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SLDTSPLAAARYHGDQAATPGMLDFAVNVRHPHPPHWLVELLAQRLTTLARYPSIEDTQRAQDAAALRHR RTRAEVLPLAGAAEGFALLSNLRPVRAAIIAPSFTEPAAALSAAGIPVHHVVLAPPFRLDEAAVPDDADL VVVGNPTNPTSVLHSREQLLALRRPGRILVVDEAFADAVPGEPQSLAGNCLPDVLVLRSLTKTWSLAGLR VGYALGAPDLLDRLTRMRAHWPVGTLPLTAIAACCTPEAVAEAAADARLLLAARAEMVSGLGSVGASVVD GCAPFVLFGVPDADELRKRLHQRGIAIRRCDTFVGLDDGYLRAAVRPEWPQLVDAIAEVRQAGRSGRRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3307 | cobC | - | 100% (350) | aminotransferase CobC |
| M. marinum M | MMAR_5326 | hisC2 | 6e-15 | 34.32% (169) | histidinol-phosphate aminotransferase HisC2 |
| M. marinum M | MMAR_2396 | hisC1 | 3e-13 | 28.77% (351) | histidinol-phosphate aminotransferase HisC1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2256c | cobC | 1e-146 | 77.59% (348) | hypothetical protein Mb2256c |
| M. gilvum PYR-GCK | Mflv_3612 | - | 4e-14 | 28.01% (357) | histidinol-phosphate aminotransferase |
| M. tuberculosis H37Rv | Rv2231c | cobC | 1e-146 | 77.59% (348) | hypothetical protein Rv2231c |
| M. leprae Br4923 | MLBr_01488 | - | 5e-12 | 30.33% (244) | N-succinyldiaminopimelate aminotransferase |
| M. abscessus ATCC 19977 | MAB_1902 | - | 1e-119 | 64.69% (337) | hypothetical protein MAB_1902 |
| M. avium 104 | MAV_2208 | - | 1e-143 | 75.66% (341) | hypothetical protein MAV_2208 |
| M. smegmatis MC2 155 | MSMEG_1491 | - | 3e-12 | 33.13% (166) | histidinol-phosphate aminotransferase 2 |
| M. thermoresistible (build 8) | TH_1662 | hisC2 | 1e-15 | 33.51% (188) | PROBABLE HISTIDINOL-PHOSPHATE AMINOTRANSFERASE HISC2 |
| M. ulcerans Agy99 | MUL_1321 | cobC | 0.0 | 98.57% (350) | hypothetical protein MUL_1321 |
| M. vanbaalenii PYR-1 | Mvan_2805 | - | 9e-13 | 27.02% (359) | histidinol-phosphate aminotransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3307|M.marinum_M -----------------MSLDTSPLAAARYHGDQAATPGMLDFAVNVRHP
MUL_1321|M.ulcerans_Agy99 ----------------MVSLDTSPLAAARYHGDQAATPGMLDFAVNVRHP
Mb2256c|M.bovis_AF2122/97 MLWILGPHTGPLLFDAVASLDTSPLAAARYHGDQDVAPGVLDFAVNVRHD
Rv2231c|M.tuberculosis_H37Rv MLWILGPHTGPLLFDAVASLDTSPLAAARYHGDQDVAPGVLDFAVNVRHD
MAV_2208|M.avium_104 ----------------MASLNLSP-PAARYHGDQAVAPGMLDFAVNVRHS
MAB_1902|M.abscessus_ATCC_1997 --------------------MTGPRKGARYHGDQALIPGVLDFAVNVRAA
Mflv_3612|M.gilvum_PYR-GCK --MTVFEAGGPGFGVTLDDLPLRDDLRGKSPYGAPQLVVPVRLNTNENPH
Mvan_2805|M.vanbaalenii_PYR-1 ------MTGVPGSSITLDDLPLRDDLRGKSPYGAPQLSVPVRLNTNENPH
MSMEG_1491|M.smegmatis_MC2_155 ----------------------MEAVDALPP-----AVNPLALSLNEFPY
TH_1662|M.thermoresistible__bu --------------VTARLRPELADIPAYVPG--KMVPGAIKIASNETVH
MLBr_01488|M.leprae_Br4923 -------MSPFGRVSATLPVFPWDTLADAKAVAESHPDGIVDLSVGTPVD
: : .
MMAR_3307|M.marinum_M HPPHWLVELLAQRLTTLA----RYPSIE-DTQRAQDAAALRHRRTR----
MUL_1321|M.ulcerans_Agy99 HPPHWLVELLAQRLTTLA----RYPSIE-DTQCAQDAAALRHRRTR----
Mb2256c|M.bovis_AF2122/97 RPPEWLVRQLAALLPELA----RYPSTD-DVHRAQDAVAERHGRTR----
Rv2231c|M.tuberculosis_H37Rv RPPEWLVRQLAALLPELA----RYPSTD-DVHRAQDAVAERHGRTR----
MAV_2208|M.avium_104 RPPQWLLDRLAARLPDLA----RYPGDD-DVHRAQDAAAERHGRRR----
MAB_1902|M.abscessus_ATCC_1997 APPPWLRDRLASRLDELG----SYPRRE-DEQRAVDAVAERHGRPP----
Mflv_3612|M.gilvum_PYR-GCK PPTQALIDDVARSVREVAGELHRYPDRD-AVALRTDLAAYLTAQTGNP-V
Mvan_2805|M.vanbaalenii_PYR-1 PPTRALIDDVAQSVREVAGELHRYPDRD-AVALRTDLAAYLSAQTGTA-V
MSMEG_1491|M.smegmatis_MC2_155 PPLPAVKAALSAAVDAAN----RYPEFL-PERLRSLIAGRVGVDE-----
TH_1662|M.thermoresistible__bu PPLPSVREAIARAGETLN----RYPDNG-YLDLRDRLARHVGFAP-----
MLBr_01488|M.leprae_Br4923 PVAPLIQEALAAASSVAG-----YPTTAGTARLREAAVAALDRRYGITGL
: :: ** .
MMAR_3307|M.marinum_M --AEVLPLAGAAEGFALLSNLRP---VRAAIIAPSFTEPAAALSAAGIPV
MUL_1321|M.ulcerans_Agy99 --AEVLPLAGAAEGFALLSNLRP---VRAAIIAPSFTEPAAALSAAGIPV
Mb2256c|M.bovis_AF2122/97 --DEVLPLVGAAEGFALLHNLSP---VRAAIVVPAFTEPAIALSAAGITA
Rv2231c|M.tuberculosis_H37Rv --DEVLPLVGAAEGFALLHNLSP---VRAAIVVPAFTEPAIALSAAGITA
MAV_2208|M.avium_104 --DEVLPLAGAAEAFALLSNLRP---KRAAVIAPSFTEPAAALSAAGVPV
MAB_1902|M.abscessus_ATCC_1997 --DEVLLLAGAAEGFAMLPRLNP---RRAAVVAPGFTEPEAVLADAGIPL
Mflv_3612|M.gilvum_PYR-GCK GVENVWAANGSNEILQQLLQAFGGPGRSALGFVPSYSMHPIIADGTQTRW
Mvan_2805|M.vanbaalenii_PYR-1 GVENVWAANGSNEILQQLLQAFGGPGRSALGFVPSYSMHPIISDGTQTRW
MSMEG_1491|M.smegmatis_MC2_155 --GQVIIGVGATGVIMQVLHAVTSPGDTMVMSAPTFDGYPIFAQMARLRS
TH_1662|M.thermoresistible__bu --EHISVGCGSVSLCQQLVQITAGAGDEVLFGWRSFEIYPLQVRTAGAVP
MLBr_01488|M.leprae_Br4923 TEAAVLPVIGTKELIAWLPTLLG--LRAGDVVVVPELAYPTYNVGARLAG
: *: : :
MMAR_3307|M.marinum_M HHVVLAP----PFRL-DEAAVPDDADLVVVGNPTNPTSVLHSREQLLALR
MUL_1321|M.ulcerans_Agy99 HHVVLAP----PFRL-DEAAVPDDADLVVVGNPTNPTSVLHSREQLLALR
Mb2256c|M.bovis_AF2122/97 HHVVLKP----PFVL-DTAHVPDDADLVVVGNPTNPTSVLHLREQLLELR
Rv2231c|M.tuberculosis_H37Rv HHVVLKP----PFVL-DTAHVPDDADLVVVGNPTNPTSVLHLREQLLELR
MAV_2208|M.avium_104 HHVVLEP----PFGL-HGAAVPEEADLVVVGNPTNPTAVLHGREQLLALR
MAB_1902|M.abscessus_ATCC_1997 EHVVLPP----PFTLGDTVRVPDEADLVVVGNPTNPTGVLHTREQLLALR
Mflv_3612|M.gilvum_PYR-GCK LAANRADDFSLDAAAAATAIKEHAPDVVFVTSPNNPTGQSVSLDDLRVLL
Mvan_2805|M.vanbaalenii_PYR-1 LVANRGDDFGLDAAVAATAIKEHTPDVVFVTSPNNPSGQSVSLDDLRLLL
MSMEG_1491|M.smegmatis_MC2_155 VTVDLDVYGHHNLHAMADAARDAR--VVVVCRPHNPTGTIEPAEDIERFL
TH_1662|M.thermoresistible__bu VQVPLTDHTFDLDAILAAITDRTR--LIFICNPNNPTSTVVDPDALARFV
MLBr_01488|M.leprae_Br4923 ARVLRADS--------LTQLGLQSPALFYLNSPSNPTGQVLAVNHLRKMV
. :. : * **:. : : :
MMAR_3307|M.marinum_M RP-----GRILVVDEAFA--DAVPGEPQSLAG----NCLPDVLVLRSLTK
MUL_1321|M.ulcerans_Agy99 RP-----GRILVVDEAFA--DAVPGEPQSLAG----DCLPDVLVLRSLTK
Mb2256c|M.bovis_AF2122/97 RP-----GRILVVDEAFA--DWVPGEPQSLAD----DSLPDVLVLRSLTK
Rv2231c|M.tuberculosis_H37Rv RP-----GRILVVDEAFA--DWVPGEPQSLAD----DSLPDVLVLRSLTK
MAV_2208|M.avium_104 RP-----GRLLVVDEAFA--DAIPGEPQSLAG----DALPDVLVLRSLTK
MAB_1902|M.abscessus_ATCC_1997 RP-----GRILVVDEAFI--DAVPGEPESVAS----LSLPGLVVLRSLTK
Mflv_3612|M.gilvum_PYR-GCK DALSSQSGGIMIVDEAYG--EFS-SQPSAIA--LLAQYPTRLVVSRTMSK
Mvan_2805|M.vanbaalenii_PYR-1 DALCLQDGGVMIVDEAYG--EFS-SQPSAIG--LIESYPGKLVVTRTMSK
MSMEG_1491|M.smegmatis_MC2_155 LES-IPEDTVVLLDEAYA--EFL-GPANRIDGPRLVERFRNVVVVRTFSK
TH_1662|M.thermoresistible__bu AA--VPEHILIALDEAYI--EYV-RPPFVPDSLGLVRAHDNVVVLRTFSK
MLBr_01488|M.leprae_Br4923 GWAR-NRGVVVVSDECYLGLGWDAEPFSVLHPLVCDGNHTGLLAVHSLSK
:: **.: ::. ::::*
MMAR_3307|M.marinum_M TWSLAGLRVGYALGAPDLLDRLTRMRAHWPVGTLPLTAIAACCTPEAVAE
MUL_1321|M.ulcerans_Agy99 TWSLAGLRVGYALGTPDLLDRLTRIRAHWPVGTLPLTAIAACCTPEAVAE
Mb2256c|M.bovis_AF2122/97 TWSLAGLRVGYALGSPDVLARLTVQRAHWPLGTLQLTAIAACCAPRAVAA
Rv2231c|M.tuberculosis_H37Rv TWSLAGLRVGYALGSPDVLARLTVQRAHWPLGTLQLTAIAACCAPRAVAA
MAV_2208|M.avium_104 TWALAGLRVGYALGAPEVLARLTAQRAHWPVGTLQLTALAACCGRRAVAD
MAB_1902|M.abscessus_ATCC_1997 TWALAGLRAGYAVGDPELLRRLARGRAHWPLGTLQLEALAACNTAQAVGS
Mflv_3612|M.gilvum_PYR-GCK AFAFAGGRLGYLVAAPAVIDAMLLVRLPYHLSSVTQAAARAALR--HAEE
Mvan_2805|M.vanbaalenii_PYR-1 AFAFAGGRVGYLVAAPAVIDAMLLVRLPYHLSSVTQAAARAALR--HADD
MSMEG_1491|M.smegmatis_MC2_155 AYGLAGLRIGYGFCAPQLARQLWTMQLPFGIGLPALVAVAASYD--AEGQ
TH_1662|M.thermoresistible__bu AYGLAGLRVGYAVAAPEIVTALGKVYVPFSVSTLAQAAAIASLD--AADE
MLBr_01488|M.leprae_Br4923 SSSLAGYRAGFVAGDPDLVAELLAVRKHAGMMVPTPVQAAMVAALGDDAH
: .:** * *: * : : :
MMAR_3307|M.marinum_M AAADARLLLAARAEMVSGLGSVGASVVDGCA-PFVLF-GVPDADELRKRL
MUL_1321|M.ulcerans_Agy99 AAADARLLLAARAEMVSGLGSVGASVVDGCA-PFVLF-SVPDADELRKRL
Mb2256c|M.bovis_AF2122/97 AAADAVRLTALRAEMVAGLRSVGAEVVDGAA-PFVLF-NIADADGLRNYL
Rv2231c|M.tuberculosis_H37Rv AAADAVRLTALRAEMVAGLRSVGAEVVDGAA-PFVLF-NIADADGLRNYL
MAV_2208|M.avium_104 AAAGAERLSRLREKMAAGLASVGADVLDGRA-PFVLF-RMPDAVRVRKLL
MAB_1902|M.abscessus_ATCC_1997 AVLDAQRLVETRHRQAEGLRGLGLAVTEGVA-PFLLV-AVPHADLMRKHL
Mflv_3612|M.gilvum_PYR-GCK TLSSVATLVAERERVSTALTELGFRVIPSDS-NFVLFGEFADAPATWQRY
Mvan_2805|M.vanbaalenii_PYR-1 TLGSVATLIAERERVSQALTGMGFRVIPSDA-NFILFGEFADAPATWQRY
MSMEG_1491|M.smegmatis_MC2_155 LRQRIRMISAERRFLQMRLRSMGVYSTDGQA-NFVYLPATG--VPWHDVF
TH_1662|M.thermoresistible__bu LLARTDEVVAERARVTAALRDAGYTVPESGA-NFVWLPLAERTVDFVNSA
MLBr_01488|M.leprae_Br4923 EREQRDRYARRRDVLLPAVVSAGFTVDHSEAGLYLWASRGEPCRDSVEWF
* : * . : :: .
MMAR_3307|M.marinum_M HQRGIAIRRCDTFVGLDDGYLRAAVRPEWPQLVDAIAEVRQAGRSGRRR
MUL_1321|M.ulcerans_Agy99 HQRGIAIRRCDTFVGLDDGYLRAAVRPEWPQLVDAIAEVRQAGRSGRRR
Mb2256c|M.bovis_AF2122/97 QSKGIAVRRGDTFVGLDARYLRAAVRPEWPVLVAAIAEWAKRG--GRR-
Rv2231c|M.tuberculosis_H37Rv QSKGIAVRRGDTFVGLDARYLRAAVRPEWPVLVAAIAEWAKRG--GRR-
MAV_2208|M.avium_104 HDKGIAVRRGDTFVGLDERYLRAAVRPEWPLLVQAIAEAQR--------
MAB_1902|M.abscessus_ATCC_1997 KVKNIAVRRCDTFVGLDGDYLRVAVRPEWPELVQAMKEIL---------
Mflv_3612|M.gilvum_PYR-GCK LDEGVLIR---DVGIPGYLRTTIGLADENDALLAASARIGAP-------
Mvan_2805|M.vanbaalenii_PYR-1 LDEGVLIR---DVGIPGYLRTTIGLAEENDALLAASARIGAP-------
MSMEG_1491|M.smegmatis_MC2_155 DDAGLKVR---HYADGG-VRVTVGTRESTREVLRATRLALR--------
TH_1662|M.thermoresistible__bu AEDRLLVR---PYGTDG-VRVTVAAPHENDAFLSFATRWISER------
MLBr_01488|M.leprae_Br4923 AQRGILVALGEFYGPGGCQHVRVALTASDERIAAVVARLS---------
: : . . . .