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MTITRDTLRKATALSLVLTLAVASVLVGGKLWRAVEKNSYAAYFAETNGLFVGDEVRILGVAVGAIDKIE PQSAGSKVTFSVDKKYAIPAAARAAVLSPSLVTARAIQLVPAYAGGPTLSPGAAIPLSRTAVPVEWDDFR KQLEKLTDALQPTTAGGVNSVGEFVNSAADNLRGQGDTARDTVLKLSEAISALGDHADDIFSTVRNLQLL VSALYSSSDLLASFNTNLAAVTTLLTNTPNEVGSALKSLDGALTDVRDFLAENREAMGVTVDRLGSITTA LNDSRGDVKQILHIAPTVFQNFLNIYQPAQSAMTGILALNNFADIPQFICSSIEAASRARLARVSKLCLQ YLNPIIKNRIYNYIPAGINPFVGTQARPSEITYSEDWLRPGYTPSDGGPPPEAPAPPGQPAPADQPPAEP GPPPNPTSNSLQVLRDLMLPTGPS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2064 | - | - | 100% (444) | virulence factor mce family protein |
| M. avium 104 | MAV_2535 | - | e-134 | 56.42% (436) | virulence factor mce family protein |
| M. avium 104 | MAV_4548 | - | 1e-77 | 39.90% (391) | virulence factor mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0607 | mce2Da | 1e-80 | 38.33% (420) | hypothetical protein Mb0607 |
| M. gilvum PYR-GCK | Mflv_2104 | - | 1e-123 | 51.67% (449) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1969 | mce3D | 1e-124 | 53.10% (435) | MCE-family protein MCE3D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 3e-77 | 38.89% (378) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4150c | - | 1e-77 | 36.98% (430) | MCE-family protein |
| M. marinum M | MMAR_4054 | mce3D_1 | 1e-129 | 53.88% (438) | MCE-family protein Mce3D_1 |
| M. smegmatis MC2 155 | MSMEG_0349 | - | 1e-122 | 51.80% (444) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_3797 | - | 1e-139 | 57.83% (434) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3921 | mce3D_1 | 1e-129 | 54.04% (433) | MCE-family protein Mce3D_1 |
| M. vanbaalenii PYR-1 | Mvan_0925 | - | 1e-124 | 52.05% (440) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0607|M.bovis_AF2122/97 MSTIFDIRSLRLPKLSAKVVVVGGLVVVLAVVAAAAGARLYRKLTTTTVV
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
MMAR_4054|M.marinum_M ----------MIRRTKTWLAVLLVGLL---AAGVVVLLRTTEVVNRTNVV
MUL_3921|M.ulcerans_Agy99 ----------MIRRTKTWLAVLLVGLL---AAGVVVLLRTTEVVNRTNVV
Mflv_2104|M.gilvum_PYR-GCK -----------MKNLRLWVGLVLVALL---VVGVALLVRTTDKVNRVNVV
TH_3797|M.thermoresistible__bu -------VTQLNRHRNIALAAVLVLTL---VAGMIILVRMYAASDRVQYT
Rv1969|M.tuberculosis_H37Rv ---------MTTKLRRARSVLATALVL---VAGVILAMRTADAAARTTVV
MSMEG_0349|M.smegmatis_MC2_155 ---------MRISKKQLTLAAGLVVVM---VAGVLVGFRMTGPAARTTIT
Mvan_0925|M.vanbaalenii_PYR-1 ---------MTKRKWALGVAVALVLVL---VGGVVAAIRISNVGNRTHVT
MAV_2064|M.avium_104 ---------MTITRDTLRKATALSLVLTLAVASVLVGGKLWRAVEKNSYA
MAB_4150c|M.abscessus_ATCC_199 ---------MTTSKTWLKRGAFAMLSV---ALVGGLLYWVWPSRGTYKIV
: .
Mb0607|M.bovis_AF2122/97 AYFSEALALYPGDKVQIMGVRVGSIDKIEPAGDKMRVTLHYSNKYQVPAT
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
MMAR_4054|M.marinum_M AYFENSNGVFTGDEVRILGVPVGKITSIEPQPESVKVSFWYDSKYKVPAD
MUL_3921|M.ulcerans_Agy99 AYFENSNGVFTGDEVRILGVPVGKITSIEPQPESVRVSFWYDSKYIVPAD
Mflv_2104|M.gilvum_PYR-GCK AYFENSNGIYEGDDVRILGVPVGRITSIEPEPERVKISFWYDDRYDVPAD
TH_3797|M.thermoresistible__bu AYFENSNGVYPGDEVRILGVPVGQIDTVEPEPDRAKITFWVSEKYRVPAD
Rv1969|M.tuberculosis_H37Rv AYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQPLRAKISFWFDRKYRVPAD
MSMEG_0349|M.smegmatis_MC2_155 AYFANSNGLFAGDDVLILGVPVGKVKEIEPLPERAKVTFWVDKEFQVPAD
Mvan_0925|M.vanbaalenii_PYR-1 AYFTNSTGIYTGDDVRILGVRVGQIDTIEAQPEQVKITFWVDDRYKIPAD
MAV_2064|M.avium_104 AYFAETNGLFVGDEVRILGVAVGAIDKIEPQSAGSKVTFSVDKKYAIPAA
MAB_4150c|M.abscessus_ATCC_199 GHFASAVGLYPGDDVRILGVKAGRISAVEPREGDVKVTMEMPDKFKVPEG
:* : .:: **.* * *: .* : : . :::: .: :*
Mb0607|M.bovis_AF2122/97 ATASILNPSLVASRTIQLSPPYTGGPVLQDGAVIPIERTQVPVEWDQLRD
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKGGPALGDNAVIPLERTQVPVEWDELRD
MMAR_4054|M.marinum_M AKAAILSPTLVTSRAIQLTPAYTGGPAMSDNAVIPRQRTAVPVEWDDVRA
MUL_3921|M.ulcerans_Agy99 AKAAILSPTLVTSRAIQLTPAYTGGPAMSDNAVIPRQRTAVPVEWDDVRA
Mflv_2104|M.gilvum_PYR-GCK AAAAILSPALVTARAIQLTPVYTGGPVLGDNAVIPLQRTVVPVEWDQVRA
TH_3797|M.thermoresistible__bu VRAVILSPQLVTARSIELTPAYTGGPTLQPGEVIPEDRTAVPVEWDDLRE
Rv1969|M.tuberculosis_H37Rv AAAAILSPQLVTGRAIQLTPPYAGGPTMADGTVIPQERTVVPVEWDDLRA
MSMEG_0349|M.smegmatis_MC2_155 ATAAILSPQLVTGRAIQLTPPYESGPELPDDAVIPIERTAVPVSWDDFRV
Mvan_0925|M.vanbaalenii_PYR-1 AQAVILSPSLVSARAIQLVPAYDGGPVMPTQAVIPLERTAVPVEWDDLRG
MAV_2064|M.avium_104 ARAAVLSPSLVTARAIQLVPAYAGGPTLSPGAAIPLSRTAVPVEWDDFRK
MAB_4150c|M.abscessus_ATCC_199 AQAIIMAPNLVTARFVQLTPAYTDGKALQDGASLGLDKTAVPIEWDEVKT
. * :: * **:.* ::* * * .* : : .:* **:.**:.:
Mb0607|M.bovis_AF2122/97 SINGILRQLGPTERQPKGPFGDLIESAADNLAGKGRQLNETLNSLSQALT
MLBr_02592|M.leprae_Br4923 SITKIISKLGPTKEQPKGPFGDVIESFADGLAGKGKQINATLDSLSRALT
MMAR_4054|M.marinum_M QLAKLTKELQPTEPGGVSPLGSVINTAADNLRGEGANIRDTVIKLSQAFS
MUL_3921|M.ulcerans_Agy99 QLAKLTKELQPTEPGGVSPLGSVINTAADNLRGEGANIRDTVIKLSQAFS
Mflv_2104|M.gilvum_PYR-GCK QLERLSETLQPTEPGGVSPLGSVINTTAENLRGQGADIRETVIKLSQAFS
TH_3797|M.thermoresistible__bu QLEKLTDALQPTEPGGVSTLGEFINTSAENLRGQGTDIRETVIKLSQAIS
Rv1969|M.tuberculosis_H37Rv QLQRLTALLQPTRPGGVSTLGALINTAADNLRGQGATIRDTIIKLSQAIS
MSMEG_0349|M.smegmatis_MC2_155 QLEKLTRTLQPETPGGTSALGNFINTAADNLRGEGDNIRDALVKLSKTVT
Mvan_0925|M.vanbaalenii_PYR-1 QLQKLVDALQPTQPGGISTVGAFVNMAAENLRGSGADIHDTIIQLSQAFS
MAV_2064|M.avium_104 QLEKLTDALQPTTAGGVNSVGEFVNSAADNLRGQGDTARDTVLKLSEAIS
MAB_4150c|M.abscessus_ATCC_199 ELAKLSDSLGPQG-QSKGPVSDFINQAATTFDGNGDSFRNAVRELSQAAG
.: : * * .... .:: * : *.* . :: .**.:
Mb0607|M.bovis_AF2122/97 ALNEGRGDFVAITRSLALFVSALYQNDQQFVALNENLAEFTDWFTKSDHD
MLBr_02592|M.leprae_Br4923 ALNEGRGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLAHSDTD
MMAR_4054|M.marinum_M ALGDHSTDIFSTVKNLAILVSALQDSTNFMRQLNQNLATVTGLLANDPNE
MUL_3921|M.ulcerans_Agy99 ALGDHSTDIFSTVKNLAILVSALQDSTNLMRQLNQNLATVTGLLANDPNE
Mflv_2104|M.gilvum_PYR-GCK ALGDRSTDIFSTIKNLAILVSALQDSTDLMRQLNQNLASVSGLLTDGPDE
TH_3797|M.thermoresistible__bu ILGDHSDDLFTSIKNVSLLVSALHDSTDLLRQLNANLAQATGLLTNGPNE
Rv1969|M.tuberculosis_H37Rv ALGDHSKDIFSTVTNLSTLVTALHDSADLLERLNHNLAAVTSLLADGPDK
MSMEG_0349|M.smegmatis_MC2_155 TVSDHKDDVFSTLNNLATLVSALRDSTDVLAALNRNMAAVSALLADSPDE
Mvan_0925|M.vanbaalenii_PYR-1 ALGDHSDDVFATIRDLSLVVTALQESKDVLRALNDNLAATTALLANQPGE
MAV_2064|M.avium_104 ALGDHADDIFSTVRNLQLLVSALYSSSDLLASFNTNLAAVTTLLTNTPNE
MAB_4150c|M.abscessus_ATCC_199 RLGDSRTDLFGTIKNLQTLVDALANSNEQIVQFSTHLASVSKVLAASTEN
:.: *.. .: .* ** . : : :. ::* : :: .
Mb0607|M.bovis_AF2122/97 LADTVERIDDVLGTVRKFVSDNRSVLAADVNNLADATTTLVQPEPRDGLE
MLBr_02592|M.leprae_Br4923 LSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNNTVVQPEPLNGVE
MMAR_4054|M.marinum_M VANAVRNLGDTVGEVQRFVADNREALGTTSDKLAGVSQALN--DSLDDVK
MUL_3921|M.ulcerans_Agy99 VANAVRNLGDTVGEVQRFVADNREALGTTSDKLAGVSQALN--DSLDDVK
Mflv_2104|M.gilvum_PYR-GCK VANAIRDLNAAVGDVQSFVAENRESLGTTSDKLAGVTTALT--ESLEDIK
TH_3797|M.thermoresistible__bu VGQALADLDAAVRDVTDFVADNREAVGTTTNRLASITSALD--ESVEEVK
Rv1969|M.tuberculosis_H37Rv IGQAAEDLNAVVADVGSFAAEHREAIGTASDKLASITTALV--DSLDDIK
MSMEG_0349|M.smegmatis_MC2_155 VGQAIADLNSLAVDVKSFVVENRDAVGTTSDVSASISTALV--QSLDDIK
Mvan_0925|M.vanbaalenii_PYR-1 VDRAIADINDVVTEVTGFAAENREPVGTASDLLASISDTLN--RSLDDIK
MAV_2064|M.avium_104 VGSALKSLDGALTDVRDFLAENREAMGVTVDRLGSITTALN--DSRGDVK
MAB_4150c|M.abscessus_ATCC_199 LGATLGALNQALTDVRGFLGDTNSALIDQVNKLSDFVKIFS--DQSDDLE
: : :. * * . .. : : . . ::
Mb0607|M.bovis_AF2122/97 TALHVLPTYASNFNNLYYPLHSSLVGQFVFPNFANPIQLICS-AIQAGSR
MLBr_02592|M.leprae_Br4923 TFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQFICS-AIQAGSR
MMAR_4054|M.marinum_M QFLHVAPNTLQNYVNIWQPAQGAVSAVPMLNNFANPISFLCG-AIQAASR
MUL_3921|M.ulcerans_Agy99 QFLHVAPNTLQNYVNIWQPAQGAVSAVPMLNNFANPISFLCG-AIQAASR
Mflv_2104|M.gilvum_PYR-GCK QFLHVAPSTFQNYINIWQPAQGAVSSVPQINNFANPIQFLCG-AVQAASR
TH_3797|M.thermoresistible__bu QALHIAPNTLANFYNIYQPAQAALTGALAVNNFADPVSFLCG-AIQAASR
Rv1969|M.tuberculosis_H37Rv QTLHISPTVLQNFNNIFEPANGALTGALAGNNMANPIAFLCG-AIQAASR
MSMEG_0349|M.smegmatis_MC2_155 QSLHIFPTTLANFGNIYEPANGSLTGALAINNFSDPISFICG-AIEAASR
Mvan_0925|M.vanbaalenii_PYR-1 QTLHVAPTQLANFVNMYPPAVGGFAGAFSLNNFANPIQFLCG-AIEAASR
MAV_2064|M.avium_104 QILHIAPTVFQNFLNIYQPAQSAMTGILALNNFADIPQFICS-SIEAASR
MAB_4150c|M.abscessus_ATCC_199 QILHVAPNGLANFYNIYNPAAGTLNGMLSIPNLANPVQFICGGVFETGTK
**: *. * ::: * . . . *::: ::*. .::.::
Mb0607|M.bovis_AF2122/97 LGYQESAELCAQYLAPVLDALKFNYLPFGSNPFSSAATLPKEVAYSE---
MLBr_02592|M.leprae_Br4923 LGYQESAELCAQYLSPVLDAIKFNYFPFGLNLFSTAEVLPKEVAYSE---
MMAR_4054|M.marinum_M LGYEQSAKLCVQYLAPIIKNRQYNFLPFGQNLFVGASARPNELTYSE---
MUL_3921|M.ulcerans_Agy99 LGYEQSAKLCVQYLAPIIKNRQYNFLPFGQNLFVGASARPNELTYSE---
Mflv_2104|M.gilvum_PYR-GCK LGAEESAKLCVQYLAPIIKNRQYNFPPLGLNQLVGATTRPNELTYSE---
TH_3797|M.thermoresistible__bu LGAEESSKLCVQYLAPIVKNRQYNFLPFGLNPFVGAAARPNEITYSE---
Rv1969|M.tuberculosis_H37Rv LGGEQAAKLCVQYLAPIVKNRQYNYPPLGANLFVGAQARPNEVTYSE---
MSMEG_0349|M.smegmatis_MC2_155 LGAERSAKLCVQYLAPIVKNRQFNFPPFGENTFVGAQARPNEITFSE---
Mvan_0925|M.vanbaalenii_PYR-1 LGAEQAAKLCVQYLAPIVKNRQYNFPPLGINPVVGAVARPNEITYSE---
MAV_2064|M.avium_104 ARLARVSKLCLQYLNPIIKNRIYNYIPAGINPFVGTQARPSEITYSE---
MAB_4150c|M.abscessus_ATCC_199 TEYLKRAEICRERMGPVLRRATFNYAPILLHPINQISAYKGQIIYDTPET
. :::* : : *:: :*: * : . . :: :.
Mb0607|M.bovis_AF2122/97 ----ERLRPPPGYKDTTVPGIFSRDTPFSHGNHEPGWVVAPGMQGMQVQP
MLBr_02592|M.leprae_Br4923 ----ARLQPPSGYKDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQVGP
MMAR_4054|M.marinum_M ----DWLRP--DYIPP--QAIPPQAIPPQQAPPAAAPPAQAPPPAVGPPL
MUL_3921|M.ulcerans_Agy99 ----DWLRP--DYIPP--QAIP-----PQQAPPAAAPPAQAPPPAVGLPL
Mflv_2104|M.gilvum_PYR-GCK ----DWLRP--DYIPPG-GPAPAPAAGVPTGDPAGLPPGQGPLLLDAPPG
TH_3797|M.thermoresistible__bu ----DWMRP--DYRPMS-LPAP-----ADQSLPAEEP-------------
Rv1969|M.tuberculosis_H37Rv ----DWLRP--DYVAPV-ADTPPD--------PAAAV-------------
MSMEG_0349|M.smegmatis_MC2_155 ----DWLRP--DYIPPA-QPVTQDL--DPEVLPAEAA-------------
Mvan_0925|M.vanbaalenii_PYR-1 ----DWLRP--DYVPPP-QAPLNDPAPVESPLPAEAP-------------
MAV_2064|M.avium_104 ----DWLRP--GYTPSDGGPPPEAPAPPGQPAPADQPPAEP---------
MAB_4150c|M.abscessus_ATCC_199 EAKSQAPREDLVWVRPNGAPPPPKPSPQDLSALMLGPDEVNAPPPPGTEV
: :
Mb0607|M.bovis_AF2122/97 FTANMLTPESLAELLGGPDIAPPAAGNQLARTAECV--------------
MLBr_02592|M.leprae_Br4923 ITAALMTPDSLAELMGGPDIEPIQSNLQTPPGPPTAYDEHPVPPPIGLQA
MMAR_4054|M.marinum_M PAEAPATPDPAAGLRG--IMVPQGVGS-----------------------
MUL_3921|M.ulcerans_Agy99 PAEAPATPDPAAGLRG--IMVPQGVGS-----------------------
Mflv_2104|M.gilvum_PYR-GCK AAEMPVPTNPTDGLHG--MMVPPGGGS-----------------------
TH_3797|M.thermoresistible__bu VVPAVRAADPSQGLPG--LMIPHGGGR-----------------------
Rv1969|M.tuberculosis_H37Rv --TVD----PATGLRG--MMMPPGGGS-----------------------
MSMEG_0349|M.smegmatis_MC2_155 --PTDGSADPSAGLPG--LMIPTEAGS-----------------------
Mvan_0925|M.vanbaalenii_PYR-1 ----------ATNLQD--MLLPAGAGS-----------------------
MAV_2064|M.avium_104 GPPPNPTSNSLQVLRD--LMLPTGPS------------------------
MAB_4150c|M.abscessus_ATCC_199 RPAEPGPVPPGFPVTADDAPPPAIPGAPR---------------------
: * .
Mb0607|M.bovis_AF2122/97 ---------------------------------------
MLBr_02592|M.leprae_Br4923 SVPIPSPRPDVVPGPVAPTPSPAANVGDPPLPAELGAGQ
MMAR_4054|M.marinum_M ---------------------------------------
MUL_3921|M.ulcerans_Agy99 ---------------------------------------
Mflv_2104|M.gilvum_PYR-GCK ---------------------------------------
TH_3797|M.thermoresistible__bu ---------------------------------------
Rv1969|M.tuberculosis_H37Rv ---------------------------------------
MSMEG_0349|M.smegmatis_MC2_155 ---------------------------------------
Mvan_0925|M.vanbaalenii_PYR-1 ---------------------------------------
MAV_2064|M.avium_104 ---------------------------------------
MAB_4150c|M.abscessus_ATCC_199 ---------------------------------------