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LWILGPHTGPLLFDAVASLDTSPLAAARYHGDQDVAPGVLDFAVNVRHDRPPEWLVRQLAALLPELARYP STDDVHRAQDAVAERHGRTRDEVLPLVGAAEGFALLHNLSPVRAAIVVPAFTEPAIALSAAGITAHHVVL KPPFVLDTAHVPDDADLVVVGNPTNPTSVLHLREQLLELRRPGRILVVDEAFADWVPGEPQSLADDSLPD VLVLRSLTKTWSLAGLRVGYALGSPDVLARLTVQRAHWPLGTLQLTAIAACCAPRAVAAAAADAVRLTAL RAEMVAGLRSVGAEVVDGAAPFVLFNIADADGLRNYLQSKGIAVRRGDTFVGLDARYLRAAVRPEWPVLV AAIAEWAKRGGRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2231c | cobC | - | 100% (364) | hypothetical protein Rv2231c |
| M. tuberculosis H37Rv | Rv1178 | - | 1e-14 | 27.73% (339) | N-succinyldiaminopimelate aminotransferase |
| M. tuberculosis H37Rv | Rv3772 | hisC2 | 8e-13 | 32.93% (164) | putative aminotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2256c | cobC | 0.0 | 100.00% (364) | hypothetical protein Mb2256c |
| M. gilvum PYR-GCK | Mflv_2171 | - | 6e-14 | 29.11% (347) | N-succinyldiaminopimelate aminotransferase |
| M. leprae Br4923 | MLBr_01488 | - | 2e-14 | 30.00% (270) | N-succinyldiaminopimelate aminotransferase |
| M. abscessus ATCC 19977 | MAB_1902 | - | 1e-116 | 64.29% (336) | hypothetical protein MAB_1902 |
| M. marinum M | MMAR_3307 | cobC | 1e-145 | 77.59% (348) | aminotransferase CobC |
| M. avium 104 | MAV_2208 | - | 1e-147 | 76.76% (340) | hypothetical protein MAV_2208 |
| M. smegmatis MC2 155 | MSMEG_5121 | - | 6e-15 | 27.70% (343) | N-succinyldiaminopimelate aminotransferase |
| M. thermoresistible (build 8) | TH_1662 | hisC2 | 1e-13 | 33.53% (167) | PROBABLE HISTIDINOL-PHOSPHATE AMINOTRANSFERASE HISC2 |
| M. ulcerans Agy99 | MUL_1321 | cobC | 1e-146 | 77.43% (350) | hypothetical protein MUL_1321 |
| M. vanbaalenii PYR-1 | Mvan_4528 | - | 4e-14 | 28.53% (361) | N-succinyldiaminopimelate aminotransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2231c|M.tuberculosis_H37Rv ----MLWILGPHTGPLLFDAVASLDTSPLAAARYHGDQDVAPGVLDFAVN
Mb2256c|M.bovis_AF2122/97 ----MLWILGPHTGPLLFDAVASLDTSPLAAARYHGDQDVAPGVLDFAVN
MMAR_3307|M.marinum_M ---------------------MSLDTSPLAAARYHGDQAATPGMLDFAVN
MUL_1321|M.ulcerans_Agy99 --------------------MVSLDTSPLAAARYHGDQAATPGMLDFAVN
MAV_2208|M.avium_104 --------------------MASLNLSP-PAARYHGDQAVAPGMLDFAVN
MAB_1902|M.abscessus_ATCC_1997 ------------------------MTGPRKGARYHGDQALIPGVLDFAVN
Mflv_2171|M.gilvum_PYR-GCK MRTEPTAELARRRLRAPVSASLPVFPWDTLADVTAAARAHESGIVDLSVG
Mvan_4528|M.vanbaalenii_PYR-1 -----------------------MFPWDTLADATAAARAHPDGIVDLSVG
MSMEG_5121|M.smegmatis_MC2_155 ------------MVRQRRSATLPEFPWDTLADVTALARSHPDGIVDLSVG
MLBr_01488|M.leprae_Br4923 -----------MSPFGRVSATLPVFPWDTLADAKAVAESHPDGIVDLSVG
TH_1662|M.thermoresistible__bu --------------------VTARLRPELADIPAYVPGKMVPGAIKIASN
* :.:: .
Rv2231c|M.tuberculosis_H37Rv VRHDRPPEWLVRQLAALLPELARYPSTDDVHRAQDAVAERHGR-------
Mb2256c|M.bovis_AF2122/97 VRHDRPPEWLVRQLAALLPELARYPSTDDVHRAQDAVAERHGR-------
MMAR_3307|M.marinum_M VRHPHPPHWLVELLAQRLTTLARYPSIEDTQRAQDAAALRHRR-------
MUL_1321|M.ulcerans_Agy99 VRHPHPPHWLVELLAQRLTTLARYPSIEDTQCAQDAAALRHRR-------
MAV_2208|M.avium_104 VRHSRPPQWLLDRLAARLPDLARYPGDDDVHRAQDAAAERHGR-------
MAB_1902|M.abscessus_ATCC_1997 VRAAAPPPWLRDRLASRLDELGSYPRREDEQRAVDAVAERHGR-------
Mflv_2171|M.gilvum_PYR-GCK TPVDEVAPVIRDALAAAGSAPG-YPTTHGTTALRDAAVAALHRRYGITGL
Mvan_4528|M.vanbaalenii_PYR-1 TPVDDVAPVIRDALAAASSAPG-YPTTHGTPALREAAVSALRRRYGITHL
MSMEG_5121|M.smegmatis_MC2_155 TPVDPVAPVIRDALAAGSSSPG-YPTTAGTPELREAMVRALDRRYGITGL
MLBr_01488|M.leprae_Br4923 TPVDPVAPLIQEALAAASSVAG-YPTTAGTARLREAAVAALDRRYGITGL
TH_1662|M.thermoresistible__bu ETVHPPLPSVREAIARAGETLNRYPDN-GYLDLRDRLARHVGFAPEHISV
: :* ** . : .
Rv2231c|M.tuberculosis_H37Rv TRDEVLPLVGAAEGFALLHNLSPVR--AAIVVPAFTEPAIALSAAGITAH
Mb2256c|M.bovis_AF2122/97 TRDEVLPLVGAAEGFALLHNLSPVR--AAIVVPAFTEPAIALSAAGITAH
MMAR_3307|M.marinum_M TRAEVLPLAGAAEGFALLSNLRPVR--AAIIAPSFTEPAAALSAAGIPVH
MUL_1321|M.ulcerans_Agy99 TRAEVLPLAGAAEGFALLSNLRPVR--AAIIAPSFTEPAAALSAAGIPVH
MAV_2208|M.avium_104 RRDEVLPLAGAAEAFALLSNLRPKR--AAVIAPSFTEPAAALSAAGVPVH
MAB_1902|M.abscessus_ATCC_1997 PPDEVLLLAGAAEGFAMLPRLNPRR--AAVVAPGFTEPEAVLADAGIPLE
Mflv_2171|M.gilvum_PYR-GCK DPAAVLPVIGTKELIAWLPTLLGLGAADTVVVPELAYPTYEVGAL-LAGA
Mvan_4528|M.vanbaalenii_PYR-1 APGSVLPAIGTKELIAWLPTVLGLGAGDTVVVPELAYPTYEVGAL-LAGA
MSMEG_5121|M.smegmatis_MC2_155 TPQTVLPVIGTKELIAWLPTLLGLGSDDVVVVPELAYPTYEVGAR-LAGA
MLBr_01488|M.leprae_Br4923 TEAAVLPVIGTKELIAWLPTLLGLRAGDVVVVPELAYPTYNVGAR-LAGA
TH_1662|M.thermoresistible__bu GCGSVSLCQQLVQITAGAGDEVLFGWRSFEIYPLQVRTAGAVPVQVPLTD
* : * : * . . :
Rv2231c|M.tuberculosis_H37Rv HVVLKPPFVL-DTAHVPDDADLVVVGNPTNPT----SVLHLREQLLELRR
Mb2256c|M.bovis_AF2122/97 HVVLKPPFVL-DTAHVPDDADLVVVGNPTNPT----SVLHLREQLLELRR
MMAR_3307|M.marinum_M HVVLAPPFRL-DEAAVPDDADLVVVGNPTNPT----SVLHSREQLLALRR
MUL_1321|M.ulcerans_Agy99 HVVLAPPFRL-DEAAVPDDADLVVVGNPTNPT----SVLHSREQLLALRR
MAV_2208|M.avium_104 HVVLEPPFGL-HGAAVPEEADLVVVGNPTNPT----AVLHGREQLLALRR
MAB_1902|M.abscessus_ATCC_1997 HVVLPPPFTLGDTVRVPDEADLVVVGNPTNPT----GVLHTREQLLALRR
Mflv_2171|M.gilvum_PYR-GCK AVVRADSLTQ----LGPAAPPLVYLNSPSNPTGKVLGVDHLRKVVGWARD
Mvan_4528|M.vanbaalenii_PYR-1 AVARADSLTQ----LGPSVPALVYVNSPSNPTGRVLGVDHLRKVVGWARD
MSMEG_5121|M.smegmatis_MC2_155 QVLRADSLTQ----IGPQVPALIYLNSPSNPTGRVLGRDHLRKVVTWARE
MLBr_01488|M.leprae_Br4923 RVLRADSLTQ----LGLQSPALFYLNSPSNPTGQVLAVNHLRKMVGWARN
TH_1662|M.thermoresistible__bu HTFDLDAILA----AITDRTRLIFICNPNNPTSTVVDPDALARFVAAVPE
. .: . *. : .*.*** . :
Rv2231c|M.tuberculosis_H37Rv PGRILVVDEAFA------DWVPGEPQSLADDSLPDVLVLRSLTKTWSLAG
Mb2256c|M.bovis_AF2122/97 PGRILVVDEAFA------DWVPGEPQSLADDSLPDVLVLRSLTKTWSLAG
MMAR_3307|M.marinum_M PGRILVVDEAFA------DAVPGEPQSLAGNCLPDVLVLRSLTKTWSLAG
MUL_1321|M.ulcerans_Agy99 PGRILVVDEAFA------DAVPGEPQSLAGDCLPDVLVLRSLTKTWSLAG
MAV_2208|M.avium_104 PGRLLVVDEAFA------DAIPGEPQSLAGDALPDVLVLRSLTKTWALAG
MAB_1902|M.abscessus_ATCC_1997 PGRILVVDEAFI------DAVPGEPESVASLSLPGLVVLRSLTKTWALAG
Mflv_2171|M.gilvum_PYR-GCK RGVLVASDECYLGLGWDATPVSVLHPDVCDGDHTGLLAIHSLSKTSSLAG
Mvan_4528|M.vanbaalenii_PYR-1 RGVLVASDECYLGLGWDVAPVSVLHPDVCDGDHTGLLAVHSLSKTSSLAG
MSMEG_5121|M.smegmatis_MC2_155 RGVLVASDECYLGLSWDADPVSVLHPSVCDGDHTGLLAIHSLSKTSSLAG
MLBr_01488|M.leprae_Br4923 RGVVVVSDECYLGLGWDAEPFSVLHPLVCDGNHTGLLAVHSLSKSSSLAG
TH_1662|M.thermoresistible__bu H-ILIALDEAYIEY---VRPPFVPDSLGLVRAHDNVVVLRTFSKAYGLAG
::. **.: .::.:::::*: .***
Rv2231c|M.tuberculosis_H37Rv LRVGYALGSPDVLARLTVQRAHWPLGTLQLTAIAACCAPRAVAAAAADAV
Mb2256c|M.bovis_AF2122/97 LRVGYALGSPDVLARLTVQRAHWPLGTLQLTAIAACCAPRAVAAAAADAV
MMAR_3307|M.marinum_M LRVGYALGAPDLLDRLTRMRAHWPVGTLPLTAIAACCTPEAVAEAAADAR
MUL_1321|M.ulcerans_Agy99 LRVGYALGTPDLLDRLTRIRAHWPVGTLPLTAIAACCTPEAVAEAAADAR
MAV_2208|M.avium_104 LRVGYALGAPEVLARLTAQRAHWPVGTLQLTALAACCGRRAVADAAAGAE
MAB_1902|M.abscessus_ATCC_1997 LRAGYAVGDPELLRRLARGRAHWPLGTLQLEALAACNTAQAVGSAVLDAQ
Mflv_2171|M.gilvum_PYR-GCK YRAGFVAGDPAVVAELLAVRKHAGMMVPTPIQAAMVAALDDDAHERTQRA
Mvan_4528|M.vanbaalenii_PYR-1 YRAGFVAGDPAVVAELLAVRKHAGMMVPTPIQAAMVAALDDDAHEREQRE
MSMEG_5121|M.smegmatis_MC2_155 YRAGFVAGDPAVVAELLAVRKHAGMMVPGPIQVAMVAALDDDEHEALQRD
MLBr_01488|M.leprae_Br4923 YRAGFVAGDPDLVAELLAVRKHAGMMVPTPVQAAMVAALGDDAHEREQRD
TH_1662|M.thermoresistible__bu LRVGYAVAAPEIVTALG--KVYVPFSVSTLAQAAAIASLDAADELLARTD
*.*:. . * :: * : : . . *
Rv2231c|M.tuberculosis_H37Rv RLTALRAEMVAGLRSVGAEVVDGAAPFVLFNIAD--ADGLRNYLQSKGIA
Mb2256c|M.bovis_AF2122/97 RLTALRAEMVAGLRSVGAEVVDGAAPFVLFNIAD--ADGLRNYLQSKGIA
MMAR_3307|M.marinum_M LLLAARAEMVSGLGSVGASVVDGCAPFVLFGVPD--ADELRKRLHQRGIA
MUL_1321|M.ulcerans_Agy99 LLLAARAEMVSGLGSVGASVVDGCAPFVLFSVPD--ADELRKRLHQRGIA
MAV_2208|M.avium_104 RLSRLREKMAAGLASVGADVLDGRAPFVLFRMPD--AVRVRKLLHDKGIA
MAB_1902|M.abscessus_ATCC_1997 RLVETRHRQAEGLRGLGLAVTEGVAPFLLVAVPH--ADLMRKHLKVKNIA
Mflv_2171|M.gilvum_PYR-GCK RYQRRRDALLPALVSAGFTVDHSEAGLYLWATRDEPCRDTLAWLAQRGIL
Mvan_4528|M.vanbaalenii_PYR-1 RYARRRDALLPALLAAGFTVDHSEAGLYLWATRGEPCRDTVTWLAQKGIL
MSMEG_5121|M.smegmatis_MC2_155 RYAQRRNLLLPAFREAGFTVDHSEAGLYLWATRGEACRDTLRWLAERGIL
MLBr_01488|M.leprae_Br4923 RYARRRDVLLPAVVSAGFTVDHSEAGLYLWASRGEPCRDSVEWFAQRGIL
TH_1662|M.thermoresistible__bu EVVAERARVTAALRDAGYTVPESGANFVWLPLAER-TVDFVNSAAEDRLL
* .. * * .. * : :
Rv2231c|M.tuberculosis_H37Rv VRRGDTFVGLDARYLRAAVRPEWPVLVAAIAEWAKRG--GRR-
Mb2256c|M.bovis_AF2122/97 VRRGDTFVGLDARYLRAAVRPEWPVLVAAIAEWAKRG--GRR-
MMAR_3307|M.marinum_M IRRCDTFVGLDDGYLRAAVRPEWPQLVDAIAEVRQAGRSGRRR
MUL_1321|M.ulcerans_Agy99 IRRCDTFVGLDDGYLRAAVRPEWPQLVDAIAEVRQAGRSGRRR
MAV_2208|M.avium_104 VRRGDTFVGLDERYLRAAVRPEWPLLVQAIAEAQR--------
MAB_1902|M.abscessus_ATCC_1997 VRRCDTFVGLDGDYLRVAVRPEWPELVQAMKEIL---------
Mflv_2171|M.gilvum_PYR-GCK VAPGEFYGPRGTRHVRVALTATDERIDAAVERLGS--------
Mvan_4528|M.vanbaalenii_PYR-1 VAPGEFYGPRGARHVRVALTATDERIAAAVARLADSAR-----
MSMEG_5121|M.smegmatis_MC2_155 VAPGEFYGPAGDRYVRVALTATDERIQQAAERLAG--------
MLBr_01488|M.leprae_Br4923 VALGEFYGPGGCQHVRVALTASDERIAAVVARLS---------
TH_1662|M.thermoresistible__bu VRP---YGTDGVRVTVAAPHENDAFLSFATRWISER-------
: : . .* : .