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ARTDNDTWDINESVGATALGVAGGRAAETRSADPLISDPYAKLFLEAAGDGIWRVYLDDELPAELVGADP QFEDRMQAMLGYTACRTKFFDDYFLAAAGEGIRQIVILAAGLDSRAWRLAWPAGCVVYEIDQPKVLEFKI GTLKSHAVDPIASHVSVGIDLRLDWPKALAQAGFDASAPTAWSAEGLLPYLTADAQGLLFDRIQSLSAPG SRVAVEAFTNEFFSPESFARREEQTERYRQAAIRLGGKDITESGNLLYEEERTEVVDWLQAHGWTVTAAT SAEDLMAASNRAVPAGLDAAVPESVFVEGRLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2576 | - | - | 100% (313) | methyltransferase |
| M. avium 104 | MAV_0301 | - | 2e-94 | 54.31% (313) | methyltransferase, putative, family protein |
| M. avium 104 | MAV_4557 | - | 7e-94 | 54.63% (313) | methyltransferase, putative, family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3793c | - | 2e-88 | 52.75% (309) | hypothetical protein Mb3793c |
| M. gilvum PYR-GCK | Mflv_0743 | - | 4e-75 | 51.77% (311) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv3767c | - | 2e-88 | 52.75% (309) | hypothetical protein Rv3767c |
| M. leprae Br4923 | MLBr_02640 | - | 1e-68 | 50.35% (286) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_3886c | - | 1e-90 | 54.69% (309) | hypothetical protein MAB_3886c |
| M. marinum M | MMAR_0955 | - | 5e-90 | 53.72% (309) | hypothetical protein MMAR_0955 |
| M. smegmatis MC2 155 | MSMEG_0095 | - | 7e-76 | 50.53% (285) | methyltransferase |
| M. thermoresistible (build 8) | TH_4502 | - | 9e-77 | 51.49% (303) | PUTATIVE methyltransferase |
| M. ulcerans Agy99 | MUL_0706 | - | 3e-89 | 53.40% (309) | hypothetical protein MUL_0706 |
| M. vanbaalenii PYR-1 | Mvan_0104 | - | 2e-75 | 53.31% (287) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3793c|M.bovis_AF2122/97 --MPRTDNDSWAITESVGATALGVAAARAAETESDNPLINDPFARIFVDA
Rv3767c|M.tuberculosis_H37Rv --MPRTDNDSWAITESVGATALGVAAARAAETESDNPLINDPFARIFVDA
MMAR_0955|M.marinum_M --MARTEDDSWEITESVGATALGVASARAAETRSQHPLISDPFAQVFLDA
MUL_0706|M.ulcerans_Agy99 --MARTEDDSWEITESVGATALGVASARAAETRSQHPLISDPFAQVFLDA
MAB_3886c|M.abscessus_ATCC_199 --MARRDGDSWEITESVGTTALGVASARDAETRSPNPLISDPYAGHFLAA
MAV_2576|M.avium_104 --MARTDNDTWDINESVGATALGVAGGRAAETRSADPLISDPYAKLFLEA
Mflv_0743|M.gilvum_PYR-GCK MSSLRTDDDTWDIASSVGATAVMVAAARAAETERHDALINDPYAKVLVEG
Mvan_0104|M.vanbaalenii_PYR-1 MSSLRTDNDTWDIASSVGATAVMVAAARAAETERPEPLIDDPYAKILVAG
MSMEG_0095|M.smegmatis_MC2_155 MSSLRTDDDTWDIATSVGSTAVMVAAARAGETERDDALIRDPYAKILVAG
TH_4502|M.thermoresistible__bu MSSLRTDDDTWDIATSVGSTAVMVAASRAAETEREDALIRDPYAKVLVAG
MLBr_02640|M.leprae_Br4923 ---MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTN
* ..*:* * ***:**: **..* .** ..** **:* ::
Mb3793c|M.bovis_AF2122/97 AGDG-IWSMYTNR-TLLAGATDLDPDLRAPIQQMIDFMAARTAFFDEYFL
Rv3767c|M.tuberculosis_H37Rv AGDG-IWSMYTNR-TLLAGATDLDPDLRAPIQQMIDFMAARTAFFDEYFL
MMAR_0955|M.marinum_M VGDG-VWNWHSAP-QLPAELLEIEPDLPLQMEAMVSYMASRTAFFDEFFL
MUL_0706|M.ulcerans_Agy99 VGDG-VWNWHSAP-QLPAELLEIEPDLPLQMEAMVSYMASRTAFFDEFFL
MAB_3886c|M.abscessus_ATCC_199 AGDG-AWNAYRFDGEPPAALVEAEPRLVERIDAMRSYVACRTKFFDDFFG
MAV_2576|M.avium_104 AGDG-IWRVYLDD-ELPAELVGADPQFEDRMQAMLGYTACRTKFFDDYFL
Mflv_0743|M.gilvum_PYR-GCK AGAG-AWRFIADE-DLVAKASESDTEVGALFEHMKNYQAVRTHFFDAFFS
Mvan_0104|M.vanbaalenii_PYR-1 AGNG-AWQYIADD-GFVAKVTESDPEIGPLFEHMKNYQAVRTHFFDAFFA
MSMEG_0095|M.smegmatis_MC2_155 AGTG-VWETVLDS-EFAAKIENLDPEAAAIFAHMGNYQAVRTHFFDAYYR
TH_4502|M.thermoresistible__bu AGTG-VWELILDD-DFTAKIEAADPETAAIFDHMGNYQAVRTHFFDTYFA
MLBr_02640|M.leprae_Br4923 TGAGALWEAMLDP-SMVAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFN
.* * * * :. . * .: * ** *** ::
Mb3793c|M.bovis_AF2122/97 ATADAGVRQVVILASGLDSRAWRLPWPDGTVVYELDQPKVLEFKSATLRQ
Rv3767c|M.tuberculosis_H37Rv ATADAGVRQVVILASGLDSRAWRLPWPDGTVVYELDQPKVLEFKSATLRQ
MMAR_0955|M.marinum_M DATRAGIGQAVILAAGLDSRAWRLPWPAGTTVFELDQPRVLEFKAATLAE
MUL_0706|M.ulcerans_Agy99 DATRAGIGQAVILAAGLDSRAWRLPWPAGTTVFELDQPRVLEFKAATLAE
MAB_3886c|M.abscessus_ATCC_199 DASTSGIRQAVILASGLDARAWRLDWPRDAVLFELDLPRVLAFKAETLDK
MAV_2576|M.avium_104 AAAGEGIRQIVILAAGLDSRAWRLAWPAGCVVYEIDQPKVLEFKIGTLKS
Mflv_0743|M.gilvum_PYR-GCK AAVDAGVRQIVILASGLDSRAFRLPWPAGTVVYEIDQPLVLDYKSSTLAA
Mvan_0104|M.vanbaalenii_PYR-1 AAVDAGIRQIVILASGLDSRAFRLPWPAGTTVFEIDQPLVLAYKSSTLAS
MSMEG_0095|M.smegmatis_MC2_155 EAADAGIRQIVILASGLDSRAYRLDWPAGTTVYEIDQPKVLEYKSATLRE
TH_4502|M.thermoresistible__bu RAAEAGIRQVVILASGLDSRAYRLPWPDGTVVYEIDQPKVLEYKSATLAA
MLBr_02640|M.leprae_Br4923 NAVIDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAE
: *: * ****:***:**:** ** . .::*:* * ** :* **
Mb3793c|M.bovis_AF2122/97 HGAQPASQLVNVPIDLRQDWPKALQKAGFDPSKPCAWLAEGLVRYLPARA
Rv3767c|M.tuberculosis_H37Rv HGAQPASQLVNVPIDLRQDWPKALQKAGFDPSKPCAWLAEGLVRYLPARA
MMAR_0955|M.marinum_M HGAEPACGRVAVAVDLRQDWPTALRQAGFDPSVPSVWSAEGLMPYLPAVA
MUL_0706|M.ulcerans_Agy99 HGAEPACGRVAVAVDLRQDWPTALRQAGFDPSVSSVWSAEGLMPYLPAVA
MAB_3886c|M.abscessus_ATCC_199 QGATPRIRHVPVAVDLRDDWPAALRAGGFDVGRPAAWIAEGLLPYLPPAA
MAV_2576|M.avium_104 HAVDPIASHVSVGIDLRLDWPKALAQAGFDASAPTAWSAEGLLPYLTADA
Mflv_0743|M.gilvum_PYR-GCK HGVAPTAERREVPIDLRQDWPAALVATGFDPARPTAWLAEGLLMYLPADA
Mvan_0104|M.vanbaalenii_PYR-1 HGVQPTADRREVPIDLRQDWPTALTHAGFDADQPTAWLAEGLLMYLPADA
MSMEG_0095|M.smegmatis_MC2_155 HGIEPVAQRREVPVDLRFDWPTALHDAGFDASLPTAWLAEGLLMYLPAEA
TH_4502|M.thermoresistible__bu HGVQPAADRREVAVDLRHDWPKALRAKGFDPQQRTAWLAEGLLMYLPADA
MLBr_02640|M.leprae_Br4923 HGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPATA
:. * * :*** *** ** *** .* ****: **.. *
Mb3793c|M.bovis_AF2122/97 QDLLFERIDALSRPGSWLASNVPGAGFLDPERMRRQRADMRRMRAAAAKL
Rv3767c|M.tuberculosis_H37Rv QDLLFERIDALSRPGSWLASNVPGAGFLDPERMRRQRADMRRMRAAAAKL
MMAR_0955|M.marinum_M QDLLFERVQGLTVRASRIAVEALGPKFLDPQVRANRSARMERIRAVMAHV
MUL_0706|M.ulcerans_Agy99 QDLLFERVQGLTVRASRIAVEALGPKFLDPQVRANRSARIERIRAVMAHV
MAB_3886c|M.abscessus_ATCC_199 QDLLFERIDTLSAPGSRIAVENFGEDFFNPETLARQRERGQAFRRVAEEM
MAV_2576|M.avium_104 QGLLFDRIQSLSAPGSRVAVEAFTNEFFSPESFARREEQTERYRQAAIRL
Mflv_0743|M.gilvum_PYR-GCK QDRLFAQITELSAPGSQVAAESMGVHAPD-----RRERMRERFASIASQI
Mvan_0104|M.vanbaalenii_PYR-1 QDRLFAQITELSAPGSRVAAESMGIHAQD-----RRERMRERFASITAQF
MSMEG_0095|M.smegmatis_MC2_155 QDRLFELVTELSAPGSRIAVETAGVAATD-----RREAMRERFKKFADQL
TH_4502|M.thermoresistible__bu QDRLFENITALSAPGSRLAVETAAEEPVD-----RREQMRARMERIASQF
MLBr_02640|M.leprae_Br4923 QDGLFTEIGGLSAVGSRIAVETSPLHGDE-----WREQMQLRFRRVSDAL
*. ** : *: .* :* : . : .
Mb3793c|M.bovis_AF2122/97 VET-EISDVDDLWYAEQRTAVAEWLRERGWDVSTATLPE-LLARYGRS--
Rv3767c|M.tuberculosis_H37Rv VET-EISDVDDLWYAEQRTAVAEWLRERGWDVSTATLPE-LLARYGRS--
MMAR_0955|M.marinum_M EPQREIPRTDELWYFEEREDVGDWFRRHDWDVTVTPSGE-LMAGYGRA--
MUL_0706|M.ulcerans_Agy99 EPQREIPRTDELWYFEEREDVGDWFRRHDWDVTVTPSGE-LMAGYGRA--
MAB_3886c|M.abscessus_ATCC_199 QGQ-DIPDVADLWYLEERTDAGEFLAGRGWRVTSETAVA-LLGRHGRD--
MAV_2576|M.avium_104 GGK-DITESGNLLYEEERTEVVDWLQAHGWTVTAATSAEDLMAASNRA--
Mflv_0743|M.gilvum_PYR-GCK DIEP-MDITELTYEDPDRAEVAEWLAAHGWTAQAVPSQD-AMRRLDRY--
Mvan_0104|M.vanbaalenii_PYR-1 DVEP-MDITELTYEDPDRADVAQWLTAHGWRAEAVPSQD-EMRRLHRL--
MSMEG_0095|M.smegmatis_MC2_155 NLSSALDIQELVYDDPDRADVAEWLDAHGWRARGVHALD-EMRRLDRL--
TH_4502|M.thermoresistible__bu GLEKALDVAQLMYDDPDRADVPEWLTGHGWRTEWVSAPD-EMRRLDRF--
MLBr_02640|M.leprae_Br4923 GFEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPD-EMRRVGRWGD
: :* . ::: :.* . : *
Mb3793c|M.bovis_AF2122/97 -IPHSGED----------SIPPNLFVSAQRATS
Rv3767c|M.tuberculosis_H37Rv -IPHSGED----------SIPPNLFVSAQRATS
MMAR_0955|M.marinum_M -AAAQVED----------RVPTNLFVAAQRK--
MUL_0706|M.ulcerans_Agy99 -AAAQVED----------RVPTNLFVAAQRN--
MAB_3886c|M.abscessus_ATCC_199 -IPADLPD----------ATPNSAFLFAQKAD-
MAV_2576|M.avium_104 -VPAGLDA----------AVPESVFVEGRLR--
Mflv_0743|M.gilvum_PYR-GCK -VEVADSD----------GQSFSTFTTGTKL--
Mvan_0104|M.vanbaalenii_PYR-1 -VEIADGD----------DQSFSTFTTAVKR--
MSMEG_0095|M.smegmatis_MC2_155 -VELPDDP---------DRAAFSTFVTAQRL--
TH_4502|M.thermoresistible__bu -VAAAMPPGDDADAADLDDTAFSKFVTAERPS-
MLBr_02640|M.leprae_Br4923 GVPMADDK-----------DAFAEFVTAHRL--
. * .