLERALAAGTSVPRPFWREAATGQIDAITGLWLAPVTAR
TH_2278|M.thermoresistible__bu MARNLLMHTCADFERAFAEGDPVPRASWQAVGNGLIDAIVGLWRAPVTEP
Mb0310|M.bovis_AF2122/97 VVAELTAFAVALSDGVYFAGHLEPDTTDVERMYRRLRQALEALIPVLLEE
Rv0302|M.tuberculosis_H37Rv VVAELTAFAVALSDGVYFAGHLEPDTTDVERMYRRLRQALEALIPVLLEE
MAV_2626|M.avium_104 QLYVSLINTLAAAARSGHGLSEAQLHNYVDTWVGMLTAPVSYETRALIAD
MAB_0835c|M.abscessus_ATCC_199 GVTHAVTLTCVVLGDIAHTNRLMSLSGTYLDDGQMNAQLIDMVTAILAGP
: . :
Mflv_2416|M.gilvum_PYR-GCK P---
Mvan_4236|M.vanbaalenii_PYR-1 A---
MSMEG_4858|M.smegmatis_MC2_155 DR--
MMAR_4764|M.marinum_M E---
MUL_0335|M.ulcerans_Agy99 E---
TH_2278|M.thermoresistible__bu PQ--
Mb0310|M.bovis_AF2122/97 T---
Rv0302|M.tuberculosis_H37Rv T---
MAV_2626|M.avium_104 DDD-
MAB_0835c|M.abscessus_ATCC_199 PDES