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VIDTLGRLVVGVVKAGHRQRTWLSGLALLVTLVVGGAYLALGALRVNPLESTYQVTIRLPESGGLLANQD VSVRGIRVGRITSLRPIPSGVEVVANINAHTKIPASSPVRVSGLSPAGEQYIDFEPTSNTGPFLSNGSVI GPQHTTTPIPLSQVLADADGLIAQTDPKKLEIVKRELSLSNQGPQKLTDIIDGSTFLLSTMDPVLPQTVS MLKTSRVVLMTLSDKNAGLSVAARNVGDLMAGVNKMDRGYRRLVDQTPHALSTVDNLFDDNSDTMVGLLA NLVTTARVVYLRVPALNAVFPNYRGSTLEALMTTMHEHGLWATADIYPRYTCDYGTPRRPSSSADYPEPF LYTYCRDDDPQVLVRGAKNAPRPGGDDTAGPPPGADLGQTTDPTPKGRFTIPTPYGGPVLPIEPPH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0107 | - | - | 100% (416) | mce related protein |
| M. avium 104 | MAV_2383 | - | e-157 | 63.57% (409) | mce related protein |
| M. avium 104 | MAV_0953 | - | 4e-28 | 26.84% (339) | mce-family protein mce1f |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0180 | mce1F | 2e-21 | 26.16% (367) | MCE-family protein MCE1F |
| M. gilvum PYR-GCK | Mflv_0005 | - | 1e-156 | 62.89% (415) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv0174 | mce1F | 2e-21 | 26.16% (367) | MCE-family protein MCE1F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 2e-18 | 23.46% (422) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4511c | - | 1e-156 | 63.22% (416) | putative Mce family protein |
| M. marinum M | MMAR_3869 | mce5F | 1e-162 | 63.70% (416) | Mce family protein Mce5F |
| M. smegmatis MC2 155 | MSMEG_1148 | - | 1e-152 | 61.15% (417) | mce related protein |
| M. thermoresistible (build 8) | TH_2636 | - | 1e-106 | 57.65% (340) | PUTATIVE mce related protein |
| M. ulcerans Agy99 | MUL_3801 | mce5F | 1e-162 | 63.94% (416) | Mce family protein Mce5F |
| M. vanbaalenii PYR-1 | Mvan_0964 | - | 1e-156 | 62.41% (415) | hypothetical protein Mvan_0964 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3869|M.marinum_M MITPIANAVVRVVRAGHRQQTWLSVAGLVLTLVVAAAYLLVGALRLTPFA
MUL_3801|M.ulcerans_Agy99 MITPIANAVVRVVRAGHRQQTWLSVAGLVLTLVVAAAYLLVGALRLTPFA
Mflv_0005|M.gilvum_PYR-GCK MINALADSVVRVVRTVHRGRAWLSAGALVFILVVAAAYLFVGALQVNPLA
Mvan_0964|M.vanbaalenii_PYR-1 MIGSVADAVVGVARFGYRRRAWLSTAALIMTLVVASAYLFFGALQVNPLA
MSMEG_1148|M.smegmatis_MC2_155 MINAVADRIVGLVRFGYRKRSWLSALGLVMTLVVATAYLFFGALQVNPLD
TH_2636|M.thermoresistible__bu MIGAVADRIVALVRFGHRRRATLSTIGLILTLVVATAYLLFGALQVNPFA
MAV_0107|M.avium_104 MIDTLGRLVVGVVKAGHRQRTWLSGLALLVTLVVGGAYLALGALRVNPLE
MAB_4511c|M.abscessus_ATCC_199 MIDAVANAVVAAVRAGHRQKSMLSTLALVLTLVLAVTYLCVGALRANPFA
Mb0180|M.bovis_AF2122/97 ----------MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIPSLVG---I
Rv0174|M.tuberculosis_H37Rv ----------MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIPSLVG---I
MLBr_02594|M.leprae_Br4923 ----------MLTPLIRRQLVLFAILTVISLTVLGVYYLQIPSLVG---I
. * :: :: *:. ** . :*
MMAR_3869|M.marinum_M SSYRVTVSLPESGGLLPNQDVALRGVRIGRIESLHITESGVDAIASITSQ
MUL_3801|M.ulcerans_Agy99 SSYRVTVSLPESGGLLPNQDVALRGVRIGRIESLHLTESGVDAIASITSQ
Mflv_0005|M.gilvum_PYR-GCK KSYRVTVQLPESAGLLPNQNVTLRGVPIGRVERLDITPAGVDAVVSMDSS
Mvan_0964|M.vanbaalenii_PYR-1 SSYRVTVELPESAGLLPNQNVTMRGVPIGRVERLDITPAGVNAVVSVDSS
MSMEG_1148|M.smegmatis_MC2_155 SDYGLTVQLPESAGLLPDQDVTLRGVPIGRVERLDITPSGVNAIVKVKST
TH_2636|M.thermoresistible__bu SSYQVTVALPESGGLLPNQAVTLRGVPVGRVERLDITPEGVNAVVDIDSA
MAV_0107|M.avium_104 STYQVTIRLPESGGLLANQDVSVRGIRVGRITSLRPIPSGVEVVANINAH
MAB_4511c|M.abscessus_ATCC_199 STYRVTVKLSESGGLLPRQDVALRGVKIGTVQSLRITPQGVEATAEILSK
Mb0180|M.bovis_AF2122/97 GQYTLKADLPASGGLYPTANVTYRGITIGKVTAVEPTDQGARVTMSIASN
Rv0174|M.tuberculosis_H37Rv GQYTLKADLPASGGLYPTANVTYRGITIGKVTAVEPTDQGARVTMSIASN
MLBr_02594|M.leprae_Br4923 GRYSLKAELSATGGLYPTANVTYRGIAIGKVTDVEPTATGAEATMSIDSR
* :. *. :.** . *: **: :* : : *. . .: :
MMAR_3869|M.marinum_M VKIPASSAVHVSALSPAGEQFLDFE--PESDTGPYLGEGAVIGVDQARVP
MUL_3801|M.ulcerans_Agy99 VKIPASSTVHVSALSPAGEQFLDFE--PESDTGPYLSEGAVIGVDQARVP
Mflv_0005|M.gilvum_PYR-GCK VAVPMSSAVRVSGLSPAGEQYIDFV--ADSDAGPYLENGSVIAQDNTTVP
Mvan_0964|M.vanbaalenii_PYR-1 AAVPVASSVRVSGLSPAGEQYIDFV--ADSGDGPYLADGAVVSQDNTVVP
MSMEG_1148|M.smegmatis_MC2_155 VRIPEASDVRVSGLSPAGEQYIDFIDVPAEDSSRFLADGAVIRQGQATVP
TH_2636|M.thermoresistible__bu VKIPDSSAVRVSGLSPAGEQYIDFI--PEEDTGRYLADGAHIGQGTATVP
MAV_0107|M.avium_104 TKIPASSPVRVSGLSPAGEQYIDFE--PTSNTGPFLSNGSVIGPQHTTTP
MAB_4511c|M.abscessus_ATCC_199 YKIPAAAKVRVAGLSPAGEQYINFEG-TPGQHGPYLSDGSVIAEG-VQVP
Mb0180|M.bovis_AF2122/97 YKIPVDASANVHSVSAVGEQYIDLVS--TGAPGKYFSSGQTITKG--TVP
Rv0174|M.tuberculosis_H37Rv YKIPVDASANVHSVSAVGEQYIDLVS--TGAPGKYFSSGQTITKG--TVP
MLBr_02594|M.leprae_Br4923 YKIPIDSAANVHSVSAVGEQYLDLVS--SGNPGKYLAPGQTITKS--KIP
:* : ..* .:*..***:::: . :: * : *
MMAR_3869|M.marinum_M VSLAQLLGDANGLLAQIDPHQVELIKKELSLSQAGP-KKLAAIVDGGTFL
MUL_3801|M.ulcerans_Agy99 VSLAQLLGDANGLRAQIDPHQVELIKKVLSLSQAGP-KKLAAIVDGGTFL
Mflv_0005|M.gilvum_PYR-GCK VSLADLLANADGALSQVDPGKLEVIKHELSMTEAGP-QKLADIIDGGTFL
Mvan_0964|M.vanbaalenii_PYR-1 VSLADLLANADGALAQADPAKLELIKRELSMSEAGP-QKLADIIDGGTFL
MSMEG_1148|M.smegmatis_MC2_155 VSLADLLADADGALGQVDTAKIELIKRELSLTDAGP-QKLADIVDGGTFL
TH_2636|M.thermoresistible__bu VPLAELLADADGALAQADVEKLEIIRRELSLSPAGP-QKLKDIVDGGTFL
MAV_0107|M.avium_104 IPLSQVLADADGLIAQTDPKKLEIVKRELSLSNQGP-QKLTDIIDGSTFL
MAB_4511c|M.abscessus_ATCC_199 VTLAKLLADADGVLAQVDPKKLELIKKELGLTKEGP-RKLTEIIDGGTFL
Mb0180|M.bovis_AF2122/97 SEIGPALDNSNRGLAALPTEKIGLLLDETAQAVGGLGPALQRLVDSTQAI
Rv0174|M.tuberculosis_H37Rv SEIGPALDNSNRGLAALPTEKIGLLLDETAQAVGGLGPALQRLVDSTQAI
MLBr_02594|M.leprae_Br4923 IEIGPALDSVNRGLAALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAI
:. * . : . :: : . : * * ::.. :
MMAR_3869|M.marinum_M LSTLDSVLPETTSIIRTGRVVLNLVADKNAGLAATAVALDRTLAGVARMQ
MUL_3801|M.ulcerans_Agy99 LSTLDSVLPETTSIIRTSRVVLNLIADKNAGLAATAVTLDRTLAGVARMQ
Mflv_0005|M.gilvum_PYR-GCK LTTLDSVLPETSSMLRTSRVVFTLAADKNAGIEVASDNLAQTFDGVNRMR
Mvan_0964|M.vanbaalenii_PYR-1 LTTLDSVLPETSSMLRTSRVVLTLAADKNAGIEVASQNLDQVFDGVNRMR
MSMEG_1148|M.smegmatis_MC2_155 LSTLDSVLPETSSLLRTSRVVFTLMADKNPGISVASDNLTETFTGMDKMR
TH_2636|M.thermoresistible__bu LSTLDSVLPETSSLLRTSRVVFTLIDDKNAGIDVAADNLADTFDGVNRMR
MAV_0107|M.avium_104 LSTMDPVLPQTVSMLKTSRVVLMTLSDKNAGLSVAARNVGDLMAGVNKMD
MAB_4511c|M.abscessus_ATCC_199 LSTLDSVLPETTSILKNSRVVLTLAADKNAGIKATADGLGRTLRGVEKMQ
Mb0180|M.bovis_AF2122/97 VGDFKTNIGDVNDIIENSGPILDSQVNTGDQIERWARKLNNLAAQTATRD
Rv0174|M.tuberculosis_H37Rv VGDFKTNIGDVNDIIENSGPILDSQVNTGDQIERWARKLNNLAAQTATRD
MLBr_02594|M.leprae_Br4923 VDAFKTNITDVNDIIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQD
: :.. : :. .::... :: ... : :
MMAR_3869|M.marinum_M GGYRSLTERTPHTLAAIDHLFADNSDTMVQLLGSMATAAQLLY-------
MUL_3801|M.ulcerans_Agy99 GGYRSLTERTPHTLAAIDHLFADNSDTMVQLLGSMATAAQLLY-------
Mflv_0005|M.gilvum_PYR-GCK DGFRRLTDRAPGTLNSVDNLFADNSDTMVQLLGNLTTTSQLLY-------
Mvan_0964|M.vanbaalenii_PYR-1 QGFRTLTEQTPETLAEVDNLFADNSETMVQLLGSLTSTSQLLY-------
MSMEG_1148|M.smegmatis_MC2_155 EGYRRLTNQTPETLAAVDNLFVDNSDTMVQLLGNLTTASRLLY-------
TH_2636|M.thermoresistible__bu EGYRRLTDQTPEVLAHVDNLFADNSDTMVQLLGNLTTTSRLLY-------
MAV_0107|M.avium_104 RGYRRLVDQTPHALSTVDNLFDDNSDTMVGLLANLVTTARVVY-------
MAB_4511c|M.abscessus_ATCC_199 NGYRTLIDRTPKTLSAIDNLFSDNSDTMVQLLASLATTSQMLY-------
Mb0180|M.bovis_AF2122/97 QNVRSILSQAAPTADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAGVE
Rv0174|M.tuberculosis_H37Rv QNVRSILSQAAPTADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAGVE
MLBr_02594|M.leprae_Br4923 QHLKSILSQAAPTADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVE
: : .::. . :: :* . ::: *..: ::
MMAR_3869|M.marinum_M ---------------------------------LRVPALNALFPDYRGSV
MUL_3801|M.ulcerans_Agy99 ---------------------------------LRVPALNALFPDYRGSV
Mflv_0005|M.gilvum_PYR-GCK ---------------------------------LRVPALHALFPDYRTSV
Mvan_0964|M.vanbaalenii_PYR-1 ---------------------------------LRVPALNALFPAHRTSV
MSMEG_1148|M.smegmatis_MC2_155 ---------------------------------LRVPALNALFPSYRTSV
TH_2636|M.thermoresistible__bu ---------------------------------LRVPALNALFPSHRTSV
MAV_0107|M.avium_104 ---------------------------------LRVPALNAVFPNYRGST
MAB_4511c|M.abscessus_ATCC_199 ---------------------------------VRTPAINAFFPNYRGST
Mb0180|M.bovis_AF2122/97 QLLVFLPQGAAIAQTVLTPTPGAAQLPLAPAINYPPPCLTGFLPASEWRS
Rv0174|M.tuberculosis_H37Rv QLLVFLPQGAAIAQTVLTPTPGAAQLPLAPAINYPPPCLTGFLPASEWRS
MLBr_02594|M.leprae_Br4923 QMLVFLPQGASIAQTASATFPNMAALDLALSINQPPPCLTGFIPAAEWRS
*.: ..:* .
MMAR_3869|M.marinum_M LDALASAFHDHGVWATAELYPRYTCDYGTPSYLPSAADYPEPFMYTYCRD
MUL_3801|M.ulcerans_Agy99 LDALASAFHDHGVWATAELYPRYTCDYGTPSYLPSAADYPEPFMYTYCRD
Mflv_0005|M.gilvum_PYR-GCK LDAIGSAMHDNGLWATGEIYPRYTCDYGTPRRPPSSADFPEPFMYNYCRD
Mvan_0964|M.vanbaalenii_PYR-1 LDAIGSIMHDNGLWATGDIYPRYSCDYGTPRLPPSSADYPEAFMYTYCRD
MSMEG_1148|M.smegmatis_MC2_155 LDALGTAIHDGGLWGTAEPYPRYTCDYGTPKLPPSSADFPEPFMYTYCRD
TH_2636|M.thermoresistible__bu LDALGAAMHDGGLWGXXXP-PTICCNARRTRPPPI---------------
MAV_0107|M.avium_104 LEALMTTMHEHGLWATADIYPRYTCDYGTPRRPSSSADYPEPFLYTYCRD
MAB_4511c|M.abscessus_ATCC_199 FGAIADTMRDNGIWVTADLYPRYACDYGTPRVPPSSADFPEPPVYTYCAD
Mb0180|M.bovis_AF2122/97 PADTSPRPLPSGTYCKIPQDAQLQ-VRGARNIPCVDVPGKRAATPKECRS
Rv0174|M.tuberculosis_H37Rv PADTSPRPLPSGTYCKIPQDAQLQ-VRGARNIPCVDVLGKRAATPKECRS
MLBr_02594|M.leprae_Br4923 PADTSLQPLPVGTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRECRD
* : .
MMAR_3869|M.marinum_M DDPAVSIRG----------------AKNAPRPGGDDTAGPPPGADLGRRT
MUL_3801|M.ulcerans_Agy99 DDPAVSIRG----------------AKNAPRPGGDDTAGPPPGADLGRRT
Mflv_0005|M.gilvum_PYR-GCK DHPGVLVRG----------------AKNAPRPAGDDTAGPPPGADLGRQT
Mvan_0964|M.vanbaalenii_PYR-1 DHPGVLVRG----------------AKNAPRPAGDDTAGPPAGADLGRTT
MSMEG_1148|M.smegmatis_MC2_155 VHPGVLVRG----------------AKNAPRPADDDTAGPPPGADLGRQT
TH_2636|M.thermoresistible__bu --------------------------------------------------
MAV_0107|M.avium_104 DDPQVLVRG----------------AKNAPRPGGDDTAGPPPGADLGQTT
MAB_4511c|M.abscessus_ATCC_199 DDPAVLIRG----------------AKNAPRPAGDDTAGPPPGADLGKKT
Mb0180|M.bovis_AF2122/97 KDPYVPLGTNPWFGDPNQILTCPAPGARCDQPVKPGLVIPAPSINTGLNP
Rv0174|M.tuberculosis_H37Rv KDPYVPLGTNPWFGDPNQILTCPAPGARCDQPVKPGLVIPAPSINTGLNP
MLBr_02594|M.leprae_Br4923 SKPYVPLGTNPWFGDPNQLLTCPAPGARCDQPVKPGLVIPAPTVDNGLNP
MMAR_3869|M.marinum_M DPTPRGRFTIP--------------------------TPYGGPVLPIEPP
MUL_3801|M.ulcerans_Agy99 DPTPRGRFTIP--------------------------TPYGGPVLPIEPP
Mflv_0005|M.gilvum_PYR-GCK DPTPRGRYTIP--------------------------TPYGGPTLPIEPP
Mvan_0964|M.vanbaalenii_PYR-1 DPTPKGRYTIP--------------------------TPYGGPTLPIEPP
MSMEG_1148|M.smegmatis_MC2_155 DPTPRGRYTIP--------------------------TPYGGPTLPIEPP
TH_2636|M.thermoresistible__bu --------------------------------------------------
MAV_0107|M.avium_104 DPTPKGRFTIP--------------------------TPYGGPVLPIEPP
MAB_4511c|M.abscessus_ATCC_199 DPTPKGRFTIP--------------------------TPPGGPTLPIEPP
Mb0180|M.bovis_AF2122/97 APADQVQGTPPPVSDPLQRPGSGTVQCNGQQPNPCVYTPTSGPSAVYSPA
Rv0174|M.tuberculosis_H37Rv APADQVQGTPPPVSDPLQRPGSGTVQCNGQQPNPCVYTPTSGPSAVYSPA
MLBr_02594|M.leprae_Br4923 APADRLPGTPPPVSDPLSQPRSGSVQCNGQQPNTCVYTPSGPPSAVYSPQ
MMAR_3869|M.marinum_M H--------------------------------
MUL_3801|M.ulcerans_Agy99 H--------------------------------
Mflv_0005|M.gilvum_PYR-GCK R--------------------------------
Mvan_0964|M.vanbaalenii_PYR-1 R--------------------------------
MSMEG_1148|M.smegmatis_MC2_155 R--------------------------------
TH_2636|M.thermoresistible__bu ---------------------------------
MAV_0107|M.avium_104 H--------------------------------
MAB_4511c|M.abscessus_ATCC_199 R--------------------------------
Mb0180|M.bovis_AF2122/97 SGELVGPDGVKYAVANSSTTGDDGWKEMLAPAS
Rv0174|M.tuberculosis_H37Rv SGELVGPDGVKYAVANSSTTGDDGWKEMLAPAS
MLBr_02594|M.leprae_Br4923 SGELVGPDGVAYAVENSTKTGDDGWKEMLAPAG