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RNAPAPDESWQMVEEAVFRLFEELAGKNAGEHLAIGGRLAELGWSEIEAEYPVQAGELLFRAQGRSLALT DCLDRIVLAELAAVLDGPADHVLLPDLSTGCVAGSDADRVSGIVLGPLEGRIVVPVSGSTGTVSVGVVDA ARLDGQRLDTFDVSAHWTRASGSLDVPLIEASTEWKQAVTAAHRALATELVELAERALRIAVEHVSVRVQ FGAPIGSFQSPRHALADASAVLAGARALLGESWRDGGELLALAAKAAAGRAHRAVSDVALQVCGAIGLTA EHDLHRYVTRGFQVDALCGSHDQLEGLLAERLFEDSDEGWATGRALPAVVTWADETAE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2562 | - | - | 100% (339) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1823 | - | e-123 | 68.40% (326) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1631 | - | 2e-20 | 30.82% (305) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3594 | fadE33 | 6e-20 | 31.27% (291) | acyl-CoA dehydrogenase FADE33 |
| M. gilvum PYR-GCK | Mflv_2434 | - | 3e-18 | 28.06% (310) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3564 | fadE33 | 7e-20 | 31.27% (291) | acyl-CoA dehydrogenase FADE33 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 9e-06 | 25.17% (151) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0593c | - | 2e-17 | 33.63% (226) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_5053 | fadE33 | 1e-19 | 32.64% (239) | acyl-CoA dehydrogenase FadE33 |
| M. smegmatis MC2 155 | MSMEG_4845 | - | 1e-22 | 28.96% (297) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4138 | - | 1e-114 | 64.81% (324) | PUTATIVE putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4129 | fadE33 | 9e-20 | 32.64% (239) | acyl-CoA dehydrogenase FadE33 |
| M. vanbaalenii PYR-1 | Mvan_4218 | - | 2e-21 | 29.93% (304) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5053|M.marinum_M --------------MT----EEREMLRETVAALVNKHASPAAVRSAMESE
MUL_4129|M.ulcerans_Agy99 --------------MT----EEREMLRETVAALVNKHASPAAVRSAMESE
Mb3594|M.bovis_AF2122/97 --------------MTPP--EERQMLRETVASLVAKHAGPAAVRAAMASD
Rv3564|M.tuberculosis_H37Rv --------------MTPP--EERQMLRETVASLVAKHAGPAAVRAAMASD
MAB_0593c|M.abscessus_ATCC_199 --------------MSPSGNTERQMLRDTVRSLVTKRADSAAVRTAFESE
MAV_2562|M.avium_104 ------------MRNAPAPDESWQMVEEAVFRLFEELAGKNAGEHLAIGG
TH_4138|M.thermoresistible__bu -------------MTASQVDESWPMVEEAVFRLFDEIAAK--QDHVAIDP
Mflv_2434|M.gilvum_PYR-GCK -------MTVAIKDDAAMDEASLGMLEASLRKTMSSASGP------KLDA
Mvan_4218|M.vanbaalenii_PYR-1 -------------MAPGMDEASLDMLEASLRKTMLSSSGP------ELDA
MSMEG_4845|M.smegmatis_MC2_155 -----------------MDAESLGLLEETLRKTMLSASGA------KLDA
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
:. . :
MMAR_5053|M.marinum_M RGYDETLWRLLCEQV----------GAAALVIPEELGGAGGELADAAIVL
MUL_4129|M.ulcerans_Agy99 RGYDETLWRLLCEQV----------GAAALVIPEELGGAGGELADAAIVL
Mb3594|M.bovis_AF2122/97 RGYDESLWRLLCEQV----------GAAALVIPEELGGAGGELADAAIVV
Rv3564|M.tuberculosis_H37Rv RGYDESLWRLLCEQV----------GAAALVIPEELGGAGGELADAAIVV
MAB_0593c|M.abscessus_ATCC_199 RGYDENLWAVLCEQV----------GAAALLIPEESGGAGGELADAAVVV
MAV_2562|M.avium_104 RLAELGWSEIEAEYP----------VQAGELLFRAQGRSLALTDCLDRIV
TH_4138|M.thermoresistible__bu LLSELGWADIESEYP----------VEACALLFRAQGRSLALTDALDRVM
Mflv_2434|M.gilvum_PYR-GCK ALTELGWADMLTEAP----------ELAIPLYFRLLGETGSHASILVDVV
Mvan_4218|M.vanbaalenii_PYR-1 ALTEMGWADMLSEVP----------ELAVPLVFRLLGETGSHASVLVDVV
MSMEG_4845|M.smegmatis_MC2_155 ALAELGWAEMLSDMP----------EVAMPLVFRLLGETGSHASVLNDVL
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
. * : . . . :
MMAR_5053|M.marinum_M QELGRALVP---SPLLGTTLAELALLAAAEPDAKTLAGLAEGSSIGALVL
MUL_4129|M.ulcerans_Agy99 QELGRALVP---SPLLGTTLAELALLAAAEPDAKTLAGLAEGSSIGALVL
Mb3594|M.bovis_AF2122/97 QELGRALVP---SPLLGTTLAELALLAAAKPDAQALTELAQGSAIGALVL
Rv3564|M.tuberculosis_H37Rv QELGRALVP---SPLLGTTLAELALLAAAKPDAQALTELAQGSAIGALVL
MAB_0593c|M.abscessus_ATCC_199 EELGRGLVP---SPLMGTLWAELALLEAGY-EGELLEALAAGESIGAVAF
MAV_2562|M.avium_104 LAELAAVLD---GPADHVLLPDLSTGCVAGSDADRVSGIVLGPLEGRIVV
TH_4138|M.thermoresistible__bu IAEMASLVE---EPVDCVVLPALAQASVPSSNEGQVKGIVLGPLRGRVLV
Mflv_2434|M.gilvum_PYR-GCK LHATGNAIG---DTVE-LPLPYAGNAWVVWDRGGASEATGEDRGPESLDP
Mvan_4218|M.vanbaalenii_PYR-1 LHATGNTIG---DTVE-LPLPYAGNGWVVWDRGGASEATGDDRSPESLDP
MSMEG_4845|M.smegmatis_MC2_155 LETIGGLPG---GTP---PMPYAGGGWVVWERRDSTDS------ADSANP
MLBr_00737|M.leprae_Br4923 KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
. . .
MMAR_5053|M.marinum_M DPD------------YVLNGDTADVVVASTEGQLSRWTRFSAHRVATMDP
MUL_4129|M.ulcerans_Agy99 DPD------------YVLNGDTADVVVASTEGQLSRWTRFSAHRVATMDP
Mb3594|M.bovis_AF2122/97 DPD------------YVVNGDIADIVVAATSGQLTRWTRFSAQPVATMDP
Rv3564|M.tuberculosis_H37Rv DPD------------YVVNGDIADIVVAATSGQLTRWTRFSAQPVATMDP
MAB_0593c|M.abscessus_ATCC_199 DPG------------YVVNGDIADVVLTVQGETVCRAGQVTALALSTLDP
MAV_2562|M.avium_104 P----------------VSGSTGTVSVGVVDAARLDGQRLDTFDVSAHW-
TH_4138|M.thermoresistible__bu P----------------VSGAMGTVSATVVDADQLRATRLNTFDSSVVW-
Mflv_2434|M.gilvum_PYR-GCK T----------------LGG------------------------------
Mvan_4218|M.vanbaalenii_PYR-1 T----------------LGG------------------------------
MSMEG_4845|M.smegmatis_MC2_155 T----------------LGG------------------------------
MLBr_00737|M.leprae_Br4923 KADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHKDDE
.*
MMAR_5053|M.marinum_M TRRLAQLRAEETAFLG--------------------------EDPGLADA
MUL_4129|M.ulcerans_Agy99 TRRLAQLRAEETAFLG--------------------------ENPGLADA
Mb3594|M.bovis_AF2122/97 TRRLARLQSEETEPLC--------------------------PDPGIADT
Rv3564|M.tuberculosis_H37Rv TRRLARLQSEETEPLC--------------------------PDPGIADT
MAB_0593c|M.abscessus_ATCC_199 TRRLASIAVGAAEPVG--------------------------TAPGLIDK
MAV_2562|M.avium_104 TRASGSLDVPLIEAST--------------------------EWKQAVTA
TH_4138|M.thermoresistible__bu TRVEGATDGELVDAST--------------------------EWARAVAA
Mflv_2434|M.gilvum_PYR-GCK --------LPLRREEE--------------------------GYPIRVAE
Mvan_4218|M.vanbaalenii_PYR-1 --------LPLRREEE--------------------------GYPIRLAE
MSMEG_4845|M.smegmatis_MC2_155 --------LPLRKVPD--------------------------GQLLRISE
MLBr_00737|M.leprae_Br4923 GFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATLDH
MMAR_5053|M.marinum_M AAILLAAEQIGAAERCLELTVEYAKSRVQFGRPIGSFQALKHRMADLYVE
MUL_4129|M.ulcerans_Agy99 AGILLAAEQIGAAERCLELTVEYAKSRVQFGRPIGSFQALKHRMADLYVE
Mb3594|M.bovis_AF2122/97 AAILLAAEQIGAAERCLQLTVEYAKSRVQFGRPIGSFQALKHRMADLYVT
Rv3564|M.tuberculosis_H37Rv AAILLAAEQIGAAERCLQLTVEYAKSRVQFGRPIGSFQALKHRMADLYVT
MAB_0593c|M.abscessus_ATCC_199 AGLLLAAEQVGAAARALDLTVEYTKTRVQFGRAIGSFQALKHRMADLYVL
MAV_2562|M.avium_104 AHRALATELVELAERALRIAVEHVSVRVQFGAPIGSFQSPRHALADASAV
TH_4138|M.thermoresistible__bu AHRALATELIALADRALQIAVEHVSVRVQFGSPIGSLQSPRHLLAAAAAK
Mflv_2434|M.gilvum_PYR-GCK ARVAVGWWLVGSARAMLALARQHALDRVQFGKPIAGFQAVRHRLAETLVA
Mvan_4218|M.vanbaalenii_PYR-1 ARVAVGWWLVGSARAMLSLARQHALDRVQFGKPIASFQAVRHRLAETLVA
MSMEG_4845|M.smegmatis_MC2_155 ARRALGWWLVGSARAMLALARQHAMDRVQFGAPIATFQAVRHRLAETLVA
MLBr_00737|M.leprae_Br4923 TRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMK
: :. : * * : :. * *** .*. :*: :. :*
MMAR_5053|M.marinum_M VAAARAVVTEACTAPTP------TSAATARLAACEALCAVAAEGIQLHGG
MUL_4129|M.ulcerans_Agy99 VAAARAVVTEACTAPTP------TSAATARLAACEALCAVAAEGIQLHGG
Mb3594|M.bovis_AF2122/97 IAAARAVVADACHAPTP------TNAATARLAASEALSTAAAEGIQLHGG
Rv3564|M.tuberculosis_H37Rv IAAARAVVADACHAPTP------TNAATARLAASEALSTAAAEGIQLHGG
MAB_0593c|M.abscessus_ATCC_199 VESARATVYQAIHDLTP------EGATVARIKASEALSAVSGDSIQLHGG
MAV_2562|M.avium_104 LAGARALLGESWRDGGE------LLALAAKAAAGRAHRAVSDVALQVCGA
TH_4138|M.thermoresistible__bu LEGARALLDDSWHYGGV------LSAQVAKVSAGRAHRAVSDAVLQVCGA
Mflv_2434|M.gilvum_PYR-GCK IEGAEATLSLPSADNPD------LSSLLAKAAAGKAALTAAKNCQQVLGG
Mvan_4218|M.vanbaalenii_PYR-1 IEGAEATLSLPGADNPD------LTALLAKAAAGKAALTAAMHCQQVLGG
MSMEG_4845|M.smegmatis_MC2_155 IEGAEATLSQPNADNVD------LTSLLAKAAAGKAALTAARHCQQVLGG
MLBr_00737|M.leprae_Br4923 VEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTDAVQLFGG
: .*. : . : :: * .: *: *.
MMAR_5053|M.marinum_M IAITWEHDMHLYFKRAHGSTHLLASPPELLRRLESEALGAG---------
MUL_4129|M.ulcerans_Agy99 IAITWEHDMHLYFKRAHGSTHLLASPPELLRRLESEALGAG---------
Mb3594|M.bovis_AF2122/97 IAITWEHDMHLYFKRAHGSAQLLESPREVLRRLESEVWES----------
Rv3564|M.tuberculosis_H37Rv IAITWEHDMHLYFKRAHGSAQLLESPREVLRRLESEVWES----------
MAB_0593c|M.abscessus_ATCC_199 IAITWEHDAHLYFKRAHGSALLLGTPRQLLPNLETAAGL-----------
MAV_2562|M.avium_104 IGLTAEHDLHRYVTRGFQVDALCGSHDQLEGLLAERLFEDSDEGWATGRA
TH_4138|M.thermoresistible__bu VGLTAEHDLHRYVRRGMQIDSLCGSYRQLESLLADRLS----AIYAPGRA
Mflv_2434|M.gilvum_PYR-GCK IGFTEEHGLQHHVKRTLVLDGLLGSSRELTRRAGAGLR--------ARGS
Mvan_4218|M.vanbaalenii_PYR-1 IGFTEEHHLHRHVKRALVLDGLLGSSRELTRRAGAGLR--------ARGS
MSMEG_4845|M.smegmatis_MC2_155 IGFTAEHELHTHVERVLVLDGLLGNARELTRKAGSGMR--------ARGT
MLBr_00737|M.leprae_Br4923 AGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR-----------
. * :. . .. .
MMAR_5053|M.marinum_M -PSIP--------
MUL_4129|M.ulcerans_Agy99 -PSIP--------
Mb3594|M.bovis_AF2122/97 -P-----------
Rv3564|M.tuberculosis_H37Rv -P-----------
MAB_0593c|M.abscessus_ATCC_199 -------------
MAV_2562|M.avium_104 LPAVVTWADETAE
TH_4138|M.thermoresistible__bu LPAIINVN-----
Mflv_2434|M.gilvum_PYR-GCK VPRLAQL------
Mvan_4218|M.vanbaalenii_PYR-1 APRLAQL------
MSMEG_4845|M.smegmatis_MC2_155 APRMAQV------
MLBr_00737|M.leprae_Br4923 -------------