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MTGTSAIELYYDPFDSDIDDNPYPVWQRMREEAPLYYNEKYNFYALSRYEDVARELPNWQTYQSGRGTTA DILFSNVEVPPGILLFEDPPLHDLHRRLLSRVFTPRRMLAVEDLVRGFCVRELDPLVGAGGFDFIRDLGA MMPMRTIGYLLGIPEEDQEKIRDRSVANIELSRDSDPAAVDANVFANSIALFAEYIEWRADHPSDDLMTE LLRAEIDEPDGTRRPLSRTEVLAYTAMIAGAGNETTARLIGFMGQLLSDHPDQRRELAADPSLIPGAVEE TLRFEPPSPVQARYVARDAEHYGRVVPEGSFMLLLNGSANRDPRRFTDPDRYDIHRQGGGHLSFGQGLHF CLGSALARMEARVAFEEVLKRWRDWEVDYANAERARTASVRGWARLPVVTGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2138 | - | - | 100% (402) | cytochrome P450 superfamily protein |
| M. avium 104 | MAV_0366 | - | e-128 | 53.13% (399) | cytochrome P450 superfamily protein |
| M. avium 104 | MAV_2984 | - | e-123 | 51.75% (400) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 1e-70 | 40.91% (396) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_4145 | - | 0.0 | 79.44% (394) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 1e-70 | 40.91% (396) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-36 | 31.37% (322) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 9e-68 | 39.60% (404) | cytochrome P450 |
| M. marinum M | MMAR_4753 | cyp189A7 | 1e-129 | 53.87% (401) | cytochrome P450 189A7 Cyp189A7 |
| M. smegmatis MC2 155 | MSMEG_3693 | - | 1e-125 | 53.57% (392) | cytochrome P450 monooxygenase |
| M. thermoresistible (build 8) | TH_4114 | - | 1e-131 | 55.05% (396) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0324 | cyp189A7 | 1e-128 | 53.12% (401) | cytochrome P450 189A7 Cyp189A7 |
| M. vanbaalenii PYR-1 | Mvan_4221 | - | 1e-126 | 55.30% (396) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0789c|M.bovis_AF2122/97 ------------------MTVRVG--------DPE-LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv ------------------MTVRVG--------DPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 ------------------MTVAET--------SAVPLVFDPYDYDFHEDP
MAV_2138|M.avium_104 ------------------MTGTS----------AIELYYDPFDSDIDDNP
Mflv_4145|M.gilvum_PYR-GCK ------------------MPAHD----------TVELYYDPYDFAIDDNP
MMAR_4753|M.marinum_M ------------------MTVTA----------ASDVYFDPYDVELNADP
MUL_0324|M.ulcerans_Agy99 ------------------MTVTA----------ASDVYFDPYDVELNADP
Mvan_4221|M.vanbaalenii_PYR-1 ------------------MTISADDSDVQNADTAAELYYDPYNVDLNMDP
MSMEG_3693|M.smegmatis_MC2_155 -----------MTVDDSGVVVTG----------VAGPYYDPYDVGIVADP
TH_4114|M.thermoresistible__bu -------------------MATV----------ETDVYYDPYDVDIVADP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: :*
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVSMDK
MAV_2138|M.avium_104 YPVWQRMREEAPLYYNEKYNFYALSRYEDVARELPNWQTYQSGRGTTADI
Mflv_4145|M.gilvum_PYR-GCK YPVWRRMRDEAPLYYNDKYNFFALSRYADVSRALPDWQNYRSGKGTTADI
MMAR_4753|M.marinum_M YPMFRRLREEAPLYYNAQHGFYALSRFADVDRAIVDYQTFSSARGAILEI
MUL_0324|M.ulcerans_Agy99 YPMFRRLREEAPLYYNAQHGFYALSRFADVDRAIVDYQTFSSARGAILEF
Mvan_4221|M.vanbaalenii_PYR-1 HGVFARLREEAPLYYNDKHDFYALSRYEDVNKGVIDHQTFISGRGALLEI
MSMEG_3693|M.smegmatis_MC2_155 YPVYARLRDEAPLYHNERYGFWALSRHADVESALANWETFSNSRSDILEL
TH_4114|M.thermoresistible__bu YPVYARLRDEAPIYYNERYDFWALSRYADVEKALLNWETFSNSRSDILEL
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
. : : : .*: : ..* . * . . .
Mb0789c|M.bovis_AF2122/97 SSRTSEAYR----VMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
Rv0766c|M.tuberculosis_H37Rv SSRTSEAYR----VMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
MAB_1216c|M.abscessus_ATCC_199 ASFGPHAKL----VMSFLAMDDPEHLRLRALVSKGFTPRRIRELEGQVVA
MAV_2138|M.avium_104 LFSNVEVP-----PGILLFEDPPLHDLHRRLLSRVFTPRRMLAVEDLVRG
Mflv_4145|M.gilvum_PYR-GCK LFNGIEVP-----PGILLFEDPPLHDIHRRLLSRVFTPRRMLAVEDLVRG
MMAR_4753|M.marinum_M IKANIDIP-----AGVLVFEDPPVHDVHRKLLSRMFTPRKINDLEPKIRE
MUL_0324|M.ulcerans_Agy99 IKANIDIP-----AGVLVFEDPPVHDVHRKLLSRMFTPRKINDLEPKIRE
Mvan_4221|M.vanbaalenii_PYR-1 IKSGMEIP-----PGTLIFEDPPIHNIHRNLLSRVFTPRKVQALEPQIRE
MSMEG_3693|M.smegmatis_MC2_155 VKSDFDMP-----PGVMMFTDPPMHTMLRGLMSRVFTPRRMAEIEDQIRR
TH_4114|M.thermoresistible__bu VQSDFDMP-----PGVMMFQDPPMHTMLRGLMSRVFTPRRMAALEEQIRA
MLBr_02088|M.leprae_Br4923 QAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAA
:: * * * * *:*: *:*: : :* :
Mb0789c|M.bovis_AF2122/97 LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDR------
Rv0766c|M.tuberculosis_H37Rv LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDR------
MAB_1216c|M.abscessus_ATCC_199 LARTHLDRALANASDRSFDFIAEYAGKLPMDVISELMGVPESDR------
MAV_2138|M.avium_104 FCVRELDPLVGAGG---FDFIRDLGAMMPMRTIGYLLGIPEEDQ------
Mflv_4145|M.gilvum_PYR-GCK FCARALDPLRDGDG---FDFVGDLGAFMPMRTIGYLLGIPEEGQ------
MMAR_4753|M.marinum_M FCARSLDPLIGSGR---FDFVADLGAQMPMRVIGMLLGVPEEDQ------
MUL_0324|M.ulcerans_Agy99 FCARSLDPLIGSGR---FDFVADLGAQMPMRVIGMLLGVPEEDQ------
Mvan_4221|M.vanbaalenii_PYR-1 FTARCLDPLTGTNR---FDFVRDLGAQMPMRVIGMLLGIPEEDQ------
MSMEG_3693|M.smegmatis_MC2_155 YCVRCLDPLVGSDR---FDIIAELASTMPMRVIGMLLGIPESEQ------
TH_4114|M.thermoresistible__bu YCVRCLDPLVGAEG---FDIIAELAAMMPMRVIGMLLGIPESDQ------
MLBr_02088|M.leprae_Br4923 LVDSLLDKGAAAGQ---FDVIADLAFPLAVAVICRLLGVPYEDAPEFGRV
** **.: : . :.: .* *:*:*
Mb0789c|M.bovis_AF2122/97 -ARIRALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPANN
Rv0766c|M.tuberculosis_H37Rv -ARIRALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPANN
MAB_1216c|M.abscessus_ATCC_199 -ARIRELADGVMHREDGLADVPPEAIQASFDLMTYYIEMVRERRRRPTED
MAV_2138|M.avium_104 -EKIRDRSVANIELSRDSDPAAVDANVFANSI-ALFAEYIEWRADHPSDD
Mflv_4145|M.gilvum_PYR-GCK -EQIRRRTDQNIAVG--DAAGDVSATVFAESL-ALFAEYIEWRSTHPSDD
MMAR_4753|M.marinum_M -EAARDFATAQLRTEAGKPMKASADGMVSG---DFFAHYIDWRAEHPSSD
MUL_0324|M.ulcerans_Agy99 -EAARDFATAQLRTEAGKPMKASADGMVSG---DFFAHYIDWRAEHPSSD
Mvan_4221|M.vanbaalenii_PYR-1 -RRVTDHGEATLQSDS-------VDLMATG---EVFAEFIDHRTEHPSDD
MSMEG_3693|M.smegmatis_MC2_155 -IGVRDANDANLRTKPGAPMKVAQADKIADG--RIYADYVEWRSKNPSDD
TH_4114|M.thermoresistible__bu -ISVRDANDANLRTKPGAPMKVADPGRIADG--SIYAEYIDWRARNPSDD
MLBr_02088|M.leprae_Br4923 SALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGED
: . : * .:
Mb0789c|M.bovis_AF2122/97 LTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYW
Rv0766c|M.tuberculosis_H37Rv LTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYW
MAB_1216c|M.abscessus_ATCC_199 LTSALLQAEIDGD-----RLTDEEVLAFLFLMVIAGNETTTKLLANAVYW
MAV_2138|M.avium_104 LMTELLRAEIDEPDGTRRPLSRTEVLAYTAMIAGAGNETTARLIGFMGQL
Mflv_4145|M.gilvum_PYR-GCK LMTELLNAEVDEPGGSRRRLERNEVLAYTAMIAGAGGETTARLIGFMGEL
MMAR_4753|M.marinum_M IMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAGKV
MUL_0324|M.ulcerans_Agy99 IMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAGKV
Mvan_4221|M.vanbaalenii_PYR-1 IMTDLLNAEFEDETGTRRRLRRDELLMYLTVIATAGSETTTRLIGWAGKT
MSMEG_3693|M.smegmatis_MC2_155 LMTALLGVEFTDEHGVTRKLTRKEVLHYTQVVAGAGNETTGRLIGWLAKV
TH_4114|M.thermoresistible__bu LMTALLNVEFTDEHGVVRKLTRREVLHYTQVVAGAGNETTGRLIGWLAKV
MLBr_02088|M.leprae_Br4923 LISRLIELDESGD-----QLTEEEIIATCGLLLVAGHETTVNLIANAVLA
: : *: : * *:: :: ** *** .*:.
Mb0789c|M.bovis_AF2122/97 AAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
Rv0766c|M.tuberculosis_H37Rv AAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
MAB_1216c|M.abscessus_ATCC_199 GHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAEDITVYDTKI
MAV_2138|M.avium_104 LSDHPDQRRELAADPSLIPGAVEETLRFEPPSPVQARYVARDAEHYGRVV
Mflv_4145|M.gilvum_PYR-GCK LGNHPDQRRELVADPSLIPSAVEETLRFEPPSPVQARYVAHDVEWYGQTV
MMAR_4753|M.marinum_M LAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGESV
MUL_0324|M.ulcerans_Agy99 LAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGQSV
Mvan_4221|M.vanbaalenii_PYR-1 LADYPEQRAQLVADPALIPQAIEEILRWEPPALQIARYVTRDVEYYGQVV
MSMEG_3693|M.smegmatis_MC2_155 LAEHPDQRRQIEQDRSLLTRAVDETLRFEPTGPHVARWVARDFEAYGQTV
TH_4114|M.thermoresistible__bu LAEHPDQRRDVYEDRSLLGRVIEETLRFEPTGPHVARWMARDFECYGTTV
MLBr_02088|M.leprae_Br4923 MLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTL
* * : : ::* **::.. .* :.* :
Mb0789c|M.bovis_AF2122/97 PEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCLGA
Rv0766c|M.tuberculosis_H37Rv PEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCLGA
MAB_1216c|M.abscessus_ATCC_199 PAGDILLLLPGSANRDDRVFD-DADQYRIGREIGAKLVSFGSGAHFCLGA
MAV_2138|M.avium_104 PEGSFMLLLNGSANRDPRRFT-DPDRYDIHRQGGG-HLSFGQGLHFCLGS
Mflv_4145|M.gilvum_PYR-GCK PEGSFMLLLNGSANRDDARYT-DPDTFDIHRTGG--HLSFGQGLHFCLGS
MMAR_4753|M.marinum_M PEGSIMMMLIGAANRDHRQFPPDGDVFDIRREPHQ-HLTFSVGTHYCLGS
MUL_0324|M.ulcerans_Agy99 PEGSIMMMLIGAANRDHRQFRPDGDVFNIRREPHQ-HLTFSVGTHYCLGS
Mvan_4221|M.vanbaalenii_PYR-1 PEGSAMLMLVGSANRDHRRFPPNGDVFDIHRELRS-HMTFGAGTHFCMGN
MSMEG_3693|M.smegmatis_MC2_155 PAGSAMLLLFGAANRDPRRYT-DPDVFDIHRDNIS-HLTFGKGLHYCLGA
TH_4114|M.thermoresistible__bu PAGSAMLLLFGAANRDPRRYD-DPDTFNIHRERGS-HLTFGKGLHFCLGA
MLBr_02088|M.leprae_Br4923 TEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPSSR-HLAFAVGSHFCLGA
. *. :::* .:**** : * : * ::*. * *:*:*
Mb0789c|M.bovis_AF2122/97 HLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR-
Rv0766c|M.tuberculosis_H37Rv HLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR-
MAB_1216c|M.abscessus_ATCC_199 HLARMEAKVALTELFTRISGYEIDERNSVRVHSSNVRGFAHLPMTVQLRE
MAV_2138|M.avium_104 ALARMEARVAFEEVLKRWRDWEVDYANAERARTASVRGWARLPVVTGG--
Mflv_4145|M.gilvum_PYR-GCK ALARLEARVAFEEVLTRWPDWEVDYDNAERARTSSVRGWARMPVLAR---
MMAR_4753|M.marinum_M ALARLEGRIALEEILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD---
MUL_0324|M.ulcerans_Agy99 ALARLEGRIALEDILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD---
Mvan_4221|M.vanbaalenii_PYR-1 ALARLEGKIALEEILKRFPTWEVDWPNAVPSQTTAVRGWESMPTIVS---
MSMEG_3693|M.smegmatis_MC2_155 NLARLEGRVALDELLNRFPEWDIDYSTARLAPTSTVRGWERLDVLVG---
TH_4114|M.thermoresistible__bu NLARLEGRVALDELLNRWPEWDIDYDTAQLAPTSTVRGWERLRIVFP---
MLBr_02088|M.leprae_Br4923 ALARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQV----
***:*. ::: : * :: . :** :
Mb0789c|M.bovis_AF2122/97 --
Rv0766c|M.tuberculosis_H37Rv --
MAB_1216c|M.abscessus_ATCC_199 GR
MAV_2138|M.avium_104 --
Mflv_4145|M.gilvum_PYR-GCK --
MMAR_4753|M.marinum_M --
MUL_0324|M.ulcerans_Agy99 --
Mvan_4221|M.vanbaalenii_PYR-1 --
MSMEG_3693|M.smegmatis_MC2_155 --
TH_4114|M.thermoresistible__bu --
MLBr_02088|M.leprae_Br4923 --