For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. thermoresistible (build 8) TH_2923 (-)

annotation: putative N5, N10-methylenetetrahydromethanopterin reductase-related
coordinates: 4183293 - 4184255
length: 321

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2923--100% (321)putative N5, N10-methylenetetrahydromethanopterin reductase-related
M. thermoresistible (build 8)TH_1626-2e-2831.31% (297) PROBABLE OXIDOREDUCTASE
M. thermoresistible (build 8)TH_3181-3e-2330.24% (248) PUTATIVE conserved hypothetical protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1395-1e-2632.05% (259) oxidoreductase
M. gilvum PYR-GCKMflv_4583-3e-4235.06% (308) luciferase family protein
M. tuberculosis H37RvRv1360-1e-2632.05% (259) oxidoreductase
M. leprae Br4923MLBr_00269-2e-1025.00% (232) putative F420-dependent glucose-6-phosphate dehydrogenase
M. abscessus ATCC 19977MAB_2053-2e-4839.35% (310) luciferase-like
M. marinum MMMAR_1372-1e-2229.06% (265) hypothetical protein MMAR_1372
M. avium 104MAV_2543-1e-13771.92% (317) 5,10-methylenetetrahydromethanopterin reductase
M. smegmatis MC2 155MSMEG_0341-5e-3232.52% (286) hypothetical protein MSMEG_0341
M. ulcerans Agy99MUL_2504-2e-2330.34% (267) hypothetical protein MUL_2504
M. vanbaalenii PYR-1Mvan_0319-2e-4134.43% (305) luciferase family protein

CLUSTAL 2.0.9 multiple sequence alignment


TH_2923|M.thermoresistible__bu      ----------------------VAVEAEAVGASVFCAGEFADISAYVT--
MAV_2543|M.avium_104                -----MDWGLPWPGP------ALAAQAETAGAQAFCAGEFADLNAYIT--
Mflv_4583|M.gilvum_PYR-GCK          ----MSTYGLSVLGADLKSLAQTAQAADAAGFDAVWASEFYSRSGSIS--
Mvan_0319|M.vanbaalenii_PYR-1       ----MSTYGLSVLGADLKSLAQTAQAADAAGFDAVWASEFYSRSGSIS--
MAB_2053|M.abscessus_ATCC_1997      ----MSTYGVSVLGADLATLVETAEATDLAGFDAAWASEFYSRSGSIS--
Mb1395|M.bovis_AF2122/97            MGGARRLKLDGSIPNQLARAADAAVALERNGFDGGWTAEAS-HDPFLP--
Rv1360|M.tuberculosis_H37Rv         MGGARRLKLDGSIPNQLARAADAAVALERNGFDGGWTAEAS-HDPFLP--
MSMEG_0341|M.smegmatis_MC2_155      MAGAEEAGISG-LLGQAARAQD-------IGFDGIWSTDVD-RDPFLP--
MMAR_1372|M.marinum_M               -----MHIDVMTIPQPLAQIGDLARRTQAAGFSGLLFTETG-RTAYLN--
MUL_2504|M.ulcerans_Agy99           -----MHIDVMTIPQPLAQIGDLARRTQAAGLSGLLFTETG-RTAYLN--
MLBr_00269|M.leprae_Br4923          MAELRLGYKASAEQFAPRELVELGVAAEAHGMDSATVSDHFQPWRHQGGH
                                                                  * .     :           

TH_2923|M.thermoresistible__bu      -------AAEMALSTTSAMVGPGIAYAFARS-PFVHASSVRHLSKRAPGR
MAV_2543|M.avium_104                -------ATEMALGTSGAYIGPGIAYAFARS-PFVHAAAVRHLWTLAPGR
Mflv_4583|M.gilvum_PYR-GCK          -------MAAMANSTQNCRIGSSILYGVGRS-PLVLATEARDLDELSNRR
Mvan_0319|M.vanbaalenii_PYR-1       -------MAAMANSTQNCRIGSSILYGVGRS-PLVLATEARDLDELSNGR
MAB_2053|M.abscessus_ATCC_1997      -------MAAMAARTKRCRIGSSILYGVGRS-PLVLATEARDLDELSGGR
Mb1395|M.bovis_AF2122/97            -------LLLAAEHTSRLELGTNIAVAFARN-PMIVANVGWDLQTYSKGR
Rv1360|M.tuberculosis_H37Rv         -------LLLAAEHTSRLELGTNIAVAFARN-PMIVANVGWDLQTYSKGR
MSMEG_0341|M.smegmatis_MC2_155      -------LAVAAMTTTNVQLGTGIAVAFARN-PMTTAMAANDLQEMSDGR
MMAR_1372|M.marinum_M               -------AAIASQAAPGLELSTGVAVAFPRS-PFVTAATAWELQEATGGK
MUL_2504|M.ulcerans_Agy99           -------AAIASQAAPGLELSTGVAVAFPRS-PFVTAATAWELQEATGGK
MLBr_00269|M.leprae_Br4923          ASFSLSWMTAVGERTNRILLGTSVLTPTFRYNPAVIGQAFATMGCLYPNR
                                               .  :    :...:     *  *   .     :      :

TH_2923|M.thermoresistible__bu      VFLGLGA--GTARMNSDWFCV--DSSHPAPRMAELIEVIRLFLH-AENGE
MAV_2543|M.avium_104                VFLGLGS--GTSRMNKDWFGV--DAAHPAPRMAELIEAIRAFLN-AENGE
Mflv_4583|M.gilvum_PYR-GCK          LVLGIGN--GTKRMMSDWHGVP-DTSAPALRMEELVMLLRRIWN-LHEG-
Mvan_0319|M.vanbaalenii_PYR-1       LVLGIGN--GTKRMMSDWHGVP-DTSAPALRMEELVMLLRRIWN-LHEG-
MAB_2053|M.abscessus_ATCC_1997      VVLGLGN--GTRRMMSDWHGVE-DTSAPALRMEELVPLVRRIWN-LHEG-
Mb1395|M.bovis_AF2122/97            LILGLGT--QIRPHIEKRFSM--PWGHPARRMREFVAALRAIWLAWQDGT
Rv1360|M.tuberculosis_H37Rv         LILGLGT--QIRPHIEKRFSM--PWGHPARRMREFVAALRAIWLAWQDGT
MSMEG_0341|M.smegmatis_MC2_155      FVLGLGT--QIQAHIERRFSM--PWSAPAERMSEYVNAIRAIWRSWRTGE
MMAR_1372|M.marinum_M               FRLGLGT--QVRTHVVRRYGM--AFERPGPRLRDYVLAVKACFSAFRTGT
MUL_2504|M.ulcerans_Agy99           FRLGLGT--QVRTHVVRRYGM--AFERPGPRLRDYVLAVKACFSAFRTGT
MLBr_00269|M.leprae_Br4923          VFLGVGTGEALNEVATGYQGAWPEFKERFARLRESVRLMRELWR----GD
                                    . **:*                        *: : :  ::        * 

TH_2923|M.thermoresistible__bu      KIRYSGDFYRVDADIRAPVFG---RLDVPILIGAFNRIMLRTAGRVADGV
MAV_2543|M.avium_104                RVRYEGRFYTIDADIRAPVLG---RLDVPILIGAFNKIMLRTVGRTADGV
Mflv_4583|M.gilvum_PYR-GCK          PIHHEGRFYRMNLTPTGDVGPP--SRPIPIVTAGVRPRMCEAAGRVADGL
Mvan_0319|M.vanbaalenii_PYR-1       PVHHEGRFYRMNLTPTGDMGPS--SRPIPIVTAGVRPRMCEAAGRVADGL
MAB_2053|M.abscessus_ATCC_1997      PVRHEGRFYRMNLVPTGDVAPP--QRAIPIITAGVRPRMCEVAGRVADGL
Mb1395|M.bovis_AF2122/97            KLCFEGEFYTHKIMTPMFTPEPQPYPVPRVFIAAVGEAMTEMCGEVADGH
Rv1360|M.tuberculosis_H37Rv         KLCFEGEFYTHKIMTPMFTPEPQPYPVPRVFIAAVGEAMTEMCGEVADGH
MSMEG_0341|M.smegmatis_MC2_155      RLDFRGDHYQHTLMTPMFTPTPHPHGDPKIVISAVGPRMTRVAARDADGL
MMAR_1372|M.marinum_M               -LDHHGEFYDLDFITPQWSAGPIDAPDPKVDVAAVNPWMLRMAGEVADGV
MUL_2504|M.ulcerans_Agy99           -LDHHGEFYDLDLITPQWSAGPIDAPDPKVDIAAVNPWMLRMAGEVADGV
MLBr_00269|M.leprae_Br4923          RVDFDGDYYQLKGASIYDVPEG----GVPIYIAAGGPEVAKYAGRAGEGF
                                     : . * .*                    :  ..    : .  .. .:* 

TH_2923|M.thermoresistible__bu      LGHGLFTDRWWDEVVGPEITAGATAAGRRTEDLKRWGWVITAVNDEDPQR
MAV_2543|M.avium_104                LGHGLFTDRWWTEVVEPELVRGAEASGRDPAELRRWGWLITAIDNDDPAR
Mflv_4583|M.gilvum_PYR-GCK          AGHPLFTTTYVEEIVRPAIARGAARTGRDPNDVEIISMVMCAIHD-DAEV
Mvan_0319|M.vanbaalenii_PYR-1       AGHPLFTTTYVEEIVRPAIARGAAHTGRDANDVEIISMVMCAIHD-DAEV
MAB_2053|M.abscessus_ATCC_1997      AGHPLFTTTYVEEVARPAVVRGAERAGRDPADIEIVSMVICAVHD-DPQI
Mb1395|M.bovis_AF2122/97            LGHPMVSKRYLTEVSVPALLRGLARSGRDRSAFEVSCEVMVATGADDAEL
Rv1360|M.tuberculosis_H37Rv         LGHPMVSKRYLTEVSVPALLRGLARSGRDRSAFEVSCEVMVATGADDAEL
MSMEG_0341|M.smegmatis_MC2_155      LVHGFTTQRYLSEVTLPIVEEELRKVGRRRADFTISYPGLIASGSTDEEL
MMAR_1372|M.marinum_M               HIHPLGELGYLTRHVVPNVAKGAAKAGRSPADIAVIVPVMTIVGDSEEER
MUL_2504|M.ulcerans_Agy99           HIHPLGELGYLTRHVVPNVAKGAAKAGRSPADIAVILPVMTIVGDSDEER
MLBr_00269|M.leprae_Br4923          VCTSGKGEELYTEKLIPAVLEGAAVAGRDADDIDKMIEIKMSYDP-DPEQ
                                                .   * :       **    .             :   

TH_2923|M.thermoresistible__bu      AIT--DARLQIAFYLTVKTYDSLVELHGWQDQVSAIRTAFRSGDPRSMAR
MAV_2543|M.avium_104                AIR--DARLQIAFYLTVKTYDSLVELHGWTDEVARIRSAFRSGHPETIAD
Mflv_4583|M.gilvum_PYR-GCK          ARR--ELAQQIAFYSSVKSYETVLDVNGFASEGRTIREAFAKGDFPAMFA
Mvan_0319|M.vanbaalenii_PYR-1       ARR--ELAQQIAFYSSVKSYETVLDVNGFASEGRTIREAFAQRDFPAMFA
MAB_2053|M.abscessus_ATCC_1997      ARR--EAAQQIAFYSSVKTYEHVLDVSGFARQGAAIRDAFARRDLPAMFA
Mb1395|M.bovis_AF2122/97            AAACTATRKQIAFYGSTPAYRKVLEQHGWGDLHPELHRLSKLGEWEAMGG
Rv1360|M.tuberculosis_H37Rv         AAACTATRKQIAFYGSTPAYRKVLEQHGWGDLHPELHRLSKLGEWEAMGG
MSMEG_0341|M.smegmatis_MC2_155      TRAVSAVRRQIAFYGSTPAYRHVLELHGWHDLHTELHRLSKAGDWTTMTG
MMAR_1372|M.marinum_M               AIERESVRASMAFYGSTPNYAFIWDEAGFEGTTARIREKQKAGDFPAMMA
MUL_2504|M.ulcerans_Agy99           AIERESVRASMAFYGSTPNYAFIWDEAGFEGTTARIREKQKAGDFPAMMA
MLBr_00269|M.leprae_Br4923          ALS------NIRFWAPLSLAAEQKHSIDDPIEMEKVADALPIEQVAKRWI
                                    :        .: *: .        .  .       :       .      

TH_2923|M.thermoresistible__bu      HVTDDMLWAIAVCGDSDQAAEMLAARKRLPDTAILAAPSFLVSPRRRAGY
MAV_2543|M.avium_104                HVTDDMLWSIAICGDDTQAREMLATRKRVPDTAFASPPSFLVGRRRRSGY
Mflv_4583|M.gilvum_PYR-GCK          AVSEEMIDTMGVAGTAHEVREQLRRYDGVLDHIMLYSPSVGIAAERVQQN
Mvan_0319|M.vanbaalenii_PYR-1       AVSEEMIDTMGVAGTAHEVREQLRRYDGVLDHIMLYSPSVGIAAERVQQN
MAB_2053|M.abscessus_ATCC_1997      AVTDDMIDAMAVAGTAAEVREGLRRYEGVLDHIVLYSPSIGLAPERIAEN
Mb1395|M.bovis_AF2122/97            LIDDEMLGAFAVVGPVDTIAGALRNRCEGVVDR-----VLPIFMAASQEC
Rv1360|M.tuberculosis_H37Rv         LIDDEMLGAFAVVGPVDTIAGALRNRCEGVVDR-----VLPIFMAASQEC
MSMEG_0341|M.smegmatis_MC2_155      LIDDEVLNTFAAVGEPTEAGAEVVTRFAGLVDRFTLLTPYPLGDEAAAAI
MMAR_1372|M.marinum_M               QISDEHVDAFATESSWDGLADALTDKYGGIATR--LVMYNALGDPGRFER
MUL_2504|M.ulcerans_Agy99           QISDEHIDAFATESSWDGLADALTDKYGGIATR--LVMYNALGDPGRFER
MLBr_00269|M.leprae_Br4923          VVSDPDEAVARVGQYVTWGLNHLVFHAPGHNQR--------RFLELFEKD
                                     : :                  :                           

TH_2923|M.thermoresistible__bu      DAAGLRLMADRS-----------
MAV_2543|M.avium_104                GAAATRVLSQLH-----------
Mflv_4583|M.gilvum_PYR-GCK          LDSIIGECSPASMSPGQSGPGST
Mvan_0319|M.vanbaalenii_PYR-1       LDSIIGECSPASMSPGQSGPGST
MAB_2053|M.abscessus_ATCC_1997      LGSLIRDCAPAFAGGKGDQSG--
Mb1395|M.bovis_AF2122/97            INAALQDFRR-------------
Rv1360|M.tuberculosis_H37Rv         INAALQDFRR-------------
MSMEG_0341|M.smegmatis_MC2_155      VAGARAATARA------------
MMAR_1372|M.marinum_M               YGEVARRMHG-------------
MUL_2504|M.ulcerans_Agy99           YGEVARRMHG-------------
MLBr_00269|M.leprae_Br4923          LAPRLRRLG--------------