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MTTPGKLNKARVPPYKTAGLGLVLVFALVVALVYLQFRGEFTPKTQLTMLSARAGLVMDPGSKVTYNGVE IGRVDTISEVTRDGESAAKFILDVDPRYIHLIPANVNADIKATTVFGGKYVSLTTPKNPTKRRITPKDVI DVRSVTTEINTLFQTLTSIAEKVDPVKLNLTLSAAAEALTGLGDKFGESIVNANTVLDDLNSRMPQSRHD IQQLAALGDVYADAAPDLFDFLDSSVTTARTINAQQAELDSALLAAAGFGNTTADVFDRGGPYLQRGVAD LVPTATLLDTYSPELFCTIRNFYDADPLAKAAAGGGNGYSLRTNSEILSGIGISLLSPLALATNGAAIGI GLVAGLIASPLAVAANLAGALPGIVGGAPNPYTYPENLPRVNARGGPGGAPGCWQPITRDLWPAPYLVMD TGASLAPYNHMEVGSPYAVEYVWGRQVGDNTINP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0175 | mce1A | - | 100% (454) | MCE-family protein MCE1A |
| M. bovis AF2122 / 97 | Mb0604 | mce2A | e-152 | 62.61% (436) | MCE-family protein MCE2A |
| M. bovis AF2122 / 97 | Mb3529c | mce4A | 8e-45 | 30.53% (416) | MCE-family protein MCE4A |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0711 | - | 1e-152 | 58.81% (454) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv0169 | mce1A | 0.0 | 99.56% (454) | MCE-family protein MCE1A |
| M. leprae Br4923 | MLBr_02589 | mce1A | 1e-177 | 66.52% (454) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 2e-57 | 33.10% (432) | MCE-family protein |
| M. marinum M | MMAR_0412 | mce1A | 1e-180 | 68.94% (454) | MCE-family protein Mce1A |
| M. avium 104 | MAV_5015 | - | 0.0 | 69.60% (454) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0134 | - | 1e-147 | 58.48% (448) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_0154 | - | 1e-144 | 56.61% (454) | virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_1062 | mce1A | 1e-180 | 68.72% (454) | MCE-family protein Mce1A |
| M. vanbaalenii PYR-1 | Mvan_0134 | - | 1e-157 | 60.88% (455) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0175|M.bovis_AF2122/97 MTTPGK----LNKARVPPYKTAGLGLVLVFALVVALVYLQFRGEFTPKTQ
Rv0169|M.tuberculosis_H37Rv MTTPGK----LNKARVPPYKTAGLGLVLVFALVVALVYLQFRGEFTPKTQ
MLBr_02589|M.leprae_Br4923 MTSSTK----INASRKPPYKLAGVGLLVVAVVIFGLVYGQFRGNFTPKSK
MAV_5015|M.avium_104 MARPVQ----TNAPRTPPYKLAGLAILVVGALALTLIYGQFRGNFTPKTS
MMAR_0412|M.marinum_M MTKPGK----LNKVNEPPYKIAGIALFLVGLLILSLVYLQFRGDFDRKVK
MUL_1062|M.ulcerans_Agy99 MTKPGK----LNKVNEPPYKIAGIALFLVGLLILSLVYLQFRGDFDRKVK
Mflv_0711|M.gilvum_PYR-GCK MTAP------MNTKRQPPYKIAGVVLALVTILILVLVYLQFRGDFLPRTQ
Mvan_0134|M.vanbaalenii_PYR-1 MTVPQA---ALNTRRQPPYKLAGLVLAILTVIAVTLVYLQFRGDFMARTQ
TH_0154|M.thermoresistible__bu MTAP------LNAPRTPPYKIVGVVLLLVVALVVTLVWMQFRGAFTPRTQ
MSMEG_0134|M.smegmatis_MC2_155 MTEPPAPTAPLNKPKTPPYKLAGLILGLVGVLVLALTWMQFRGQFEDKVQ
MAB_4153c|M.abscessus_ATCC_199 ---------MSDTSTRRAVRLAGTVLASVLVLLTVLTYLAYNDAFADTKP
: . : .* : : : * : :.. *
Mb0175|M.bovis_AF2122/97 LTMLSARAGLVMDPGSKVTYNGVEIGRVDTISEVTRDGESAAKFILDVDP
Rv0169|M.tuberculosis_H37Rv LTMLSARAGLVMDPGSKVTYNGVEIGRVDTISEVTRDGESAAKFILDVDP
MLBr_02589|M.leprae_Br4923 LTMLADRAGLVMDRGSKITYNGVKIGRVADISETVRNGRPVAEFTLDVYP
MAV_5015|M.avium_104 LTMLASRAGLVMDPGSKVTYNGVEIGRVGTISETVRDGKPAAKFTLEVYP
MMAR_0412|M.marinum_M LTMFSERAGLVMDPGSKVTYNGVQIGRVDTISEITRDGKPAAKFVLNVYP
MUL_1062|M.ulcerans_Agy99 LTMFSERAGLVMDPGSKVTYNGVQIGRVDTISEITRDGKPAAKFVLNVYP
Mflv_0711|M.gilvum_PYR-GCK LTMISARSGLSLDSGSKVTFNGVEIGKVSEVEETTVGGEPRAKILLEVNP
Mvan_0134|M.vanbaalenii_PYR-1 LTMISARSGLSMDPGAKVTYNGVEIGRVGNVEETSVDGEPRAKIILDVNP
TH_0154|M.thermoresistible__bu LTLLADRAGLVMDPGSKVTFNGVEIGRVAQIHADTSDDRTRANIVLDVDP
MSMEG_0134|M.smegmatis_MC2_155 LTVLSGRAGLSMDPGSKVTFNGVPIGRLASIDVVEVDDNPEARLTLDVDP
MAB_4153c|M.abscessus_ATCC_199 ITVVSPRAGLVMEEGGKVKFHGLQIGKVTSISYAN----DQAKLELAVNA
:*:.: *:** :: *.*:.::*: **:: : *.: * * .
Mb0175|M.bovis_AF2122/97 RYIHLIPANVNADIKATTVFGGKYVSLTTPKNPTKRRITPKDVIDVRSVT
Rv0169|M.tuberculosis_H37Rv RYIHLIPANVNADIKATTVFGGKYVSLTTPKNPTKRRITPKDVIDVRSVT
MLBr_02589|M.leprae_Br4923 RYLSLIPANVNADIKATTVFGGKYVSLTTPEHPSQKRLTPQTVIDARSVT
MAV_5015|M.avium_104 RYLKLIPSNVNADIKATTVFGGKYVSLTTPANPSPQKITPHTIIDARSVT
MMAR_0412|M.marinum_M RYLPLIPENVDAQIKATTVFGGKYVSLTTPEHPSNKKLSAHSVINASAVT
MUL_1062|M.ulcerans_Agy99 RYLPLIPENVDAQIKATTVFGGKYVSLTTPEHPSNKKLSAHSVINASAVT
Mflv_0711|M.gilvum_PYR-GCK KYLKLIPRNVNADISATTVFGNKYVSFTSPENPQSERISASDVIDVTSVT
Mvan_0134|M.vanbaalenii_PYR-1 KYLDLIPSNVNADISATTVFGNKYVSFTTPEDPRPERISASDVIDVTSVT
TH_0154|M.thermoresistible__bu KYVDLIPSNADVEIKASTVFGNKYVAFASPPDPSLTPITSAATIDVTKVT
MSMEG_0134|M.smegmatis_MC2_155 KYLDLIPENANVELRATTVFGNKYISFLSPKNPSAERLSASTPIRAQGVT
MAB_4153c|M.abscessus_ATCC_199 KDLRLIPSNATVRIAGTTVFGAKSVEFLAPQKPSDSSLRPGATVTAEAVA
: : *** *. . : .:**** * : : :* .* : . : . *:
Mb0175|M.bovis_AF2122/97 TEINTLFQTLTSIAEKVDPVKLNLTLSAAAEALTGLGDKFGESIVNANTV
Rv0169|M.tuberculosis_H37Rv TEINTLFQTLTSIAEKVDPVKLNLTLSAAAEALTGLGDKFGESIVNANTV
MLBr_02589|M.leprae_Br4923 TEINTLFQTITLIAEKVDPIKLNLTLSAAAQSLAGLGERFGQSIVNGNSV
MAV_5015|M.avium_104 TEINTLFQTITSIAEKVDPVKLNLTLSAAAQSLSGLGEKFGQSVVNANAL
MMAR_0412|M.marinum_M TEINTLFETLTSISEKVDPVKLNLTLSAAAEALTGLGNRFGEAIANGNEI
MUL_1062|M.ulcerans_Agy99 IEINTLFETLTSISEKVDPVKLNLTLSAAAEALTGLGNRFGEAIANGNEI
Mflv_0711|M.gilvum_PYR-GCK TEFNTLFETVVEIAEQVDPIKLNQTLTATAQALDGLGDRFGESIINGNQI
Mvan_0134|M.vanbaalenii_PYR-1 TEFNTLFETVVSLADQVDPIKLNQTLTATAQALDGLGDRFGESIINGNQI
TH_0154|M.thermoresistible__bu TEFNTLFQTVVDIARQVDPIKLNQTLTATAQALDGLGDRFGESIIDGNAI
MSMEG_0134|M.smegmatis_MC2_155 TEFNTLFETITAISEQVDPIKLNETLTAAAQALDGLGDKFGRSIVDGNAI
MAB_4153c|M.abscessus_ATCC_199 LEVNTVFENLTRLLGKIDPVNLNATLTAVGEGLRGNGDNFGQGLVELDQY
*.**:*:.:. : ::**::** **:*..:.* * *:.**..: : :
Mb0175|M.bovis_AF2122/97 LDDLNSRMPQSRHDIQQLAALGDVYADAAPDLFDFLDSSVTTARTINAQQ
Rv0169|M.tuberculosis_H37Rv LDDLNSRMPQSRHDIQQLAALGDVYADAAPDLFDFLDSSVTTARTINAQQ
MLBr_02589|M.leprae_Br4923 LDDVNSQLPQARHDIQQLASLGDTYANSASDFFDFLNNSIVTSRTINQQQ
MAV_5015|M.avium_104 LDDVNPRMPQARKDIQGLAALGDTYADASPDLFDFLNNAVITSRTINAQQ
MMAR_0412|M.marinum_M LDDINPQMPQARRDIQQLAALGDVYADAAPDLFDFLNNSVPTARTINAQQ
MUL_1062|M.ulcerans_Agy99 LDDINPQMPQARRDIQQLAALGDVYADAAPDLFDFLNNSVPTARTINAQQ
Mflv_0711|M.gilvum_PYR-GCK LAEINPQMPQIRRDNQLLADFGEVYSNAAPDLFDGLQNAVTTARTLNEQQ
Mvan_0134|M.vanbaalenii_PYR-1 LSEINPQMPQIRRDNQLLADLGDVYADAAPDLFDGLQNAVTTARTLNEQQ
TH_0154|M.thermoresistible__bu LDDLNPQMPQIRYDVQRLADLNAVYAAAAPDLFDGLENAVTTAQTLYQER
MSMEG_0134|M.smegmatis_MC2_155 LADVNPRMPQIRRDITGLANLGEVYADASPDLFDGLDNAVTTARTLNEQR
MAB_4153c|M.abscessus_ATCC_199 LDQLNPKLPALQQDFRQAGQVGQIYGDAAPDIVRILDNLPALSRTVVDQQ
* ::*.::* : * . .. *. ::.*:. *:. ::*: ::
Mb0175|M.bovis_AF2122/97 AELDSALLAAAGFGNTTADVFDRGGPYLQRGVADLVPTATLLDTYSPELF
Rv0169|M.tuberculosis_H37Rv AELDSALLAAAGFGNTTADVFDRGGPYLQRGVADLVPTATLLDTYSPELF
MLBr_02589|M.leprae_Br4923 KDLDQVLLAAVGFGNTGADIFSRSGPYLARGAADLVPTAQLLDTYSPAIF
MAV_5015|M.avium_104 KDLDQALLSAAGFGNTGADLFTKGGPYLARGAHDLVPTAQLLDTYSPELY
MMAR_0412|M.marinum_M HDLDAALLAAVGFGNTGADVFERGGPYLARGAADLVPSAQLLDTYSPELF
MUL_1062|M.ulcerans_Agy99 HDLDAALLAAVGFGNTGADVFERGGPYLARGAADLVPSAQLLDTYSPELF
Mflv_0711|M.gilvum_PYR-GCK GDVDQALMAAVGFGNTGGDIFERGGPYLVRGARDLVPTSALLDKYSPSFF
Mvan_0134|M.vanbaalenii_PYR-1 GDVDQALMAAVGFGNTGGDVFERGGPYLARGAEDLVPTTALLDKYSPSFF
TH_0154|M.thermoresistible__bu GNLDQTLLASIGFGNTAGEVFERGGPYLVRGSEDLVTVTEILDYHSPALF
MSMEG_0134|M.smegmatis_MC2_155 GNLDQALVAAVGFGNTGGDIFERGGPYLVRGAQDLLPTSALLDEYSPALF
MAB_4153c|M.abscessus_ATCC_199 QDLKATLLAAIGLGNNGYETLAPAEKDLTAALQRLRAPATLLGRYSPEIP
::. .*::: *:**. : : . * . * . : :*. :** :
Mb0175|M.bovis_AF2122/97 CTIRNFYDADPLAKAAAGGGNGYSLRTNSEILSGIGISLLSPLALATNGA
Rv0169|M.tuberculosis_H37Rv CTIRNFYDADPLAKAASGGGNGYSLRTNSEILSGIGISLLSPLALATNGA
MLBr_02589|M.leprae_Br4923 CTLRNYHDIEPKVTSFLGG-NGYSINDHVELLSGLGF-LLNPTSAIS---
MAV_5015|M.avium_104 CTLHNYHDIVPITGASEGGFNGYSLNMNTEVTSGLGL-LLNPVATIP---
MMAR_0412|M.marinum_M CTLRNYHDVEPQAYKFLGG-NGYSLNSHTTPLSALGM-MLNPASLVP---
MUL_1062|M.ulcerans_Agy99 CTLRNYHDVEPQAYKFLGG-NGYSLNSHTTPLSALGM-MLNPASLVP---
Mflv_0711|M.gilvum_PYR-GCK CMMRNYHDVEPKIADALGG-NGYSLKTHSQVLG-----------------
Mvan_0134|M.vanbaalenii_PYR-1 CMIRNYHDVEPKIADALGG-NGYSLKTHSEVLG-----------------
TH_0154|M.thermoresistible__bu CMIRNYHDVAPKVAASLGG-NGYSLRQHAFLVG-----------------
MSMEG_0134|M.smegmatis_MC2_155 CTIRNYHDAAPKLAGALGG-NGYSLLTNSLVVG-----------------
MAB_4153c|M.abscessus_ATCC_199 CTLQAISKALVTFTPLIGGVRPGLFLTNSFPLG-----------------
* :: . ** . : : .
Mb0175|M.bovis_AF2122/97 AIGIGLVAGLIASPLAVAANLAG-ALPGIVGGAPNPYTYPENLPRVNARG
Rv0169|M.tuberculosis_H37Rv AIGIGLVAGLIAPPLAVAANLAG-ALPGIVGGAPNPYTYPENLPRVNARG
MLBr_02589|M.leprae_Br4923 ---------IIGAGVLSQGLLAPLGLAGVVNGAANPYIYPENLPRVNARG
MAV_5015|M.avium_104 ---------VLAS------LVG--GIAGLVGGAPNPYIYPENLPRVNARG
MMAR_0412|M.marinum_M ---------LLIS------QVGG-LAAGLVGGAPNPYIYPENLPRVNAHG
MUL_1062|M.ulcerans_Agy99 ---------LLIS------QVGG-LAAGLVGGAPNPYIYPENLPRVNAHG
Mflv_0711|M.gilvum_PYR-GCK ------------------------------LGAGNAYVYPDNLPRVNAKG
Mvan_0134|M.vanbaalenii_PYR-1 ------------------------------LGAGNAYVYPDNLPRVNAKG
TH_0154|M.thermoresistible__bu ------------------------------P--GNPYVYPDNLPRVNATG
MSMEG_0134|M.smegmatis_MC2_155 ------------------------------V--GNPYVYPDNLPRVNAKG
MAB_4153c|M.abscessus_ATCC_199 ---------------------------------APVYTYPDSLPIVNASG
* **:.** *** *
Mb0175|M.bovis_AF2122/97 GP--GGAPGCWQPITRDLWP-APYLVMDTGAS-LAPYNHMEVGSPYAVEY
Rv0169|M.tuberculosis_H37Rv GP--GGAPGCWQPITRDLWP-APYLVMDTGAS-LAPYNHMEVGSPYAVEY
MLBr_02589|M.leprae_Br4923 GP--GGAPGCWQHITRDLWP-TPELVMDTGNS-IAPYNHLDSGSPYAIEY
MAV_5015|M.avium_104 GP--GGAPGCWQPITHDLWP-APELVIDSGNS-LAPYNHLDTGSPYAIEY
MMAR_0412|M.marinum_M GP--GGAPGCWQSITHDFWP-APELVMDTGNS-LAPYNHLETGSPFVLEY
MUL_1062|M.ulcerans_Agy99 GP--GGAPGCWQSITHDFWP-APELVMDTGNS-LAPYNHLETGSPFVLEY
Mflv_0711|M.gilvum_PYR-GCK GP--GGRPGCWQPITRDLWP-APFLVLDTGAS-VAPYNHMELGQPLFTEY
Mvan_0134|M.vanbaalenii_PYR-1 GP--GGRPGCWQPITRDLWP-APFLVLDTGAS-IAPYNHMELGQPLLTEY
TH_0154|M.thermoresistible__bu GP--GGRPGCWQPITRDLWP-APYLVMDTGAS-LAPYNHIELGKPFAIEY
MSMEG_0134|M.smegmatis_MC2_155 GP--EGRPGCWQPITRDLWP-FPYLVMDTGAS-IAPYNHFELGQPMFAEY
MAB_4153c|M.abscessus_ATCC_199 GPNCRGLPNIPTKMQNGSWFRSPFLVTDNAYIPYKPLEELQVNAPDTLQY
** * *. : .. * * ** *.. * :.:: . * :*
Mb0175|M.bovis_AF2122/97 VWGRQVGDNTINP
Rv0169|M.tuberculosis_H37Rv VWGRQVGDNTINP
MLBr_02589|M.leprae_Br4923 VWGRQVGDNTINP
MAV_5015|M.avium_104 VWGRQVGDNTINP
MMAR_0412|M.marinum_M VWGRQVGDYTINP
MUL_1062|M.ulcerans_Agy99 VWGRQVGDYTINP
Mflv_0711|M.gilvum_PYR-GCK VWGRQVGEHTINP
Mvan_0134|M.vanbaalenii_PYR-1 VWGRQVGEHTINP
TH_0154|M.thermoresistible__bu VWGRQIGEYTINP
MSMEG_0134|M.smegmatis_MC2_155 VWGRQVGENTINP
MAB_4153c|M.abscessus_ATCC_199 LYNGAFAKRSEF-
::. ... :