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IRAVAGFANLVVRAVRTGHRQQVWLSVAGLVLILVVATAYLLIGALRVTPFASSYRVTVQLPESGGLLPN QDVALRGVRIGRIESLQITDNGVNAVAAITSKVRIPANTVAHVSALSPAGEQFINFEAASDAGPYLHDGS FITSERTTVPVSLAQLLGDADGLLAQVDPRKIELIKKELSLSKEGPAKLTAIVDGGLFLLSTLDSVLPET TSIIKTSRVVLNLASDKNNGLGAAATELNHTLTGVARMQAGYRRLTSQTPQTLSAVDNLFADNSDTMVQL LGSMATMSQLLYLRVPALNALFPDYRGSVLDAVTSVFHDHGVWATADLYPRYVCDYGTPAHASSAADYYE PFMYTYCRDDDPAVSIRGAKNAPRPGGDDTAGPPPGADLGRRTDPTPRGRYTIPTPYGGPQLPIEPPH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2383 | - | - | 100% (419) | mce related protein |
| M. avium 104 | MAV_0107 | - | e-157 | 63.57% (409) | mce related protein |
| M. avium 104 | MAV_1807 | - | 1e-24 | 28.26% (407) | virulence factor mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0610 | mce2F | 9e-25 | 25.59% (379) | MCE-family protein MCE2F |
| M. gilvum PYR-GCK | Mflv_0005 | - | 1e-163 | 67.39% (414) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv0594 | mce2F | 9e-25 | 25.59% (379) | MCE-family protein MCE2F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 1e-24 | 25.06% (419) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_1005c | - | 1e-164 | 67.86% (420) | putative MCE family protein |
| M. marinum M | MMAR_3869 | mce5F | 0.0 | 79.76% (415) | Mce family protein Mce5F |
| M. smegmatis MC2 155 | MSMEG_1148 | - | 1e-155 | 65.95% (420) | mce related protein |
| M. thermoresistible (build 8) | TH_2636 | - | 1e-108 | 61.63% (331) | PUTATIVE mce related protein |
| M. ulcerans Agy99 | MUL_3801 | mce5F | 0.0 | 79.28% (415) | Mce family protein Mce5F |
| M. vanbaalenii PYR-1 | Mvan_0964 | - | 1e-159 | 65.46% (414) | hypothetical protein Mvan_0964 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3869|M.marinum_M MITPIA---NAVVRVVRAGHRQQTWLSVAGLVLTLVVAAAYLLVGALRLT
MUL_3801|M.ulcerans_Agy99 MITPIA---NAVVRVVRAGHRQQTWLSVAGLVLTLVVAAAYLLVGALRLT
MAV_2383|M.avium_104 MIRAVAGFANLVVRAVRTGHRQQVWLSVAGLVLILVVATAYLLIGALRVT
MAB_1005c|M.abscessus_ATCC_199 MINAIA---NGLVGSVRAAHRRKMLLSGIALAAVLLIAIGYLTVGALRVS
Mflv_0005|M.gilvum_PYR-GCK MINALA---DSVVRVVRTVHRGRAWLSAGALVFILVVAAAYLFVGALQVN
Mvan_0964|M.vanbaalenii_PYR-1 MIGSVA---DAVVGVARFGYRRRAWLSTAALIMTLVVASAYLFFGALQVN
MSMEG_1148|M.smegmatis_MC2_155 MINAVA---DRIVGLVRFGYRKRSWLSALGLVMTLVVATAYLFFGALQVN
TH_2636|M.thermoresistible__bu MIGAVA---DRIVALVRFGHRRRATLSTIGLILTLVVATAYLLFGALQVN
Mb0610|M.bovis_AF2122/97 -------------MLTRAIKTQLVLLTVLAVIAVVVLGWYFLRIPSLVG-
Rv0594|M.tuberculosis_H37Rv -------------MLTRAIKTQLVLLTVLAVIAVVVLGWYFLRIPSLVG-
MLBr_02594|M.leprae_Br4923 -------------MLTPLIRRQLVLFAILTVISLTVLGVYYLQIPSLVG-
. :: : ::. :* . :*
MMAR_3869|M.marinum_M PFASSYRVTVSLPESGGLLPNQDVALRGVRIGRIESLHITESGVDAIASI
MUL_3801|M.ulcerans_Agy99 PFASSYRVTVSLPESGGLLPNQDVALRGVRIGRIESLHLTESGVDAIASI
MAV_2383|M.avium_104 PFASSYRVTVQLPESGGLLPNQDVALRGVRIGRIESLQITDNGVNAVAAI
MAB_1005c|M.abscessus_ATCC_199 PFSGTYRVKVQLPESGGLLPNQDVALRGVKIGTVQSLDITQQGVDAVAEI
Mflv_0005|M.gilvum_PYR-GCK PLAKSYRVTVQLPESAGLLPNQNVTLRGVPIGRVERLDITPAGVDAVVSM
Mvan_0964|M.vanbaalenii_PYR-1 PLASSYRVTVELPESAGLLPNQNVTMRGVPIGRVERLDITPAGVNAVVSV
MSMEG_1148|M.smegmatis_MC2_155 PLDSDYGLTVQLPESAGLLPDQDVTLRGVPIGRVERLDITPSGVNAIVKV
TH_2636|M.thermoresistible__bu PFASSYQVTVALPESGGLLPNQAVTLRGVPVGRVERLDITPEGVNAVVDI
Mb0610|M.bovis_AF2122/97 --IGRYTLYAELPRSGGLYRTANVTYRGITIGKVTGVEPTERGARATMSI
Rv0594|M.tuberculosis_H37Rv --IGRYTLYAELPRSGGLYRTANVTYRGITIGKVTGVEPTERGARATMSI
MLBr_02594|M.leprae_Br4923 --IGRYSLKAELSATGGLYPTANVTYRGIAIGKVTDVEPTATGAEATMSI
* : . *. :.** *: **: :* : :. * *. * :
MMAR_3869|M.marinum_M TSQVKIPASSAVHVSALSPAGEQFLDFE--PESDTGPYLGEGAVIGVDQA
MUL_3801|M.ulcerans_Agy99 TSQVKIPASSTVHVSALSPAGEQFLDFE--PESDTGPYLSEGAVIGVDQA
MAV_2383|M.avium_104 TSKVRIPANTVAHVSALSPAGEQFINFE--AASDAGPYLHDGSFITSERT
MAB_1005c|M.abscessus_ATCC_199 QSKYKIPVSAKVRVTGLSPAGEQYINFE--GVSDQGPFLKDGAVISQG-A
Mflv_0005|M.gilvum_PYR-GCK DSSVAVPMSSAVRVSGLSPAGEQYIDFV--ADSDAGPYLENGSVIAQDNT
Mvan_0964|M.vanbaalenii_PYR-1 DSSAAVPVASSVRVSGLSPAGEQYIDFV--ADSGDGPYLADGAVVSQDNT
MSMEG_1148|M.smegmatis_MC2_155 KSTVRIPEASDVRVSGLSPAGEQYIDFIDVPAEDSSRFLADGAVIRQGQA
TH_2636|M.thermoresistible__bu DSAVKIPDSSAVRVSGLSPAGEQYIDFI--PEEDTGRYLADGAHIGQGTA
Mb0610|M.bovis_AF2122/97 DNGYQIPTDASANVHSVSAVGEQFVDLVS--TRTSGPYLRHGQTITTT--
Rv0594|M.tuberculosis_H37Rv DNGYQIPTDASANVHSVSAVGEQFVDLVS--TRTSGPYLRHGQTITTT--
MLBr_02594|M.leprae_Br4923 DSRYKIPIDSAANVHSVSAVGEQYLDLVS--SGNPGKYLAPGQTITKS--
. :* : ..* .:*..***:::: . :* * :
MMAR_3869|M.marinum_M RVPVSLAQLLGDANGLLAQIDPHQVELIKKELSLSQAGP-KKLAAIVDGG
MUL_3801|M.ulcerans_Agy99 RVPVSLAQLLGDANGLRAQIDPHQVELIKKVLSLSQAGP-KKLAAIVDGG
MAV_2383|M.avium_104 TVPVSLAQLLGDADGLLAQVDPRKIELIKKELSLSKEGP-AKLTAIVDGG
MAB_1005c|M.abscessus_ATCC_199 QVPVTLAKLLADADGLLAQVDPKKLELIKKELSLSKEGP-RKLTEIIDGG
Mflv_0005|M.gilvum_PYR-GCK TVPVSLADLLANADGALSQVDPGKLEVIKHELSMTEAGP-QKLADIIDGG
Mvan_0964|M.vanbaalenii_PYR-1 VVPVSLADLLANADGALAQADPAKLELIKRELSMSEAGP-QKLADIIDGG
MSMEG_1148|M.smegmatis_MC2_155 TVPVSLADLLADADGALGQVDTAKIELIKRELSLTDAGP-QKLADIVDGG
TH_2636|M.thermoresistible__bu TVPVPLAELLADADGALAQADVEKLEIIRRELSLSPAGP-QKLKDIVDGG
Mb0610|M.bovis_AF2122/97 TVPSQIGPALDAANRGLAVLPKDRVASVLHEASEAVGGLGSSLNRLIEAT
Rv0594|M.tuberculosis_H37Rv TVPSQIGPALDAANRGLAVLPKDRVASVLHEASEAVGGLGSSLNRLIEAT
MLBr_02594|M.leprae_Br4923 KIPIEIGPALDSVNRGLAALPKEKIGSLLDETAQAVGGLGPALQRLVSST
:* :. * .: . :: : : : * * ::..
MMAR_3869|M.marinum_M TFLLSTLDSVLPETTSIIRTGRVVLNLVADKNAGLAATAVALDRTLAGVA
MUL_3801|M.ulcerans_Agy99 TFLLSTLDSVLPETTSIIRTSRVVLNLIADKNAGLAATAVTLDRTLAGVA
MAV_2383|M.avium_104 LFLLSTLDSVLPETTSIIKTSRVVLNLASDKNNGLGAAATELNHTLTGVA
MAB_1005c|M.abscessus_ATCC_199 TFLLNTLDSVLPETTSILRSSRVVLTLASDKNSGIQATANELGRTLRGID
Mflv_0005|M.gilvum_PYR-GCK TFLLTTLDSVLPETSSMLRTSRVVFTLAADKNAGIEVASDNLAQTFDGVN
Mvan_0964|M.vanbaalenii_PYR-1 TFLLTTLDSVLPETSSMLRTSRVVLTLAADKNAGIEVASQNLDQVFDGVN
MSMEG_1148|M.smegmatis_MC2_155 TFLLSTLDSVLPETSSLLRTSRVVFTLMADKNPGISVASDNLTETFTGMD
TH_2636|M.thermoresistible__bu TFLLSTLDSVLPETSSLLRTSRVVFTLIDDKNAGIDVAADNLADTFDGVN
Mb0610|M.bovis_AF2122/97 QAIAHDVRGSLEDIDDIIERSAPIIDSQVNSGNEIARWAANLNTLAAQTA
Rv0594|M.tuberculosis_H37Rv QAIAHDVRGSLEDIDDIIERSAPIIDSQVNSGNEIARWAANLNTLAAQTA
MLBr_02594|M.leprae_Br4923 QAIVDAFKTNITDVNDIIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSA
: . : : .::. . :: ... : *
MMAR_3869|M.marinum_M RMQGGYRSLTERTPHTLAAIDHLFADNSDTMVQLLGSMATAAQLLYLRVP
MUL_3801|M.ulcerans_Agy99 RMQGGYRSLTERTPHTLAAIDHLFADNSDTMVQLLGSMATAAQLLYLRVP
MAV_2383|M.avium_104 RMQAGYRRLTSQTPQTLSAVDNLFADNSDTMVQLLGSMATMSQLLYLRVP
MAB_1005c|M.abscessus_ATCC_199 KMQNGYRTLVDRTPNTLHSVDNLFDDNSDTMVTLLGSLATASKLLYLRVP
Mflv_0005|M.gilvum_PYR-GCK RMRDGFRRLTDRAPGTLNSVDNLFADNSDTMVQLLGNLTTTSQLLYLRVP
Mvan_0964|M.vanbaalenii_PYR-1 RMRQGFRTLTEQTPETLAEVDNLFADNSETMVQLLGSLTSTSQLLYLRVP
MSMEG_1148|M.smegmatis_MC2_155 KMREGYRRLTNQTPETLAAVDNLFVDNSDTMVQLLGNLTTASRLLYLRVP
TH_2636|M.thermoresistible__bu RMREGYRRLTDQTPEVLAHVDNLFADNSDTMVQLLGNLTTTSRLLYLRVP
Mb0610|M.bovis_AF2122/97 QTDPAVRSILANAAPTADQVNATFSDVRESLPQTLANLEVVIDMLKRYHN
Rv0594|M.tuberculosis_H37Rv QTDPAVRSILANAAPTADQVNATFSDVRESLPQTLANLEVVIDMLKRYHN
MLBr_02594|M.leprae_Br4923 RQDQHLKSILSQAAPTADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHH
: : : .:. . :: * * ::: *..: :*
MMAR_3869|M.marinum_M ALN--ALFPDYRGSVLDALASAFHDHG-----VWATAELYPRYTCDYGTP
MUL_3801|M.ulcerans_Agy99 ALN--ALFPDYRGSVLDALASAFHDHG-----VWATAELYPRYTCDYGTP
MAV_2383|M.avium_104 ALN--ALFPDYRGSVLDAVTSVFHDHG-----VWATADLYPRYVCDYGTP
MAB_1005c|M.abscessus_ATCC_199 ALN--ALFPNYRGSVFDALMSIMHEGG-----IWATADLYPRYVCDYPTP
Mflv_0005|M.gilvum_PYR-GCK ALH--ALFPDYRTSVLDAIGSAMHDNG-----LWATGEIYPRYTCDYGTP
Mvan_0964|M.vanbaalenii_PYR-1 ALN--ALFPAHRTSVLDAIGSIMHDNG-----LWATGDIYPRYSCDYGTP
MSMEG_1148|M.smegmatis_MC2_155 ALN--ALFPSYRTSVLDALGTAIHDGG-----LWGTAEPYPRYTCDYGTP
TH_2636|M.thermoresistible__bu ALN--ALFPSHRTSVLDALGAAMHDGG-----LWGXXXP-PTICCNARRT
Mb0610|M.bovis_AF2122/97 GVEQALVFLPQSGAIAQSVTTEFPGQAGLGVGGLALNQPPPCLTGFLPAS
Rv0594|M.tuberculosis_H37Rv GVEQALVFLPQSGAIAQSVTTEFPGQAGLGVGGLALNQPPPCLTGFLPAS
MLBr_02594|M.leprae_Br4923 GVEQMLVFLPQGASIAQTASATFPNMAALDLA-LSINQPPPCLTGFIPAA
.:. :* :: :: : : . . * .
MMAR_3869|M.marinum_M SYLPSAADYPEPFMYT-YCRDDDPA--VSIRGAKN------------APR
MUL_3801|M.ulcerans_Agy99 SYLPSAADYPEPFMYT-YCRDDDPA--VSIRGAKN------------APR
MAV_2383|M.avium_104 AHASSAADYYEPFMYT-YCRDDDPA--VSIRGAKN------------APR
MAB_1005c|M.abscessus_ATCC_199 RLPGSAADYPEPFLYANYCADEDPA--VLIRGAKN------------APR
Mflv_0005|M.gilvum_PYR-GCK RRPPSSADFPEPFMYN-YCRDDHPG--VLVRGAKN------------APR
Mvan_0964|M.vanbaalenii_PYR-1 RLPPSSADYPEAFMYT-YCRDDHPG--VLVRGAKN------------APR
MSMEG_1148|M.smegmatis_MC2_155 KLPPSSADFPEPFMYT-YCRDVHPG--VLVRGAKN------------APR
TH_2636|M.thermoresistible__bu RPPPI---------------------------------------------
Mb0610|M.bovis_AF2122/97 EWRSPADTSTAPLPKGTYCRIPMDA-SNVVRGARNNPCVDVPGKRAATPR
Rv0594|M.tuberculosis_H37Rv EWRSPADTSTAPLPKGTYCRIPMDA-SNVVRGARNNPCVDVPGKRAATPR
MLBr_02594|M.leprae_Br4923 EWRSPADTSLQPLPVGTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPR
MMAR_3869|M.marinum_M PGGDDTAGPPPGAD--------------LGRRTDPTPRGRFTIPTP----
MUL_3801|M.ulcerans_Agy99 PGGDDTAGPPPGAD--------------LGRRTDPTPRGRFTIPTP----
MAV_2383|M.avium_104 PGGDDTAGPPPGAD--------------LGRRTDPTPRGRYTIPTP----
MAB_1005c|M.abscessus_ATCC_199 PAGDDTAGPPMGAD--------------MGKKADPTPKGRFQVPTP----
Mflv_0005|M.gilvum_PYR-GCK PAGDDTAGPPPGAD--------------LGRQTDPTPRGRYTIPTP----
Mvan_0964|M.vanbaalenii_PYR-1 PAGDDTAGPPAGAD--------------LGRTTDPTPKGRYTIPTP----
MSMEG_1148|M.smegmatis_MC2_155 PADDDTAGPPPGAD--------------LGRQTDPTPRGRYTIPTP----
TH_2636|M.thermoresistible__bu --------------------------------------------------
Mb0610|M.bovis_AF2122/97 ECRSNEAYVPGGTNPWYGDPNQMLSCPAPAARCDQPVKPGQVIPAPSVNN
Rv0594|M.tuberculosis_H37Rv ECRSNEAYVPGGTNPWYGDPNQMLSCPAPAARCDQPVKPGQVIPAPSVNN
MLBr_02594|M.leprae_Br4923 ECRDSKPYVPLGTNPWFGDPNQLLTCPAPGARCDQPVKPGLVIPAPTVDN
MMAR_3869|M.marinum_M ----YGGPVLPIEPPH----------------------------------
MUL_3801|M.ulcerans_Agy99 ----YGGPVLPIEPPH----------------------------------
MAV_2383|M.avium_104 ----YGGPQLPIEPPH----------------------------------
MAB_1005c|M.abscessus_ATCC_199 ----YGGPTLPIEPPH----------------------------------
Mflv_0005|M.gilvum_PYR-GCK ----YGGPTLPIEPPR----------------------------------
Mvan_0964|M.vanbaalenii_PYR-1 ----YGGPTLPIEPPR----------------------------------
MSMEG_1148|M.smegmatis_MC2_155 ----YGGPTLPIEPPR----------------------------------
TH_2636|M.thermoresistible__bu --------------------------------------------------
Mb0610|M.bovis_AF2122/97 GINPLPADQLPGTPPPVNDPLQRPGSGTVQCNGQQPNPCVYTPSTFPTTI
Rv0594|M.tuberculosis_H37Rv GINPLPADQLPGTPPPVNDPLQRPGSGTVQCNGQQPNPCVYTPSTFPTTI
MLBr_02594|M.leprae_Br4923 GLNPAPADRLPGTPPPVSDPLSQPRSGSVQCNGQQPNTCVYTPSGPPSAV
MMAR_3869|M.marinum_M -------------------------------------
MUL_3801|M.ulcerans_Agy99 -------------------------------------
MAV_2383|M.avium_104 -------------------------------------
MAB_1005c|M.abscessus_ATCC_199 -------------------------------------
Mflv_0005|M.gilvum_PYR-GCK -------------------------------------
Mvan_0964|M.vanbaalenii_PYR-1 -------------------------------------
MSMEG_1148|M.smegmatis_MC2_155 -------------------------------------
TH_2636|M.thermoresistible__bu -------------------------------------
Mb0610|M.bovis_AF2122/97 YDVQSGKVVAPDGVVYSVEASTHAGADGWKVMLAPTG
Rv0594|M.tuberculosis_H37Rv YDVQSGKVVAPDGVVYSVEASTHAGADGWKVMLAPTG
MLBr_02594|M.leprae_Br4923 YSPQSGELVGPDGVAYAVENSTKTGDDGWKEMLAPAG