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M. avium 104 MAV_2584 (-)

annotation: beta-ketoadipyl CoA thiolase
coordinates: 2620275 - 2621462
length: 395

ATTTSRAAIVAAARTPIGTARKGTLANMPAIELAKPVVQAVVERSGLDAADFDDLVLAESMQGGGDSARY
IAVALGMLDIPGLAVNRQCASSLSAIAVGAGQIASGMSRAILAGGMESLSTGPIMQKRKLFTAGKSPEDY
AQWFPESHPPTAEAPAMDMSITVAHNCNLQYGITREDQDNWALRSHQRAIRAIDTGAFTDEIIPLQVPQA
DGSVITFAEDEHPRRGSSMESLAGLKVLHPEIEGFTVTAGNSSGINDAAAVVALASPDTQQDVLASVLSW
TQVGLDPTRTGSGPIKAIPKALELAGRKLEDVALFEINEAFAAQAVACARELGLDEEIVNVYGSGISLGH
PIAATGARMVTSAIYELRRRGGGIGVLSMCAGGGMGAAMVIEVA*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. avium 104MAV_2584--100% (395)beta-ketoadipyl CoA thiolase
M. avium 104MAV_1863-0.092.66% (395) beta-ketoadipyl CoA thiolase
M. avium 104MAV_2127-e-11656.56% (389) acetyl-CoA C-acyltransferase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1103cfadA31e-6238.42% (406) acetyl-CoA acetyltransferase
M. gilvum PYR-GCKMflv_4356-1e-11656.49% (393) acetyl-CoA acetyltransferase
M. tuberculosis H37RvRv1074cfadA31e-6238.42% (406) acetyl-CoA acetyltransferase
M. leprae Br4923MLBr_01158fadA44e-5635.43% (398) acetyl-CoA acetyltransferase
M. abscessus ATCC 19977MAB_1192c-8e-6439.16% (406) acetyl-CoA acetyltransferase
M. marinum MMMAR_4788-1e-10551.28% (392) beta-ketoacyl CoA thiolase
M. smegmatis MC2 155MSMEG_2224-1e-11756.38% (392) acetyl-CoA C-acyltransferase
M. thermoresistible (build 8)TH_0166fadA68e-5436.34% (399) PROBABLE ACETYL-CoA ACETYLTRANSFERASE FADA6
M. ulcerans Agy99MUL_0357-1e-10551.28% (392) beta-ketoacyl CoA thiolase
M. vanbaalenii PYR-1Mvan_1988-1e-11656.30% (389) acetyl-CoA acetyltransferases

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4356|M.gilvum_PYR-GCK          ----------------MSTPVIVGAARTAIGRSFKGTLVNTPPETLITTV
Mvan_1988|M.vanbaalenii_PYR-1       ----------------MPTPVIVGAARTAIGRSFKGTLVNTPPETLITTV
MSMEG_2224|M.smegmatis_MC2_155      -------------MKIMPKPVIVGAARTAIGRSFKGTLVNTPPETLITTV
MAV_2584|M.avium_104                ------------MATTTSRAAIVAAARTPIGTARKGTLANMPAIELAKPV
MMAR_4788|M.marinum_M               ----------------MPEAVIVAALRTPIGTARKGTLRDTNAFDLAHHV
MUL_0357|M.ulcerans_Agy99           MCGRLLASAPPKWRKPVPEAVIVAALRTPIGTARKGTLRDTNAFDLAHHV
Mb1103c|M.bovis_AF2122/97           ----------------MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQM
Rv1074c|M.tuberculosis_H37Rv        ----------------MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQM
MAB_1192c|M.abscessus_ATCC_199      ----------------MPEAVIVSTARSPIGRAGKGSLVSMRPDDLAAQM
TH_0166|M.thermoresistible__bu      --------------MAMTEAYIVDAVRTPVGKR-NGGLSGAHPADMAAHV
MLBr_01158|M.leprae_Br4923          ----------------MTTSVIVTGARTPIGKL-MGSLKDFSASDLGAIT
                                                     . . **   *:.:*    * * .  .  :    

Mflv_4356|M.gilvum_PYR-GCK          LPEVIR-RSGVDPADIDDIIFAESHYGGG---DLARYAADAIGL-QHVPG
Mvan_1988|M.vanbaalenii_PYR-1       LPEVVR-RSGVDPADIDDIIFAESHYGGG---DLARYAADAVGL-QHVPG
MSMEG_2224|M.smegmatis_MC2_155      LPEIVR-RSGVDPADIDDIIFAESHYGGG---DLARYAADATGL-QHVPG
MAV_2584|M.avium_104                VQAVVE-RSGLDAADFDDLVLAESMQGGG---DSARYIAVALGM-LDIPG
MMAR_4788|M.marinum_M               VSEAT---ADLDPGQIDDVILGEGLYGGG---VIARHAAITAGL-GHVPG
MUL_0357|M.ulcerans_Agy99           VSEAT---ADLDPGQIDDVILGEGLYGGG---VIARHAAITAGL-GHVPG
Mb1103c|M.bovis_AF2122/97           VRAALDKVPALNPHQIDDLMMGCGLPGGESGFNIARVVAVALGY-DFLPG
Rv1074c|M.tuberculosis_H37Rv        VRAALDKVPALNPHQIDDLMMGCGLPGGESGFNIARVVAVALGY-DFLPG
MAB_1192c|M.abscessus_ATCC_199      VRAALDKVPALDPKDVDDLMLGCGQPGGEAGFNIGRAVAVQLGY-DFLPG
TH_0166|M.thermoresistible__bu      IKTLVG-RHDFDPAAIDDVIFGCLDNIGSQAGDIARTAALAAGLPESVPG
MLBr_01158|M.leprae_Br4923          IAAALK-KANVAPSIVQYVIIGQVLTAGAG-QMPARQAAVAAGIGWDVPA
                                    :         . .  .: :::.     *      .*  *   *    :*.

Mflv_4356|M.gilvum_PYR-GCK          QSVNRHCAGSLTAIGNAAAQIGSGMERVMIAGGVQSLSMTPLVNWR----
Mvan_1988|M.vanbaalenii_PYR-1       QSVNRHCAGSLTAIGNASAQIGSGMERVLIAGGVQSLSMTPLVNWR----
MSMEG_2224|M.smegmatis_MC2_155      QSVNRHCAGSLTAIGNAAAQIGSGMERVLIAGGVQSLSMTPLVNWR----
MAV_2584|M.avium_104                LAVNRQCASSLSAIAVGAGQIASGMSRAILAGGMESLSTGPIMQKRKL--
MMAR_4788|M.marinum_M               LAQNRHCAAGQAAVQGAAASVRAGMDQLIIAGGVNSASTSPRPRMQ----
MUL_0357|M.ulcerans_Agy99           LAQNRHCAAGQAAVQGAAASVRAGMDQLIIAGGVNSASTSPRPRMQ----
Mb1103c|M.bovis_AF2122/97           TTVNRYCSSSLQTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPD
Rv1074c|M.tuberculosis_H37Rv        TTVNRYCSSSLQTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPD
MAB_1192c|M.abscessus_ATCC_199      TTVNRYCSSSLQTTRMAFHAIKAGEGHAFISAGVETVSRFPKGTSDGWPD
TH_0166|M.thermoresistible__bu      VTIDRQCGSAQQAVHFAAQGVMSGTVDLIVAGGVQKMSQFPILSAF----
MLBr_01158|M.leprae_Br4923          LTINKMCLSGLDAIALADQLIRAGEFDVVVAGGQESMTKAPHLLMD----
                                     : :: * ..  :   .   : :*    .::.* :. :  .         

Mflv_4356|M.gilvum_PYR-GCK          -------IPGPELKFEERWMPPTHVETPDAPTKDMSITVG---WNTAQAA
Mvan_1988|M.vanbaalenii_PYR-1       -------IPGPELKFEERWMPPTHVETPDAPTKDMSITVG---WNTAQAA
MSMEG_2224|M.smegmatis_MC2_155      -------IPGPELKFEERWMPPTHVETPDAPTKDMSITVG---WNTAQAA
MAV_2584|M.avium_104                ------FTAGKSPEDYAQWFPESHPPTAEAPAMDMSITVA---HNCNLQY
MMAR_4788|M.marinum_M               -------IDGEWVD----WFPPTHPDRPDAPNMDMSITVG---WNAAVAA
MUL_0357|M.ulcerans_Agy99           -------IDGEWVD----WFPPTHPDRPDAPNMDMSITVG---WNAAVAA
Mb1103c|M.bovis_AF2122/97           TKNPLFDGAQERSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVAIMT
Rv1074c|M.tuberculosis_H37Rv        TKNPLFDGAQERSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVAIMT
MAB_1192c|M.abscessus_ATCC_199      SHNPLYADAEARTATAAQGATEWHDPRNDGLTPDVYIAMGQTAENVALHT
TH_0166|M.thermoresistible__bu      -------AAGEPYGATDPWTGCEG---WQARYGDQEISQFRGAEMIAEHW
MLBr_01158|M.leprae_Br4923          ---------SRSGYKYGDVTIVDHLAYDGLHDVFTNQPMGALTEQRNDVE
                                                                         .            

Mflv_4356|M.gilvum_PYR-GCK          GITREDMDAWAARSHQRAVAAQDDGKFLDEIVPLKVEQFDGSVIDFSVDE
Mvan_1988|M.vanbaalenii_PYR-1       GITREEMDVWAVRSHQRAVAAIDAGKFVDEIVPLKVTQFDGSVIDFSVDE
MSMEG_2224|M.smegmatis_MC2_155      GISREEMDAWAARSHQRAIAAIDAGKFLDEIVPLKVTQFDGSVIDFSVDE
MAV_2584|M.avium_104                GITREDQDNWALRSHQRAIRAIDTGAFTDEIIPLQVPQADGSVITFAEDE
MMAR_4788|M.marinum_M               GVSRAEMDAWALRSHRNAIAAIDEGRFKEEIVPIPTPHG-----LFCVDE
MUL_0357|M.ulcerans_Agy99           GVSRAEMDAWALRSHRNAIAAIDEGRFKEEIVPIPTPHG-----LFCVDE
Mb1103c|M.bovis_AF2122/97           GISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLPDG----TTVSTDD
Rv1074c|M.tuberculosis_H37Rv        GISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLPDG----TTVSTDD
MAB_1192c|M.abscessus_ATCC_199      GISREDQDHWGVRSQNRAEKAIADGFFEREITPVTLADG----TVVAKDD
TH_0166|M.thermoresistible__bu      KLSREDNEKFALESHRRAVAAIEAGYFDKEITPY---------ADATVDE
MLBr_01158|M.leprae_Br4923          KFTRQEQDEFAARSHQKAAAAWKDGVFADEVVPVSIPQSKGDSLQFTEDE
                                     .:* : : :. .*:..*  *   * *  *: *               *:

Mflv_4356|M.gilvum_PYR-GCK          QPRRDTSVEKLAGLKVLHPEIEGFSITAGNASGTNDAAAGVALVEADYAA
Mvan_1988|M.vanbaalenii_PYR-1       SPRRDTTLEKLAGLKVLHPEIEGFSITAGNASGTNDAAAGVALVDADYAA
MSMEG_2224|M.smegmatis_MC2_155      HPRRDTTVEKLAGLKVLHPEIEGFSITAGNSSGTNDAAAGVAVVDSEYAA
MAV_2584|M.avium_104                HPRRGSSMESLAGLKVLHPEIEGFTVTAGNSSGINDAAAVVALASPDTQQ
MMAR_4788|M.marinum_M               HPRRDTTMEKLAALKPLHPEIDGFSITAGNACGANDGAAVLTIASDRMAQ
MUL_0357|M.ulcerans_Agy99           HPRRDTTMEKLAALKPLHPEIDGFSITAGNACGANDGAAVLTIASDRMAQ
Mb1103c|M.bovis_AF2122/97           GPRPGTTYEKVSELKPAFRPNG--TVTAGNACPLNDGAAAVVITSDTKAK
Rv1074c|M.tuberculosis_H37Rv        GPRPGTTYEKVSELKPAFRPNG--TVTAGNACPLNDGAAAVVITSDTKAK
MAB_1192c|M.abscessus_ATCC_199      GPRAGTTYEAISQLKPVFRPNG--TITAGNACPLNDGAAALVVMSDVRAK
TH_0166|M.thermoresistible__bu      GPRPDTSLEKMASLPTL---IEGGVLTAAVASQISDGAAALLVASKDAVD
MLBr_01158|M.leprae_Br4923          GIRANTSAESLAGLKPAFRCGG--TITPGSASQISDGAATVVVMNKEKAQ
                                      * .:: * :: *           :*.. :.  .*.** : : .     

Mflv_4356|M.gilvum_PYR-GCK          ANGLTVMAKVRSWGAVGVAPRDTGLGGVKVIGRVLDKAGLKPSDVTLWEI
Mvan_1988|M.vanbaalenii_PYR-1       ANGLNVMAKVKAWGAVGVAPRDTGLGGVKVIGRVLDRAGLKPSDVALWEI
MSMEG_2224|M.smegmatis_MC2_155      ANGLNVMATVRAWGAVGVPPRDTGLGGVRVIGKVLDRAGLKPSDVALWEI
MAV_2584|M.avium_104                D----VLASVLSWTQVGLDPTRTGSGPIKAIPKALELAGRKLEDVALFEI
MMAR_4788|M.marinum_M               GLGMPALARVLSWASVGVDPAATGLAPVEAIPKALARGHLSISDVDLFEI
MUL_0357|M.ulcerans_Agy99           GLGMPALARVLSWASVGVDPAATGLAPVEAIPKALARGHLSISDVDLFEI
Mb1103c|M.bovis_AF2122/97           ELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDIDLVEI
Rv1074c|M.tuberculosis_H37Rv        ELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDIDLVEI
MAB_1192c|M.abscessus_ATCC_199      ELGLTPLARIVSTGVSGLSPEIMGLGPIEAVKRALANAGKSIGDIDLFEI
TH_0166|M.thermoresistible__bu      RFNLTPRARIHHMSVRGADPVMMLTAPIPATQHALKRAGMSIDDIDAVEI
MLBr_01158|M.leprae_Br4923          QLGLTWLVEIGAHGVVAGPDSTLQSQPANAIKKAVDREGISVEQLDVVEI
                                           . :      .            .  :.:        ::   **

Mflv_4356|M.gilvum_PYR-GCK          NEAFASVPIAAVREYGIDEELVNFSGSGCSLGHPIAASGARMITTLIYEL
Mvan_1988|M.vanbaalenii_PYR-1       NEAFASVPIAACKEYGIDEELVNFSGSGCSLGHPIAASGARMITTLIYEL
MSMEG_2224|M.smegmatis_MC2_155      NEAFASVPIAACKEYGLDEELVNFNGSGCSLGHPIAASGARMVTTLVYEL
MAV_2584|M.avium_104                NEAFAAQAVACARELGLDEEIVNVYGSGISLGHPIAATGARMVTSAIYEL
MMAR_4788|M.marinum_M               NEAFASMCVATVKLLELDADRVNVSGSGCSLGHPVAATGARMLVTLVHEL
MUL_0357|M.ulcerans_Agy99           NEAFASMCVATVKLLELDADRVNVSGSGCSLGHPVAATGARMLVTLVHEL
Mb1103c|M.bovis_AF2122/97           NEAFAVQVLGSARELGIDEDKLNISGGAIALGHPFGMTGARITTTLLNNL
Rv1074c|M.tuberculosis_H37Rv        NEAFAVQVLGSARELGIDEDKLNISGGAIALGHPFGMTGARITTTLLNNL
MAB_1192c|M.abscessus_ATCC_199      NEAFAVQVLGSARALGIDEDKLNVSGGAIALGHPFGMTGARITATLLNNL
TH_0166|M.thermoresistible__bu      NEAFAPVVLAWLAELGADPARVNPNGGAIALGHPIGCTGARLMTSLLHHL
MLBr_01158|M.leprae_Br4923          NEAFAAVALASARELGIAPELVNVNGGAIAVGHPLGMSGARITLHVALEL
                                    *****   :.           :*  *.. ::***.. :***:      .*

Mflv_4356|M.gilvum_PYR-GCK          QRRGGGIGVAAMCAGGGQGGGVVIEV---
Mvan_1988|M.vanbaalenii_PYR-1       QRRGGGIGVAAMCAGGGQGGGVVIEV---
MSMEG_2224|M.smegmatis_MC2_155      QRRGGGIGVAAMCAGGGQGGAVVIEV---
MAV_2584|M.avium_104                RRRGGGIGVLSMCAGGGMGAAMVIEVA--
MMAR_4788|M.marinum_M               RRRGGGIGLAAMCAGGGMGSATVIEVAAP
MUL_0357|M.ulcerans_Agy99           RRRGGGIGLAAMCAGGGMGSATVIEVAAP
Mb1103c|M.bovis_AF2122/97           QTYDKTFGLETMCVGGGQGMAMVIERLA-
Rv1074c|M.tuberculosis_H37Rv        QTYDKTFGLETMCVGGGQGMAMVIERLA-
MAB_1192c|M.abscessus_ATCC_199      TTYDKTFGVETMCVGGGQGMAMVIERLA-
TH_0166|M.thermoresistible__bu      ERTGGRYGLQTMCEGGGQANVTIIERL--
MLBr_01158|M.leprae_Br4923          ARRGSGYGVAALCGAGGQGDALILRAV--
                                       .   *: ::* .** .   ::.