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MASLNLSPPAARYHGDQAVAPGMLDFAVNVRHSRPPQWLLDRLAARLPDLARYPGDDDVHRAQDAAAERH GRRRDEVLPLAGAAEAFALLSNLRPKRAAVIAPSFTEPAAALSAAGVPVHHVVLEPPFGLHGAAVPEEAD LVVVGNPTNPTAVLHGREQLLALRRPGRLLVVDEAFADAIPGEPQSLAGDALPDVLVLRSLTKTWALAGL RVGYALGAPEVLARLTAQRAHWPVGTLQLTALAACCGRRAVADAAAGAERLSRLREKMAAGLASVGADVL DGRAPFVLFRMPDAVRVRKLLHDKGIAVRRGDTFVGLDERYLRAAVRPEWPLLVQAIAEAQR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2208 | - | - | 100% (342) | hypothetical protein MAV_2208 |
| M. avium 104 | MAV_3186 | hisC | 2e-11 | 30.98% (184) | histidinol-phosphate aminotransferase |
| M. avium 104 | MAV_0250 | hisC | 2e-11 | 27.48% (262) | putative aminotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2256c | cobC | 1e-147 | 76.76% (340) | hypothetical protein Mb2256c |
| M. gilvum PYR-GCK | Mflv_1195 | - | 8e-13 | 28.19% (188) | putative aminotransferase |
| M. tuberculosis H37Rv | Rv2231c | cobC | 1e-147 | 76.76% (340) | hypothetical protein Rv2231c |
| M. leprae Br4923 | MLBr_01488 | - | 8e-12 | 28.18% (291) | N-succinyldiaminopimelate aminotransferase |
| M. abscessus ATCC 19977 | MAB_1902 | - | 1e-117 | 65.76% (330) | hypothetical protein MAB_1902 |
| M. marinum M | MMAR_3307 | cobC | 1e-143 | 75.66% (341) | aminotransferase CobC |
| M. smegmatis MC2 155 | MSMEG_5121 | - | 2e-12 | 26.39% (341) | N-succinyldiaminopimelate aminotransferase |
| M. thermoresistible (build 8) | TH_1662 | hisC2 | 5e-14 | 26.33% (281) | PROBABLE HISTIDINOL-PHOSPHATE AMINOTRANSFERASE HISC2 |
| M. ulcerans Agy99 | MUL_1321 | cobC | 1e-142 | 74.93% (343) | hypothetical protein MUL_1321 |
| M. vanbaalenii PYR-1 | Mvan_5611 | - | 1e-12 | 28.27% (191) | putative aminotransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3307|M.marinum_M -----------------MSLDTSPLAAARYHGDQAATPGMLDFAVNVRHP
MUL_1321|M.ulcerans_Agy99 ----------------MVSLDTSPLAAARYHGDQAATPGMLDFAVNVRHP
Mb2256c|M.bovis_AF2122/97 MLWILGPHTGPLLFDAVASLDTSPLAAARYHGDQDVAPGVLDFAVNVRHD
Rv2231c|M.tuberculosis_H37Rv MLWILGPHTGPLLFDAVASLDTSPLAAARYHGDQDVAPGVLDFAVNVRHD
MAV_2208|M.avium_104 ----------------MASLNLSP-PAARYHGDQAVAPGMLDFAVNVRHS
MAB_1902|M.abscessus_ATCC_1997 --------------------MTGPRKGARYHGDQALIPGVLDFAVNVRAA
Mflv_1195|M.gilvum_PYR-GCK -------MRAGHKLSQVSARLRPELADLPAYTPGRTVPGAIKIASNETVH
Mvan_5611|M.vanbaalenii_PYR-1 ----------------MSARLRPELADLPAYAPGKTVPGAIKIASNETVH
TH_1662|M.thermoresistible__bu ----------------VTARLRPELADIPAYVPGKMVPGAIKIASNETVH
MLBr_01488|M.leprae_Br4923 ------MSPFGRVSATLPVFPWDTLADAKAVAES-HPDGIVDLSVGTPVD
MSMEG_5121|M.smegmatis_MC2_155 ------MVRQ-RRSATLPEFPWDTLADVTALARS-HPDGIVDLSVGTPVD
* :.:: .
MMAR_3307|M.marinum_M HPPHWLVELLAQRLTTLARYPS------IEDTQRAQDAAALRHRRTRAEV
MUL_1321|M.ulcerans_Agy99 HPPHWLVELLAQRLTTLARYPS------IEDTQCAQDAAALRHRRTRAEV
Mb2256c|M.bovis_AF2122/97 RPPEWLVRQLAALLPELARYPS------TDDVHRAQDAVAERHGRTRDEV
Rv2231c|M.tuberculosis_H37Rv RPPEWLVRQLAALLPELARYPS------TDDVHRAQDAVAERHGRTRDEV
MAV_2208|M.avium_104 RPPQWLLDRLAARLPDLARYPG------DDDVHRAQDAAAERHGRRRDEV
MAB_1902|M.abscessus_ATCC_1997 APPPWLRDRLASRLDELGSYPR------REDEQRAVDAVAERHGRPPDEV
Mflv_1195|M.gilvum_PYR-GCK GPLPSVRAAIADAVGGINRYPDNGYVDLNERLAKYVGFAPENISVGCGSV
Mvan_5611|M.vanbaalenii_PYR-1 GPLPSVRAAIEKAIDGINRYPDNGYVELRERLAKHVNFAPEYISVGCGSV
TH_1662|M.thermoresistible__bu PPLPSVREAIARAGETLNRYPDNGYLDLRDRLARHVGFAPEHISVGCGSV
MLBr_01488|M.leprae_Br4923 PVAPLIQEALAAASSVAGYPTTAGTARLREAAVAALDRRYGITGLTEAAV
MSMEG_5121|M.smegmatis_MC2_155 PVAPVIRDALAAGSSSPGYPTTAGTPELREAMVRALDRRYGITGLTPQTV
: : . : . *
MMAR_3307|M.marinum_M LPLAGAAEGFALLSN--LRPVRAAIIAPSFTEPAAALSAAGIPVHHVVLA
MUL_1321|M.ulcerans_Agy99 LPLAGAAEGFALLSN--LRPVRAAIIAPSFTEPAAALSAAGIPVHHVVLA
Mb2256c|M.bovis_AF2122/97 LPLVGAAEGFALLHN--LSPVRAAIVVPAFTEPAIALSAAGITAHHVVLK
Rv2231c|M.tuberculosis_H37Rv LPLVGAAEGFALLHN--LSPVRAAIVVPAFTEPAIALSAAGITAHHVVLK
MAV_2208|M.avium_104 LPLAGAAEAFALLSN--LRPKRAAVIAPSFTEPAAALSAAGVPVHHVVLE
MAB_1902|M.abscessus_ATCC_1997 LLLAGAAEGFAMLPR--LNPRRAAVVAPGFTEPEAVLADAGIPLEHVVLP
Mflv_1195|M.gilvum_PYR-GCK SLCQQLIQITATVGDEVLFGWRSFEIYPLQVRTAGATPVQVPLT-DHTFD
Mvan_5611|M.vanbaalenii_PYR-1 SLCQQLIQITSTVGDEVLFGWRSFEIYPLQVRTAGATPVQVPLT-DHTFD
TH_1662|M.thermoresistible__bu SLCQQLVQITAGAGDEVLFGWRSFEIYPLQVRTAGAVPVQVPLT-DHTFD
MLBr_01488|M.leprae_Br4923 LPVIGTKELIAWLP--TLLGLRAGDVVVVPELAYPTYNVGARLAGARVLR
MSMEG_5121|M.smegmatis_MC2_155 LPVIGTKELIAWLP--TLLGLGSDDVVVVPELAYPTYEVGARLAGAQVLR
: : * : : . . .:
MMAR_3307|M.marinum_M PPFRL-DEAAVPDDADLVVVGNPTNPTSVLHSREQLLALRRPGR----IL
MUL_1321|M.ulcerans_Agy99 PPFRL-DEAAVPDDADLVVVGNPTNPTSVLHSREQLLALRRPGR----IL
Mb2256c|M.bovis_AF2122/97 PPFVL-DTAHVPDDADLVVVGNPTNPTSVLHLREQLLELRRPGR----IL
Rv2231c|M.tuberculosis_H37Rv PPFVL-DTAHVPDDADLVVVGNPTNPTSVLHLREQLLELRRPGR----IL
MAV_2208|M.avium_104 PPFGL-HGAAVPEEADLVVVGNPTNPTAVLHGREQLLALRRPGR----LL
MAB_1902|M.abscessus_ATCC_1997 PPFTLGDTVRVPDEADLVVVGNPTNPTGVLHTREQLLALRRPGR----IL
Mflv_1195|M.gilvum_PYR-GCK LDAML---AAITDRTRLIFVCNPNNPSSTVVDPGALARFVAAVP-PHILV
Mvan_5611|M.vanbaalenii_PYR-1 LDAML---AAITDRTRLIFVCNPNNPTSTVVDPDALARFVEAVP-PHIMV
TH_1662|M.thermoresistible__bu LDAIL---AAITDRTRLIFICNPNNPTSTVVDPDALARFVAAVP-EHILI
MLBr_01488|M.leprae_Br4923 ADSLT---QLGLQSPALFYLNSPSNPTGQVLAVNHLRKMVGWARNRGVVV
MSMEG_5121|M.smegmatis_MC2_155 ADSLT---QIGPQVPALIYLNSPSNPTGRVLGRDHLRKVVTWARERGVLV
: . *. : .*.**:. : * . ::
MMAR_3307|M.marinum_M VVDEAFADAVPGEPQS------LAGNCLPDVLVLRSLTKTWSLAGLRVGY
MUL_1321|M.ulcerans_Agy99 VVDEAFADAVPGEPQS------LAGDCLPDVLVLRSLTKTWSLAGLRVGY
Mb2256c|M.bovis_AF2122/97 VVDEAFADWVPGEPQS------LADDSLPDVLVLRSLTKTWSLAGLRVGY
Rv2231c|M.tuberculosis_H37Rv VVDEAFADWVPGEPQS------LADDSLPDVLVLRSLTKTWSLAGLRVGY
MAV_2208|M.avium_104 VVDEAFADAIPGEPQS------LAGDALPDVLVLRSLTKTWALAGLRVGY
MAB_1902|M.abscessus_ATCC_1997 VVDEAFIDAVPGEPES------VASLSLPGLVVLRSLTKTWALAGLRAGY
Mflv_1195|M.gilvum_PYR-GCK VLDEAYIEYVRGDLVPDSFG---LVRAHSNVVVLRTFSKAYGLAGLRIGY
Mvan_5611|M.vanbaalenii_PYR-1 VVDEAYVEYIRDGLAPDSFG---LVRAHSNVVVLRTFSKAYGLAGLRIGY
TH_1662|M.thermoresistible__bu ALDEAYIEYVRPPFVPDSLG---LVRAHDNVVVLRTFSKAYGLAGLRVGY
MLBr_01488|M.leprae_Br4923 VSDECYLGLGWDAEPFSVLHPLVCDGNHTGLLAVHSLSKSSSLAGYRAGF
MSMEG_5121|M.smegmatis_MC2_155 ASDECYLGLSWDADPVSVLHPSVCDGDHTGLLAIHSLSKTSSLAGYRAGF
. **.: .::.:::::*: .*** * *:
MMAR_3307|M.marinum_M ALGAPDLLDRLTRMRAHWPVGTLPLTAIAACCTPEAVAEAAADARLLLAA
MUL_1321|M.ulcerans_Agy99 ALGTPDLLDRLTRIRAHWPVGTLPLTAIAACCTPEAVAEAAADARLLLAA
Mb2256c|M.bovis_AF2122/97 ALGSPDVLARLTVQRAHWPLGTLQLTAIAACCAPRAVAAAAADAVRLTAL
Rv2231c|M.tuberculosis_H37Rv ALGSPDVLARLTVQRAHWPLGTLQLTAIAACCAPRAVAAAAADAVRLTAL
MAV_2208|M.avium_104 ALGAPEVLARLTAQRAHWPVGTLQLTALAACCGRRAVADAAAGAERLSRL
MAB_1902|M.abscessus_ATCC_1997 AVGDPELLRRLARGRAHWPLGTLQLEALAACNTAQAVGSAVLDAQRLVET
Mflv_1195|M.gilvum_PYR-GCK AVADPDIVTALSKV--YVPFTATTVSQAAAIACLDAADELLERTDAVVAE
Mvan_5611|M.vanbaalenii_PYR-1 AVADPDIIAALSKV--YVPFTATSVSQAAAIACLDAADELLERTDAVVAE
TH_1662|M.thermoresistible__bu AVAAPEIVTALGKV--YVPFSVSTLAQAAAIASLDAADELLARTDEVVAE
MLBr_01488|M.leprae_Br4923 VAGDPDLVAELLAVRKHAGMMVPTPVQAAMVAALGDDAHEREQRDRYARR
MSMEG_5121|M.smegmatis_MC2_155 VAGDPAVVAELLAVRKHAGMMVPGPIQVAMVAALDDDEHEALQRDRYAQR
. . * :: * : . . *
MMAR_3307|M.marinum_M RAEMVSGLGSVGASVVDGCAPFVLFG--VPDADELRKRLHQRGIAIRRCD
MUL_1321|M.ulcerans_Agy99 RAEMVSGLGSVGASVVDGCAPFVLFS--VPDADELRKRLHQRGIAIRRCD
Mb2256c|M.bovis_AF2122/97 RAEMVAGLRSVGAEVVDGAAPFVLFN--IADADGLRNYLQSKGIAVRRGD
Rv2231c|M.tuberculosis_H37Rv RAEMVAGLRSVGAEVVDGAAPFVLFN--IADADGLRNYLQSKGIAVRRGD
MAV_2208|M.avium_104 REKMAAGLASVGADVLDGRAPFVLFR--MPDAVRVRKLLHDKGIAVRRGD
MAB_1902|M.abscessus_ATCC_1997 RHRQAEGLRGLGLAVTEGVAPFLLVA--VPHADLMRKHLKVKNIAVRRCD
Mflv_1195|M.gilvum_PYR-GCK RTRVSAALREAGYDLPPSQAN-FVWLPLVGRAQQFAADAADARIIVRP--
Mvan_5611|M.vanbaalenii_PYR-1 RTRVSAALREAGYDLPPSQAN-FVWLPLVGRAQQFAADAANSRVIVRP--
TH_1662|M.thermoresistible__bu RARVTAALRDAGYTVPESGAN-FVWLPLAERTVDFVNSAAEDRLLVRP--
MLBr_01488|M.leprae_Br4923 RDVLLPAVVSAGFTVDHSEAGLYLWASRGEPCRDSVEWFAQRGILVALGE
MSMEG_5121|M.smegmatis_MC2_155 RNLLLPAFREAGFTVDHSEAGLYLWATRGEACRDTLRWLAERGILVAPGE
* .. * : . * : : :
MMAR_3307|M.marinum_M TFVGLDDGYLRAAVRPEWPQLVDAIAEVRQAGRSGRRR
MUL_1321|M.ulcerans_Agy99 TFVGLDDGYLRAAVRPEWPQLVDAIAEVRQAGRSGRRR
Mb2256c|M.bovis_AF2122/97 TFVGLDARYLRAAVRPEWPVLVAAIAEWAKRG--GRR-
Rv2231c|M.tuberculosis_H37Rv TFVGLDARYLRAAVRPEWPVLVAAIAEWAKRG--GRR-
MAV_2208|M.avium_104 TFVGLDERYLRAAVRPEWPLLVQAIAEAQR--------
MAB_1902|M.abscessus_ATCC_1997 TFVGLDGDYLRVAVRPEWPELVQAMKEIL---------
Mflv_1195|M.gilvum_PYR-GCK -YGEDGVRVTVASPDENDMFLDFARDWIARP-------
Mvan_5611|M.vanbaalenii_PYR-1 -YGEDGVRVTIAAPHENDAFLGFARGWDGLR-------
TH_1662|M.thermoresistible__bu -YGTDGVRVTVAAPHENDAFLSFATRWISER-------
MLBr_01488|M.leprae_Br4923 FYGPGGCQHVRVALTASDERIAAVVARLS---------
MSMEG_5121|M.smegmatis_MC2_155 FYGPAGDRYVRVALTATDERIQQAAERLAG--------
: . .: : .