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VPNRRSRIHPAWWTALLLATGVVVVVFTAASFNGWFRSWIPVTLQSDRSGLIMEPGGKVKMRGLEVGRVG DVNAVRGGTSVELEIDPAYAEFIPSNVSAEIDANTVFGAKYVDLVYPDDPSPQRLKSGQILRSRNVTTEV NTVFQNLVDLLDKVDPAKLNAILSALAEGLRGQGPAIGEATTAANEVLHALNPRSDTVRADWQSLAAASE TYSDAAQDIMAVLDSFTTTAVTLDEQSSALDALLVNAAGLARSGIDLLGVSKDDFVHTVNTLEPTTGLLE KYSPSLTCLLVGAQWFLDNGGRDYVGGNGYSIVLDATLTWGQDPYRYPRNLPIVGAKGGPGGKPGCGSLP DVTQQFPVRHLVTNTGWGTGNDIRVNPGIGFPGWANYFPVTRAVPEPPSIRNIGPSAPGPVPYPGAPPRG APLYAPDGSPLFPGLPPAPPPGAPREPGPTPGSEPFVPSVPALMQPTPAPVPGPGPAPGPAAP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0922 | - | - | 100% (483) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_4604 | - | e-167 | 60.00% (480) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_3982 | - | e-160 | 61.07% (447) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0604 | mce2A | 8e-65 | 39.39% (358) | MCE-family protein MCE2A |
| M. gilvum PYR-GCK | Mflv_2101 | - | 1e-170 | 61.33% (481) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1966 | mce3A | 1e-137 | 57.28% (419) | MCE-family protein MCE3A |
| M. leprae Br4923 | MLBr_02589 | mce1A | 2e-59 | 35.04% (391) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 4e-55 | 35.31% (337) | MCE-family protein |
| M. marinum M | MMAR_4051 | mce3A_1 | 1e-174 | 62.89% (485) | MCE-family protein Mce3A_1 |
| M. avium 104 | MAV_2532 | - | 1e-156 | 59.73% (447) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0346 | - | 1e-166 | 61.32% (468) | virulence factor |
| M. thermoresistible (build 8) | TH_2548 | - | 1e-144 | 57.37% (441) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3918 | mce3A_1 | 1e-173 | 62.47% (485) | MCE-family protein Mce3A_1 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4051|M.marinum_M -----MDDRKEGLHPAWHTLILVLLFVAAMWVTYALFMGSLRSVVPVTLT
MUL_3918|M.ulcerans_Agy99 -----MDDRKEGLHPAWHTLILVLLFVAAMWVTYALFMGSLRSVVPVTLT
Mflv_2101|M.gilvum_PYR-GCK -----MDD--DGLKPGWWTLILVAVFAVAIFVTYALFTGSLKSTVPVTLT
MAV_2532|M.avium_104 ----------------------------------------------MTLT
Mvan_0922|M.vanbaalenii_PYR-1 -----MPNRRSRIHPAWWTALLLATGVVVVVFTAASFNGWFRSWIPVTLQ
MSMEG_0346|M.smegmatis_MC2_155 ---MQPRFRDARIKPAWWTWILIAALGVFFFTTGSLFAGTFRSFVPVTLV
Rv1966|M.tuberculosis_H37Rv ---MRRGPGRHRLHDAWWTLILFAVIGVAVLVTAVSFTGSLRSTVPVTLA
TH_2548|M.thermoresistible__bu -------------------VILVAAVTVFIVVTSAFFRGAFTATVPVTLS
Mb0604|M.bovis_AF2122/97 -MPTLVTRKNRRAWLYVEGVVLLLVGALVLVLVYKQFRGEFTPKTELTMV
MLBr_02589|M.leprae_Br4923 MTSSTKINASRKPPYKLAGVGLLVVAVVIFGLVYGQFRGNFTPKSKLTML
MAB_4153c|M.abscessus_ATCC_199 -----MSDTSTRRAVRLAGTVLASVLVLLTVLTYLAYNDAFADTKPITVV
:*:
MMAR_4051|M.marinum_M SERSGLVMETNAKVKLRGVQVGRVASIVGGGKGA-TPVALTLEIDSDQIR
MUL_3918|M.ulcerans_Agy99 SERSGLVMETNAKVKLRGVQVGRVASIVGGGKGA-TPVALTLEIDSDQIR
Mflv_2101|M.gilvum_PYR-GCK SDRAGLVMETNAKVKLRGVQVGRVSDISVTGRQD-PTVALQLEIDPDQVQ
MAV_2532|M.avium_104 ADRSGLIMEPGAKVKLRGVQVGRVTSIHSGD-----PVTLRLELYPEQLQ
Mvan_0922|M.vanbaalenii_PYR-1 SDRSGLIMEPGGKVKMRGLEVGRVGDVNAVRGG----TSVELEIDPAYAE
MSMEG_0346|M.smegmatis_MC2_155 SDRSGLVMETGAKVKLNGVEVGRVSEIRGGASG----VSLQLEIEPDQIR
Rv1966|M.tuberculosis_H37Rv ADRSGLVMDSGAKVMMRGVQVGRVAQIGRIEWAQ-NGASLRLEIDPDQIR
TH_2548|M.thermoresistible__bu AERSGIILEPNAKVKMRGVEVGKVAHV---EATG-GAAQVRLELFPEQLA
Mb0604|M.bovis_AF2122/97 ASRAGLVMEAGSKVTYNGVEIGRVGSISEIERDGRPAAKLVLDVNPRYIS
MLBr_02589|M.leprae_Br4923 ADRAGLVMDRGSKITYNGVKIGRVADISETVRNGRPVAEFTLDVYPRYLS
MAB_4153c|M.abscessus_ATCC_199 SPRAGLVMEEGGKVKFHGLQIGKVTSISYAN----DQAKLELAVNAKDLR
: *:*:::: ..*: .*:::*:* : . . * : .
MMAR_4051|M.marinum_M YIPANVQAEIRATTVFGAKFVDLVYPQDPSPQRLKAGQVLMSRNVTSEAN
MUL_3918|M.ulcerans_Agy99 YIPANVQAEIRATTVFGAKFVDLIYPEDPSPQRLKAGQVLMSRNVTSEAN
Mflv_2101|M.gilvum_PYR-GCK YIPANVEAQIRATTIFGAKFVDLVFPDDPSNQRLEAGQVLQSRNVTTEVN
MAV_2532|M.avium_104 YIPANVTAQITATTAFGGKYVDLQIPESPSPRRLAAGAVVRSRNVTTEVN
Mvan_0922|M.vanbaalenii_PYR-1 FIPSNVSAEIDANTVFGAKYVDLVYPDDPSPQRLKSGQILRSRNVTTEVN
MSMEG_0346|M.smegmatis_MC2_155 FIPANVEARITATTAFGAKYVDLSYPDNPTGQHLAAGAVLRSRNVSTEVN
Rv1966|M.tuberculosis_H37Rv YIPANVEAQISATTAFGAKFVDLVMPQNPSRARLSAGAVLHSKNVSTEIN
TH_2548|M.thermoresistible__bu RIPANVMAEIDSTTAFGAKFVNLVYPDNPSEERLTAGAVLHADRVATEVN
Mb0604|M.bovis_AF2122/97 LIPVNVVADIEAATLFGNKYVALSAPKIPQQQRISSHDVIDVGSVTTEFN
MLBr_02589|M.leprae_Br4923 LIPANVNADIKATTVFGGKYVSLTTPEHPSQKRLTPQTVIDARSVTTEIN
MAB_4153c|M.abscessus_ATCC_199 LIPSNATVRIAGTTVFGAKSVEFLAPQKPSDSSLRPGATVTAEAVALEVN
** *. . * . * ** * * : *. * : . : *: * *
MMAR_4051|M.marinum_M TVFQNLVAVLDQIDPAKLNAALSALAEGLRGQGPLIGQATTDANQVLLEL
MUL_3918|M.ulcerans_Agy99 TVFQNLVAVLDQIDPAKLNAALSALAEGLRGQGPLIGQATTDANQVLLEL
Mflv_2101|M.gilvum_PYR-GCK TVFQNLVAVLDQVDAAKLNSTLSALADGVRGQGERIGRATTDANQVLLAL
MAV_2532|M.avium_104 TVFQNLVAVLNQVDTPKLNAVLTALGDGLRGKGEALGEATTDLNEVLGAI
Mvan_0922|M.vanbaalenii_PYR-1 TVFQNLVDLLDKVDPAKLNAILSALAEGLRGQGPAIGEATTAANEVLHAL
MSMEG_0346|M.smegmatis_MC2_155 TVFENLTDVLKMVDPAKLNAVLSALAEGFRGQGERMGQAITDANEVLMAI
Rv1966|M.tuberculosis_H37Rv TVFENVVDLLNMIDPLKLNAVLTAVADAVRGQGERIGQATTDLNEVLEAL
TH_2548|M.thermoresistible__bu TVFENVVELIGMIDPAKLNAVLSATAEAVRGQGERIGEATTALSEVLQAV
Mb0604|M.bovis_AF2122/97 TLFETITSIAEKVDPIELNATLSAVAQAPDGLGGKFGESIVNGNQILAQL
MLBr_02589|M.leprae_Br4923 TLFQTITLIAEKVDPIKLNLTLSAAAQSLAGLGERFGQSIVNGNSVLDDV
MAB_4153c|M.abscessus_ATCC_199 TVFENLTRLLGKIDPVNLNATLTAVGEGLRGNGDNFGQGLVELDQYLDQL
*:*:.:. : :*. :** *:* .:. * * :*.. . .. * :
MMAR_4051|M.marinum_M NPRYETVTADLRAVKDFNDTFSAAAQDILDTLNALSTTSTTITSHSTQLD
MUL_3918|M.ulcerans_Agy99 NPRYETVTADLRAVKDFNDTFSAAAQDILDTLNALSTTSTTITGHSTQLD
Mflv_2101|M.gilvum_PYR-GCK NPRNETITEDLRALDQFNQTYSAAAQNILATLDAASTTSTTVVNQAKELD
MAV_2532|M.avium_104 NPRSETIRADSRALEGFSDTYSAAAHDIVTVLDAGSTTSATVSNNAQALD
Mvan_0922|M.vanbaalenii_PYR-1 NPRSDTVRADWQSLAAASETYSDAAQDIMAVLDSFTTTAVTLDEQSSALD
MSMEG_0346|M.smegmatis_MC2_155 NPRQDTIREDWRAMGEVSAAYDHAADDIVKILDAGTTTAETVTSHRSELD
Rv1966|M.tuberculosis_H37Rv NARGDTIGGNWRSLKNFTDTYDAAAQDILTILNAASTTSATVVNHSTQLD
TH_2548|M.thermoresistible__bu NDRSGLIREDWRAFKAFNDTYAAVAEDLLTVLDAASVTSETLVDHSAALD
Mb0604|M.bovis_AF2122/97 NPRLPQLGYDVRRLADLGEVYVDASPDLWSFLQNALTTARTLTSQQRDLD
MLBr_02589|M.leprae_Br4923 NSQLPQARHDIQQLASLGDTYANSASDFFDFLNNSIVTSRTINQQQKDLD
MAB_4153c|M.abscessus_ATCC_199 NPKLPALQQDFRQAGQVGQIYGDAAPDIVRILDNLPALSRTVVDQQQDLK
* : : : : : :: *: . : *: : *.
MMAR_4051|M.marinum_M ALLLATIGLSNTGISLLAPNQANLIKAINALEPTTNLLYKYSPEYTCLLE
MUL_3918|M.ulcerans_Agy99 ALLLATIGLSNTGISLLAPNQANLIKAINALEPTTNLLYKYSPEYTCLLE
Mflv_2101|M.gilvum_PYR-GCK ALLLAAIGLSNSGIDLLAPNQANLIKAVNTLAPTTNLLHKYSPSYTCLLL
MAV_2532|M.avium_104 SLLLNVIGLSHSGIGLIGPNKDNLVHGVNLLESTTRLLMKYNPELTCTLL
Mvan_0922|M.vanbaalenii_PYR-1 ALLVNAAGLARSGIDLLGVSKDDFVHTVNTLEPTTGLLEKYSPSLTCLLV
MSMEG_0346|M.smegmatis_MC2_155 TLLLNVIGFGRAGVDLLAPSFTNLVNAVNGFAPTSDLLMKYQPEYTCLLD
Rv1966|M.tuberculosis_H37Rv ALLLNAIGLSNAGTNLLGSSRDNLVGAADILAPTTSLLFKYNPEYTCFLQ
TH_2548|M.thermoresistible__bu ALLLSVTGFGRAGSGLLEESRDDLVTAARVLEPTTALLHRYSPSYTCLLQ
Mb0604|M.bovis_AF2122/97 AALLAATGAGNTGEDVFARGGPYLARAAADLVPTATLLDTYSPELFCMIR
MLBr_02589|M.leprae_Br4923 QVLLAAVGFGNTGADIFSRSGPYLARGAADLVPTAQLLDTYSPAIFCTLR
MAB_4153c|M.abscessus_ATCC_199 ATLLAAIGLGNNGYETLAPAEKDLTAALQRLRAPATLLGRYSPEIPCTLQ
*: . * .. * : : : ..: ** *.* * :
MMAR_4051|M.marinum_M GAKYLLDHGGYEAPGGN-GRS-----------------------------
MUL_3918|M.ulcerans_Agy99 GAKYLLDHGGYEAPGGN-GRS-----------------------------
Mflv_2101|M.gilvum_PYR-GCK GAKHLLDEGGYEAPGGN-GRT-----------------------------
MAV_2532|M.avium_104 GSKYDAEFFGDVAGGHN-GYS-----------------------------
Mvan_0922|M.vanbaalenii_PYR-1 GAQWFLDNGGRDYVGGN-GYS-----------------------------
MSMEG_0346|M.smegmatis_MC2_155 GSVSLLQNGHVDAFGGN-GRS-----------------------------
Rv1966|M.tuberculosis_H37Rv GAKWYLDNGGYAAWGGADGRT-----------------------------
TH_2548|M.thermoresistible__bu GAQLLLENGAYDVYGGADGRS-----------------------------
Mb0604|M.bovis_AF2122/97 NFHDAAPKVADAVGGNGYS-------------------------------
MLBr_02589|M.leprae_Br4923 NYHDIEPKVTSFLGGNGYSINDHVELLSGLGFLLNPTSAISIIGAGVLSQ
MAB_4153c|M.abscessus_ATCC_199 AISKALVTFTPLIGGVRPG-------------------------------
* .
MMAR_4051|M.marinum_M -----LVLDAALALGDDPYRFPDNLPIIGAKGGP--GGKPGCGSLPIVDN
MUL_3918|M.ulcerans_Agy99 -----LVLDAALALGDDPYRFPDNLPIIGAKGGP--GGKPGCGSLPIVDN
Mflv_2101|M.gilvum_PYR-GCK -----LVLDTSLSFGDDPYQYPRHLPIIGAKGGP--GGKPGCGSLPKVAE
MAV_2532|M.avium_104 -----VTLDVALLLGDEAYRYPDNLPINGAKGGP--GGQPGCGSLPDVSK
Mvan_0922|M.vanbaalenii_PYR-1 -----IVLDATLTWGQDPYRYPRNLPIVGAKGGP--GGKPGCGSLPDVTQ
MSMEG_0346|M.smegmatis_MC2_155 -----AIFDIGLLLGNDPYHYPDDLPIVGAKGGP--GGKPGCGSLPDVAK
Rv1966|M.tuberculosis_H37Rv -----LQLDVALLFGNDPYVYPDNLPVVAAKGGP--GGRPGCGPLPDATH
TH_2548|M.thermoresistible__bu -----LIFDVGLLPGNDLYEYPRHLPVVAAKGGP--GGRPGCGSLPDVAE
Mb0604|M.bovis_AF2122/97 -----LAAAGTILGAPNPYVYPDNLPRVNAHGGP--GGRPGCWQTITREL
MLBr_02589|M.leprae_Br4923 GLLAPLGLAGVVNGAANPYIYPENLPRVNARGGP--GGAPGCWQHITRDL
MAB_4153c|M.abscessus_ATCC_199 -----LFLTNSFPLGAPVYTYPDSLPIVNASGGPNCRGLPNIPTKMQNGS
. . * :* ** * *** * *.
MMAR_4051|M.marinum_M NWPVRNLVTNTGFGTGMDWRPNPGIGFPGWANYFPVTRGTPEPPSIRNLF
MUL_3918|M.ulcerans_Agy99 NWPVRNLVTNTGFGTGMDWRPNPGIGFPGWANYFPVTRGTPEPPSIRNLF
Mflv_2101|M.gilvum_PYR-GCK NWPVRNLVTNTGFGSGLDWRPNPGIAFPTYANYLPVTRAVPEPPSVRNLF
MAV_2532|M.avium_104 NFPLRYLVTNTGWGRGLDMRPNPGIGFPGYVDYLPVTRGTPQPPSLR-HP
Mvan_0922|M.vanbaalenii_PYR-1 QFPVRHLVTNTGWGTGNDIRVNPGIGFPGWANYFPVTRAVPEPPSIR-NI
MSMEG_0346|M.smegmatis_MC2_155 NFPVRQLVTNTGWGTGLDIRPNPGIGFPGWANYFPVTRGIPQPPIIRNLG
Rv1966|M.tuberculosis_H37Rv NFPVRQLVTNTGWGTGLDIRPNPGIGHPCWANYFPVTRAVPEPPSIRQCI
TH_2548|M.thermoresistible__bu NFPVRKLITDTGWGTGLDIRPNPGIGSPCFANWFPVTRAVPEPPSIRTCL
Mb0604|M.bovis_AF2122/97 WP-APYLVMDTG------------------ASLAPYNHVELGQPMFTEYV
MLBr_02589|M.leprae_Br4923 WP-TPELVMDTG------------------NSIAPYNHLDSGSPYAIEYV
MAB_4153c|M.abscessus_ATCC_199 WFRSPFLVTDNAY-----------------IPYKPLEELQVNAPDTLQYL
*: :.. * . *
MMAR_4051|M.marinum_M GGPAPGPIPYPGAPPYGAELYAPDGTPLWPGLPPAPPPG--APRESGPTP
MUL_3918|M.ulcerans_Agy99 GGPAPGPIPYPGAPPYGAELYAPDGTPLWPGLPPAPPPG--APRESGPTP
Mflv_2101|M.gilvum_PYR-GCK GGPAIGPIPYPGAPAYGAQLYAPDGTPLWPGLPPAPPPG--APRDPGPRP
MAV_2532|M.avium_104 GGTAPGPMPYPGAPPYGAPQYAPDGTPLYPGLPPAPPPG--RPRDAGPPP
Mvan_0922|M.vanbaalenii_PYR-1 GPSAPGPVPYPGAPPRGAPLYAPDGSPLFPGLPPAPPPG--APREPGPTP
MSMEG_0346|M.smegmatis_MC2_155 GGPAPGPIPYPGAPPYGADLYADDGTPLWPGLPPAPPPSDQPPPDPNNPP
Rv1966|M.tuberculosis_H37Rv PGPAIGPNPAAGEQP-----------------------------------
TH_2548|M.thermoresistible__bu PGPAIGPVPYPGAPPYGAPMYGPGGVPLWPGVPPAGPEP-------GPAQ
Mb0604|M.bovis_AF2122/97 WGRQYGENTINP--------------------------------------
MLBr_02589|M.leprae_Br4923 WGRQVGDNTINP--------------------------------------
MAB_4153c|M.abscessus_ATCC_199 YNGAFAKRSEF---------------------------------------
. .
MMAR_4051|M.marinum_M -GSEPFVVPAPAQAQPTPLP----PAPLPQEVAPSP-
MUL_3918|M.ulcerans_Agy99 -GSEPFVVPASAQAQPTPLP----PAPLPQEVAPSP-
Mflv_2101|M.gilvum_PYR-GCK -GSEPFVVPHPSQMQPTAVPYPFVPPPVPAQPGPPR-
MAV_2532|M.avium_104 AGSEPFTPPVPGAIQPTCGVLNQVCEPLPPPPNVPGP
Mvan_0922|M.vanbaalenii_PYR-1 -GSEPFVPSVPALMQPTPAP---VPGPGPAPGPAAP-
MSMEG_0346|M.smegmatis_MC2_155 PGAEPFVPPAPAAMTPTQ-------------------
Rv1966|M.tuberculosis_H37Rv -------------------------------------
TH_2548|M.thermoresistible__bu PDSNGQTPP----------------------------
Mb0604|M.bovis_AF2122/97 -------------------------------------
MLBr_02589|M.leprae_Br4923 -------------------------------------
MAB_4153c|M.abscessus_ATCC_199 -------------------------------------