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VTKRKWALGVAVALVLVLVGGVVAAIRISNVGNRTHVTAYFTNSTGIYTGDDVRILGVRVGQIDTIEAQP EQVKITFWVDDRYKIPADAQAVILSPSLVSARAIQLVPAYDGGPVMPTQAVIPLERTAVPVEWDDLRGQL QKLVDALQPTQPGGISTVGAFVNMAAENLRGSGADIHDTIIQLSQAFSALGDHSDDVFATIRDLSLVVTA LQESKDVLRALNDNLAATTALLANQPGEVDRAIADINDVVTEVTGFAAENREPVGTASDLLASISDTLNR SLDDIKQTLHVAPTQLANFVNMYPPAVGGFAGAFSLNNFANPIQFLCGAIEAASRLGAEQAAKLCVQYLA PIVKNRQYNFPPLGINPVVGAVARPNEITYSEDWLRPDYVPPPQAPLNDPAPVESPLPAEAPATNLQDML LPAGAGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0925 | - | - | 100% (427) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_3979 | - | e-144 | 59.33% (418) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_4601 | - | e-142 | 56.66% (443) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0178 | mce1D | 1e-78 | 40.63% (379) | MCE-family protein MCE1D |
| M. gilvum PYR-GCK | Mflv_2104 | - | 1e-145 | 57.79% (443) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1969 | mce3D | 1e-144 | 61.50% (426) | MCE-family protein MCE3D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 2e-80 | 41.42% (379) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4150c | - | 7e-69 | 34.31% (411) | MCE-family protein |
| M. marinum M | MMAR_4054 | mce3D_1 | 1e-148 | 59.64% (446) | MCE-family protein Mce3D_1 |
| M. avium 104 | MAV_2535 | - | 1e-146 | 58.45% (438) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_0349 | - | 1e-140 | 57.08% (431) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_3797 | - | 1e-147 | 58.04% (429) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3921 | mce3D_1 | 1e-147 | 58.96% (441) | MCE-family protein Mce3D_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0178|M.bovis_AF2122/97 MSTIFDIRNLRLPQLSRASVVIGSLVVVLALAAGIVGVRLYQKLTNNTVV
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
MMAR_4054|M.marinum_M -------------MIRRTKTWLAVLLVGLLAAGVVVLLRTTEVVNRTNVV
MUL_3921|M.ulcerans_Agy99 -------------MIRRTKTWLAVLLVGLLAAGVVVLLRTTEVVNRTNVV
Mflv_2104|M.gilvum_PYR-GCK --------------MKNLRLWVGLVLVALLVVGVALLVRTTDKVNRVNVV
MAV_2535|M.avium_104 ---------------------MAIALTAVLLGGIVTVVRSAAGVGRTTVV
TH_3797|M.thermoresistible__bu ----------VTQLNRHRNIALAAVLVLTLVAGMIILVRMYAASDRVQYT
Rv1969|M.tuberculosis_H37Rv ------------MTTKLRRARSVLATALVLVAGVILAMRTADAAARTTVV
MSMEG_0349|M.smegmatis_MC2_155 ------------MRISKKQLTLAAGLVVVMVAGVLVGFRMTGPAARTTIT
Mvan_0925|M.vanbaalenii_PYR-1 ------------MTKRKWALGVAVALVLVLVGGVVAAIRISNVGNRTHVT
MAB_4150c|M.abscessus_ATCC_199 ------------MTTSKTWLKRGAFAMLSVALVGGLLYWVWPSRGTYKIV
.
Mb0178|M.bovis_AF2122/97 AYFTQANALYVGDKVQIMGLPVGSIDKIEPAGDKMKVTFHYQNKYKVPAN
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
MMAR_4054|M.marinum_M AYFENSNGVFTGDEVRILGVPVGKITSIEPQPESVKVSFWYDSKYKVPAD
MUL_3921|M.ulcerans_Agy99 AYFENSNGVFTGDEVRILGVPVGKITSIEPQPESVRVSFWYDSKYIVPAD
Mflv_2104|M.gilvum_PYR-GCK AYFENSNGIYEGDDVRILGVPVGRITSIEPEPERVKISFWYDDRYDVPAD
MAV_2535|M.avium_104 GYFANSTGLYNGDSVVILGVPVGKIEKIEPEPDRVRITFWLNDKYKVPAD
TH_3797|M.thermoresistible__bu AYFENSNGVYPGDEVRILGVPVGQIDTVEPEPDRAKITFWVSEKYRVPAD
Rv1969|M.tuberculosis_H37Rv AYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQPLRAKISFWFDRKYRVPAD
MSMEG_0349|M.smegmatis_MC2_155 AYFANSNGLFAGDDVLILGVPVGKVKEIEPLPERAKVTFWVDKEFQVPAD
Mvan_0925|M.vanbaalenii_PYR-1 AYFTNSTGIYTGDDVRILGVRVGQIDTIEAQPEQVKITFWVDDRYKIPAD
MAB_4150c|M.abscessus_ATCC_199 GHFASAVGLYPGDDVRILGVKAGRISAVEPREGDVKVTMEMPDKFKVPEG
:* : .:: **.* * *: .* : : . :::: .: :* .
Mb0178|M.bovis_AF2122/97 ASAVILNPTLVASRNIQLEPPYRGGPVLADNAVIPVERTQVPTEWDELRD
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKGGPALGDNAVIPLERTQVPVEWDELRD
MMAR_4054|M.marinum_M AKAAILSPTLVTSRAIQLTPAYTGGPAMSDNAVIPRQRTAVPVEWDDVRA
MUL_3921|M.ulcerans_Agy99 AKAAILSPTLVTSRAIQLTPAYTGGPAMSDNAVIPRQRTAVPVEWDDVRA
Mflv_2104|M.gilvum_PYR-GCK AAAAILSPALVTARAIQLTPVYTGGPVLGDNAVIPLQRTVVPVEWDQVRA
MAV_2535|M.avium_104 VKAAILSPSLVTPRSIQLTPAYTGGPALADHAVIPQQRTAVPVEYDDFRQ
TH_3797|M.thermoresistible__bu VRAVILSPQLVTARSIELTPAYTGGPTLQPGEVIPEDRTAVPVEWDDLRE
Rv1969|M.tuberculosis_H37Rv AAAAILSPQLVTGRAIQLTPPYAGGPTMADGTVIPQERTVVPVEWDDLRA
MSMEG_0349|M.smegmatis_MC2_155 ATAAILSPQLVTGRAIQLTPPYESGPELPDDAVIPIERTAVPVSWDDFRV
Mvan_0925|M.vanbaalenii_PYR-1 AQAVILSPSLVSARAIQLVPAYDGGPVMPTQAVIPLERTAVPVEWDDLRG
MAB_4150c|M.abscessus_ATCC_199 AQAIIMAPNLVTARFVQLTPAYTDGKALQDGASLGLDKTAVPIEWDEVKT
. * *: * **: * ::* * * .* : : ::* ** .:*:.:
Mb0178|M.bovis_AF2122/97 SVSHIIDELGPTPEQPKGPFGEVIEAFADGLAGKGKQINTTLNSLSQALN
MLBr_02592|M.leprae_Br4923 SITKIISKLGPTKEQPKGPFGDVIESFADGLAGKGKQINATLDSLSRALT
MMAR_4054|M.marinum_M QLAKLTKELQPTEPGGVSPLGSVINTAADNLRGEGANIRDTVIKLSQAFS
MUL_3921|M.ulcerans_Agy99 QLAKLTKELQPTEPGGVSPLGSVINTAADNLRGEGANIRDTVIKLSQAFS
Mflv_2104|M.gilvum_PYR-GCK QLERLSETLQPTEPGGVSPLGSVINTTAENLRGQGADIRETVIKLSQAFS
MAV_2535|M.avium_104 QLEKLTQVLQPTAPGGTSTLGAFINTAADNLRGQGPDIRKTVIELSQAIS
TH_3797|M.thermoresistible__bu QLEKLTDALQPTEPGGVSTLGEFINTSAENLRGQGTDIRETVIKLSQAIS
Rv1969|M.tuberculosis_H37Rv QLQRLTALLQPTRPGGVSTLGALINTAADNLRGQGATIRDTIIKLSQAIS
MSMEG_0349|M.smegmatis_MC2_155 QLEKLTRTLQPETPGGTSALGNFINTAADNLRGEGDNIRDALVKLSKTVT
Mvan_0925|M.vanbaalenii_PYR-1 QLQKLVDALQPTQPGGISTVGAFVNMAAENLRGSGADIHDTIIQLSQAFS
MAB_4150c|M.abscessus_ATCC_199 ELAKLSDSLGPQGQ-SKGPVSDFINQAATTFDGNGDSFRNAVRELSQAAG
.: :: * * .... .:: * : *.* :. :: .**::
Mb0178|M.bovis_AF2122/97 ALNEGRGDFFAVVRSLALFVNALHQDDQQFVALNKNLAEFTDRLTHSDAD
MLBr_02592|M.leprae_Br4923 ALNEGRGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLAHSDTD
MMAR_4054|M.marinum_M ALGDHSTDIFSTVKNLAILVSALQDSTNFMRQLNQNLATVTGLLANDPNE
MUL_3921|M.ulcerans_Agy99 ALGDHSTDIFSTVKNLAILVSALQDSTNLMRQLNQNLATVTGLLANDPNE
Mflv_2104|M.gilvum_PYR-GCK ALGDRSTDIFSTIKNLAILVSALQDSTDLMRQLNQNLASVSGLLTDGPDE
MAV_2535|M.avium_104 ALGDHSNDLFSTVKNLSILVSALHDSSDLLQQLNQNLAEVTGLLANDPNE
TH_3797|M.thermoresistible__bu ILGDHSDDLFTSIKNVSLLVSALHDSTDLLRQLNANLAQATGLLTNGPNE
Rv1969|M.tuberculosis_H37Rv ALGDHSKDIFSTVTNLSTLVTALHDSADLLERLNHNLAAVTSLLADGPDK
MSMEG_0349|M.smegmatis_MC2_155 TVSDHKDDVFSTLNNLATLVSALRDSTDVLAALNRNMAAVSALLADSPDE
Mvan_0925|M.vanbaalenii_PYR-1 ALGDHSDDVFATIRDLSLVVTALQESKDVLRALNDNLAATTALLANQPGE
MAB_4150c|M.abscessus_ATCC_199 RLGDSRTDLFGTIKNLQTLVDALANSNEQIVQFSTHLASVSKVLAASTEN
:.: *.* : .: .* ** . : : :. ::* : *: .
Mb0178|M.bovis_AF2122/97 LSNAIQQFDSLLAVARPFFAKNREVLTHDVNNLATVTTTLLQPDPLDGLE
MLBr_02592|M.leprae_Br4923 LSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNNTVVQPEPLNGVE
MMAR_4054|M.marinum_M VANAVRNLGDTVGEVQRFVADNREALGTTSDKLAGVSQALNDS--LDDVK
MUL_3921|M.ulcerans_Agy99 VANAVRNLGDTVGEVQRFVADNREALGTTSDKLAGVSQALNDS--LDDVK
Mflv_2104|M.gilvum_PYR-GCK VANAIRDLNAAVGDVQSFVAENRESLGTTSDKLAGVTTALTES--LEDIK
MAV_2535|M.avium_104 VANAVRNLNDVVGDVRGFVAENRDALGTTSDKLASVTQAVTDS--LGDVK
TH_3797|M.thermoresistible__bu VGQALADLDAAVRDVTDFVADNREAVGTTTNRLASITSALDES--VEEVK
Rv1969|M.tuberculosis_H37Rv IGQAAEDLNAVVADVGSFAAEHREAIGTASDKLASITTALVDS--LDDIK
MSMEG_0349|M.smegmatis_MC2_155 VGQAIADLNSLAVDVKSFVVENRDAVGTTSDVSASISTALVQS--LDDIK
Mvan_0925|M.vanbaalenii_PYR-1 VDRAIADINDVVTEVTGFAAENREPVGTASDLLASISDTLNRS--LDDIK
MAB_4150c|M.abscessus_ATCC_199 LGATLGALNQALTDVRGFLGDTNSALIDQVNKLSDFVKIFSDQ--SDDLE
: : :. . * . .. : : : . . ::
Mb0178|M.bovis_AF2122/97 TVLHIFPTLAANINQLYHPTHGGVVSLSAFTNFANPMEFICS-SIQAGSR
MLBr_02592|M.leprae_Br4923 TFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQFICS-AIQAGSR
MMAR_4054|M.marinum_M QFLHVAPNTLQNYVNIWQPAQGAVSAVPMLNNFANPISFLCG-AIQAASR
MUL_3921|M.ulcerans_Agy99 QFLHVAPNTLQNYVNIWQPAQGAVSAVPMLNNFANPISFLCG-AIQAASR
Mflv_2104|M.gilvum_PYR-GCK QFLHVAPSTFQNYINIWQPAQGAVSSVPQINNFANPIQFLCG-AVQAASR
MAV_2535|M.avium_104 QLLHTAPTAFQNFLNIYQPAQGTLTGALAFNNFANTIQFLCG-AVEAASR
TH_3797|M.thermoresistible__bu QALHIAPNTLANFYNIYQPAQAALTGALAVNNFADPVSFLCG-AIQAASR
Rv1969|M.tuberculosis_H37Rv QTLHISPTVLQNFNNIFEPANGALTGALAGNNMANPIAFLCG-AIQAASR
MSMEG_0349|M.smegmatis_MC2_155 QSLHIFPTTLANFGNIYEPANGSLTGALAINNFSDPISFICG-AIEAASR
Mvan_0925|M.vanbaalenii_PYR-1 QTLHVAPTQLANFVNMYPPAVGGFAGAFSLNNFANPIQFLCG-AIEAASR
MAB_4150c|M.abscessus_ATCC_199 QILHVAPNGLANFYNIYNPAAGTLNGMLSIPNLANPVQFICGGVFETGTK
** *. * ::: *: . . . *:::.: *:*. .::.::
Mb0178|M.bovis_AF2122/97 LGYQESAELCAQYLAPVLDAIKFNYFPFGLNVASTASTLPKEIAYSEPRL
MLBr_02592|M.leprae_Br4923 LGYQESAELCAQYLSPVLDAIKFNYFPFGLNLFSTAEVLPKEVAYSEARL
MMAR_4054|M.marinum_M LGYEQSAKLCVQYLAPIIKNRQYNFLPFGQNLFVGASARPNELTYSEDWL
MUL_3921|M.ulcerans_Agy99 LGYEQSAKLCVQYLAPIIKNRQYNFLPFGQNLFVGASARPNELTYSEDWL
Mflv_2104|M.gilvum_PYR-GCK LGAEESAKLCVQYLAPIIKNRQYNFPPLGLNQLVGATTRPNELTYSEDWL
MAV_2535|M.avium_104 LGAKESAKLCVQYLAPIIKNRQVNFPPLGENLFVGAAARPNELTYSEDWL
TH_3797|M.thermoresistible__bu LGAEESSKLCVQYLAPIVKNRQYNFLPFGLNPFVGAAARPNEITYSEDWM
Rv1969|M.tuberculosis_H37Rv LGGEQAAKLCVQYLAPIVKNRQYNYPPLGANLFVGAQARPNEVTYSEDWL
MSMEG_0349|M.smegmatis_MC2_155 LGAERSAKLCVQYLAPIVKNRQFNFPPFGENTFVGAQARPNEITFSEDWL
Mvan_0925|M.vanbaalenii_PYR-1 LGAEQAAKLCVQYLAPIVKNRQYNFPPLGINPVVGAVARPNEITYSEDWL
MAB_4150c|M.abscessus_ATCC_199 TEYLKRAEICRERMGPVLRRATFNYAPILLHPINQISAYKGQIIYDTPET
. :::* : :.*:: *: *: : . :: :.
Mb0178|M.bovis_AF2122/97 QPPNGYKDTTVPGIWVPDTPLSHRNTQPGWVVAPGMQGVQVGPITQGLLT
MLBr_02592|M.leprae_Br4923 QPPSGYKDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQVGPITAALMT
MMAR_4054|M.marinum_M RP-----DYIPP-QAIPPQAIPPQQAPP----------------------
MUL_3921|M.ulcerans_Agy99 RP-----DYIPP-QAIP-----PQQAPP----------------------
Mflv_2104|M.gilvum_PYR-GCK RP-----DYIPPGGPAPAPAAGVPTGDP----------------------
MAV_2535|M.avium_104 RP-----DYVPP-HPDSPPTGDAPAPPA----------------------
TH_3797|M.thermoresistible__bu RP-----DYRPM--------------------------------------
Rv1969|M.tuberculosis_H37Rv RP-----DYVAP--------------------------------------
MSMEG_0349|M.smegmatis_MC2_155 RP-----DYIPP--------------------------------------
Mvan_0925|M.vanbaalenii_PYR-1 RP-----DYVPP--------------------------------------
MAB_4150c|M.abscessus_ATCC_199 EAKSQAPREDLVWVRPNGAPPPPKPSPQ----------------------
..
Mb0178|M.bovis_AF2122/97 PESLAELMGGPDIAPPSSGLQTPPGPPNAYDEYPVLPPIGLQAPQVPIPP
MLBr_02592|M.leprae_Br4923 PDSLAELMGGPDIEPIQSNLQTPPGPPTAYDEHPVPPPIGLQAS-VPIPS
MMAR_4054|M.marinum_M ----------AAAPPAQAPPPAVGPPLPAEAPATPDPAAGLRGIMVPQ--
MUL_3921|M.ulcerans_Agy99 ----------AAAPPAQAPPPAVGLPLPAEAPATPDPAAGLRGIMVPQ--
Mflv_2104|M.gilvum_PYR-GCK ----------AGLPPGQGPLLLDAPPGAAEMPVPTNPTDGLHGMMVPP--
MAV_2535|M.avium_104 ----------AGATPAEAPPPAADAPPPAQA-APTNPAEGLRGMMMPP--
TH_3797|M.thermoresistible__bu ----------SLPAPADQSLPAEEPVVPAVR--AADPSQGLPGLMIPH--
Rv1969|M.tuberculosis_H37Rv -----------VADTPPD------PAAAVTVD----PATGLRGMMMPP--
MSMEG_0349|M.smegmatis_MC2_155 -----------AQPVTQDLDPEVLPAEAAPTDGSADPSAGLPGLMIPT--
Mvan_0925|M.vanbaalenii_PYR-1 -----------PQAPLNDPAP-VESPLPAEA-----PATNLQDMLLPA--
MAB_4150c|M.abscessus_ATCC_199 ----------DLSALMLGPDEVNAPPPPGTEVRPAEPGPVPPGFPVTADD
* :.
Mb0178|M.bovis_AF2122/97 PPPGPDVIPGPVPPTPAPVG----APLPAEAGGGQ
MLBr_02592|M.leprae_Br4923 P--RPDVVPGPVAPTPSPAANVGDPPLPAELGAGQ
MMAR_4054|M.marinum_M -------------------------------GVGS
MUL_3921|M.ulcerans_Agy99 -------------------------------GVGS
Mflv_2104|M.gilvum_PYR-GCK -------------------------------GGGS
MAV_2535|M.avium_104 -------------------------------GGGQ
TH_3797|M.thermoresistible__bu -------------------------------GGGR
Rv1969|M.tuberculosis_H37Rv -------------------------------GGGS
MSMEG_0349|M.smegmatis_MC2_155 -------------------------------EAGS
Mvan_0925|M.vanbaalenii_PYR-1 -------------------------------GAGS
MAB_4150c|M.abscessus_ATCC_199 AP------------------------PPAIPGAPR