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ATTKSRAAIVAAARTPIGTARKGTLANVPAVELAKPVVTAVVERSGLDAAEFDDFVLAESMQGGGDSARY IAVALGLTDVAGLAVNRQCASSLSAIAVGAGQIAAGMSRAILAGGMESLSTAPIMQKRKPFTSGKSPEDY VQWFPESHPPTAEAPAMDMSITVAHNCNLQYGISREDQDEWALRSHQRAIKAIDAGSFADEIIPIQVPQA DGSTITFAEDEHPRRGSSMESLAGLKVLHPEIEGFTVTAGNSSGINDAAAVVALASPDTAAETLAHVLSW TQVGLDPTRTGSGPIKAIPKALELAGRKLEDVALFEINEAFAAQAVACARELRLDEEIVNVYGSGISLGH PIAATGARMVTSAIYELRRRGGGIGVLSMCAGGGMGAAMVIEVA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1863 | - | - | 100% (395) | beta-ketoadipyl CoA thiolase |
| M. avium 104 | MAV_2584 | - | 0.0 | 92.66% (395) | beta-ketoadipyl CoA thiolase |
| M. avium 104 | MAV_2127 | - | e-114 | 55.78% (389) | acetyl-CoA C-acyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1103c | fadA3 | 2e-61 | 38.18% (406) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_4356 | - | 1e-115 | 55.98% (393) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv1074c | fadA3 | 2e-61 | 38.18% (406) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_01158 | fadA4 | 6e-56 | 35.93% (398) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_1192c | - | 9e-62 | 38.59% (412) | acetyl-CoA acetyltransferase |
| M. marinum M | MMAR_4788 | - | 1e-106 | 52.30% (392) | beta-ketoacyl CoA thiolase |
| M. smegmatis MC2 155 | MSMEG_2224 | - | 1e-117 | 56.63% (392) | acetyl-CoA C-acyltransferase |
| M. thermoresistible (build 8) | TH_0166 | fadA6 | 3e-52 | 36.09% (399) | PROBABLE ACETYL-CoA ACETYLTRANSFERASE FADA6 |
| M. ulcerans Agy99 | MUL_0357 | - | 1e-106 | 52.30% (392) | beta-ketoacyl CoA thiolase |
| M. vanbaalenii PYR-1 | Mvan_1988 | - | 1e-115 | 56.04% (389) | acetyl-CoA acetyltransferases |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01158|M.leprae_Br4923 ----------------MTTSVIVTGARTPIGKLM-GSLKDFSASDLGAIT
TH_0166|M.thermoresistible__bu --------------MAMTEAYIVDAVRTPVGKRN-GGLSGAHPADMAAHV
Mb1103c|M.bovis_AF2122/97 ----------------MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQM
Rv1074c|M.tuberculosis_H37Rv ----------------MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQM
MAB_1192c|M.abscessus_ATCC_199 ----------------MPEAVIVSTARSPIGRAGKGSLVSMRPDDLAAQM
Mflv_4356|M.gilvum_PYR-GCK ----------------MSTPVIVGAARTAIGRSFKGTLVNTPPETLITTV
Mvan_1988|M.vanbaalenii_PYR-1 ----------------MPTPVIVGAARTAIGRSFKGTLVNTPPETLITTV
MSMEG_2224|M.smegmatis_MC2_155 -------------MKIMPKPVIVGAARTAIGRSFKGTLVNTPPETLITTV
MAV_1863|M.avium_104 ------------MATTKSRAAIVAAARTPIGTARKGTLANVPAVELAKPV
MMAR_4788|M.marinum_M ----------------MPEAVIVAALRTPIGTARKGTLRDTNAFDLAHHV
MUL_0357|M.ulcerans_Agy99 MCGRLLASAPPKWRKPVPEAVIVAALRTPIGTARKGTLRDTNAFDLAHHV
. . ** *:.:* * * . . :
MLBr_01158|M.leprae_Br4923 IAAALKKA-NVAPSIVQYVIIGQVLTAG--AGQMPARQAAVAAGIGWDVP
TH_0166|M.thermoresistible__bu IKTLVGRH-DFDPAAIDDVIFGCLDNIGSQAGDI-ARTAALAAGLPESVP
Mb1103c|M.bovis_AF2122/97 VRAALDKVPALNPHQIDDLMMGCGLPGG-ESGFNIARVVAVALGYDF-LP
Rv1074c|M.tuberculosis_H37Rv VRAALDKVPALNPHQIDDLMMGCGLPGG-ESGFNIARVVAVALGYDF-LP
MAB_1192c|M.abscessus_ATCC_199 VRAALDKVPALDPKDVDDLMLGCGQPGG-EAGFNIGRAVAVQLGYDF-LP
Mflv_4356|M.gilvum_PYR-GCK LPEVIRRS-GVDPADIDDIIFAESHYGG----GDLARYAADAIGLQH-VP
Mvan_1988|M.vanbaalenii_PYR-1 LPEVVRRS-GVDPADIDDIIFAESHYGG----GDLARYAADAVGLQH-VP
MSMEG_2224|M.smegmatis_MC2_155 LPEIVRRS-GVDPADIDDIIFAESHYGG----GDLARYAADATGLQH-VP
MAV_1863|M.avium_104 VTAVVERS-GLDAAEFDDFVLAESMQGG----GDSARYIAVALGLTD-VA
MMAR_4788|M.marinum_M VSEAT--A-DLDPGQIDDVILGEGLYGG----GVIARHAAITAGLGH-VP
MUL_0357|M.ulcerans_Agy99 VSEAT--A-DLDPGQIDDVILGEGLYGG----GVIARHAAITAGLGH-VP
: . . .: .::. * .* * * :.
MLBr_01158|M.leprae_Br4923 ALTINKMCLSGLDAIALADQLIRAGEFDVVVAGGQESMTKAPHLLMDSR-
TH_0166|M.thermoresistible__bu GVTIDRQCGSAQQAVHFAAQGVMSGTVDLIVAGGVQKMSQFP-ILSAFA-
Mb1103c|M.bovis_AF2122/97 GTTVNRYCSSSLQTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWP
Rv1074c|M.tuberculosis_H37Rv GTTVNRYCSSSLQTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWP
MAB_1192c|M.abscessus_ATCC_199 GTTVNRYCSSSLQTTRMAFHAIKAGEGHAFISAGVETVSRFPKGTSDGWP
Mflv_4356|M.gilvum_PYR-GCK GQSVNRHCAGSLTAIGNAAAQIGSGMERVMIAGGVQSLSMTPLVNWRIPG
Mvan_1988|M.vanbaalenii_PYR-1 GQSVNRHCAGSLTAIGNASAQIGSGMERVLIAGGVQSLSMTPLVNWRIPG
MSMEG_2224|M.smegmatis_MC2_155 GQSVNRHCAGSLTAIGNAAAQIGSGMERVLIAGGVQSLSMTPLVNWRIPG
MAV_1863|M.avium_104 GLAVNRQCASSLSAIAVGAGQIAAGMSRAILAGGMESLSTAPIMQKRKPF
MMAR_4788|M.marinum_M GLAQNRHCAAGQAAVQGAAASVRAGMDQLIIAGGVNSASTSPRPRMQIDG
MUL_0357|M.ulcerans_Agy99 GLAQNRHCAAGQAAVQGAAASVRAGMDQLIIAGGVNSASTSPRPRMQIDG
. : :: * .. : . : :* .::.* :. : .
MLBr_01158|M.leprae_Br4923 --SGYKYGDV---TIVDHLAYDGLHDVFTNQP-----MGALT--EQRNDV
TH_0166|M.thermoresistible__bu --AGEPYG-----ATDPWTGCEGWQARYGDQE-----ISQFRGAEMIAEH
Mb1103c|M.bovis_AF2122/97 DTKNPLFDGAQERSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVAIM
Rv1074c|M.tuberculosis_H37Rv DTKNPLFDGAQERSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVAIM
MAB_1192c|M.abscessus_ATCC_199 DSHNPLYADAEARTATAAQGATEWHDPRNDGLTPDVYIAMGQTAENVALH
Mflv_4356|M.gilvum_PYR-GCK PELKFEE------RWMPPTHVETPDAPTKDMS--------ITVGWNTAQA
Mvan_1988|M.vanbaalenii_PYR-1 PELKFEE------RWMPPTHVETPDAPTKDMS--------ITVGWNTAQA
MSMEG_2224|M.smegmatis_MC2_155 PELKFEE------RWMPPTHVETPDAPTKDMS--------ITVGWNTAQA
MAV_1863|M.avium_104 TSGKSPEDYV---QWFPESHPPTAEAPAMDMS--------ITVAHNCNLQ
MMAR_4788|M.marinum_M ---EWVD-------WFPPTHPDRPDAPNMDMS--------ITVGWNAAVA
MUL_0357|M.ulcerans_Agy99 ---EWVD-------WFPPTHPDRPDAPNMDMS--------ITVGWNAAVA
. :
MLBr_01158|M.leprae_Br4923 EKFTRQEQDEFAARSHQKAAAAWKDGVFADEVVPVSIPQSKGDSLQFTED
TH_0166|M.thermoresistible__bu WKLSREDNEKFALESHRRAVAAIEAGYFDKEITPY---------ADATVD
Mb1103c|M.bovis_AF2122/97 TGISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLP----DGTTVSTD
Rv1074c|M.tuberculosis_H37Rv TGISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLP----DGTTVSTD
MAB_1192c|M.abscessus_ATCC_199 TGISREDQDHWGVRSQNRAEKAIADGFFEREITPVTLA----DGTVVAKD
Mflv_4356|M.gilvum_PYR-GCK AGITREDMDAWAARSHQRAVAAQDDGKFLDEIVPLKVEQFDGSVIDFSVD
Mvan_1988|M.vanbaalenii_PYR-1 AGITREEMDVWAVRSHQRAVAAIDAGKFVDEIVPLKVTQFDGSVIDFSVD
MSMEG_2224|M.smegmatis_MC2_155 AGISREEMDAWAARSHQRAIAAIDAGKFLDEIVPLKVTQFDGSVIDFSVD
MAV_1863|M.avium_104 YGISREDQDEWALRSHQRAIKAIDAGSFADEIIPIQVPQADGSTITFAED
MMAR_4788|M.marinum_M AGVSRAEMDAWALRSHRNAIAAIDEGRFKEEIVPIPTPHG-----LFCVD
MUL_0357|M.ulcerans_Agy99 AGVSRAEMDAWALRSHRNAIAAIDEGRFKEEIVPIPTPHG-----LFCVD
.:* : : :. .*:..* * * * *: * *
MLBr_01158|M.leprae_Br4923 EGIRANTSAESLAGLKPAFRCGG--TITPGSASQISDGAATVVVMNKEKA
TH_0166|M.thermoresistible__bu EGPRPDTSLEKMASL-PTLIEGG--VLTAAVASQISDGAAALLVASKDAV
Mb1103c|M.bovis_AF2122/97 DGPRPGTTYEKVSELKPAFRPNG--TVTAGNACPLNDGAAAVVITSDTKA
Rv1074c|M.tuberculosis_H37Rv DGPRPGTTYEKVSELKPAFRPNG--TVTAGNACPLNDGAAAVVITSDTKA
MAB_1192c|M.abscessus_ATCC_199 DGPRAGTTYEAISQLKPVFRPNG--TITAGNACPLNDGAAALVVMSDVRA
Mflv_4356|M.gilvum_PYR-GCK EQPRRDTSVEKLAGLKVLHPEIEGFSITAGNASGTNDAAAGVALVEADYA
Mvan_1988|M.vanbaalenii_PYR-1 ESPRRDTTLEKLAGLKVLHPEIEGFSITAGNASGTNDAAAGVALVDADYA
MSMEG_2224|M.smegmatis_MC2_155 EHPRRDTTVEKLAGLKVLHPEIEGFSITAGNSSGTNDAAAGVAVVDSEYA
MAV_1863|M.avium_104 EHPRRGSSMESLAGLKVLHPEIEGFTVTAGNSSGINDAAAVVALASPDTA
MMAR_4788|M.marinum_M EHPRRDTTMEKLAALKPLHPEIDGFSITAGNACGANDGAAVLTIASDRMA
MUL_0357|M.ulcerans_Agy99 EHPRRDTTMEKLAALKPLHPEIDGFSITAGNACGANDGAAVLTIASDRMA
: * .:: * :: * :*.. :. .*.** : : . .
MLBr_01158|M.leprae_Br4923 QQLGLTWLVEIGAHGVVAGPDSTLQSQPANAIKKAVDREGISVEQLDVVE
TH_0166|M.thermoresistible__bu DRFNLTPRARIHHMSVRGADPVMMLTAPIPATQHALKRAGMSIDDIDAVE
Mb1103c|M.bovis_AF2122/97 KELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDIDLVE
Rv1074c|M.tuberculosis_H37Rv KELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDIDLVE
MAB_1192c|M.abscessus_ATCC_199 KELGLTPLARIVSTGVSGLSPEIMGLGPIEAVKRALANAGKSIGDIDLFE
Mflv_4356|M.gilvum_PYR-GCK AANGLTVMAKVRSWGAVGVAPRDTGLGGVKVIGRVLDKAGLKPSDVTLWE
Mvan_1988|M.vanbaalenii_PYR-1 AANGLNVMAKVKAWGAVGVAPRDTGLGGVKVIGRVLDRAGLKPSDVALWE
MSMEG_2224|M.smegmatis_MC2_155 AANGLNVMATVRAWGAVGVPPRDTGLGGVRVIGKVLDRAGLKPSDVALWE
MAV_1863|M.avium_104 AET----LAHVLSWTQVGLDPTRTGSGPIKAIPKALELAGRKLEDVALFE
MMAR_4788|M.marinum_M QGLGMPALARVLSWASVGVDPAATGLAPVEAIPKALARGHLSISDVDLFE
MUL_0357|M.ulcerans_Agy99 QGLGMPALARVLSWASVGVDPAATGLAPVEAIPKALARGHLSISDVDLFE
. : . . :.: :: *
MLBr_01158|M.leprae_Br4923 INEAFAAVALASARELGIAPELVNVNGGAIAVGHPLGMSGARITLHVALE
TH_0166|M.thermoresistible__bu INEAFAPVVLAWLAELGADPARVNPNGGAIALGHPIGCTGARLMTSLLHH
Mb1103c|M.bovis_AF2122/97 INEAFAVQVLGSARELGIDEDKLNISGGAIALGHPFGMTGARITTTLLNN
Rv1074c|M.tuberculosis_H37Rv INEAFAVQVLGSARELGIDEDKLNISGGAIALGHPFGMTGARITTTLLNN
MAB_1192c|M.abscessus_ATCC_199 INEAFAVQVLGSARALGIDEDKLNVSGGAIALGHPFGMTGARITATLLNN
Mflv_4356|M.gilvum_PYR-GCK INEAFASVPIAAVREYGIDEELVNFSGSGCSLGHPIAASGARMITTLIYE
Mvan_1988|M.vanbaalenii_PYR-1 INEAFASVPIAACKEYGIDEELVNFSGSGCSLGHPIAASGARMITTLIYE
MSMEG_2224|M.smegmatis_MC2_155 INEAFASVPIAACKEYGLDEELVNFNGSGCSLGHPIAASGARMVTTLVYE
MAV_1863|M.avium_104 INEAFAAQAVACARELRLDEEIVNVYGSGISLGHPIAATGARMVTSAIYE
MMAR_4788|M.marinum_M INEAFASMCVATVKLLELDADRVNVSGSGCSLGHPVAATGARMLVTLVHE
MUL_0357|M.ulcerans_Agy99 INEAFASMCVATVKLLELDADRVNVSGSGCSLGHPVAATGARMLVTLVHE
****** :. :* *.. ::***.. :***: .
MLBr_01158|M.leprae_Br4923 LARRGSGYGVAALCGAGGQGDALILRAV--
TH_0166|M.thermoresistible__bu LERTGGRYGLQTMCEGGGQANVTIIERL--
Mb1103c|M.bovis_AF2122/97 LQTYDKTFGLETMCVGGGQGMAMVIERLA-
Rv1074c|M.tuberculosis_H37Rv LQTYDKTFGLETMCVGGGQGMAMVIERLA-
MAB_1192c|M.abscessus_ATCC_199 LTTYDKTFGVETMCVGGGQGMAMVIERLA-
Mflv_4356|M.gilvum_PYR-GCK LQRRGGGIGVAAMCAGGGQGGGVVIEV---
Mvan_1988|M.vanbaalenii_PYR-1 LQRRGGGIGVAAMCAGGGQGGGVVIEV---
MSMEG_2224|M.smegmatis_MC2_155 LQRRGGGIGVAAMCAGGGQGGAVVIEV---
MAV_1863|M.avium_104 LRRRGGGIGVLSMCAGGGMGAAMVIEVA--
MMAR_4788|M.marinum_M LRRRGGGIGLAAMCAGGGMGSATVIEVAAP
MUL_0357|M.ulcerans_Agy99 LRRRGGGIGLAAMCAGGGMGSATVIEVAAP
* . *: ::* .** . ::.