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M. thermoresistible (build 8) TH_4114 (-)

annotation: cytochrome P450
coordinates: 1530316 - 1531515
length: 400

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4114--100% (400)cytochrome P450
M. thermoresistible (build 8)TH_3021-e-13758.88% (394) PUTATIVE cytochrome P450
M. thermoresistible (build 8)TH_2671-e-13256.41% (390) PUTATIVE cytochrome P450 monooxygenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0789ccyp1236e-7039.04% (397) cytochrome P450 123
M. gilvum PYR-GCKMflv_1257-1e-13457.00% (393) cytochrome P450
M. tuberculosis H37RvRv0766ccyp1236e-7039.04% (397) cytochrome P450 123
M. leprae Br4923MLBr_02088-5e-4232.49% (397) putative cytochrome p450
M. abscessus ATCC 19977MAB_1216c-1e-6739.26% (405) cytochrome P450
M. marinum MMMAR_0928cyp189A60.082.44% (393) cytochrome P450 189A6 Cyp189A6
M. avium 104MAV_0366-0.084.56% (395) cytochrome P450 superfamily protein
M. smegmatis MC2 155MSMEG_3693-0.085.35% (389) cytochrome P450 monooxygenase
M. ulcerans Agy99MUL_0324cyp189A71e-13757.18% (397) cytochrome P450 189A7 Cyp189A7
M. vanbaalenii PYR-1Mvan_3187-0.084.01% (394) cytochrome P450

CLUSTAL 2.0.9 multiple sequence alignment


Mb0789c|M.bovis_AF2122/97           --------------------MTVRVGDPE-------LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv        --------------------MTVRVGDPE-------LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199      --------------------MTVAETSAVP------LVFDPYDYDFHEDP
MSMEG_3693|M.smegmatis_MC2_155      ---------------------MTVDDSGVVVTGVAGPYYDPYDVGIVADP
Mvan_3187|M.vanbaalenii_PYR-1       ----------------------MADD----------LYYDPYDQGIVADP
MMAR_0928|M.marinum_M               --------------MATHIEAAQAHDT--------DVYYDPYDVNITANP
MAV_0366|M.avium_104                --------------------MTVANDT--------AVYYDPYDIGIITDP
TH_4114|M.thermoresistible__bu      --------------------MATVETD---------VYYDPYDVDIVADP
Mflv_1257|M.gilvum_PYR-GCK          -------------------------MS--------DLYYDPWHVDIDIDP
MUL_0324|M.ulcerans_Agy99           --------------------MTVTAAS--------DVYFDPYDVELNADP
MLBr_02088|M.leprae_Br4923          MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
                                                                              .     :*

Mb0789c|M.bovis_AF2122/97           YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
Rv0766c|M.tuberculosis_H37Rv        YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
MAB_1216c|M.abscessus_ATCC_199      YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVSMDK
MSMEG_3693|M.smegmatis_MC2_155      YPVYARLRDEAPLYHNERYGFWALSRHADVESALANWETFSNSRSDILEL
Mvan_3187|M.vanbaalenii_PYR-1       YPTYARLRDEAPLYYNGRYDFWALSRHADVEKALQDWSTFSNSRSDILEL
MMAR_0928|M.marinum_M               YPTYARLREQAPLYYNQRYDFWAISRHADVEKALADWQTFSNSRSDILEL
MAV_0366|M.avium_104                YPTYARLREEAPIYYNERYDFWALSRHSDVERALANWQVFSNRRSDILEL
TH_4114|M.thermoresistible__bu      YPVYARLRDEAPIYYNERYDFWALSRYADVEKALLNWETFSNSRSDILEL
Mflv_1257|M.gilvum_PYR-GCK          YPTYRRLRDEAPVYRNDEHGFWGLSRYADVDVALKDTTRLSSAKGDILEV
MUL_0324|M.ulcerans_Agy99           YPMFRRLREEAPLYYNAQHGFYALSRFADVDRAIVDYQTFSSARGAILEF
MLBr_02088|M.leprae_Br4923          FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
                                    :* :  * : .*:       :  .* . *   .: .    *.     :  

Mb0789c|M.bovis_AF2122/97           SSRTSEAYR----VMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
Rv0766c|M.tuberculosis_H37Rv        SSRTSEAYR----VMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
MAB_1216c|M.abscessus_ATCC_199      ASFGPHAKL----VMSFLAMDDPEHLRLRALVSKGFTPRRIRELEGQVVA
MSMEG_3693|M.smegmatis_MC2_155      VKSDFDMP-----PGVMMFTDPPMHTMLRGLMSRVFTPRRMAEIEDQIRR
Mvan_3187|M.vanbaalenii_PYR-1       IKSDFDMP-----KGVMMFEDPPEHTMLRGLMSRVFTPRRMAEIEDQIRR
MMAR_0928|M.marinum_M               IKSKYDMP-----PGVMMFEDPPVHTMLRGVMSRVFTPRRMAQLEDQIRR
MAV_0366|M.avium_104                IQSKFDMP-----GGVMMFQDPPEHTVLRGLMSRVFTPRRMAALEDQIRQ
TH_4114|M.thermoresistible__bu      VQSDFDMP-----PGVMMFQDPPMHTMLRGLMSRVFTPRRMAALEEQIRA
Mflv_1257|M.gilvum_PYR-GCK          VMADPVMP-----PGIFINEDPPLHTIHRAIVARAFTPKKMRAIEDKIRA
MUL_0324|M.ulcerans_Agy99           IKANIDIP-----AGVLVFEDPPVHDVHRKLLSRMFTPRKINDLEPKIRE
MLBr_02088|M.leprae_Br4923          QAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAA
                                                    ::  * * *   * :::: *:*: :  :* .:  

Mb0789c|M.bovis_AF2122/97           LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIR--
Rv0766c|M.tuberculosis_H37Rv        LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIR--
MAB_1216c|M.abscessus_ATCC_199      LARTHLDRALANASDRSFDFIAEYAGKLPMDVISELMGVPESDRARIR--
MSMEG_3693|M.smegmatis_MC2_155      YCVRCLDPLVGSDR---FDIIAELASTMPMRVIGMLLGIPESEQIGVR--
Mvan_3187|M.vanbaalenii_PYR-1       YCVNCLDPLVGSDG---FDVIAELAAMMPMRVIGMLLGIPESEQVSVR--
MMAR_0928|M.marinum_M               FCVRCLDPLVGRDS---FDIIAELASMMPMRVIGMLLGIPESDQIGVR--
MAV_0366|M.avium_104                YCIRCLDPLVGSSS---FDIIAELASMMPMRVIGMLLGIPESEQVSVR--
TH_4114|M.thermoresistible__bu      YCVRCLDPLVGAEG---FDIIAELAAMMPMRVIGMLLGIPESDQISVR--
Mflv_1257|M.gilvum_PYR-GCK          FCVACLDPLVGGDR---FDFVEDLGAELPMRTIGMLAGIPNSEQPAVR--
MUL_0324|M.ulcerans_Agy99           FCARSLDPLIGSGR---FDFVADLGAQMPMRVIGMLLGVPEEDQEAAR--
MLBr_02088|M.leprae_Br4923          LVDSLLDKGAAAGQ---FDVIADLAFPLAVAVICRLLGVPYEDAPEFGRV
                                         **          **.: : .  :.: .*  * *:*  :       

Mb0789c|M.bovis_AF2122/97           -----ALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPANN
Rv0766c|M.tuberculosis_H37Rv        -----ALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPANN
MAB_1216c|M.abscessus_ATCC_199      -----ELADGVMHREDGLADVPPEAIQASFDLMTYYIEMVRERRRRPTED
MSMEG_3693|M.smegmatis_MC2_155      -----DANDANLRTKPGAP--MKVAQADKIADGRIYADYVEWRSKNPSDD
Mvan_3187|M.vanbaalenii_PYR-1       -----DANDANLRTRPGAP--MKVADPDRIADGRIYSDYVEWRAANPSDD
MMAR_0928|M.marinum_M               -----DANDANLRTQPGTP--MKVARPDKIADGSIYADYIDWRAKNPSDD
MAV_0366|M.avium_104                -----DANDANLRTKPGAP--LRVADADSIADGRIYADYVEWRSKNPSDD
TH_4114|M.thermoresistible__bu      -----DANDANLRTKPGAP--MKVADPGRIADGSIYAEYIDWRARNPSDD
Mflv_1257|M.gilvum_PYR-GCK          -----EHANEVLRNEAGKP--MAID-KDRYFTGEMFGEYIEWRENNPSDD
MUL_0324|M.ulcerans_Agy99           -----DFATAQLRTEAGKP--MKAS-ADGMVSGDFFAHYIDWRAEHPSSD
MLBr_02088|M.leprae_Br4923          SALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGED
                                               :      .                  . :      * .:

Mb0789c|M.bovis_AF2122/97           LTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYW
Rv0766c|M.tuberculosis_H37Rv        LTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYW
MAB_1216c|M.abscessus_ATCC_199      LTSALLQAEIDGD-----RLTDEEVLAFLFLMVIAGNETTTKLLANAVYW
MSMEG_3693|M.smegmatis_MC2_155      LMTALLGVEFTDEHGVTRKLTRKEVLHYTQVVAGAGNETTGRLIGWLAKV
Mvan_3187|M.vanbaalenii_PYR-1       LMTALLNVEFTDEAGVHRKLTRKEVLHYTQVVAGAGNETTGRLIGWLAKV
MMAR_0928|M.marinum_M               LMTALLNVEFDDEHAVRRKLTRTEVLHYTQVVAGAGNETTGRLIGWLAKV
MAV_0366|M.avium_104                LMTTLLNVEFDDEDGVRRKLTRKEVLHYTQVVAGAGNETTGRLIGWLAKV
TH_4114|M.thermoresistible__bu      LMTALLNVEFTDEHGVVRKLTRREVLHYTQVVAGAGNETTGRLIGWLAKV
Mflv_1257|M.gilvum_PYR-GCK          LITELLNVEFEDETGTVRKLTKQELTVFLAVVAGAGVETTGRLFGWMGKV
MUL_0324|M.ulcerans_Agy99           IMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAGKV
MLBr_02088|M.leprae_Br4923          LISRLIELDESGD-----QLTEEEIIATCGLLLVAGHETTVNLIANAVLA
                                    : : *:  :  .:     :*   *:     ::  ** *** .*:.     

Mb0789c|M.bovis_AF2122/97           AAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAH-DLTLYDTT
Rv0766c|M.tuberculosis_H37Rv        AAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAH-DLTLYDTT
MAB_1216c|M.abscessus_ATCC_199      GHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAE-DITVYDTK
MSMEG_3693|M.smegmatis_MC2_155      LAEHPDQRRQIEQDRSLLTRAVDETLRFEPTGPHVARWVAR-DFEAYGQT
Mvan_3187|M.vanbaalenii_PYR-1       LAEHPQQRREIVEDRSLLGRAVDETLRFEPTGPHVARYLAR-DFEYDGTT
MMAR_0928|M.marinum_M               LAEHPDQRRQVHQDRSLLTRTVDETLRFEPTGPHVARFTLR-DYHCYDTT
MAV_0366|M.avium_104                LAEHPDQRREVYRDRSLLTRTVDETLRFEPTGPHVARWMAA-DFECYGTT
TH_4114|M.thermoresistible__bu      LAEHPDQRRDVYEDRSLLGRVIEETLRFEPTGPHVARWMAR-DFECYGTT
Mflv_1257|M.gilvum_PYR-GCK          LAEHPDQRKELTSTPALIPSAIEELLRFEPPGPHVARYVATDDVTFHGVV
MUL_0324|M.ulcerans_Agy99           LAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTR-DLRYYGQS
MLBr_02088|M.leprae_Br4923          MLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAK-DMTIGQTT
                                      .:* *   :          ::* **::..   :.*     *       

Mb0789c|M.bovis_AF2122/97           IPEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCLG
Rv0766c|M.tuberculosis_H37Rv        IPEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCLG
MAB_1216c|M.abscessus_ATCC_199      IPAGDILLLLPGSANRDDRVFD-DADQYRIGREIGAKLVSFGSGAHFCLG
MSMEG_3693|M.smegmatis_MC2_155      VPAGSAMLLLFGAANRDPRRYT-DPDVFDIHRDNISHLT-FGKGLHYCLG
Mvan_3187|M.vanbaalenii_PYR-1       VPAGSAILLLFGAANRDERRYR-NPDTFDIHRDNISHLT-FGKGLHYCLG
MMAR_0928|M.marinum_M               VPAGSAILMLFGAANRDPRRYH-DPDTFDIRRDNISHLT-FGKGVHYCLG
MAV_0366|M.avium_104                VPAGSAMLLLFGAANRDPRRYT-DPDTFNIHRDNISHIT-FGKGVHYCLG
TH_4114|M.thermoresistible__bu      VPAGSAMLLLFGAANRDPRRYD-DPDTFNIHRERGSHLT-FGKGLHFCLG
Mflv_1257|M.gilvum_PYR-GCK          IPAGSPLLLMLASANRDERQFD-DPDRFDIHRKQGGHLT-FGRGAHFCVG
MUL_0324|M.ulcerans_Agy99           VPEGSIMMMLIGAANRDHRQFRPDGDVFNIRREPHQHLT-FSVGTHYCLG
MLBr_02088|M.leprae_Br4923          LTEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPSSRHLA-FAVGSHFCLG
                                    :. *. :::: .:****   :    * :   *    ::. *. * *:*:*

Mb0789c|M.bovis_AF2122/97           AHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR
Rv0766c|M.tuberculosis_H37Rv        AHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR
MAB_1216c|M.abscessus_ATCC_199      AHLARMEAKVALTELFTRISGYEIDERNSVRVHSSNVRGFAHLPMTVQLR
MSMEG_3693|M.smegmatis_MC2_155      ANLARLEGRVALDELLNRFPEWDIDYSTARLAPTSTVRGWERLDVLVG--
Mvan_3187|M.vanbaalenii_PYR-1       ANLARLEGRVALDELLNRWPEWNIDYDTARLAPTSTVRGWEHLRMLVG--
MMAR_0928|M.marinum_M               ANLARLEGRVALDELLNRWPQWDIDYDSLQLAPTSTVRGWERLRVLVS--
MAV_0366|M.avium_104                ANLARLEGRVALDELLNRWPEWDIDYDTAQLASTSTVRGWERLRIVVP--
TH_4114|M.thermoresistible__bu      ANLARLEGRVALDELLNRWPEWDIDYDTAQLAPTSTVRGWERLRIVFP--
Mflv_1257|M.gilvum_PYR-GCK          APLARLEGRVALEEVLKRWPEWDIDMSGARRSRTSTVRGWDSMPAVIR--
MUL_0324|M.ulcerans_Agy99           SALARLEGRIALEDILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD--
MLBr_02088|M.leprae_Br4923          AALARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQV---
                                    : ***:*. ::*  :  *    ::         .  :**   :   .   

Mb0789c|M.bovis_AF2122/97           ---
Rv0766c|M.tuberculosis_H37Rv        ---
MAB_1216c|M.abscessus_ATCC_199      EGR
MSMEG_3693|M.smegmatis_MC2_155      ---
Mvan_3187|M.vanbaalenii_PYR-1       ---
MMAR_0928|M.marinum_M               ---
MAV_0366|M.avium_104                ---
TH_4114|M.thermoresistible__bu      ---
Mflv_1257|M.gilvum_PYR-GCK          ---
MUL_0324|M.ulcerans_Agy99           ---
MLBr_02088|M.leprae_Br4923          ---