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VTLTADRSGLIMEPGAKVKLRGVQVGRVTSIHSGDPVTLRLELYPEQLQYIPANVTAQITATTAFGGKYV DLQIPESPSPRRLAAGAVVRSRNVTTEVNTVFQNLVAVLNQVDTPKLNAVLTALGDGLRGKGEALGEATT DLNEVLGAINPRSETIRADSRALEGFSDTYSAAAHDIVTVLDAGSTTSATVSNNAQALDSLLLNVIGLSH SGIGLIGPNKDNLVHGVNLLESTTRLLMKYNPELTCTLLGSKYDAEFFGDVAGGHNGYSVTLDVALLLGD EAYRYPDNLPINGAKGGPGGQPGCGSLPDVSKNFPLRYLVTNTGWGRGLDMRPNPGIGFPGYVDYLPVTR GTPQPPSLRHPGGTAPGPMPYPGAPPYGAPQYAPDGTPLYPGLPPAPPPGRPRDAGPPPAGSEPFTPPVP GAIQPTCGVLNQVCEPLPPPPNVPGP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2532 | - | - | 100% (446) | virulence factor Mce family protein |
| M. avium 104 | MAV_2061 | - | e-100 | 50.00% (368) | virulence factor Mce family protein |
| M. avium 104 | MAV_4126 | - | 4e-59 | 37.82% (357) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0175 | mce1A | 2e-53 | 34.50% (400) | MCE-family protein MCE1A |
| M. gilvum PYR-GCK | Mflv_2101 | - | 1e-156 | 62.81% (449) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1966 | mce3A | 1e-126 | 59.16% (382) | MCE-family protein MCE3A |
| M. leprae Br4923 | MLBr_02589 | mce1A | 5e-54 | 35.79% (366) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 1e-54 | 38.26% (311) | MCE-family protein |
| M. marinum M | MMAR_4051 | mce3A_1 | 1e-159 | 62.78% (446) | MCE-family protein Mce3A_1 |
| M. smegmatis MC2 155 | MSMEG_0346 | - | 1e-152 | 62.56% (430) | virulence factor |
| M. thermoresistible (build 8) | TH_2690 | - | 1e-134 | 58.19% (397) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3918 | mce3A_1 | 1e-159 | 62.78% (446) | MCE-family protein Mce3A_1 |
| M. vanbaalenii PYR-1 | Mvan_0922 | - | 1e-155 | 59.73% (447) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4051|M.marinum_M -----MDDRKEGLHPAWHTLILVLLFVAAMWVTYALFMGSLRSVVPVTLT
MUL_3918|M.ulcerans_Agy99 -----MDDRKEGLHPAWHTLILVLLFVAAMWVTYALFMGSLRSVVPVTLT
Mflv_2101|M.gilvum_PYR-GCK -----MDD--DGLKPGWWTLILVAVFAVAIFVTYALFTGSLKSTVPVTLT
MAV_2532|M.avium_104 ----------------------------------------------MTLT
Mvan_0922|M.vanbaalenii_PYR-1 -----MPNRRSRIHPAWWTALLLATGVVVVVFTAASFNGWFRSWIPVTLQ
Rv1966|M.tuberculosis_H37Rv ---MRRGPGRHRLHDAWWTLILFAVIGVAVLVTAVSFTGSLRSTVPVTLA
MSMEG_0346|M.smegmatis_MC2_155 ---MQPRFRDARIKPAWWTWILIAALGVFFFTTGSLFAGTFRSFVPVTLV
TH_2690|M.thermoresistible__bu -------------------LLLIASIVCLVVVCSVLFVGAHKSYAPVLLT
Mb0175|M.bovis_AF2122/97 MTTPGKLNKARVPPYKTAGLGLVLVFALVVALVYLQFRGEFTPKTQLTML
MLBr_02589|M.leprae_Br4923 MTSSTKINASRKPPYKLAGVGLLVVAVVIFGLVYGQFRGNFTPKSKLTML
MAB_4153c|M.abscessus_ATCC_199 -----MSDTSTRRAVRLAGTVLASVLVLLTVLTYLAYNDAFADTKPITVV
: :
MMAR_4051|M.marinum_M SERSGLVMETNAKVKLRGVQVGRVASIVGGGK-GATPVALTLEIDSDQIR
MUL_3918|M.ulcerans_Agy99 SERSGLVMETNAKVKLRGVQVGRVASIVGGGK-GATPVALTLEIDSDQIR
Mflv_2101|M.gilvum_PYR-GCK SDRAGLVMETNAKVKLRGVQVGRVSDISVTGR-QDPTVALQLEIDPDQVQ
MAV_2532|M.avium_104 ADRSGLIMEPGAKVKLRGVQVGRVTSIHSGD-----PVTLRLELYPEQLQ
Mvan_0922|M.vanbaalenii_PYR-1 SDRSGLIMEPGGKVKMRGLEVGRVGDVNAVRG-G---TSVELEIDPAYAE
Rv1966|M.tuberculosis_H37Rv ADRSGLVMDSGAKVMMRGVQVGRVAQIGRIEW-AQNGASLRLEIDPDQIR
MSMEG_0346|M.smegmatis_MC2_155 SDRSGLVMETGAKVKLNGVEVGRVSEIR---G-GASGVSLQLEIEPDQIR
TH_2690|M.thermoresistible__bu SERSGLVMERGAKVKLRGVEVGRVAQITG----GSEPVKLQLDIEPAKLR
Mb0175|M.bovis_AF2122/97 SARAGLVMDPGSKVTYNGVEIGRVDTISEVTRDGESAAKFILDVDPRYIH
MLBr_02589|M.leprae_Br4923 ADRAGLVMDRGSKITYNGVKIGRVADISETVRNGRPVAEFTLDVYPRYLS
MAB_4153c|M.abscessus_ATCC_199 SPRAGLVMEEGGKVKFHGLQIGKVTSISYAN----DQAKLELAVNAKDLR
: *:**:*: ..*: .*:::*:* : . . * : .
MMAR_4051|M.marinum_M YIPANVQAEIRATTVFGAKFVDLVYPQDPSPQRLKAGQVLMSRNVTSEAN
MUL_3918|M.ulcerans_Agy99 YIPANVQAEIRATTVFGAKFVDLIYPEDPSPQRLKAGQVLMSRNVTSEAN
Mflv_2101|M.gilvum_PYR-GCK YIPANVEAQIRATTIFGAKFVDLVFPDDPSNQRLEAGQVLQSRNVTTEVN
MAV_2532|M.avium_104 YIPANVTAQITATTAFGGKYVDLQIPESPSPRRLAAGAVVRSRNVTTEVN
Mvan_0922|M.vanbaalenii_PYR-1 FIPSNVSAEIDANTVFGAKYVDLVYPDDPSPQRLKSGQILRSRNVTTEVN
Rv1966|M.tuberculosis_H37Rv YIPANVEAQISATTAFGAKFVDLVMPQNPSRARLSAGAVLHSKNVSTEIN
MSMEG_0346|M.smegmatis_MC2_155 FIPANVEARITATTAFGAKYVDLSYPDNPTGQHLAAGAVLRSRNVSTEVN
TH_2690|M.thermoresistible__bu FIPANVEAEIEATTAFGAKFVNLIVPDDPSPQRLSPGDVLTSRNVSTEVN
Mb0175|M.bovis_AF2122/97 LIPANVNADIKATTVFGGKYVSLTTPKNPTKRRITPKDVIDVRSVTTEIN
MLBr_02589|M.leprae_Br4923 LIPANVNADIKATTVFGGKYVSLTTPEHPSQKRLTPQTVIDARSVTTEIN
MAB_4153c|M.abscessus_ATCC_199 LIPSNATVRIAGTTVFGAKSVEFLAPQKPSDSSLRPGATVTAEAVALEVN
**:*. . * ..* **.* *.: *. *: : . : . *: * *
MMAR_4051|M.marinum_M TVFQNLVAVLDQIDPAKLNAALSALAEGLRGQGPLIGQATTDANQVLLEL
MUL_3918|M.ulcerans_Agy99 TVFQNLVAVLDQIDPAKLNAALSALAEGLRGQGPLIGQATTDANQVLLEL
Mflv_2101|M.gilvum_PYR-GCK TVFQNLVAVLDQVDAAKLNSTLSALADGVRGQGERIGRATTDANQVLLAL
MAV_2532|M.avium_104 TVFQNLVAVLNQVDTPKLNAVLTALGDGLRGKGEALGEATTDLNEVLGAI
Mvan_0922|M.vanbaalenii_PYR-1 TVFQNLVDLLDKVDPAKLNAILSALAEGLRGQGPAIGEATTAANEVLHAL
Rv1966|M.tuberculosis_H37Rv TVFENVVDLLNMIDPLKLNAVLTAVADAVRGQGERIGQATTDLNEVLEAL
MSMEG_0346|M.smegmatis_MC2_155 TVFENLTDVLKMVDPAKLNAVLSALAEGFRGQGERMGQAITDANEVLMAI
TH_2690|M.thermoresistible__bu TVFQNLVGVLDQIDVSKLNATLSALADGLQGQGARIGEATTSAKEVLVAM
Mb0175|M.bovis_AF2122/97 TLFQTLTSIAEKVDPVKLNLTLSAAAEALTGLGDKFGESIVNANTVLDDL
MLBr_02589|M.leprae_Br4923 TLFQTITLIAEKVDPIKLNLTLSAAAQSLAGLGERFGQSIVNGNSVLDDV
MAB_4153c|M.abscessus_ATCC_199 TVFENLTRLLGKIDPVNLNATLTAVGEGLRGNGDNFGQGLVELDQYLDQL
*:*:.:. : :* :** *:* .:.. * * :*.. . . * :
MMAR_4051|M.marinum_M NPRYETVTADLRAVKDFNDTFSAAAQDILDTLNALSTTSTTITSHSTQLD
MUL_3918|M.ulcerans_Agy99 NPRYETVTADLRAVKDFNDTFSAAAQDILDTLNALSTTSTTITGHSTQLD
Mflv_2101|M.gilvum_PYR-GCK NPRNETITEDLRALDQFNQTYSAAAQNILATLDAASTTSTTVVNQAKELD
MAV_2532|M.avium_104 NPRSETIRADSRALEGFSDTYSAAAHDIVTVLDAGSTTSATVSNNAQALD
Mvan_0922|M.vanbaalenii_PYR-1 NPRSDTVRADWQSLAAASETYSDAAQDIMAVLDSFTTTAVTLDEQSSALD
Rv1966|M.tuberculosis_H37Rv NARGDTIGGNWRSLKNFTDTYDAAAQDILTILNAASTTSATVVNHSTQLD
MSMEG_0346|M.smegmatis_MC2_155 NPRQDTIREDWRAMGEVSAAYDHAADDIVKILDAGTTTAETVTSHRSELD
TH_2690|M.thermoresistible__bu NPRMDTVRENFRSLEGFGDAYAAAADDILDVLDAAATTGTTITERTGDLE
Mb0175|M.bovis_AF2122/97 NSRMPQSRHDIQQLAALGDVYADAAPDLFDFLDSSVTTARTINAQQAELD
MLBr_02589|M.leprae_Br4923 NSQLPQARHDIQQLASLGDTYANSASDFFDFLNNSIVTSRTINQQQKDLD
MAB_4153c|M.abscessus_ATCC_199 NPKLPALQQDFRQAGQVGQIYGDAAPDIVRILDNLPALSRTVVDQQQDLK
*.: : : : :* ::. *: . . *: . *.
MMAR_4051|M.marinum_M ALLLATIGLSNTGISLLAPNQANLIKAINALEPTTNLLYKYSPEYTCLLE
MUL_3918|M.ulcerans_Agy99 ALLLATIGLSNTGISLLAPNQANLIKAINALEPTTNLLYKYSPEYTCLLE
Mflv_2101|M.gilvum_PYR-GCK ALLLAAIGLSNSGIDLLAPNQANLIKAVNTLAPTTNLLHKYSPSYTCLLL
MAV_2532|M.avium_104 SLLLNVIGLSHSGIGLIGPNKDNLVHGVNLLESTTRLLMKYNPELTCTLL
Mvan_0922|M.vanbaalenii_PYR-1 ALLVNAAGLARSGIDLLGVSKDDFVHTVNTLEPTTGLLEKYSPSLTCLLV
Rv1966|M.tuberculosis_H37Rv ALLLNAIGLSNAGTNLLGSSRDNLVGAADILAPTTSLLFKYNPEYTCFLQ
MSMEG_0346|M.smegmatis_MC2_155 TLLLNVIGFGRAGVDLLAPSFTNLVNAVNGFAPTSDLLMKYQPEYTCLLD
TH_2690|M.thermoresistible__bu DVLLSAVGFGQSGVDLLAPNSDNIVRAIRALQPTTDVLEKYHPTYTCLLQ
Mb0175|M.bovis_AF2122/97 SALLAAAGFGNTTADVFDRGGPYLQRGVADLVPTATLLDTYSPELFCTIR
MLBr_02589|M.leprae_Br4923 QVLLAAVGFGNTGADIFSRSGPYLARGAADLVPTAQLLDTYSPAIFCTLR
MAB_4153c|M.abscessus_ATCC_199 ATLLAAIGLGNNGYETLAPAEKDLTAALQRLRAPATLLGRYSPEIPCTLQ
*: . *:.. : : : ..: :* * * * :
MMAR_4051|M.marinum_M GAKYLLDHGGYEAPGG------------NGRSLVLDAALALGDD------
MUL_3918|M.ulcerans_Agy99 GAKYLLDHGGYEAPGG------------NGRSLVLDAALALGDD------
Mflv_2101|M.gilvum_PYR-GCK GAKHLLDEGGYEAPGG------------NGRTLVLDTSLSFGDD------
MAV_2532|M.avium_104 GSKYDAEFFGDVAGGH------------NGYSVTLDVALLLGDE------
Mvan_0922|M.vanbaalenii_PYR-1 GAQWFLDNGGRDYVGG------------NGYSIVLDATLTWGQD------
Rv1966|M.tuberculosis_H37Rv GAKWYLDNGGYAAWGGA-----------DGRTLQLDVALLFGND------
MSMEG_0346|M.smegmatis_MC2_155 GSVSLLQNGHVDAFGG------------NGRSAIFDIGLLLGND------
TH_2690|M.thermoresistible__bu GSVFLLNNMAYDSMGGA-----------NGKSLIVDAGLLLGDD------
Mb0175|M.bovis_AF2122/97 NFYDADPLAKAAAGGGNGYSLRTNSEILSGIGISLLSPLALATNGAAIGI
MLBr_02589|M.leprae_Br4923 NYHDIEPKVTSFLGG-NGYSINDHVELLSGLGFLLNPTSAISIIGAGV--
MAB_4153c|M.abscessus_ATCC_199 AISKALVTFTPLIGG-------------VRPGLFLTNSFPLGAP------
* . .
MMAR_4051|M.marinum_M ------------------------------PYRFPDNLPIIGAKGGP--G
MUL_3918|M.ulcerans_Agy99 ------------------------------PYRFPDNLPIIGAKGGP--G
Mflv_2101|M.gilvum_PYR-GCK ------------------------------PYQYPRHLPIIGAKGGP--G
MAV_2532|M.avium_104 ------------------------------AYRYPDNLPINGAKGGP--G
Mvan_0922|M.vanbaalenii_PYR-1 ------------------------------PYRYPRNLPIVGAKGGP--G
Rv1966|M.tuberculosis_H37Rv ------------------------------PYVYPDNLPVVAAKGGP--G
MSMEG_0346|M.smegmatis_MC2_155 ------------------------------PYHYPDDLPIVGAKGGP--G
TH_2690|M.thermoresistible__bu ------------------------------PYRYPQHLPRIAAKGGP--G
Mb0175|M.bovis_AF2122/97 GLVAGLIASPLAVAANLAGALPGIVGGAPNPYTYPENLPRVNARGGP--G
MLBr_02589|M.leprae_Br4923 -LSQGLLAP-------LG--LAGVVNGAANPYIYPENLPRVNARGGP--G
MAB_4153c|M.abscessus_ATCC_199 ------------------------------VYTYPDSLPIVNASGGPNCR
* :* ** * ***
MMAR_4051|M.marinum_M GKPGCGSLPIVDNNWPVRNLVTNTGFGTGMDWRPNPGIGFPGWANYFPVT
MUL_3918|M.ulcerans_Agy99 GKPGCGSLPIVDNNWPVRNLVTNTGFGTGMDWRPNPGIGFPGWANYFPVT
Mflv_2101|M.gilvum_PYR-GCK GKPGCGSLPKVAENWPVRNLVTNTGFGSGLDWRPNPGIAFPTYANYLPVT
MAV_2532|M.avium_104 GQPGCGSLPDVSKNFPLRYLVTNTGWGRGLDMRPNPGIGFPGYVDYLPVT
Mvan_0922|M.vanbaalenii_PYR-1 GKPGCGSLPDVTQQFPVRHLVTNTGWGTGNDIRVNPGIGFPGWANYFPVT
Rv1966|M.tuberculosis_H37Rv GRPGCGPLPDATHNFPVRQLVTNTGWGTGLDIRPNPGIGHPCWANYFPVT
MSMEG_0346|M.smegmatis_MC2_155 GKPGCGSLPDVAKNFPVRQLVTNTGWGTGLDIRPNPGIGFPGWANYFPVT
TH_2690|M.thermoresistible__bu GKPSCGSLPDATKKFPVRYLVTDTGFGTGLDIRPNPGIGFPGLANYFPVT
Mb0175|M.bovis_AF2122/97 GAPGCWQPITRDLWP-APYLVMDTG------------------ASLAPYN
MLBr_02589|M.leprae_Br4923 GAPGCWQHITRDLWP-TPELVMDTG------------------NSIAPYN
MAB_4153c|M.abscessus_ATCC_199 GLPNIPTKMQNGSWFRSPFLVTDNAY-----------------IPYKPLE
* *. ** :.. *
MMAR_4051|M.marinum_M RGTPEPPSIRNLFGGPAPGPIP-YPGAPPYGAELYAPDGTPLWPGLPPAP
MUL_3918|M.ulcerans_Agy99 RGTPEPPSIRNLFGGPAPGPIP-YPGAPPYGAELYAPDGTPLWPGLPPAP
Mflv_2101|M.gilvum_PYR-GCK RAVPEPPSVRNLFGGPAIGPIP-YPGAPAYGAQLYAPDGTPLWPGLPPAP
MAV_2532|M.avium_104 RGTPQPPSLR-HPGGTAPGPMP-YPGAPPYGAPQYAPDGTPLYPGLPPAP
Mvan_0922|M.vanbaalenii_PYR-1 RAVPEPPSIR-NIGPSAPGPVP-YPGAPPRGAPLYAPDGSPLFPGLPPAP
Rv1966|M.tuberculosis_H37Rv RAVPEPPSIRQCIPGPAIGPNP-AAGEQP---------------------
MSMEG_0346|M.smegmatis_MC2_155 RGIPQPPIIRNLGGGPAPGPIP-YPGAPPYGADLYADDGTPLWPGLPPAP
TH_2690|M.thermoresistible__bu KAMPEPPRIY-HPGGPAPGPEPPYPGGPPHGAPLYGPDGTPLWP---PAP
Mb0175|M.bovis_AF2122/97 HMEVGSPYAVEYVWGRQVGDNTINP-------------------------
MLBr_02589|M.leprae_Br4923 HLDSGSPYAIEYVWGRQVGDNTINP-------------------------
MAB_4153c|M.abscessus_ATCC_199 ELQVNAPDTLQYLYNGAFAKRSEF--------------------------
. .* . .
MMAR_4051|M.marinum_M PPG--APRESGPTP-GSEPFVVPAPAQAQPTPLP----PAPLPQEVAPSP
MUL_3918|M.ulcerans_Agy99 PPG--APRESGPTP-GSEPFVVPASAQAQPTPLP----PAPLPQEVAPSP
Mflv_2101|M.gilvum_PYR-GCK PPG--APRDPGPRP-GSEPFVVPHPSQMQPTAVPYPFVPPPVPAQPGPPR
MAV_2532|M.avium_104 PPG--RPRDAGPPPAGSEPFTPPVPGAIQPTCGVLNQVCEPLPPPPNVPG
Mvan_0922|M.vanbaalenii_PYR-1 PPG--APREPGPTP-GSEPFVPSVPALMQPTPAP---VPGPGPAPGPAAP
Rv1966|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_0346|M.smegmatis_MC2_155 PPSDQPPPDPNNPPPGAEPFVPPAPAAMTPTQ------------------
TH_2690|M.thermoresistible__bu --------------------------------------------------
Mb0175|M.bovis_AF2122/97 --------------------------------------------------
MLBr_02589|M.leprae_Br4923 --------------------------------------------------
MAB_4153c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4051|M.marinum_M -
MUL_3918|M.ulcerans_Agy99 -
Mflv_2101|M.gilvum_PYR-GCK -
MAV_2532|M.avium_104 P
Mvan_0922|M.vanbaalenii_PYR-1 -
Rv1966|M.tuberculosis_H37Rv -
MSMEG_0346|M.smegmatis_MC2_155 -
TH_2690|M.thermoresistible__bu -
Mb0175|M.bovis_AF2122/97 -
MLBr_02589|M.leprae_Br4923 -
MAB_4153c|M.abscessus_ATCC_199 -