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MSKQSSSGLIRRGGNQRNGIDPIWWAPTLFIVIGGLVALTAASFSGKFQTFVPLTLVSDRAGLVMEDGAK VKLRGVQIGQVASIGTDVKTARLQLKIQPGPFRYLPSNLEAEIKSTTAFGSKFVDLIVPERPSASPLKPG AVLRSRNVTVEVNTVFENLQAVVQALDPAKLNAILSAFAQSVRGKGERIGEAITDANSLLRTVNSRMDTI GEDWRLFGATTAVYSDAAQHILSILDSASTTSNTITDNQRSLDSLLLSAVGFSQTGINVIGANESNIVRA MNLLDPTIALMQKYSPTYTCLFQGAQWYVDHGGRDALGGNGYSVILDAALLFGDDPYRYPKHLPKVNATG GPGGRPSCGSLPDPSANFPVRALVTDTGWGAAPNEIRTNVAAGNPWWANWFPTTKNPPEAPRYFWRGGQP PP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2061 | - | - | 100% (422) | virulence factor Mce family protein |
| M. avium 104 | MAV_2532 | - | e-100 | 50.00% (368) | virulence factor Mce family protein |
| M. avium 104 | MAV_4126 | - | 3e-64 | 35.01% (417) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0604 | mce2A | 6e-63 | 37.50% (392) | MCE-family protein MCE2A |
| M. gilvum PYR-GCK | Mflv_2101 | - | 1e-115 | 51.89% (397) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1966 | mce3A | 1e-121 | 52.97% (404) | MCE-family protein MCE3A |
| M. leprae Br4923 | MLBr_02589 | mce1A | 2e-61 | 34.56% (408) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 2e-57 | 35.55% (346) | MCE-family protein |
| M. marinum M | MMAR_2882 | mce3A | 1e-115 | 50.38% (399) | MCE-family protein Mce3A |
| M. smegmatis MC2 155 | MSMEG_0346 | - | 1e-119 | 51.86% (403) | virulence factor |
| M. thermoresistible (build 8) | TH_4174 | - | 1e-116 | 50.88% (399) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3918 | mce3A_1 | 1e-113 | 50.61% (413) | MCE-family protein Mce3A_1 |
| M. vanbaalenii PYR-1 | Mvan_0922 | - | 1e-122 | 51.13% (397) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2101|M.gilvum_PYR-GCK ----------MDD----DGLKPGWWTLILVAVFAVAIFVTYALFTGSLKS
MUL_3918|M.ulcerans_Agy99 ----------MDDRK--EGLHPAWHTLILVLLFVAAMWVTYALFMGSLRS
Mvan_0922|M.vanbaalenii_PYR-1 ----------MPNRR--SRIHPAWWTALLLATGVVVVVFTAASFNGWFRS
MSMEG_0346|M.smegmatis_MC2_155 ----------MQPRFRDARIKPAWWTWILIAALGVFFFTTGSLFAGTFRS
Rv1966|M.tuberculosis_H37Rv ----------MRRGPGRHRLHDAWWTLILFAVIGVAVLVTAVSFTGSLRS
MMAR_2882|M.marinum_M ----------MGRGPGKHRLHDAWWTVILFAAIVAAILVTTVSFTGTLRP
TH_4174|M.thermoresistible__bu ---------------------LGWWAAIMITVVAGMVFVCSTLFAGTFRR
MAV_2061|M.avium_104 MSKQSSSGLIRRGGNQRNGIDPIWWAPTLFIVIGGLVALTAASFSGKFQT
Mb0604|M.bovis_AF2122/97 --------MPTLVTRKNRRAWLYVEGVVLLLVGALVLVLVYKQFRGEFTP
MLBr_02589|M.leprae_Br4923 -------MTSSTKINASRKPPYKLAGVGLLVVAVVIFGLVYGQFRGNFTP
MAB_4153c|M.abscessus_ATCC_199 ------------MSDTSTRRAVRLAGTVLASVLVLLTVLTYLAYNDAFAD
: : . :
Mflv_2101|M.gilvum_PYR-GCK TVPVTLTSDRAGLVMETNAKVKLRGVQVGRVSDISVTGRQD-PTVALQLE
MUL_3918|M.ulcerans_Agy99 VVPVTLTSERSGLVMETNAKVKLRGVQVGRVASIVGGGKGA-TPVALTLE
Mvan_0922|M.vanbaalenii_PYR-1 WIPVTLQSDRSGLIMEPGGKVKMRGLEVGRVGDVNAVRGG----TSVELE
MSMEG_0346|M.smegmatis_MC2_155 FVPVTLVSDRSGLVMETGAKVKLNGVEVGRVSEIRGGASG----VSLQLE
Rv1966|M.tuberculosis_H37Rv TVPVTLAADRSGLVMDSGAKVMMRGVQVGRVAQIGRIEWAQ-NGASLRLE
MMAR_2882|M.marinum_M HVAVTLTSERSGLVMDAGAKVMLRGVQVGRVRQID----SN-HGASLELE
TH_4174|M.thermoresistible__bu YVPVSLTADRTGLVLEKGAKVRMRGVDVGRVGAIEGGAAP----VRLELE
MAV_2061|M.avium_104 FVPLTLVSDRAGLVMEDGAKVKLRGVQIGQVASIGTDVKT----ARLQLK
Mb0604|M.bovis_AF2122/97 KTELTMVASRAGLVMEAGSKVTYNGVEIGRVGSISEIERDGRPAAKLVLD
MLBr_02589|M.leprae_Br4923 KSKLTMLADRAGLVMDRGSKITYNGVKIGRVADISETVRNGRPVAEFTLD
MAB_4153c|M.abscessus_ATCC_199 TKPITVVSPRAGLVMEEGGKVKFHGLQIGKVTSISYAN----DQAKLELA
::: : *:**::: ..*: .*:.:*:* : . . *
Mflv_2101|M.gilvum_PYR-GCK IDPDQVQYIPANVEAQIRATTIFGAKFVDLVFPDDPSNQRLEAGQVLQSR
MUL_3918|M.ulcerans_Agy99 IDSDQIRYIPANVQAEIRATTVFGAKFVDLIYPEDPSPQRLKAGQVLMSR
Mvan_0922|M.vanbaalenii_PYR-1 IDPAYAEFIPSNVSAEIDANTVFGAKYVDLVYPDDPSPQRLKSGQILRSR
MSMEG_0346|M.smegmatis_MC2_155 IEPDQIRFIPANVEARITATTAFGAKYVDLSYPDNPTGQHLAAGAVLRSR
Rv1966|M.tuberculosis_H37Rv IDPDQIRYIPANVEAQISATTAFGAKFVDLVMPQNPSRARLSAGAVLHSK
MMAR_2882|M.marinum_M IDPDQIRYIPANVEAQISATTAFGAKFVDLVIPPTPSRARLAAGAVLHSK
TH_4174|M.thermoresistible__bu IFPDKLSFIPSNVEAEIKATTAFGAKYVELIPPPAPSQARLAAGMTVHSR
MAV_2061|M.avium_104 IQPGPFRYLPSNLEAEIKSTTAFGSKFVDLIVPERPSASPLKPGAVLRSR
Mb0604|M.bovis_AF2122/97 VNPRYISLIPVNVVADIEAATLFGNKYVALSAPKIPQQQRISSHDVIDVG
MLBr_02589|M.leprae_Br4923 VYPRYLSLIPANVNADIKATTVFGGKYVSLTTPEHPSQKRLTPQTVIDAR
MAB_4153c|M.abscessus_ATCC_199 VNAKDLRLIPSNATVRIAGTTVFGAKSVEFLAPQKPSDSSLRPGATVTAE
: . :* * . * . * ** * * : * * : . :
Mflv_2101|M.gilvum_PYR-GCK NVTTEVNTVFQNLVAVLDQVDAAKLNSTLSALADGVRGQGERIGRATTDA
MUL_3918|M.ulcerans_Agy99 NVTSEANTVFQNLVAVLDQIDPAKLNAALSALAEGLRGQGPLIGQATTDA
Mvan_0922|M.vanbaalenii_PYR-1 NVTTEVNTVFQNLVDLLDKVDPAKLNAILSALAEGLRGQGPAIGEATTAA
MSMEG_0346|M.smegmatis_MC2_155 NVSTEVNTVFENLTDVLKMVDPAKLNAVLSALAEGFRGQGERMGQAITDA
Rv1966|M.tuberculosis_H37Rv NVSTEINTVFENVVDLLNMIDPLKLNAVLTAVADAVRGQGERIGQATTDL
MMAR_2882|M.marinum_M NVSTEINTVFENVVDLLNMIDPLKLNAVLSAVAEGVRGQGERIGQATTDL
TH_4174|M.thermoresistible__bu NVATEVNTVFQNLVAVLDQIDVAKLNATLSALADGVRGRGESIGQATTAV
MAV_2061|M.avium_104 NVTVEVNTVFENLQAVVQALDPAKLNAILSAFAQSVRGKGERIGEAITDA
Mb0604|M.bovis_AF2122/97 SVTTEFNTLFETITSIAEKVDPIELNATLSAVAQAPDGLGGKFGESIVNG
MLBr_02589|M.leprae_Br4923 SVTTEINTLFQTITLIAEKVDPIKLNLTLSAAAQSLAGLGERFGQSIVNG
MAB_4153c|M.abscessus_ATCC_199 AVALEVNTVFENLTRLLGKIDPVNLNATLTAVGEGLRGNGDNFGQGLVEL
*: * **:*:.: : :* :** *:* .:. * * :*.. .
Mflv_2101|M.gilvum_PYR-GCK NQVLLALNPRNETITEDLRALDQFNQTYSAAAQNILATLDAASTTSTTVV
MUL_3918|M.ulcerans_Agy99 NQVLLELNPRYETVTADLRAVKDFNDTFSAAAQDILDTLNALSTTSTTIT
Mvan_0922|M.vanbaalenii_PYR-1 NEVLHALNPRSDTVRADWQSLAAASETYSDAAQDIMAVLDSFTTTAVTLD
MSMEG_0346|M.smegmatis_MC2_155 NEVLMAINPRQDTIREDWRAMGEVSAAYDHAADDIVKILDAGTTTAETVT
Rv1966|M.tuberculosis_H37Rv NEVLEALNARGDTIGGNWRSLKNFTDTYDAAAQDILTILNAASTTSATVV
MMAR_2882|M.marinum_M NQVLQALNARRDTLRQNWRSLRDFSNTYDAAARDILTILDAASTTSTTVV
TH_4174|M.thermoresistible__bu SETLRQLNVRIDSMAQGWRSFKGFTDAYGMAAEDILAILDAAATTADTVE
MAV_2061|M.avium_104 NSLLRTVNSRMDTIGEDWRLFGATTAVYSDAAQHILSILDSASTTSNTIT
Mb0604|M.bovis_AF2122/97 NQILAQLNPRLPQLGYDVRRLADLGEVYVDASPDLWSFLQNALTTARTLT
MLBr_02589|M.leprae_Br4923 NSVLDDVNSQLPQARHDIQQLASLGDTYANSASDFFDFLNNSIVTSRTIN
MAB_4153c|M.abscessus_ATCC_199 DQYLDQLNPKLPALQQDFRQAGQVGQIYGDAAPDIVRILDNLPALSRTVV
.. * :* : . : : :: .: *: . : *:
Mflv_2101|M.gilvum_PYR-GCK NQAKELDALLLAAIGLSNSGIDLLAPNQANLIKAVNTLAPTTNLLHKYSP
MUL_3918|M.ulcerans_Agy99 GHSTQLDALLLATIGLSNTGISLLAPNQANLIKAINALEPTTNLLYKYSP
Mvan_0922|M.vanbaalenii_PYR-1 EQSSALDALLVNAAGLARSGIDLLGVSKDDFVHTVNTLEPTTGLLEKYSP
MSMEG_0346|M.smegmatis_MC2_155 SHRSELDTLLLNVIGFGRAGVDLLAPSFTNLVNAVNGFAPTSDLLMKYQP
Rv1966|M.tuberculosis_H37Rv NHSTQLDALLLNAIGLSNAGTNLLGSSRDNLVGAADILAPTTSLLFKYNP
MMAR_2882|M.marinum_M DHARSLDSLLLNVIGLADTGTNLLANNRESLTTSINILEPTTNLLFKYNP
TH_4174|M.thermoresistible__bu ARSSQLDALLLSTIGMANIGTELLGSTRDDFVTAVNEARPTTDLLLKYDP
MAV_2061|M.avium_104 DNQRSLDSLLLSAVGFSQTGINVIGANESNIVRAMNLLDPTIALMQKYSP
Mb0604|M.bovis_AF2122/97 SQQRDLDAALLAATGAGNTGEDVFARGGPYLARAAADLVPTATLLDTYSP
MLBr_02589|M.leprae_Br4923 QQQKDLDQVLLAAVGFGNTGADIFSRSGPYLARGAADLVPTAQLLDTYSP
MAB_4153c|M.abscessus_ATCC_199 DQQQDLKATLLAAIGLGNNGYETLAPAEKDLTAALQRLRAPATLLGRYSP
. *. *: . * . * . :. : .. *: *.*
Mflv_2101|M.gilvum_PYR-GCK SYTCLLLGAKHLLDEGGYEAPGG-NGRT----------------------
MUL_3918|M.ulcerans_Agy99 EYTCLLEGAKYLLDHGGYEAPGG-NGRS----------------------
Mvan_0922|M.vanbaalenii_PYR-1 SLTCLLVGAQWFLDNGGRDYVGG-NGYS----------------------
MSMEG_0346|M.smegmatis_MC2_155 EYTCLLDGSVSLLQNGHVDAFGG-NGRS----------------------
Rv1966|M.tuberculosis_H37Rv EYTCFLQGAKWYLDNGGYAAWGGADGRT----------------------
MMAR_2882|M.marinum_M EYTCLLQGTKWYLDNGGYAAWGGADGRT----------------------
TH_4174|M.thermoresistible__bu VYTCLLVGAKLYLDKGGYDALGG-NGRT----------------------
MAV_2061|M.avium_104 TYTCLFQGAQWYVDHGGRDALGG-NGYS----------------------
Mb0604|M.bovis_AF2122/97 ELFCMIRNFHDAAPKVADAVGGNGYS------------------------
MLBr_02589|M.leprae_Br4923 AIFCTLRNYHDIEPKVTSFLGGNGYSINDHVELLSGLGFLLNPTSAISII
MAB_4153c|M.abscessus_ATCC_199 EIPCTLQAISKALVTFTPLIGGVRPG------------------------
* : * .
Mflv_2101|M.gilvum_PYR-GCK ------------LVLDTSLSFGDDPYQYPRHLPIIGAKGGP--GGKPGCG
MUL_3918|M.ulcerans_Agy99 ------------LVLDAALALGDDPYRFPDNLPIIGAKGGP--GGKPGCG
Mvan_0922|M.vanbaalenii_PYR-1 ------------IVLDATLTWGQDPYRYPRNLPIVGAKGGP--GGKPGCG
MSMEG_0346|M.smegmatis_MC2_155 ------------AIFDIGLLLGNDPYHYPDDLPIVGAKGGP--GGKPGCG
Rv1966|M.tuberculosis_H37Rv ------------LQLDVALLFGNDPYVYPDNLPVVAAKGGP--GGRPGCG
MMAR_2882|M.marinum_M ------------LQLDVALLLGNDPYVFPDNLPLVAARGGP--GGAPGCG
TH_4174|M.thermoresistible__bu ------------LVADTTLLFGDDPYRYPEHLPIHNAKGGP--GGKPGCG
MAV_2061|M.avium_104 ------------VILDAALLFGDDPYRYPKHLPKVNATGGP--GGRPSCG
Mb0604|M.bovis_AF2122/97 ------------LAAAGTILGAPNPYVYPDNLPRVNAHGGP--GGRPGCW
MLBr_02589|M.leprae_Br4923 GAGVLSQGLLAPLGLAGVVNGAANPYIYPENLPRVNARGGP--GGAPGCW
MAB_4153c|M.abscessus_ATCC_199 ------------LFLTNSFPLGAPVYTYPDSLPIVNASGGPNCRGLPNIP
. . * :* ** * *** * *.
Mflv_2101|M.gilvum_PYR-GCK SLPKVAENWPVRNLVTNTGFGSG-LDWRPNPGIAFPTYANYLPVTRAVPE
MUL_3918|M.ulcerans_Agy99 SLPIVDNNWPVRNLVTNTGFGTG-MDWRPNPGIGFPGWANYFPVTRGTPE
Mvan_0922|M.vanbaalenii_PYR-1 SLPDVTQQFPVRHLVTNTGWGTG-NDIRVNPGIGFPGWANYFPVTRAVPE
MSMEG_0346|M.smegmatis_MC2_155 SLPDVAKNFPVRQLVTNTGWGTG-LDIRPNPGIGFPGWANYFPVTRGIPQ
Rv1966|M.tuberculosis_H37Rv PLPDATHNFPVRQLVTNTGWGTG-LDIRPNPGIGHPCWANYFPVTRAVPE
MMAR_2882|M.marinum_M SLPDATKNFPVRQLVTDTGWGTG-LDIRPNPGIGHPCWADYLPVTRAVPQ
TH_4174|M.thermoresistible__bu SLPDVEQNFPVRKLVTDTGFGSG-TDIRTNPGIGHPWFINFFPATRAVPE
MAV_2061|M.avium_104 SLPDPSANFPVRALVTDTGWGAAPNEIRTNVAAGNPWWANWFPTTKNPPE
Mb0604|M.bovis_AF2122/97 QTITRELWP-APYLVMDTG-ASLAPYNHVELGQPMFTEYVWGRQYGENTI
MLBr_02589|M.leprae_Br4923 QHITRDLWP-TPELVMDTG-NSIAPYNHLDSGSPYAIEYVWGRQVGDNTI
MAB_4153c|M.abscessus_ATCC_199 TKMQNGSWFRSPFLVTDNAYIPYKPLEELQVNAPDTLQYLYNGAFAKRSE
** :.. . . : : .
Mflv_2101|M.gilvum_PYR-GCK PPSVRNLFGGPAIGPIPYPGAPAYGAQLYAPDGTPLWPGLPPAPPPG--A
MUL_3918|M.ulcerans_Agy99 PPSIRNLFGGPAPGPIPYPGAPPYGAELYAPDGTPLWPGLPPAPPPG--A
Mvan_0922|M.vanbaalenii_PYR-1 PPSIRN-IGPSAPGPVPYPGAPPRGAPLYAPDGSPLFPGLPPAPPPG--A
MSMEG_0346|M.smegmatis_MC2_155 PPIIRNLGGGPAPGPIPYPGAPPYGADLYADDGTPLWPGLPPAPPPSDQP
Rv1966|M.tuberculosis_H37Rv PPSIRQCIPGPAIG--PNP----------------------AAGEQP---
MMAR_2882|M.marinum_M PPSVRPCLPGPAIG--PNPGGPPYGAALYGPGGVPLWPGVPPAPTEP---
TH_4174|M.thermoresistible__bu HPYVLG-EGPPAPGPSPSIPHGPVAAP-------------VPAPPVG---
MAV_2061|M.avium_104 APRYFWRGGQPPP-------------------------------------
Mb0604|M.bovis_AF2122/97 NP------------------------------------------------
MLBr_02589|M.leprae_Br4923 NP------------------------------------------------
MAB_4153c|M.abscessus_ATCC_199 F-------------------------------------------------
Mflv_2101|M.gilvum_PYR-GCK PRDPG-PRPGSEPFVVPHPSQMQPTAVPYPFVPPPVPAQPGPPR
MUL_3918|M.ulcerans_Agy99 PRESG-PTPGSEPFVVPASAQAQPTPLP----PAPLPQEVAPSP
Mvan_0922|M.vanbaalenii_PYR-1 PREPG-PTPGSEPFVPSVPALMQPTPAPVP-GPGPAPGPAAP--
MSMEG_0346|M.smegmatis_MC2_155 PPDPNNPPPGAEPFVPPAPAAMTPTQ------------------
Rv1966|M.tuberculosis_H37Rv --------------------------------------------
MMAR_2882|M.marinum_M -------APIPEPLAPQQETETPSP-------------------
TH_4174|M.thermoresistible__bu ------QSSPPEPTTDEPTPRTQSGQP-----------------
MAV_2061|M.avium_104 --------------------------------------------
Mb0604|M.bovis_AF2122/97 --------------------------------------------
MLBr_02589|M.leprae_Br4923 --------------------------------------------
MAB_4153c|M.abscessus_ATCC_199 --------------------------------------------