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MSTYGLSVLGADLKSLAQTAQAADAAGFDAVWASEFYSRSGSISMAAMANSTQNCRIGSSILYGVGRSPL VLATEARDLDELSNGRLVLGIGNGTKRMMSDWHGVPDTSAPALRMEELVMLLRRIWNLHEGPVHHEGRFY RMNLTPTGDMGPSSRPIPIVTAGVRPRMCEAAGRVADGLAGHPLFTTTYVEEIVRPAIARGAAHTGRDAN DVEIISMVMCAIHDDAEVARRELAQQIAFYSSVKSYETVLDVNGFASEGRTIREAFAQRDFPAMFAAVSE EMIDTMGVAGTAHEVREQLRRYDGVLDHIMLYSPSVGIAAERVQQNLDSIIGECSPASMSPGQSGPGST
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0319 | - | - | 100% (349) | luciferase family protein |
| M. vanbaalenii PYR-1 | Mvan_0358 | - | 8e-38 | 30.72% (319) | luciferase family protein |
| M. vanbaalenii PYR-1 | Mvan_2020 | - | 8e-33 | 29.85% (325) | putative oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1395 | - | 3e-35 | 33.55% (307) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4583 | - | 0.0 | 97.71% (349) | luciferase family protein |
| M. tuberculosis H37Rv | Rv1360 | - | 3e-35 | 33.55% (307) | oxidoreductase |
| M. leprae Br4923 | MLBr_00348 | - | 3e-24 | 25.55% (317) | putative coenzyme F420-dependent oxidoreductase |
| M. abscessus ATCC 19977 | MAB_2053 | - | 1e-154 | 77.15% (337) | luciferase-like |
| M. marinum M | MMAR_1372 | - | 2e-32 | 29.22% (308) | hypothetical protein MMAR_1372 |
| M. avium 104 | MAV_2543 | - | 6e-41 | 34.75% (305) | 5,10-methylenetetrahydromethanopterin reductase |
| M. smegmatis MC2 155 | MSMEG_2256 | - | 9e-35 | 30.00% (310) | hypothetical protein MSMEG_2256 |
| M. thermoresistible (build 8) | TH_2923 | - | 1e-41 | 34.43% (305) | PUTATIVE putative N5, N10-methylenetetrahydromethanopterin |
| M. ulcerans Agy99 | MUL_2504 | - | 6e-32 | 29.55% (308) | hypothetical protein MUL_2504 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1395|M.bovis_AF2122/97 MGGARR--LKLDGS----IPNQLARAADAAVALERNGFDGGWTAEAS-HD
Rv1360|M.tuberculosis_H37Rv MGGARR--LKLDGS----IPNQLARAADAAVALERNGFDGGWTAEAS-HD
MSMEG_2256|M.smegmatis_MC2_155 MTDAQNPGVKVDRG----ISSRLSDVAQTARDLETAGCDGCWTGEIN-HD
MMAR_1372|M.marinum_M --------MHIDVMT---IPQPLAQIGDLARRTQAAGFSGLLFTETG-RT
MUL_2504|M.ulcerans_Agy99 --------MHIDVMT---IPQPLAQIGDLARRTQAAGLSGLLFTETG-RT
Mvan_0319|M.vanbaalenii_PYR-1 -------MSTYGLSV---LGADLKSLAQTAQAADAAGFDAVWASEFYSRS
Mflv_4583|M.gilvum_PYR-GCK -------MSTYGLSV---LGADLKSLAQTAQAADAAGFDAVWASEFYSRS
MAB_2053|M.abscessus_ATCC_1997 -------MSTYGVSV---LGADLATLVETAEATDLAGFDAAWASEFYSRS
MAV_2543|M.avium_104 --------MDWGLPW---PGP------ALAAQAETAGAQAFCAGEFADLN
TH_2923|M.thermoresistible__bu ----------------------------VAVEAEAVGASVFCAGEFADIS
MLBr_00348|M.leprae_Br4923 -MVERANAMKLGLQLGYWAAQPPGNAAELVAAAEGAGFDAVFTGEAWGSD
. : * . *
Mb1395|M.bovis_AF2122/97 PFLPLLLAAEHTSRLELGTNIAVAFARNPMIVANVGWDLQTYSKGRLILG
Rv1360|M.tuberculosis_H37Rv PFLPLLLAAEHTSRLELGTNIAVAFARNPMIVANVGWDLQTYSKGRLILG
MSMEG_2256|M.smegmatis_MC2_155 PFLPLALAAEHTRRIQIGTSIAVAFARNPMTVAHLGWDLQAYSGGRFILG
MMAR_1372|M.marinum_M AYLNAAIASQAAPGLELSTGVAVAFPRSPFVTAATAWELQEATGGKFRLG
MUL_2504|M.ulcerans_Agy99 AYLNAAIASQAAPGLELSTGVAVAFPRSPFVTAATAWELQEATGGKFRLG
Mvan_0319|M.vanbaalenii_PYR-1 GSISMAAMANSTQNCRIGSSILYGVGRSPLVLATEARDLDELSNGRLVLG
Mflv_4583|M.gilvum_PYR-GCK GSISMAAMANSTQNCRIGSSILYGVGRSPLVLATEARDLDELSNRRLVLG
MAB_2053|M.abscessus_ATCC_1997 GSISMAAMAARTKRCRIGSSILYGVGRSPLVLATEARDLDELSGGRVVLG
MAV_2543|M.avium_104 AYITATEMALGTSGAYIGPGIAYAFARSPFVHAAAVRHLWTLAPGRVFLG
TH_2923|M.thermoresistible__bu AYVTAAEMALSTTSAMVGPGIAYAFARSPFVHASSVRHLSKRAPGRVFLG
MLBr_00348|M.leprae_Br4923 AYTPLAWWGSSTQRVRLGTSVVQLSARTPTACAMAALTLDHLSGGRHILG
. : :...: *.* * * : : **
Mb1395|M.bovis_AF2122/97 LGTQIRPHIEKRFSM-PWGHPARRMREFVAALRAIWLAWQDGTKLCFEGE
Rv1360|M.tuberculosis_H37Rv LGTQIRPHIEKRFSM-PWGHPARRMREFVAALRAIWLAWQDGTKLCFEGE
MSMEG_2256|M.smegmatis_MC2_155 LGTQIRPHIEKRFSM-PWSHPVRRMREYIAALQAIWTCWRDGTSLRFEGE
MMAR_1372|M.marinum_M LGTQVRTHVVRRYGM-AFERPGPRLRDYVLAVKACFSAFRTG-TLDHHGE
MUL_2504|M.ulcerans_Agy99 LGTQVRTHVVRRYGM-AFERPGPRLRDYVLAVKACFSAFRTG-TLDHHGE
Mvan_0319|M.vanbaalenii_PYR-1 IGNGTKRMMSDWHGVPDTSAPALRMEELVMLLRRIWN-LHEG-PVHHEGR
Mflv_4583|M.gilvum_PYR-GCK IGNGTKRMMSDWHGVPDTSAPALRMEELVMLLRRIWN-LHEG-PIHHEGR
MAB_2053|M.abscessus_ATCC_1997 LGNGTRRMMSDWHGVEDTSAPALRMEELVPLVRRIWN-LHEG-PVRHEGR
MAV_2543|M.avium_104 LGSGTSRMNKDWFGV-DAAHPAPRMAELIEAIRAFLN-AENGERVRYEGR
TH_2923|M.thermoresistible__bu LGAGTARMNSDWFCV-DSSHPAPRMAELIEVIRLFLH-AENGEKIRYSGD
MLBr_00348|M.leprae_Br4923 LGVSGPQVVEGWYGQ-PFPKPLSRTREYIDIVRQVWA---REAPVVSDGQ
:* . * * : : :: : *
Mb1395|M.bovis_AF2122/97 FYTHKIMTP--------MFTPEPQPYPVPRVFIAAVGEAMTEMCGEVADG
Rv1360|M.tuberculosis_H37Rv FYTHKIMTP--------MFTPEPQPYPVPRVFIAAVGEAMTEMCGEVADG
MSMEG_2256|M.smegmatis_MC2_155 FYTHKIMTP--------MFTPEPSPAPFPKVFVAAVGERMTEMCGEAADG
MMAR_1372|M.marinum_M FYDLDFITP--------QWSAGPIDAPDPKVDVAAVNPWMLRMAGEVADG
MUL_2504|M.ulcerans_Agy99 FYDLDLITP--------QWSAGPIDAPDPKVDIAAVNPWMLRMAGEVADG
Mvan_0319|M.vanbaalenii_PYR-1 FYRMNLTPT--------GDMGPS--SRPIPIVTAGVRPRMCEAAGRVADG
Mflv_4583|M.gilvum_PYR-GCK FYRMNLTPT--------GDVGPP--SRPIPIVTAGVRPRMCEAAGRVADG
MAB_2053|M.abscessus_ATCC_1997 FYRMNLVPT--------GDVAPP--QRAIPIITAGVRPRMCEVAGRVADG
MAV_2543|M.avium_104 FYTIDADIR--------APVLG---RLDVPILIGAFNKIMLRTVGRTADG
TH_2923|M.thermoresistible__bu FYRVDADIR--------APVFG---RLDVPILIGAFNRIMLRTAGRVADG
MLBr_00348|M.leprae_Br4923 HYPLPLTGAGATGLGKALKPITHPLRADIPIMLGAEGPKNVALAAEICDG
.* : .. .. .**
Mb1395|M.bovis_AF2122/97 HLGHPMVSKRYLTEVSVPALLRGLARSG--RDRSAFEVSCEVMVATGADD
Rv1360|M.tuberculosis_H37Rv HLGHPMVSKRYLTEVSVPALLRGLARSG--RDRSAFEVSCEVMVATGADD
MSMEG_2256|M.smegmatis_MC2_155 LLAHAFTTRRYLDEVTLPALQRGMDRTG--RSRNDFEVSCPVFLVTGSDE
MMAR_1372|M.marinum_M VHIHPLGELGYLTRHVVPNVAKGAAKAG--RSPADIAVIVPVMTIVGDSE
MUL_2504|M.ulcerans_Agy99 VHIHPLGELGYLTRHVVPNVAKGAAKAG--RSPADIAVILPVMTIVGDSD
Mvan_0319|M.vanbaalenii_PYR-1 LAGHPLFTTTYVEEIVRPAIARGAAHTG--RDANDVEIISMVMCAIHD-D
Mflv_4583|M.gilvum_PYR-GCK LAGHPLFTTTYVEEIVRPAIARGAARTG--RDPNDVEIISMVMCAIHD-D
MAB_2053|M.abscessus_ATCC_1997 LAGHPLFTTTYVEEVARPAVVRGAERAG--RDPADIEIVSMVICAVHD-D
MAV_2543|M.avium_104 VLGHGLFTDRWWTEVVEPELVRGAEASG--RDPAELRRWGWLITAIDNDD
TH_2923|M.thermoresistible__bu VLGHGLFTDRWWDEVVGPEITAGATAAG--RRTEDLKRWGWVITAVNDED
MLBr_00348|M.leprae_Br4923 WL--PIFFSPRMADMYNEWLDEGFARTGARRSREDFEICASAQIVVTEDR
: : * :* * .
Mb1395|M.bovis_AF2122/97 AELAAACTATRKQIAFYG------STPAYRKVLEQHGWGDLHPELHRLSK
Rv1360|M.tuberculosis_H37Rv AELAAACTATRKQIAFYG------STPAYRKVLEQHGWGDLHPELHRLSK
MSMEG_2256|M.smegmatis_MC2_155 HQMAEAAVATRKQLAFYG------STPAYRKVLELHGWGDLHTELHRLSL
MMAR_1372|M.marinum_M EERAIERESVRASMAFYG------STPNYAFIWDEAGFEGTTARIREKQK
MUL_2504|M.ulcerans_Agy99 EERAIERESVRASMAFYG------STPNYAFIWDEAGFEGTTARIREKQK
Mvan_0319|M.vanbaalenii_PYR-1 AEVARR--ELAQQIAFYS------SVKSYETVLDVNGFASEGRTIREAFA
Mflv_4583|M.gilvum_PYR-GCK AEVARR--ELAQQIAFYS------SVKSYETVLDVNGFASEGRTIREAFA
MAB_2053|M.abscessus_ATCC_1997 PQIARR--EAAQQIAFYS------SVKTYEHVLDVSGFARQGAAIRDAFA
MAV_2543|M.avium_104 PARAIR--DARLQIAFYL------TVKTYDSLVELHGWTDEVARIRSAFR
TH_2923|M.thermoresistible__bu PQRAIT--DARLQIAFYL------TVKTYDSLVELHGWQDQVSAIRTAFR
MLBr_00348|M.leprae_Br4923 AAAFAG---IKPFLALYMGGMGAEGTNFHADVYRRMGYAEVVDEVTALFR
:*:* . : : *: :
Mb1395|M.bovis_AF2122/97 LGEWEAMGGLIDDEMLGAFAVVGPVDTIAGALRNRCEGVVDRVLPIFMAA
Rv1360|M.tuberculosis_H37Rv LGEWEAMGGLIDDEMLGAFAVVGPVDTIAGALRNRCEGVVDRVLPIFMAA
MSMEG_2256|M.smegmatis_MC2_155 AGEWDTMGTLIDDDVLDAFAVVAPLDELADALRRRCEGAIDRVLPGFPAA
MMAR_1372|M.marinum_M AGDFPAMMAQISDEHVDAFATESSWDGLADALTDKYGGIATRLVMYNALG
MUL_2504|M.ulcerans_Agy99 AGDFPAMMAQISDEHIDAFATESSWDGLADALTDKYGGIATRLVMYNALG
Mvan_0319|M.vanbaalenii_PYR-1 QRDFPAMFAAVSEEMIDTMGVAGTAHEVREQLRRYDGVLDHIMLYSPSVG
Mflv_4583|M.gilvum_PYR-GCK KGDFPAMFAAVSEEMIDTMGVAGTAHEVREQLRRYDGVLDHIMLYSPSVG
MAB_2053|M.abscessus_ATCC_1997 RRDLPAMFAAVTDDMIDAMAVAGTAAEVREGLRRYEGVLDHIVLYSPSIG
MAV_2543|M.avium_104 SGHPETIADHVTDDMLWSIAICGDDTQAREMLATRKRVPDTAFASPPSFL
TH_2923|M.thermoresistible__bu SGDPRSMARHVTDDMLWAIAVCGDSDQAAEMLAARKRLPDTAILAAPSFL
MLBr_00348|M.leprae_Br4923 SNQKDKAAEIIPNELVDSTMIVGDVDYVCKQIAAWSAAGVTMMMVSASSV
. : :: : : . : .
Mb1395|M.bovis_AF2122/97 S-QECINAALQDFRR-----------------
Rv1360|M.tuberculosis_H37Rv S-QECINAALQDFRR-----------------
MSMEG_2256|M.smegmatis_MC2_155 VPPATVNAVLDEFRDRPPVTRL----------
MMAR_1372|M.marinum_M D-PGRFERYGEVARRMHG--------------
MUL_2504|M.ulcerans_Agy99 D-PGRFERYGEVARRMHG--------------
Mvan_0319|M.vanbaalenii_PYR-1 IAAERVQQNLDSIIGECSPASMSPGQSGPGST
Mflv_4583|M.gilvum_PYR-GCK IAAERVQQNLDSIIGECSPASMSPGQSGPGST
MAB_2053|M.abscessus_ATCC_1997 LAPERIAENLGSLIRDCAPAFAGGKGDQSG--
MAV_2543|M.avium_104 VGRRRRSGYGAAATRVLSQLH-----------
TH_2923|M.thermoresistible__bu VSPRRRAGYDAAGLRLMADRS-----------
MLBr_00348|M.leprae_Br4923 EQVRDLAGLF----------------------