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INALADSVVRVVRTVHRGRAWLSAGALVFILVVAAAYLFVGALQVNPLAKSYRVTVQLPESAGLLPNQNV TLRGVPIGRVERLDITPAGVDAVVSMDSSVAVPMSSAVRVSGLSPAGEQYIDFVADSDAGPYLENGSVIA QDNTTVPVSLADLLANADGALSQVDPGKLEVIKHELSMTEAGPQKLADIIDGGTFLLTTLDSVLPETSSM LRTSRVVFTLAADKNAGIEVASDNLAQTFDGVNRMRDGFRRLTDRAPGTLNSVDNLFADNSDTMVQLLGN LTTTSQLLYLRVPALHALFPDYRTSVLDAIGSAMHDNGLWATGEIYPRYTCDYGTPRRPPSSADFPEPFM YNYCRDDHPGVLVRGAKNAPRPAGDDTAGPPPGADLGRQTDPTPRGRYTIPTPYGGPTLPIEPPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0005 | - | - | 100% (416) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_4533 | - | 6e-29 | 26.87% (387) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_2513 | - | 2e-27 | 28.41% (271) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3524c | mce4F | 1e-24 | 25.60% (414) | MCE-family protein MCE4F |
| M. tuberculosis H37Rv | Rv3494c | mce4F | 1e-24 | 25.30% (411) | MCE-family protein MCE4F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 1e-20 | 24.43% (262) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_1005c | - | 1e-157 | 64.42% (416) | putative MCE family protein |
| M. marinum M | MMAR_3869 | mce5F | 1e-166 | 67.95% (415) | Mce family protein Mce5F |
| M. avium 104 | MAV_2383 | - | 1e-163 | 67.39% (414) | mce related protein |
| M. smegmatis MC2 155 | MSMEG_1148 | - | 0.0 | 76.79% (418) | mce related protein |
| M. thermoresistible (build 8) | TH_2636 | - | 1e-131 | 70.97% (341) | PUTATIVE mce related protein |
| M. ulcerans Agy99 | MUL_3801 | mce5F | 1e-165 | 67.23% (415) | Mce family protein Mce5F |
| M. vanbaalenii PYR-1 | Mvan_0964 | - | 0.0 | 83.65% (416) | hypothetical protein Mvan_0964 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0005|M.gilvum_PYR-GCK MINALA---DSVVRVVRTVHRGRAWLSAGALVFILVVAAAYLFVGALQVN
Mvan_0964|M.vanbaalenii_PYR-1 MIGSVA---DAVVGVARFGYRRRAWLSTAALIMTLVVASAYLFFGALQVN
MSMEG_1148|M.smegmatis_MC2_155 MINAVA---DRIVGLVRFGYRKRSWLSALGLVMTLVVATAYLFFGALQVN
TH_2636|M.thermoresistible__bu MIGAVA---DRIVALVRFGHRRRATLSTIGLILTLVVATAYLLFGALQVN
MMAR_3869|M.marinum_M MITPIA---NAVVRVVRAGHRQQTWLSVAGLVLTLVVAAAYLLVGALRLT
MUL_3801|M.ulcerans_Agy99 MITPIA---NAVVRVVRAGHRQQTWLSVAGLVLTLVVAAAYLLVGALRLT
MAV_2383|M.avium_104 MIRAVAGFANLVVRAVRTGHRQQVWLSVAGLVLILVVATAYLLIGALRVT
MAB_1005c|M.abscessus_ATCC_199 MINAIA---NGLVGSVRAAHRRKMLLSGIALAAVLLIAIGYLTVGALRVS
Mb3524c|M.bovis_AF2122/97 -------------MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFG-
Rv3494c|M.tuberculosis_H37Rv -------------MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFG-
MLBr_02594|M.leprae_Br4923 -------------MLTPLIRRQLVLFAILTVISLTVLGVYYLQIPSLVG-
:: : ::. ** . :
Mflv_0005|M.gilvum_PYR-GCK PLAKSYRVTVQLPESAGLLPNQNVTLRGVPIGRVERLDITPAGVDAVVSM
Mvan_0964|M.vanbaalenii_PYR-1 PLASSYRVTVELPESAGLLPNQNVTMRGVPIGRVERLDITPAGVNAVVSV
MSMEG_1148|M.smegmatis_MC2_155 PLDSDYGLTVQLPESAGLLPDQDVTLRGVPIGRVERLDITPSGVNAIVKV
TH_2636|M.thermoresistible__bu PFASSYQVTVALPESGGLLPNQAVTLRGVPVGRVERLDITPEGVNAVVDI
MMAR_3869|M.marinum_M PFASSYRVTVSLPESGGLLPNQDVALRGVRIGRIESLHITESGVDAIASI
MUL_3801|M.ulcerans_Agy99 PFASSYRVTVSLPESGGLLPNQDVALRGVRIGRIESLHLTESGVDAIASI
MAV_2383|M.avium_104 PFASSYRVTVQLPESGGLLPNQDVALRGVRIGRIESLQITDNGVNAVAAI
MAB_1005c|M.abscessus_ATCC_199 PFSGTYRVKVQLPESGGLLPNQDVALRGVKIGTVQSLDITQQGVDAVAEI
Mb3524c|M.bovis_AF2122/97 --IGTYGVSADFVAGGGLYKNANVTYRGVAVGRVESVGLNPNGVTAHMRL
Rv3494c|M.tuberculosis_H37Rv --IGTYGVSADFVAGGGLYKNANVTYRGVAVGRVESVGLNPNGVTAHMRL
MLBr_02594|M.leprae_Br4923 --IGRYSLKAELSATGGLYPTANVTYRGIAIGKVTDVEPTATGAEATMSI
* :.. : .** *: **: :* : : . *. * :
Mflv_0005|M.gilvum_PYR-GCK DSSVAVPMSSAVRVSGLSPAGEQYIDFV--ADSDAGPYLENGSVIAQDNT
Mvan_0964|M.vanbaalenii_PYR-1 DSSAAVPVASSVRVSGLSPAGEQYIDFV--ADSGDGPYLADGAVVSQDNT
MSMEG_1148|M.smegmatis_MC2_155 KSTVRIPEASDVRVSGLSPAGEQYIDFIDVPAEDSSRFLADGAVIRQGQA
TH_2636|M.thermoresistible__bu DSAVKIPDSSAVRVSGLSPAGEQYIDFI--PEEDTGRYLADGAHIGQGTA
MMAR_3869|M.marinum_M TSQVKIPASSAVHVSALSPAGEQFLDFE--PESDTGPYLGEGAVIGVDQA
MUL_3801|M.ulcerans_Agy99 TSQVKIPASSTVHVSALSPAGEQFLDFE--PESDTGPYLSEGAVIGVDQA
MAV_2383|M.avium_104 TSKVRIPANTVAHVSALSPAGEQFINFE--AASDAGPYLHDGSFITSERT
MAB_1005c|M.abscessus_ATCC_199 QSKYKIPVSAKVRVTGLSPAGEQYINFE--GVSDQGPFLKDGAVISQG-A
Mb3524c|M.bovis_AF2122/97 NSGTAIPSNVTATVRSVSAIGEQYIDLVP-PENPSSTKLRNGFRIQRQNT
Rv3494c|M.tuberculosis_H37Rv NSGTAIPSNVTATVRSVSAIGEQYIDLVP-PENPSSTKLRNGFRIQRQNT
MLBr_02594|M.leprae_Br4923 DSRYKIPIDSAANVHSVSAVGEQYLDLVS-SGNPG-KYLAPGQTITKS--
* :* . * .:*. ***:::: . * * :
Mflv_0005|M.gilvum_PYR-GCK TVPVSLADLLANADGALSQVDPGKLEVIKHELSMTEAGP-QKLADIIDGG
Mvan_0964|M.vanbaalenii_PYR-1 VVPVSLADLLANADGALAQADPAKLELIKRELSMSEAGP-QKLADIIDGG
MSMEG_1148|M.smegmatis_MC2_155 TVPVSLADLLADADGALGQVDTAKIELIKRELSLTDAGP-QKLADIVDGG
TH_2636|M.thermoresistible__bu TVPVPLAELLADADGALAQADVEKLEIIRRELSLSPAGP-QKLKDIVDGG
MMAR_3869|M.marinum_M RVPVSLAQLLGDANGLLAQIDPHQVELIKKELSLSQAGP-KKLAAIVDGG
MUL_3801|M.ulcerans_Agy99 RVPVSLAQLLGDANGLRAQIDPHQVELIKKVLSLSQAGP-KKLAAIVDGG
MAV_2383|M.avium_104 TVPVSLAQLLGDADGLLAQVDPRKIELIKKELSLSKEGP-AKLTAIVDGG
MAB_1005c|M.abscessus_ATCC_199 QVPVTLAKLLADADGLLAQVDPKKLELIKKELSLSKEGP-RKLTEIIDGG
Mb3524c|M.bovis_AF2122/97 RIGQDVADLLRQAETLLGSLGDTRLRELLHEAFIATNGAGPELARLIESA
Rv3494c|M.tuberculosis_H37Rv RIGQDVADLLRQAETLLGSLGDTRLRELLHEAFIATNGAGPELARLIESA
MLBr_02594|M.leprae_Br4923 KIPIEIGPALDSVNRGLAALPKEKIGSLLDETAQAVGGLGPALQRLVSST
: :. * ..: . :: : : * * ::..
Mflv_0005|M.gilvum_PYR-GCK TFLLTTLDSVLPETSSMLRTSRVVFTLAADKNAGIEVASDNLAQTFDGVN
Mvan_0964|M.vanbaalenii_PYR-1 TFLLTTLDSVLPETSSMLRTSRVVLTLAADKNAGIEVASQNLDQVFDGVN
MSMEG_1148|M.smegmatis_MC2_155 TFLLSTLDSVLPETSSLLRTSRVVFTLMADKNPGISVASDNLTETFTGMD
TH_2636|M.thermoresistible__bu TFLLSTLDSVLPETSSLLRTSRVVFTLIDDKNAGIDVAADNLADTFDGVN
MMAR_3869|M.marinum_M TFLLSTLDSVLPETTSIIRTGRVVLNLVADKNAGLAATAVALDRTLAGVA
MUL_3801|M.ulcerans_Agy99 TFLLSTLDSVLPETTSIIRTSRVVLNLIADKNAGLAATAVTLDRTLAGVA
MAV_2383|M.avium_104 LFLLSTLDSVLPETTSIIKTSRVVLNLASDKNNGLGAAATELNHTLTGVA
MAB_1005c|M.abscessus_ATCC_199 TFLLNTLDSVLPETTSILRSSRVVLTLASDKNSGIQATANELGRTLRGID
Mb3524c|M.bovis_AF2122/97 RLLVDEANANYPQVSQLIDQAGPFLQAQIRAGGDIKSLADGLARFTWQLR
Rv3494c|M.tuberculosis_H37Rv RLLVDEANANYPQVSQLIDQAGPFLQAQIRAGGDIKSLADGLARFTWQLR
MLBr_02594|M.leprae_Br4923 QAIVDAFKTNITDVNDIIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSA
:: .: .:...:: . .: . : *
Mflv_0005|M.gilvum_PYR-GCK RMRDGFRRLTDRAPGTLNSVDNLFADNSDTMVQLLG---NLTTTSQLLYL
Mvan_0964|M.vanbaalenii_PYR-1 RMRQGFRTLTEQTPETLAEVDNLFADNSETMVQLLG---SLTSTSQLLYL
MSMEG_1148|M.smegmatis_MC2_155 KMREGYRRLTNQTPETLAAVDNLFVDNSDTMVQLLG---NLTTASRLLYL
TH_2636|M.thermoresistible__bu RMREGYRRLTDQTPEVLAHVDNLFADNSDTMVQLLG---NLTTTSRLLYL
MMAR_3869|M.marinum_M RMQGGYRSLTERTPHTLAAIDHLFADNSDTMVQLLG---SMATAAQLLYL
MUL_3801|M.ulcerans_Agy99 RMQGGYRSLTERTPHTLAAIDHLFADNSDTMVQLLG---SMATAAQLLYL
MAV_2383|M.avium_104 RMQAGYRRLTSQTPQTLSAVDNLFADNSDTMVQLLG---SMATMSQLLYL
MAB_1005c|M.abscessus_ATCC_199 KMQNGYRTLVDRTPNTLHSVDNLFDDNSDTMVTLLG---SLATASKLLYL
Mb3524c|M.bovis_AF2122/97 AADPRLRDTLAGAPDAIDEANTAFSGIRPSFPALAASLANLGRVGVIYHK
Rv3494c|M.tuberculosis_H37Rv AADPRLRDTLADAPDAIDEANTAFSGIRPSFPALAASLANLGRVGVIYHK
MLBr_02594|M.leprae_Br4923 RQDQHLKSILSQAAPTADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHH
: :. . : * . :: . : :
Mflv_0005|M.gilvum_PYR-GCK RVPALHALFPDYRTSVLDAIGSAMHD-----NGLWATGEIYPRYTCDYGT
Mvan_0964|M.vanbaalenii_PYR-1 RVPALNALFPAHRTSVLDAIGSIMHD-----NGLWATGDIYPRYSCDYGT
MSMEG_1148|M.smegmatis_MC2_155 RVPALNALFPSYRTSVLDALGTAIHD-----GGLWGTAEPYPRYTCDYGT
TH_2636|M.thermoresistible__bu RVPALNALFPSHRTSVLDALGAAMHD-----GGLWGXXXP-PTICCNARR
MMAR_3869|M.marinum_M RVPALNALFPDYRGSVLDALASAFHD-----HGVWATAELYPRYTCDYGT
MUL_3801|M.ulcerans_Agy99 RVPALNALFPDYRGSVLDALASAFHD-----HGVWATAELYPRYTCDYGT
MAV_2383|M.avium_104 RVPALNALFPDYRGSVLDAVTSVFHD-----HGVWATADLYPRYVCDYGT
MAB_1005c|M.abscessus_ATCC_199 RVPALNALFPNYRGSVFDALMSIMHE-----GGIWATADLYPRYVCDYPT
Mb3524c|M.bovis_AF2122/97 SIEQLLVVFPALFAAIITSAGGVPQDEGAKLDFKIDLHDPPPCMTGFLPP
Rv3494c|M.tuberculosis_H37Rv SIEQLLVVFPALFAAIITSAGGVPQDEGAKLDFKIDLHDPPPCMTGFLPP
MLBr_02594|M.leprae_Br4923 GVEQMLVFLPQGASIAQTASATFPN--MAALDLALSINQPPPCLTGFIPA
: : ..:* : : *
Mflv_0005|M.gilvum_PYR-GCK PRRPPSSADFPEPFMYN-YCRDD--HPGVLVRGAKNAPRPAGDDTAGPP-
Mvan_0964|M.vanbaalenii_PYR-1 PRLPPSSADYPEAFMYT-YCRDD--HPGVLVRGAKNAPRPAGDDTAGPP-
MSMEG_1148|M.smegmatis_MC2_155 PKLPPSSADFPEPFMYT-YCRDV--HPGVLVRGAKNAPRPADDDTAGPP-
TH_2636|M.thermoresistible__bu TRPPPI--------------------------------------------
MMAR_3869|M.marinum_M PSYLPSAADYPEPFMYT-YCRDD--DPAVSIRGAKNAPRPGGDDTAGPP-
MUL_3801|M.ulcerans_Agy99 PSYLPSAADYPEPFMYT-YCRDD--DPAVSIRGAKNAPRPGGDDTAGPP-
MAV_2383|M.avium_104 PAHASSAADYYEPFMYT-YCRDD--DPAVSIRGAKNAPRPGGDDTAGPP-
MAB_1005c|M.abscessus_ATCC_199 PRLPGSAADYPEPFLYANYCADE--DPAVLIRGAKNAPRPAGDDTAGPP-
Mb3524c|M.bovis_AF2122/97 PLVRSPADESVREIPRDMYCKTAQNDPS-TVRGARNYPCQEFPGKRAPTV
Rv3494c|M.tuberculosis_H37Rv PLVRSPADESVREIPRDMYCKTAQNDPS-TVRGARNYPCQEFPGKRAPTV
MLBr_02594|M.leprae_Br4923 AEWRSPADTSLQPLPVGTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASP
.
Mflv_0005|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0964|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1148|M.smegmatis_MC2_155 --------------------------------------------------
TH_2636|M.thermoresistible__bu --------------------------------------------------
MMAR_3869|M.marinum_M --------------------------------------------------
MUL_3801|M.ulcerans_Agy99 --------------------------------------------------
MAV_2383|M.avium_104 --------------------------------------------------
MAB_1005c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3524c|M.bovis_AF2122/97 QLCRDPRGYVPVGTNPWRGPPIPYGTEVTDGRNILPPNKFPYIPPGADPD
Rv3494c|M.tuberculosis_H37Rv QLCRDPRGYVPVGTNPWRGPPIPYGTEVTDGRNILPPNKFPYIPPGADPD
MLBr_02594|M.leprae_Br4923 RECRDSKPYVPLGTNPWFGD----------------PNQLLTCP-----A
Mflv_0005|M.gilvum_PYR-GCK PGADLGRQTDP---------------------------------------
Mvan_0964|M.vanbaalenii_PYR-1 AGADLGRTTDP---------------------------------------
MSMEG_1148|M.smegmatis_MC2_155 PGADLGRQTDP---------------------------------------
TH_2636|M.thermoresistible__bu --------------------------------------------------
MMAR_3869|M.marinum_M PGADLGRRTDP---------------------------------------
MUL_3801|M.ulcerans_Agy99 PGADLGRRTDP---------------------------------------
MAV_2383|M.avium_104 PGADLGRRTDP---------------------------------------
MAB_1005c|M.abscessus_ATCC_199 MGADMGKKADP---------------------------------------
Mb3524c|M.bovis_AF2122/97 PGVPIVGPPPPGQVAGPGPAPHQPAQPAPPPNDNGPPPPFTSWMPPGYPP
Rv3494c|M.tuberculosis_H37Rv PGVPIVGPPPPGQVAGPGPAPHQPAQPAPPPNDNGPPPPFTSWMPPGYPP
MLBr_02594|M.leprae_Br4923 PGARCDQPVKPGLVIP------------APTVDNGLNPAPADRLPG----
Mflv_0005|M.gilvum_PYR-GCK -TPRGRYTIPTPYGGPTLPIEPPR--------------------------
Mvan_0964|M.vanbaalenii_PYR-1 -TPKGRYTIPTPYGGPTLPIEPPR--------------------------
MSMEG_1148|M.smegmatis_MC2_155 -TPRGRYTIPTPYGGPTLPIEPPR--------------------------
TH_2636|M.thermoresistible__bu --------------------------------------------------
MMAR_3869|M.marinum_M -TPRGRFTIPTPYGGPVLPIEPPH--------------------------
MUL_3801|M.ulcerans_Agy99 -TPRGRFTIPTPYGGPVLPIEPPH--------------------------
MAV_2383|M.avium_104 -TPRGRYTIPTPYGGPQLPIEPPH--------------------------
MAB_1005c|M.abscessus_ATCC_199 -TPKGRFQVPTPYGGPTLPIEPPH--------------------------
Mb3524c|M.bovis_AF2122/97 EPPQVPYPATIPPPPPPEGTGPPPGPAPGPQPQASGPAYTIYDQLSGAFA
Rv3494c|M.tuberculosis_H37Rv EPPQVPYPATIPPPPPPEGTGPPPGPAPGPQPQASGPAYTIYDQLSGAFA
MLBr_02594|M.leprae_Br4923 TPPPVSDPLSQPRSGSVQCNGQQPNTCVYTP---SGPPSAVYSPQSGELV
Mflv_0005|M.gilvum_PYR-GCK --------------------------------
Mvan_0964|M.vanbaalenii_PYR-1 --------------------------------
MSMEG_1148|M.smegmatis_MC2_155 --------------------------------
TH_2636|M.thermoresistible__bu --------------------------------
MMAR_3869|M.marinum_M --------------------------------
MUL_3801|M.ulcerans_Agy99 --------------------------------
MAV_2383|M.avium_104 --------------------------------
MAB_1005c|M.abscessus_ATCC_199 --------------------------------
Mb3524c|M.bovis_AF2122/97 DPAGGTGIFAPGMTGASSAENWVDLMRDPRQL
Rv3494c|M.tuberculosis_H37Rv DPAGGTGIFAPGMTGASSAENWVDLMRDPRQL
MLBr_02594|M.leprae_Br4923 GPDG--VAYAVENSTKTGDDGWKEMLAPAG--