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PAHDTVELYYDPYDFAIDDNPYPVWRRMRDEAPLYYNDKYNFFALSRYADVSRALPDWQNYRSGKGTTAD ILFNGIEVPPGILLFEDPPLHDIHRRLLSRVFTPRRMLAVEDLVRGFCARALDPLRDGDGFDFVGDLGAF MPMRTIGYLLGIPEEGQEQIRRRTDQNIAVGDAAGDVSATVFAESLALFAEYIEWRSTHPSDDLMTELLN AEVDEPGGSRRRLERNEVLAYTAMIAGAGGETTARLIGFMGELLGNHPDQRRELVADPSLIPSAVEETLR FEPPSPVQARYVAHDVEWYGQTVPEGSFMLLLNGSANRDDARYTDPDTFDIHRTGGHLSFGQGLHFCLGS ALARLEARVAFEEVLTRWPDWEVDYDNAERARTSSVRGWARMPVLAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4145 | - | - | 100% (398) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_1257 | - | e-121 | 53.79% (396) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_1266 | - | e-120 | 52.82% (390) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 4e-70 | 39.85% (394) | cytochrome P450 123 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 4e-70 | 39.85% (394) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 1e-36 | 29.92% (391) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 3e-65 | 39.00% (400) | cytochrome P450 |
| M. marinum M | MMAR_4753 | cyp189A7 | 1e-122 | 53.45% (391) | cytochrome P450 189A7 Cyp189A7 |
| M. avium 104 | MAV_2138 | - | 0.0 | 79.44% (394) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_6622 | - | 1e-124 | 54.73% (391) | cytochrome P450 monooxygenase |
| M. thermoresistible (build 8) | TH_2671 | - | 1e-125 | 55.90% (390) | PUTATIVE cytochrome P450 monooxygenase |
| M. ulcerans Agy99 | MUL_0324 | cyp189A7 | 1e-122 | 52.94% (391) | cytochrome P450 189A7 Cyp189A7 |
| M. vanbaalenii PYR-1 | Mvan_4221 | - | 1e-123 | 55.30% (396) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0789c|M.bovis_AF2122/97 ------------------MTVRVG--------DPE-LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv ------------------MTVRVG--------DPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 ------------------MTVAET--------SAVPLVFDPYDYDFHEDP
Mflv_4145|M.gilvum_PYR-GCK ------------------MPAHD----------TVELYYDPYDFAIDDNP
MAV_2138|M.avium_104 ------------------MTGTS----------AIELYYDPFDSDIDDNP
MMAR_4753|M.marinum_M ------------------MTVTA----------ASDVYFDPYDVELNADP
MUL_0324|M.ulcerans_Agy99 ------------------MTVTA----------ASDVYFDPYDVELNADP
Mvan_4221|M.vanbaalenii_PYR-1 ------------------MTISADDSDVQNADTAAELYYDPYNVDLNMDP
MSMEG_6622|M.smegmatis_MC2_155 ------------------MRVLD------------ELSYDPYDVEIDVDP
TH_2671|M.thermoresistible__bu ------------------MRVLGG----------SRLYYDPYDIEIDRDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: : :*
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVSMDK
Mflv_4145|M.gilvum_PYR-GCK YPVWRRMRDEAPLYYNDKYNFFALSRYADVSRALPDWQNYRSGKGTTADI
MAV_2138|M.avium_104 YPVWQRMREEAPLYYNEKYNFYALSRYEDVARELPNWQTYQSGRGTTADI
MMAR_4753|M.marinum_M YPMFRRLREEAPLYYNAQHGFYALSRFADVDRAIVDYQTFSSARGAILEI
MUL_0324|M.ulcerans_Agy99 YPMFRRLREEAPLYYNAQHGFYALSRFADVDRAIVDYQTFSSARGAILEF
Mvan_4221|M.vanbaalenii_PYR-1 HGVFARLREEAPLYYNDKHDFYALSRYEDVNKGVIDHQTFISGRGALLEI
MSMEG_6622|M.smegmatis_MC2_155 YPTYRRLRDEAPVYFNGRFGFWALSRFADVEAALRDVDNLSNAKGDILEV
TH_2671|M.thermoresistible__bu YPTYRVLRDEVPLYYNDKFDFWALSRYADVEAALRDVENLSSAKGDILEV
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
. : : : *: : ..* . * . . .
Mb0789c|M.bovis_AF2122/97 SSRTSEAYR----VMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
Rv0766c|M.tuberculosis_H37Rv SSRTSEAYR----VMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
MAB_1216c|M.abscessus_ATCC_199 ASFGPHAKL----VMSFLAMDDPEHLRLRALVSKGFTPRRIRELEGQVVA
Mflv_4145|M.gilvum_PYR-GCK LFNGIEVP-----PGILLFEDPPLHDIHRRLLSRVFTPRRMLAVEDLVRG
MAV_2138|M.avium_104 LFSNVEVP-----PGILLFEDPPLHDLHRRLLSRVFTPRRMLAVEDLVRG
MMAR_4753|M.marinum_M IKANIDIP-----AGVLVFEDPPVHDVHRKLLSRMFTPRKINDLEPKIRE
MUL_0324|M.ulcerans_Agy99 IKANIDIP-----AGVLVFEDPPVHDVHRKLLSRMFTPRKINDLEPKIRE
Mvan_4221|M.vanbaalenii_PYR-1 IKSGMEIP-----PGTLIFEDPPIHNIHRNLLSRVFTPRKVQALEPQIRE
MSMEG_6622|M.smegmatis_MC2_155 VKAEPKMP-----LGVFINEDPPLHTVHRLLVSRAFTPRKMRAIEDQIRT
TH_2671|M.thermoresistible__bu VKAEPVMP-----LGVFIHEDPPLHTVHRLLVSRAFTPRKMAAIEDQVRA
MLBr_02088|M.leprae_Br4923 QAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAA
:: * * * * *:*: *:*: : :* :
Mb0789c|M.bovis_AF2122/97 LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIRAL
Rv0766c|M.tuberculosis_H37Rv LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIRAL
MAB_1216c|M.abscessus_ATCC_199 LARTHLDRALANASDRSFDFIAEYAGKLPMDVISELMGVPESDRARIREL
Mflv_4145|M.gilvum_PYR-GCK FCARALDPLRDGDG---FDFVGDLGAFMPMRTIGYLLGIPEEGQEQIRRR
MAV_2138|M.avium_104 FCVRELDPLVGAGG---FDFIRDLGAMMPMRTIGYLLGIPEEDQEKIRDR
MMAR_4753|M.marinum_M FCARSLDPLIGSGR---FDFVADLGAQMPMRVIGMLLGVPEEDQEAARDF
MUL_0324|M.ulcerans_Agy99 FCARSLDPLIGSGR---FDFVADLGAQMPMRVIGMLLGVPEEDQEAARDF
Mvan_4221|M.vanbaalenii_PYR-1 FTARCLDPLTGTNR---FDFVRDLGAQMPMRVIGMLLGIPEEDQRRVTDH
MSMEG_6622|M.smegmatis_MC2_155 FCAACLDPLTSGDR---FDFTLDLGAEMPMRVIGMLIGIPEELQRSVRKV
TH_2671|M.thermoresistible__bu FCAACLDPLNAGDR---FDFTRDLGAEMPMRVIGMLVGMPDSLQREVRSV
MLBr_02088|M.leprae_Br4923 LVDSLLDKGAAAGQ---FDVIADLAFPLAVAVICRLLGVPYEDAPEFGRV
: ** **. : . :.: .* *:*:*
Mb0789c|M.bovis_AF2122/97 ADAVLHREDG--VADVPPPAMAAS----IELMRYYADLIAEFRR-RPANN
Rv0766c|M.tuberculosis_H37Rv ADAVLHREDG--VADVPPPAMAAS----IELMRYYADLIAEFRR-RPANN
MAB_1216c|M.abscessus_ATCC_199 ADGVMHREDG--LADVPPEAIQAS----FDLMTYYIEMVRERRR-RPTED
Mflv_4145|M.gilvum_PYR-GCK TDQNIAVG--DAAGDVSATVFAES----LALFAEYIEWRST----HPSDD
MAV_2138|M.avium_104 SVANIELSRDSDPAAVDANVFANS----IALFAEYIEWRAD----HPSDD
MMAR_4753|M.marinum_M ATAQLRTEAGKPMKASADGMVSG------DFFAHYIDWRAE----HPSSD
MUL_0324|M.ulcerans_Agy99 ATAQLRTEAGKPMKASADGMVSG------DFFAHYIDWRAE----HPSSD
Mvan_4221|M.vanbaalenii_PYR-1 GEATLQSDS-------VDLMATG------EVFAEFIDHRTE----HPSDD
MSMEG_6622|M.smegmatis_MC2_155 AGQRLRNKPGEPLPVNKDNYFNG------NMFRDYVEWRAQ----NPSDD
TH_2671|M.thermoresistible__bu AGRRLRNQPGRPLPVSRDNYFNG------DMFRDYVAWRER----HPSDD
MLBr_02088|M.leprae_Br4923 SALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGED
: : : * .:
Mb0789c|M.bovis_AF2122/97 LTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYW
Rv0766c|M.tuberculosis_H37Rv LTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYW
MAB_1216c|M.abscessus_ATCC_199 LTSALLQAEIDGD-----RLTDEEVLAFLFLMVIAGNETTTKLLANAVYW
Mflv_4145|M.gilvum_PYR-GCK LMTELLNAEVDEPGGSRRRLERNEVLAYTAMIAGAGGETTARLIGFMGEL
MAV_2138|M.avium_104 LMTELLRAEIDEPDGTRRPLSRTEVLAYTAMIAGAGNETTARLIGFMGQL
MMAR_4753|M.marinum_M IMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAGKV
MUL_0324|M.ulcerans_Agy99 IMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAGKV
Mvan_4221|M.vanbaalenii_PYR-1 IMTDLLNAEFEDETGTRRRLRRDELLMYLTVIATAGSETTTRLIGWAGKT
MSMEG_6622|M.smegmatis_MC2_155 LVTELLNVEFEDVTGTTRKLSSEELLVFLGVIANAGTETVGRLFGWLGKL
TH_2671|M.thermoresistible__bu LVTELLNVEFEDVSGTVRRLRTEELLVFLGVIANAGTETVGRLFGWLGKL
MLBr_02088|M.leprae_Br4923 LISRLIELDESGD-----QLTEEEIIATCGLLLVAGHETTVNLIANAVLA
: : *: : . * *:: :: ** **. .*:.
Mb0789c|M.bovis_AF2122/97 AAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
Rv0766c|M.tuberculosis_H37Rv AAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
MAB_1216c|M.abscessus_ATCC_199 GHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAEDITVYDTKI
Mflv_4145|M.gilvum_PYR-GCK LGNHPDQRRELVADPSLIPSAVEETLRFEPPSPVQARYVAHDVEWYGQTV
MAV_2138|M.avium_104 LSDHPDQRRELAADPSLIPGAVEETLRFEPPSPVQARYVARDAEHYGRVV
MMAR_4753|M.marinum_M LAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGESV
MUL_0324|M.ulcerans_Agy99 LAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGQSV
Mvan_4221|M.vanbaalenii_PYR-1 LADYPEQRAQLVADPALIPQAIEEILRWEPPALQIARYVTRDVEYYGQVV
MSMEG_6622|M.smegmatis_MC2_155 LGEHPDQRRALVADPSLIPGAVEEVLRYEPPVHNIARYVSADVDYHGQTI
TH_2671|M.thermoresistible__bu LGEHPDQRRELARDPALIPGAVEEVLRYESPVHNIARYVANDVEYHGQTV
MLBr_02088|M.leprae_Br4923 MLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTL
* * : : * :** **::.. .* .: * :
Mb0789c|M.bovis_AF2122/97 PEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCLGA
Rv0766c|M.tuberculosis_H37Rv PEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCLGA
MAB_1216c|M.abscessus_ATCC_199 PAGDILLLLPGSANRDDRVFD-DADQYRIGREIGAKLVSFGSGAHFCLGA
Mflv_4145|M.gilvum_PYR-GCK PEGSFMLLLNGSANRDDARYT-DPDTFDIHRTGG--HLSFGQGLHFCLGS
MAV_2138|M.avium_104 PEGSFMLLLNGSANRDPRRFT-DPDRYDIHRQGGG-HLSFGQGLHFCLGS
MMAR_4753|M.marinum_M PEGSIMMMLIGAANRDHRQFPPDGDVFDIRREPHQ-HLTFSVGTHYCLGS
MUL_0324|M.ulcerans_Agy99 PEGSIMMMLIGAANRDHRQFRPDGDVFNIRREPHQ-HLTFSVGTHYCLGS
Mvan_4221|M.vanbaalenii_PYR-1 PEGSAMLMLVGSANRDHRRFPPNGDVFDIHRELRS-HMTFGAGTHFCMGN
MSMEG_6622|M.smegmatis_MC2_155 PAGSALLLMTGAANRDERRFD-DPDRFDIRRSP-N-HLSFGRGAHFCLGA
TH_2671|M.thermoresistible__bu PAGSALLLMAGAANRDERRFE-DPDRFDIHRSSGS-HLAFGRGTHFCLGA
MLBr_02088|M.leprae_Br4923 TEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPSSR-HLAFAVGSHFCLGA
. *. :::: .:**** : * : * ::*. * *:*:*
Mb0789c|M.bovis_AF2122/97 HLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR-
Rv0766c|M.tuberculosis_H37Rv HLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR-
MAB_1216c|M.abscessus_ATCC_199 HLARMEAKVALTELFTRISGYEIDERNSVRVHSSNVRGFAHLPMTVQLRE
Mflv_4145|M.gilvum_PYR-GCK ALARLEARVAFEEVLTRWPDWEVDYDNAERARTSSVRGWARMPVLAR---
MAV_2138|M.avium_104 ALARMEARVAFEEVLKRWRDWEVDYANAERARTASVRGWARLPVVTGG--
MMAR_4753|M.marinum_M ALARLEGRIALEEILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD---
MUL_0324|M.ulcerans_Agy99 ALARLEGRIALEDILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD---
Mvan_4221|M.vanbaalenii_PYR-1 ALARLEGKIALEEILKRFPTWEVDWPNAVPSQTTAVRGWESMPTIVS---
MSMEG_6622|M.smegmatis_MC2_155 SLARVEGRVALEEILKRWPDWTVDMGNAVRAPTATVRGWDSMPAIVG---
TH_2671|M.thermoresistible__bu SLARLEGRVALEEILKRWPDWTIDADNAVRAPTATVRGWDSMPAVLG---
MLBr_02088|M.leprae_Br4923 ALARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQV----
***:*. ::: : * : : . :** :*
Mb0789c|M.bovis_AF2122/97 --
Rv0766c|M.tuberculosis_H37Rv --
MAB_1216c|M.abscessus_ATCC_199 GR
Mflv_4145|M.gilvum_PYR-GCK --
MAV_2138|M.avium_104 --
MMAR_4753|M.marinum_M --
MUL_0324|M.ulcerans_Agy99 --
Mvan_4221|M.vanbaalenii_PYR-1 --
MSMEG_6622|M.smegmatis_MC2_155 --
TH_2671|M.thermoresistible__bu --
MLBr_02088|M.leprae_Br4923 --