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VVSLDTSPLAAARYHGDQAATPGMLDFAVNVRHPHPPHWLVELLAQRLTTLARYPSIEDTQCAQDAAALR HRRTRAEVLPLAGAAEGFALLSNLRPVRAAIIAPSFTEPAAALSAAGIPVHHVVLAPPFRLDEAAVPDDA DLVVVGNPTNPTSVLHSREQLLALRRPGRILVVDEAFADAVPGEPQSLAGDCLPDVLVLRSLTKTWSLAG LRVGYALGTPDLLDRLTRIRAHWPVGTLPLTAIAACCTPEAVAEAAADARLLLAARAEMVSGLGSVGASV VDGCAPFVLFSVPDADELRKRLHQRGIAIRRCDTFVGLDDGYLRAAVRPEWPQLVDAIAEVRQAGRSGRR R
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1321 | cobC | - | 100% (351) | hypothetical protein MUL_1321 |
| M. ulcerans Agy99 | MUL_1573 | hisC1 | 1e-14 | 29.34% (351) | histidinol-phosphate aminotransferase |
| M. ulcerans Agy99 | MUL_4407 | hisC2 | 1e-14 | 33.73% (169) | putative aminotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2256c | cobC | 1e-146 | 77.43% (350) | hypothetical protein Mb2256c |
| M. gilvum PYR-GCK | Mflv_1195 | - | 1e-13 | 29.23% (195) | putative aminotransferase |
| M. tuberculosis H37Rv | Rv2231c | cobC | 1e-146 | 77.43% (350) | hypothetical protein Rv2231c |
| M. leprae Br4923 | MLBr_01258 | hisC | 4e-14 | 28.77% (351) | histidinol-phosphate aminotransferase |
| M. abscessus ATCC 19977 | MAB_1902 | - | 1e-118 | 64.39% (337) | hypothetical protein MAB_1902 |
| M. marinum M | MMAR_3307 | cobC | 0.0 | 98.57% (350) | aminotransferase CobC |
| M. avium 104 | MAV_2208 | - | 1e-142 | 74.93% (343) | hypothetical protein MAV_2208 |
| M. smegmatis MC2 155 | MSMEG_6351 | hisC | 8e-12 | 30.49% (164) | putative aminotransferase |
| M. thermoresistible (build 8) | TH_1662 | hisC2 | 2e-15 | 33.51% (188) | PROBABLE HISTIDINOL-PHOSPHATE AMINOTRANSFERASE HISC2 |
| M. vanbaalenii PYR-1 | Mvan_5611 | - | 7e-13 | 29.32% (191) | putative aminotransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1321|M.ulcerans_Agy99 ----------------MVSLDTSPLAAARYHGDQAATPGMLDFAVNVRHP
MMAR_3307|M.marinum_M -----------------MSLDTSPLAAARYHGDQAATPGMLDFAVNVRHP
Mb2256c|M.bovis_AF2122/97 MLWILGPHTGPLLFDAVASLDTSPLAAARYHGDQDVAPGVLDFAVNVRHD
Rv2231c|M.tuberculosis_H37Rv MLWILGPHTGPLLFDAVASLDTSPLAAARYHGDQDVAPGVLDFAVNVRHD
MAV_2208|M.avium_104 ----------------MASLNLSP-PAARYHGDQAVAPGMLDFAVNVRHS
MAB_1902|M.abscessus_ATCC_1997 --------------------MTGPRKGARYHGDQALIPGVLDFAVNVRAA
Mflv_1195|M.gilvum_PYR-GCK -------MRAGHKLSQVSARLRPELADLPAYTPGRTVPGAIKIASNETVH
Mvan_5611|M.vanbaalenii_PYR-1 ----------------MSARLRPELADLPAYAPGKTVPGAIKIASNETVH
MSMEG_6351|M.smegmatis_MC2_155 ----------------MSIRLRAEMADLPAYAPGKTVPGAIKIASNETVH
TH_1662|M.thermoresistible__bu ----------------VTARLRPELADIPAYVPGKMVPGAIKIASNETVH
MLBr_01258|M.leprae_Br4923 --------MNVPEPTLDDLPLRDNLRGKSPYG-AMQLLVPVLLNTNENPH
: : : *
MUL_1321|M.ulcerans_Agy99 HPPHWLVELLAQRLT----TLARYPSIEDTQCAQDAAALRHRRT-----R
MMAR_3307|M.marinum_M HPPHWLVELLAQRLT----TLARYPSIEDTQRAQDAAALRHRRT-----R
Mb2256c|M.bovis_AF2122/97 RPPEWLVRQLAALLP----ELARYPSTDDVHRAQDAVAERHGRT-----R
Rv2231c|M.tuberculosis_H37Rv RPPEWLVRQLAALLP----ELARYPSTDDVHRAQDAVAERHGRT-----R
MAV_2208|M.avium_104 RPPQWLLDRLAARLP----DLARYPGDDDVHRAQDAAAERHGRR-----R
MAB_1902|M.abscessus_ATCC_1997 APPPWLRDRLASRLD----ELGSYPRREDEQRAVDAVAERHGRP-----P
Mflv_1195|M.gilvum_PYR-GCK GPLPSVRAAIADAVG----GINRYPD-NGYVDLNERLAKYVGFA-----P
Mvan_5611|M.vanbaalenii_PYR-1 GPLPSVRAAIEKAID----GINRYPD-NGYVELRERLAKHVNFA-----P
MSMEG_6351|M.smegmatis_MC2_155 GPLPSVREAILKATD----LINRYPD-NGYLDLRERLAKHVNFA-----P
TH_1662|M.thermoresistible__bu PPLPSVREAIARAGE----TLNRYPD-NGYLDLRDRLARHVGFA-----P
MLBr_01258|M.leprae_Br4923 PPTKALVDDVVRSVQKVAVDLHRYPDRDAVALRQDLASYLTAQTGIRLGV
* : : : ** : : :
MUL_1321|M.ulcerans_Agy99 AEVLPLAGAAEGFALLSNLRPVRAAIIAPSFT----EPAAAL-SAAGIPV
MMAR_3307|M.marinum_M AEVLPLAGAAEGFALLSNLRPVRAAIIAPSFT----EPAAAL-SAAGIPV
Mb2256c|M.bovis_AF2122/97 DEVLPLVGAAEGFALLHNLSPVRAAIVVPAFT----EPAIAL-SAAGITA
Rv2231c|M.tuberculosis_H37Rv DEVLPLVGAAEGFALLHNLSPVRAAIVVPAFT----EPAIAL-SAAGITA
MAV_2208|M.avium_104 DEVLPLAGAAEAFALLSNLRPKRAAVIAPSFT----EPAAAL-SAAGVPV
MAB_1902|M.abscessus_ATCC_1997 DEVLLLAGAAEGFAMLPRLNPRRAAVVAPGFT----EPEAVL-ADAGIPL
Mflv_1195|M.gilvum_PYR-GCK ENISVGCGSVSLCQQLIQITATVGDEVLFGWRSFEIYPLQVR-TAGATPV
Mvan_5611|M.vanbaalenii_PYR-1 EYISVGCGSVSLCQQLIQITSTVGDEVLFGWRSFEIYPLQVR-TAGATPV
MSMEG_6351|M.smegmatis_MC2_155 ENISVGCGSVSLCQQLIQITSSVGDEVLFAWRSFEIYPLQVR-TAGATPV
TH_1662|M.thermoresistible__bu EHISVGCGSVSLCQQLVQITAGAGDEVLFGWRSFEIYPLQVR-TAGAVPV
MLBr_01258|M.leprae_Br4923 ENIWAANGSNEILQQLLQAFGGPGRSAIGFVPSYSMHPIIADGTHTEWLE
: *: . * . . * . :
MUL_1321|M.ulcerans_Agy99 HHVVLAPPFRL--DEAAVPDD-ADLVVVGNPTNPTSVLHSRE---QLLAL
MMAR_3307|M.marinum_M HHVVLAPPFRL--DEAAVPDD-ADLVVVGNPTNPTSVLHSRE---QLLAL
Mb2256c|M.bovis_AF2122/97 HHVVLKPPFVL--DTAHVPDD-ADLVVVGNPTNPTSVLHLRE---QLLEL
Rv2231c|M.tuberculosis_H37Rv HHVVLKPPFVL--DTAHVPDD-ADLVVVGNPTNPTSVLHLRE---QLLEL
MAV_2208|M.avium_104 HHVVLEPPFGL--HGAAVPEE-ADLVVVGNPTNPTAVLHGRE---QLLAL
MAB_1902|M.abscessus_ATCC_1997 EHVVLPPPFTLG-DTVRVPDE-ADLVVVGNPTNPTGVLHTRE---QLLAL
Mflv_1195|M.gilvum_PYR-GCK QVPLTDHTFDLDAMLAAITDR-TRLIFVCNPNNPSSTVVDPGALARFVAA
Mvan_5611|M.vanbaalenii_PYR-1 QVPLTDHTFDLDAMLAAITDR-TRLIFVCNPNNPTSTVVDPDALARFVEA
MSMEG_6351|M.smegmatis_MC2_155 AVALRDHTHDLDAMLAAITDR-TRLIFVCNPNNPTSTVVDPGELARFVAA
TH_1662|M.thermoresistible__bu QVPLTDHTFDLDAILAAITDR-TRLIFICNPNNPTSTVVDPDALARFVAA
MLBr_01258|M.leprae_Br4923 TVRADDFSLDVEAAVTAVADRKPDVVFIASPNNPSGQSISLADLRRLLDV
. : . :.: . ::.: .*.**:. :::
MUL_1321|M.ulcerans_Agy99 RRPGRILVVDEAFADAVPG--EPQSLAGDCLP--DVLVLRSLTKTWSLAG
MMAR_3307|M.marinum_M RRPGRILVVDEAFADAVPG--EPQSLAGNCLP--DVLVLRSLTKTWSLAG
Mb2256c|M.bovis_AF2122/97 RRPGRILVVDEAFADWVPG--EPQSLADDSLP--DVLVLRSLTKTWSLAG
Rv2231c|M.tuberculosis_H37Rv RRPGRILVVDEAFADWVPG--EPQSLADDSLP--DVLVLRSLTKTWSLAG
MAV_2208|M.avium_104 RRPGRLLVVDEAFADAIPG--EPQSLAGDALP--DVLVLRSLTKTWALAG
MAB_1902|M.abscessus_ATCC_1997 RRPGRILVVDEAFIDAVPG--EPESVASLSLP--GLVVLRSLTKTWALAG
Mflv_1195|M.gilvum_PYR-GCK VPPHILVVLDEAYIEYVRGDLVPDSFGLVRAHS-NVVVLRTFSKAYGLAG
Mvan_5611|M.vanbaalenii_PYR-1 VPPHIMVVVDEAYVEYIRDGLAPDSFGLVRAHS-NVVVLRTFSKAYGLAG
MSMEG_6351|M.smegmatis_MC2_155 VPPHILVVLDEAYVEYIRDGLLPDSLGLVREHR-NVVVLRTFSKAYGLAG
TH_1662|M.thermoresistible__bu VPEHILIALDEAYIEYVRPPFVPDSLGLVRAHD-NVVVLRTFSKAYGLAG
MLBr_01258|M.leprae_Br4923 VPG--ILIVDEAYGEFSSR---PSAVALVGEYPTKIVVTRTTSKAFAFAG
:: :***: : *.:.. ::* *: :*::.:**
MUL_1321|M.ulcerans_Agy99 LRVGYALGTPDLLDRLTRIRAHWPVGTLPLTAIAACCTPEAVAEAAADAR
MMAR_3307|M.marinum_M LRVGYALGAPDLLDRLTRMRAHWPVGTLPLTAIAACCTPEAVAEAAADAR
Mb2256c|M.bovis_AF2122/97 LRVGYALGSPDVLARLTVQRAHWPLGTLQLTAIAACCAPRAVAAAAADAV
Rv2231c|M.tuberculosis_H37Rv LRVGYALGSPDVLARLTVQRAHWPLGTLQLTAIAACCAPRAVAAAAADAV
MAV_2208|M.avium_104 LRVGYALGAPEVLARLTAQRAHWPVGTLQLTALAACCGRRAVADAAAGAE
MAB_1902|M.abscessus_ATCC_1997 LRAGYAVGDPELLRRLARGRAHWPLGTLQLEALAACNTAQAVGSAVLDAQ
Mflv_1195|M.gilvum_PYR-GCK LRIGYAVADPDIVTALS--KVYVPFTATTVSQAAAIACLDAADELLERTD
Mvan_5611|M.vanbaalenii_PYR-1 LRIGYAVADPDIIAALS--KVYVPFTATSVSQAAAIACLDAADELLERTD
MSMEG_6351|M.smegmatis_MC2_155 LRVGYAVADPEIVTALG--KVYVPFSATSVSQAAAIACLDAADELLARTD
TH_1662|M.thermoresistible__bu LRVGYAVAAPEIVTALG--KVYVPFSVSTLAQAAAIASLDAADELLARTD
MLBr_01258|M.leprae_Br4923 GRLGYLIATPALVEAML--LVRLPYHLSSVTQAAARAALRHADDTLGSVA
* ** :. * :: : . * : ** . .
MUL_1321|M.ulcerans_Agy99 LLLAARAEMVSGLGSVGASVVDGCAPFVLFSVPDADELRKRLHQRGIAIR
MMAR_3307|M.marinum_M LLLAARAEMVSGLGSVGASVVDGCAPFVLFGVPDADELRKRLHQRGIAIR
Mb2256c|M.bovis_AF2122/97 RLTALRAEMVAGLRSVGAEVVDGAAPFVLFNIADADGLRNYLQSKGIAVR
Rv2231c|M.tuberculosis_H37Rv RLTALRAEMVAGLRSVGAEVVDGAAPFVLFNIADADGLRNYLQSKGIAVR
MAV_2208|M.avium_104 RLSRLREKMAAGLASVGADVLDGRAPFVLFRMPDAVRVRKLLHDKGIAVR
MAB_1902|M.abscessus_ATCC_1997 RLVETRHRQAEGLRGLGLAVTEGVAPFLLVAVPHADLMRKHLKVKNIAVR
Mflv_1195|M.gilvum_PYR-GCK AVVAERTRVSAALREAGYDLPPSQANFVWLPLVGRAQQFAADAADARIIV
Mvan_5611|M.vanbaalenii_PYR-1 AVVAERTRVSAALREAGYDLPPSQANFVWLPLVGRAQQFAADAANSRVIV
MSMEG_6351|M.smegmatis_MC2_155 AVVAERTRVSDALRAAGYTLPPSQANFVWLPLAERTLDFVARAADNRIIV
TH_1662|M.thermoresistible__bu EVVAERARVTAALRDAGYTVPESGANFVWLPLAERTVDFVNSAAEDRLLV
MLBr_01258|M.leprae_Br4923 ALIAERERVTKSLVHMGFRVIPSDANFVLFGHFSDAAGAWQHYLDTGVLI
: * . .* * : . * *: . :
MUL_1321|M.ulcerans_Agy99 RCDTFVGLDD-GYLRAAVRPEWPQLVDAIAEVRQAGRSGRRR----
MMAR_3307|M.marinum_M RCDTFVGLDD-GYLRAAVRPEWPQLVDAIAEVRQAGRSGRRR----
Mb2256c|M.bovis_AF2122/97 RGDTFVGLDA-RYLRAAVRPEWPVLVAAIAEWAKRG--GRR-----
Rv2231c|M.tuberculosis_H37Rv RGDTFVGLDA-RYLRAAVRPEWPVLVAAIAEWAKRG--GRR-----
MAV_2208|M.avium_104 RGDTFVGLDE-RYLRAAVRPEWPLLVQAIAEAQR------------
MAB_1902|M.abscessus_ATCC_1997 RCDTFVGLDG-DYLRVAVRPEWPELVQAMKEIL-------------
Mflv_1195|M.gilvum_PYR-GCK RP---YGEDG-VRVTVASPDENDMFLDFARDWIARP----------
Mvan_5611|M.vanbaalenii_PYR-1 RP---YGEDG-VRVTIAAPHENDAFLGFARGWDGLR----------
MSMEG_6351|M.smegmatis_MC2_155 RP---YGEDG-VRVTIGAPHENDAFLDFAQRWIAPGGAGPRTGDSA
TH_1662|M.thermoresistible__bu RP---YGTDG-VRVTVAAPHENDAFLSFATRWISER----------
MLBr_01258|M.leprae_Br4923 RD---VGIPGYLRATTGLAEENDAFLKASSEIAATELAPATTLGAS
* * . * ::