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DWGLPWPGPALAAQAETAGAQAFCAGEFADLNAYITATEMALGTSGAYIGPGIAYAFARSPFVHAAAVRH LWTLAPGRVFLGLGSGTSRMNKDWFGVDAAHPAPRMAELIEAIRAFLNAENGERVRYEGRFYTIDADIRA PVLGRLDVPILIGAFNKIMLRTVGRTADGVLGHGLFTDRWWTEVVEPELVRGAEASGRDPAELRRWGWLI TAIDNDDPARAIRDARLQIAFYLTVKTYDSLVELHGWTDEVARIRSAFRSGHPETIADHVTDDMLWSIAI CGDDTQAREMLATRKRVPDTAFASPPSFLVGRRRRSGYGAAATRVLSQLH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2543 | - | - | 100% (331) | 5,10-methylenetetrahydromethanopterin reductase |
| M. avium 104 | MAV_2121 | - | 9e-23 | 29.85% (268) | hypothetical protein MAV_2121 |
| M. avium 104 | MAV_4719 | - | 7e-21 | 29.73% (296) | hypothetical protein MAV_4719 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1395 | - | 2e-29 | 35.10% (245) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4583 | - | 2e-42 | 35.39% (308) | luciferase family protein |
| M. tuberculosis H37Rv | Rv1360 | - | 2e-29 | 35.10% (245) | oxidoreductase |
| M. leprae Br4923 | MLBr_00348 | - | 2e-11 | 24.34% (304) | putative coenzyme F420-dependent oxidoreductase |
| M. abscessus ATCC 19977 | MAB_2053 | - | 3e-48 | 39.43% (317) | luciferase-like |
| M. marinum M | MMAR_1372 | - | 3e-23 | 28.73% (268) | hypothetical protein MMAR_1372 |
| M. smegmatis MC2 155 | MSMEG_0341 | - | 7e-29 | 30.80% (289) | hypothetical protein MSMEG_0341 |
| M. thermoresistible (build 8) | TH_2923 | - | 1e-137 | 71.92% (317) | PUTATIVE putative N5, N10-methylenetetrahydromethanopterin |
| M. ulcerans Agy99 | MUL_2504 | - | 3e-24 | 29.20% (274) | hypothetical protein MUL_2504 |
| M. vanbaalenii PYR-1 | Mvan_0319 | - | 7e-41 | 34.75% (305) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2543|M.avium_104 ----------MDWGLPWPGP------ALAAQAETAGAQAFCAGEFADLNA
TH_2923|M.thermoresistible__bu ---------------------------VAVEAEAVGASVFCAGEFADISA
Mflv_4583|M.gilvum_PYR-GCK ---------MSTYGLSVLGADLKSLAQTAQAADAAGFDAVWASEFYSRSG
Mvan_0319|M.vanbaalenii_PYR-1 ---------MSTYGLSVLGADLKSLAQTAQAADAAGFDAVWASEFYSRSG
MAB_2053|M.abscessus_ATCC_1997 ---------MSTYGVSVLGADLATLVETAEATDLAGFDAAWASEFYSRSG
Mb1395|M.bovis_AF2122/97 -----MGGARRLKLDGSIPNQLARAADAAVALERNGFDGGWTAEAS-HDP
Rv1360|M.tuberculosis_H37Rv -----MGGARRLKLDGSIPNQLARAADAAVALERNGFDGGWTAEAS-HDP
MSMEG_0341|M.smegmatis_MC2_155 -----MAGAEEAGISG-LLGQAARAQD-------IGFDGIWSTDVD-RDP
MMAR_1372|M.marinum_M ----------MHIDVMTIPQPLAQIGDLARRTQAAGFSGLLFTETG-RTA
MUL_2504|M.ulcerans_Agy99 ----------MHIDVMTIPQPLAQIGDLARRTQAAGLSGLLFTETG-RTA
MLBr_00348|M.leprae_Br4923 MVERANAMKLGLQLGYWAAQPPGNAAELVAAAEGAGFDAVFTGEAWGSDA
* . :
MAV_2543|M.avium_104 YITATEMALGTSGAYIGPGIAYAFARSPFVHAAAVRHLWTLAPGRVFLGL
TH_2923|M.thermoresistible__bu YVTAAEMALSTTSAMVGPGIAYAFARSPFVHASSVRHLSKRAPGRVFLGL
Mflv_4583|M.gilvum_PYR-GCK SISMAAMANSTQNCRIGSSILYGVGRSPLVLATEARDLDELSNRRLVLGI
Mvan_0319|M.vanbaalenii_PYR-1 SISMAAMANSTQNCRIGSSILYGVGRSPLVLATEARDLDELSNGRLVLGI
MAB_2053|M.abscessus_ATCC_1997 SISMAAMAARTKRCRIGSSILYGVGRSPLVLATEARDLDELSGGRVVLGL
Mb1395|M.bovis_AF2122/97 FLPLLLAAEHTSRLELGTNIAVAFARNPMIVANVGWDLQTYSKGRLILGL
Rv1360|M.tuberculosis_H37Rv FLPLLLAAEHTSRLELGTNIAVAFARNPMIVANVGWDLQTYSKGRLILGL
MSMEG_0341|M.smegmatis_MC2_155 FLPLAVAAMTTTNVQLGTGIAVAFARNPMTTAMAANDLQEMSDGRFVLGL
MMAR_1372|M.marinum_M YLNAAIASQAAPGLELSTGVAVAFPRSPFVTAATAWELQEATGGKFRLGL
MUL_2504|M.ulcerans_Agy99 YLNAAIASQAAPGLELSTGVAVAFPRSPFVTAATAWELQEATGGKFRLGL
MLBr_00348|M.leprae_Br4923 YTPLAWWGSSTQRVRLGTSVVQLSARTPTACAMAALTLDHLSGGRHILGL
. : :...: *.* * * : : **:
MAV_2543|M.avium_104 GSGTSRMNKDWFGV-DAAHPAPRMAELIEAIRAFLN-AENGERVRYEGRF
TH_2923|M.thermoresistible__bu GAGTARMNSDWFCV-DSSHPAPRMAELIEVIRLFLH-AENGEKIRYSGDF
Mflv_4583|M.gilvum_PYR-GCK GNGTKRMMSDWHGVPDTSAPALRMEELVMLLRRIWN-LHEG-PIHHEGRF
Mvan_0319|M.vanbaalenii_PYR-1 GNGTKRMMSDWHGVPDTSAPALRMEELVMLLRRIWN-LHEG-PVHHEGRF
MAB_2053|M.abscessus_ATCC_1997 GNGTRRMMSDWHGVEDTSAPALRMEELVPLVRRIWN-LHEG-PVRHEGRF
Mb1395|M.bovis_AF2122/97 GTQIRPHIEKRFSM-PWGHPARRMREFVAALRAIWLAWQDGTKLCFEGEF
Rv1360|M.tuberculosis_H37Rv GTQIRPHIEKRFSM-PWGHPARRMREFVAALRAIWLAWQDGTKLCFEGEF
MSMEG_0341|M.smegmatis_MC2_155 GTQIQAHIERRFSM-PWSAPAERMSEYVNAIRAIWRSWRTGERLDFRGDH
MMAR_1372|M.marinum_M GTQVRTHVVRRYGM-AFERPGPRLRDYVLAVKACFSAFRTGT-LDHHGEF
MUL_2504|M.ulcerans_Agy99 GTQVRTHVVRRYGM-AFERPGPRLRDYVLAVKACFSAFRTGT-LDHHGEF
MLBr_00348|M.leprae_Br4923 GVSGPQVVEGWYGQ-PFPKPLSRTREYIDIVRQVWA---REAPVVSDGQH
* . * * : : :: : * .
MAV_2543|M.avium_104 YTIDADIR--------APVLG---RLDVPILIGAFNKIMLRTVGRTADGV
TH_2923|M.thermoresistible__bu YRVDADIR--------APVFG---RLDVPILIGAFNRIMLRTAGRVADGV
Mflv_4583|M.gilvum_PYR-GCK YRMNLTPT--------GDVGPP--SRPIPIVTAGVRPRMCEAAGRVADGL
Mvan_0319|M.vanbaalenii_PYR-1 YRMNLTPT--------GDMGPS--SRPIPIVTAGVRPRMCEAAGRVADGL
MAB_2053|M.abscessus_ATCC_1997 YRMNLVPT--------GDVAPP--QRAIPIITAGVRPRMCEVAGRVADGL
Mb1395|M.bovis_AF2122/97 YTHKIMTP--------MFTPEPQPYPVPRVFIAAVGEAMTEMCGEVADGH
Rv1360|M.tuberculosis_H37Rv YTHKIMTP--------MFTPEPQPYPVPRVFIAAVGEAMTEMCGEVADGH
MSMEG_0341|M.smegmatis_MC2_155 YQHTLMTP--------MFTPTPHPHGDPKIVISAVGPRMTRVAARDADGL
MMAR_1372|M.marinum_M YDLDFITP--------QWSAGPIDAPDPKVDVAAVNPWMLRMAGEVADGV
MUL_2504|M.ulcerans_Agy99 YDLDLITP--------QWSAGPIDAPDPKVDIAAVNPWMLRMAGEVADGV
MLBr_00348|M.leprae_Br4923 YPLPLTGAGATGLGKALKPITHPLRADIPIMLGAEGPKNVALAAEICDGW
* : .. .. .**
MAV_2543|M.avium_104 LGHGLFTDRWWTEVVEPELVRGAEASG--RDPAELRRWGWLITAIDNDDP
TH_2923|M.thermoresistible__bu LGHGLFTDRWWDEVVGPEITAGATAAG--RRTEDLKRWGWVITAVNDEDP
Mflv_4583|M.gilvum_PYR-GCK AGHPLFTTTYVEEIVRPAIARGAARTG--RDPNDVEIISMVMCAIHD-DA
Mvan_0319|M.vanbaalenii_PYR-1 AGHPLFTTTYVEEIVRPAIARGAAHTG--RDANDVEIISMVMCAIHD-DA
MAB_2053|M.abscessus_ATCC_1997 AGHPLFTTTYVEEVARPAVVRGAERAG--RDPADIEIVSMVICAVHD-DP
Mb1395|M.bovis_AF2122/97 LGHPMVSKRYLTEVSVPALLRGLARSG--RDRSAFEVSCEVMVATGADDA
Rv1360|M.tuberculosis_H37Rv LGHPMVSKRYLTEVSVPALLRGLARSG--RDRSAFEVSCEVMVATGADDA
MSMEG_0341|M.smegmatis_MC2_155 LVHGFTTQRYLSEVTLPIVEEELRKVG--RRRADFTISYPGLIASGSTDE
MMAR_1372|M.marinum_M HIHPLGELGYLTRHVVPNVAKGAAKAG--RSPADIAVIVPVMTIVGDSEE
MUL_2504|M.ulcerans_Agy99 HIHPLGELGYLTRHVVPNVAKGAAKAG--RSPADIAVILPVMTIVGDSDE
MLBr_00348|M.leprae_Br4923 L--PIFFSPRMADMYNEWLDEGFARTGARRSREDFEICASAQIVVTEDRA
: : * * .
MAV_2543|M.avium_104 ARAIR--DARLQIAFYL------TVKTYDSLVELHGWTDEVARIRSAFRS
TH_2923|M.thermoresistible__bu QRAIT--DARLQIAFYL------TVKTYDSLVELHGWQDQVSAIRTAFRS
Mflv_4583|M.gilvum_PYR-GCK EVARR--ELAQQIAFYS------SVKSYETVLDVNGFASEGRTIREAFAK
Mvan_0319|M.vanbaalenii_PYR-1 EVARR--ELAQQIAFYS------SVKSYETVLDVNGFASEGRTIREAFAQ
MAB_2053|M.abscessus_ATCC_1997 QIARR--EAAQQIAFYS------SVKTYEHVLDVSGFARQGAAIRDAFAR
Mb1395|M.bovis_AF2122/97 ELAAACTATRKQIAFYG------STPAYRKVLEQHGWGDLHPELHRLSKL
Rv1360|M.tuberculosis_H37Rv ELAAACTATRKQIAFYG------STPAYRKVLEQHGWGDLHPELHRLSKL
MSMEG_0341|M.smegmatis_MC2_155 ELTRAVSAVRRQIAFYG------STPAYRHVLELHGWHDLHTELHRLSKA
MMAR_1372|M.marinum_M ERAIERESVRASMAFYG------STPNYAFIWDEAGFEGTTARIREKQKA
MUL_2504|M.ulcerans_Agy99 ERAIERESVRASMAFYG------STPNYAFIWDEAGFEGTTARIREKQKA
MLBr_00348|M.leprae_Br4923 AAFAG---IKPFLALYMGGMGAEGTNFHADVYRRMGYAEVVDEVTALFRS
:*:* . : : *: :
MAV_2543|M.avium_104 GHPETIADHVTDDMLWSIAICGDDTQAREMLATRKRVPDTAFASPPSFLV
TH_2923|M.thermoresistible__bu GDPRSMARHVTDDMLWAIAVCGDSDQAAEMLAARKRLPDTAILAAPSFLV
Mflv_4583|M.gilvum_PYR-GCK GDFPAMFAAVSEEMIDTMGVAGTAHEVREQLRRYDGVLDHIMLYSPSVGI
Mvan_0319|M.vanbaalenii_PYR-1 RDFPAMFAAVSEEMIDTMGVAGTAHEVREQLRRYDGVLDHIMLYSPSVGI
MAB_2053|M.abscessus_ATCC_1997 RDLPAMFAAVTDDMIDAMAVAGTAAEVREGLRRYEGVLDHIVLYSPSIGL
Mb1395|M.bovis_AF2122/97 GEWEAMGGLIDDEMLGAFAVVGPVDTIAGALRNRCEGVVDR-----VLPI
Rv1360|M.tuberculosis_H37Rv GEWEAMGGLIDDEMLGAFAVVGPVDTIAGALRNRCEGVVDR-----VLPI
MSMEG_0341|M.smegmatis_MC2_155 GDWTTMTGLIDDEVLNTFAAVGEPTEAGAEVVTRFAGLVDRFTLLTPYPL
MMAR_1372|M.marinum_M GDFPAMMAQISDEHVDAFATESSWDGLADALTDKYGGIATR--LVMYNAL
MUL_2504|M.ulcerans_Agy99 GDFPAMMAQISDEHIDAFATESSWDGLADALTDKYGGIATR--LVMYNAL
MLBr_00348|M.leprae_Br4923 NQKDKAAEIIPNELVDSTMIVGDVDYVCKQIAAWSAAGVTMMMVSASSVE
. : :: : : . :
MAV_2543|M.avium_104 GRRRRSGYGAAATRVLSQLH-----------
TH_2923|M.thermoresistible__bu SPRRRAGYDAAGLRLMADRS-----------
Mflv_4583|M.gilvum_PYR-GCK AAERVQQNLDSIIGECSPASMSPGQSGPGST
Mvan_0319|M.vanbaalenii_PYR-1 AAERVQQNLDSIIGECSPASMSPGQSGPGST
MAB_2053|M.abscessus_ATCC_1997 APERIAENLGSLIRDCAPAFAGGKGDQSG--
Mb1395|M.bovis_AF2122/97 FMAASQECINAALQDFRR-------------
Rv1360|M.tuberculosis_H37Rv FMAASQECINAALQDFRR-------------
MSMEG_0341|M.smegmatis_MC2_155 GDEAAAAIVAGARAATARA------------
MMAR_1372|M.marinum_M GDPGRFERYGEVARRMHG-------------
MUL_2504|M.ulcerans_Agy99 GDPGRFERYGEVARRMHG-------------
MLBr_00348|M.leprae_Br4923 QVRDLAGLF----------------------