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KTFSERNVIVIGAIGVLLTAAIVAGALNYNKLPFVSSGKSYSAYFDEAGGLTTGAPVRVSGAPAGQVQSI TLDGQWVLVTFTVADGIRLGDRTEASIKTTSVLGNKVLDLTTRGAGTLAGTIPVERTTSPYQLPDAIGDL TTTISGLDTGQLSASLAVLSQTLQDTPDDLRFAVAGIARFSETLNQRDAQLRDLLAHAAKATTVLGERSN DIVRLISDTNAVLAQLRTQSAALDEISTSISAVSRQLAGFIAENKTTLKPALEKLNGVLAILDNRKAQIQ ESIKGLAAYAMQFGETIAAGPFFNAYLANLVPGQFIQPFVDAAFSDLGLDPNVLLPSERTDPQVGQPGTP ALPIPYPRTGQGGDPKLTLPDAITGNPGDPRYPYRESVPAPPPGGPPPGPPAPPPPDQQAPQPPTPSPVV VPAPDEVAPGPTDSSIPQGRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0650 | - | - | 100% (442) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_2103 | - | e-163 | 64.41% (444) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_0709 | - | 1e-62 | 32.90% (465) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0177 | mce1C | 1e-65 | 33.13% (486) | MCE-family protein MCE1C |
| M. tuberculosis H37Rv | Rv1968 | mce3C | 1e-151 | 63.33% (409) | MCE-family protein MCE3C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 1e-57 | 31.50% (454) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4151c | - | 4e-63 | 39.08% (325) | MCE-family protein |
| M. marinum M | MMAR_4053 | mce3C_1 | 1e-167 | 65.82% (433) | MCE-family protein, Mce3C_1 |
| M. avium 104 | MAV_2534 | - | 1e-155 | 62.44% (434) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0348 | - | 1e-156 | 61.14% (440) | mce-family protein mce3c |
| M. thermoresistible (build 8) | TH_4469 | - | 1e-161 | 69.90% (402) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3920 | mce3C_1 | 1e-164 | 64.90% (433) | MCE-family protein, Mce3C_1 |
| M. vanbaalenii PYR-1 | Mvan_0515 | - | 0.0 | 100.00% (442) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0650|M.gilvum_PYR-GCK ----MKTFSERNVIVIGAIGVLLTAAIVAGALNYNKLPFVSSGKSYSAYF
Mvan_0515|M.vanbaalenii_PYR-1 ----MKTFSERNVIVIGAIGVLLTAAIVAGALNYNKLPFVSSGKSYSAYF
TH_4469|M.thermoresistible__bu VRPAMKPLRERNRAVIGAIGVTTLIAVTVGAFNYSKLPLPSSSRTYSAIF
Rv1968|M.tuberculosis_H37Rv ----MKSFAERNRLAIGTVGIVVVAAVALAALQYQRLPFFNQGTRVSAYF
MSMEG_0348|M.smegmatis_MC2_155 MRAEMKAFSERDPRTIGLVGIAITVVIALAALNFDKLPLLSSTKGYSAYF
MMAR_4053|M.marinum_M ----MKSFAERNQIVVGAVGLAITIGIVVGSLQYDKLPFFQSGKQYSAYF
MUL_3920|M.ulcerans_Agy99 ----MKSFAERNQIVVGAVELAITIGIVVGSLQYDKLPLFQSGKQYSACF
MAV_2534|M.avium_104 ----MKTFSERNPFIIGAIGLGAVFTLMLVSLNYDKLPFFHSDRTYSAYF
MAB_4151c|M.abscessus_ATCC_199 MPSKMSDIQEKDPVRTGIFGIAVVSMLVLVAFGYTGLPFWPQGKQYTGYF
Mb0177|M.bovis_AF2122/97 ----MRTLEPPNRMRIGLMGIVVALLVVAVGQSFTSVPMLFAKPSYYGQF
MLBr_02591|M.leprae_Br4923 ----MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFARPSYYGQF
* : : * . : : . : :*: . *
Mflv_0650|M.gilvum_PYR-GCK DEAGGLTTGAPVRVSGAPAGQVQSITLDGQWVLVTFTVADGIRLGDRTEA
Mvan_0515|M.vanbaalenii_PYR-1 DEAGGLTTGAPVRVSGAPAGQVQSITLDGQWVLVTFTVADGIRLGDRTEA
TH_4469|M.thermoresistible__bu DELGGLTTGAPVQVLGFRAGQVGRISLEPDGVLVEFTVADDIRLGEQTEA
Rv1968|M.tuberculosis_H37Rv ADAGGLRTGNTVEVSGYPVGKVSSISLDGPGVLVEFKVDTDVRLGNRTEV
MSMEG_0348|M.smegmatis_MC2_155 ADAGGLNTGATVRVSGFAVGKVERIRLDGRKVLVDFTVDSAIHLGEQSEA
MMAR_4053|M.marinum_M ADAGGLTTGVRVQVSGFRVGEVSSIELDGPRVLVKFTVDKHIRLGDHTEA
MUL_3920|M.ulcerans_Agy99 ADAGGLTTGVRVQVSGFRVGEVSSIELDGPQVLVKFTVDKHIRLGDHTEA
MAV_2534|M.avium_104 AEAGGLEPGNHVQISGYRVGQVDSVELDGPRVLVTFTVASNLRLGERTEA
MAB_4151c|M.abscessus_ATCC_199 ADSGGLESGGNVFVSGIKVGQVKDVSLAGNKVRVDFTVDRSIRLGDQSLA
Mb0177|M.bovis_AF2122/97 TDSGGLHKGDRVRIAGLGVGTVEGLKIDGDHIVVKFSIGTNT-IGTESRL
MLBr_02591|M.leprae_Br4923 TDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIGTNR-IGTASRL
: *** * * : * .* * : : : : *.: :* :
Mflv_0650|M.gilvum_PYR-GCK SIKTTSVLGNKVLDLTTRGAGTLAG--TIPVERTTSPYQLPDAIGDLTTT
Mvan_0515|M.vanbaalenii_PYR-1 SIKTTSVLGNKVLDLTTRGAGTLAG--TIPVERTTSPYQLPDAIGDLTTT
TH_4469|M.thermoresistible__bu DIKTIGLLGNKVLVVTPRGDGRLAE--TIPMERTTSPYQLPDAVGDLTAT
Rv1968|M.tuberculosis_H37Rv AIKTKGLLGSKFLDVTPRGDGRLDS--PIPIERTTSPYQLPDALGDLAAT
MSMEG_0348|M.smegmatis_MC2_155 AIKVKSLLGTKVIDVIPRGGGQLHE--PIPLERTTSPYQLPDALGDLATT
MMAR_4053|M.marinum_M AIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLATT
MUL_3920|M.ulcerans_Agy99 AIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLATT
MAV_2534|M.avium_104 AIKLRTVLGSKVLEVSPRGEGQLTG--PIPLQRTTSAYQLPDALGDLTAT
MAB_4151c|M.abscessus_ATCC_199 AIRTTTVLGEKSLSVTPAGAGRIT---EIPLGRTTTPYTLNSALSDLGAS
Mb0177|M.bovis_AF2122/97 AIRTDTILGRKVLEIEPRGAQALPPGGVLPVGQSTTPYQIYDAFFDVTKA
MLBr_02591|M.leprae_Br4923 GIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDAFFDATKV
*: :** * : : . * : :*: :: :.* .*. *
Mflv_0650|M.gilvum_PYR-GCK ISGLDTGQLSASLAVLSQTLQDTPDDLRFAVAGIARFSETLNQRDAQLRD
Mvan_0515|M.vanbaalenii_PYR-1 ISGLDTGQLSASLAVLSQTLQDTPDDLRFAVAGIARFSETLNQRDAQLRD
TH_4469|M.thermoresistible__bu ISGLDTDQLSTALRTLSETLRDTPPQLRIAVEGVARFSQTLNARDAQLRE
Rv1968|M.tuberculosis_H37Rv ISGLHTERLSESLATLAQTFADTPAHFRNAIHGVARLAQTLDERDNQLRS
MSMEG_0348|M.smegmatis_MC2_155 VENLNTDDLSAALDTMAQTFAGTPPDVKIAVAGVARLSETINKRDTELRN
MMAR_4053|M.marinum_M ISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLRG
MUL_3920|M.ulcerans_Agy99 ISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLRG
MAV_2534|M.avium_104 ISGLNTDQLSKSLAVLANTFTDTPPDLKAAVQGVARFSQTLDERDGQLRT
MAB_4151c|M.abscessus_ATCC_199 AGGIDKAQLDQSLQVITEAMRDATPQLRGALDGVASLSRTLNARDAALEQ
Mb0177|M.bovis_AF2122/97 ASGWDIETVKRSLNVLSETVDQTYPHLSAALDGVAKFSDTIGKRDEQITH
MLBr_02591|M.leprae_Br4923 ASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGARDKEIKH
. . :. :* .::::. : .. *: *:* :: *:. ** :
Mflv_0650|M.gilvum_PYR-GCK LLAHAAKATTVLGERSNDIVRLISDTNAVLAQLRTQSAALDEISTSISAV
Mvan_0515|M.vanbaalenii_PYR-1 LLAHAAKATTVLGERSNDIVRLISDTNAVLAQLRTQSAALDEISTSISAV
TH_4469|M.thermoresistible__bu LLANARTATGVLAERSDHVVRLIHDSNALLAELRAQSAGLDQLSGNIAEM
Rv1968|M.tuberculosis_H37Rv LLANAAKATGVLANRTDQIVGLVRDTNVVLAQLRTQSAALDRIWANISAV
MSMEG_0348|M.smegmatis_MC2_155 LLANARKATAVLATRTDQVVGLVQDSNALLAELRTQSDALDRVSQDISRA
MMAR_4053|M.marinum_M LLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAAL
MUL_3920|M.ulcerans_Agy99 LLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAAL
MAV_2534|M.avium_104 LLSNANKATTVLAERSDEVAKLVRDTNALLRQLRSQSSALEQISNNLAAL
MAB_4151c|M.abscessus_ATCC_199 LLTHAKSVSGILSERAGQVNKLVTDGNQLFAALDERRLAISELINRIQGL
Mb0177|M.bovis_AF2122/97 LLAQANQVASILGDRSDQVDRLLVNAKTLIAAFNERGRAVDALLGNISAF
MLBr_02591|M.leprae_Br4923 LIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAAF
*:::* .: :*. * .: *: : : :: : : .:. : :
Mflv_0650|M.gilvum_PYR-GCK SRQLAGFIAENKTTLKPALEKLNGVLAILDNRKAQIQESIKGLAAYAMQF
Mvan_0515|M.vanbaalenii_PYR-1 SRQLAGFIAENKTTLKPALEKLNGVLAILDNRKAQIQESIKGLAAYAMQF
TH_4469|M.thermoresistible__bu ARQIRELIAANRDTLKPALEKLNGVLAIVDNRKAQVQKSIRGLGDYVMAL
Rv1968|M.tuberculosis_H37Rv AEQLRGFIAENRQQLRPALDKLNGVLAIVENRKERVRQAIPLINTYVMSL
MSMEG_0348|M.smegmatis_MC2_155 ATQLRGFMADNRQQLRPMLDKLNGVLTIVDNRKDRLQEAVKLLNKYALSL
MMAR_4053|M.marinum_M GQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMSL
MUL_3920|M.ulcerans_Agy99 GQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMSL
MAV_2534|M.avium_104 ARQLKGFIAENRDTLKPALDKLNSVLAIVDNRKENVQKALVGLNKYALGL
MAB_4151c|M.abscessus_ATCC_199 SQQISGFVADNRQEFRPTMEKLSVVLDDLLDRKAHISEALKRLPGYGTAL
Mb0177|M.bovis_AF2122/97 SAQVQNLINDN-PNLNHVLEQLRILTDLLVDRKEDLAETLTILGRFSASF
MLBr_02591|M.leprae_Br4923 AAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQVAAFLPSL
. *: :: * :. :::* : : ::* : ::: : : :
Mflv_0650|M.gilvum_PYR-GCK GETIAAGPFFNAYLANLVPGQFIQPFVDAAFSDLGLDPNVLLPSE-----
Mvan_0515|M.vanbaalenii_PYR-1 GETIAAGPFFNAYLANLVPGQFIQPFVDAAFSDLGLDPNVLLPSE-----
TH_4469|M.thermoresistible__bu GESVSSGPFFKAYLANLLPGQFVQPFVDAAFSDLGLDPHVLAPSE-----
Rv1968|M.tuberculosis_H37Rv GESLSSGPFFKAYVVNLLPGQFVQPFISAAFSDLGLDPATLLPSQ-----
MSMEG_0348|M.smegmatis_MC2_155 GESVGSGPFFKAYIPNLIPGQFSQPFIDAAFSDLGLDPATLLPSQ-----
MMAR_4053|M.marinum_M GESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
MUL_3920|M.ulcerans_Agy99 GESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
MAV_2534|M.avium_104 GESVSSGPFFKAYVVNLFPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
MAB_4151c|M.abscessus_ATCC_199 GEVVSSGPGFHVNVYGFPPATLTAVAFDTYF-------------------
Mb0177|M.bovis_AF2122/97 GETFASGPYFKVLLANLVPGQILQPFVDAAFKKRGISPEDFWRSAGLPAY
MLBr_02591|M.leprae_Br4923 NEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWRSAGLPEF
.* ..:** *:. : .: * : ..: *
Mflv_0650|M.gilvum_PYR-GCK ----------------------RTDPQVGQPGTP----------------
Mvan_0515|M.vanbaalenii_PYR-1 ----------------------RTDPQVGQPGTP----------------
TH_4469|M.thermoresistible__bu ----------------------RHDPQTGQPGTP----------------
Rv1968|M.tuberculosis_H37Rv ----------------------LTDPPTGQPGTP----------------
MSMEG_0348|M.smegmatis_MC2_155 ----------------------LVDPPVGQPGTP----------------
MMAR_4053|M.marinum_M ----------------------RTDPPIGQPGTP----------------
MUL_3920|M.ulcerans_Agy99 ----------------------RTDPPIGQPGTP----------------
MAV_2534|M.avium_104 ----------------------RADPQVGQPATP----------------
MAB_4151c|M.abscessus_ATCC_199 -----------------------------QPGKL----------------
Mb0177|M.bovis_AF2122/97 RWPDPNGTRFPNGAPPPPPPVLEGTPEHPGPAVPPGSPCSYTPPADG---
MLBr_02591|M.leprae_Br4923 RFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYTPAHPGGNN
*.
Mflv_0650|M.gilvum_PYR-GCK -------------ALPIPYPRTGQGGDPKLTLPDAITGNPGDP-------
Mvan_0515|M.vanbaalenii_PYR-1 -------------ALPIPYPRTGQGGDPKLTLPDAITGNPGDP-------
TH_4469|M.thermoresistible__bu -------------ALPLPYPRTGQGGDPNVTLPEAITGNPGDP-------
Rv1968|M.tuberculosis_H37Rv -------------PLPMPYPRTGQGGEPRLTLPDAITGNPGDP-------
MSMEG_0348|M.smegmatis_MC2_155 -------------ALPVPYPRTGQGGEPRLNLPDAITGNPGDP-------
MMAR_4053|M.marinum_M -------------PLPLPFPRTGQGGEPHLKLPDAITGNPDDP-------
MUL_3920|M.ulcerans_Agy99 -------------PLPLPFPRTGQGGEPHRKLPDAITGNPDDP-------
MAV_2534|M.avium_104 -------------PLPMPFPRTGQGGEPRMTLPDAITGNPGDHPCGSPGA
MAB_4151c|M.abscessus_ATCC_199 -------------PASLSDYLNGLIGERQIMRPKSP--------------
Mb0177|M.bovis_AF2122/97 -------LPRPWDPLPCANLTQGPFGGPDFPAPLDVATSPPNPDGPPPAP
MLBr_02591|M.leprae_Br4923 TIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPNPDGLPLLP
. . . * * *
Mflv_0650|M.gilvum_PYR-GCK ------RYPYRESVPAPPPGGPPPGPPAPPPPDQQAPQPPTPSPVVVPAP
Mvan_0515|M.vanbaalenii_PYR-1 ------RYPYRESVPAPPPGGPPPGPPAPPPPDQQAPQPPTPSPVVVPAP
TH_4469|M.thermoresistible__bu ------RYPYREPLPPPAPGGPPPGP--PPGADTGS--------------
Rv1968|M.tuberculosis_H37Rv ------RYPYRPEPPAPPPGGPPPGPPAQ-------------------QP
MSMEG_0348|M.smegmatis_MC2_155 ------RYPYREPPPAPAPGGPPPGPPAPPVPGLESTPSPTPSPVYVPAP
MMAR_4053|M.marinum_M ------RYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPSSVLVPAP
MUL_3920|M.ulcerans_Agy99 ------RYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPSSVLVPAP
MAV_2534|M.avium_104 ASSGPGCYPYREPLPAPPPGGPPPGPPAQPGQGAGQS---------APLP
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0177|M.bovis_AF2122/97 G---LPIAGRPGEVPPNVPGTPVPIPQEAPPGARTLPLGPAPGPAPPPAA
MLBr_02591|M.leprae_Br4923 G---IAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPA---AP---A
Mflv_0650|M.gilvum_PYR-GCK DEVAPGPTDSSIPQGRR-----------------
Mvan_0515|M.vanbaalenii_PYR-1 DEVAPGPTDSSIPQGRR-----------------
TH_4469|M.thermoresistible__bu ENAGNGEQ--------------------------
Rv1968|M.tuberculosis_H37Rv GDQP------------------------------
MSMEG_0348|M.smegmatis_MC2_155 GEPTTPIPAGEGR---------------------
MMAR_4053|M.marinum_M GEVSAPQTAGAGR---------------------
MUL_3920|M.ulcerans_Agy99 GEVSAPQTAGAGR---------------------
MAV_2534|M.avium_104 GPAQ-PGEGGEGR---------------------
MAB_4151c|M.abscessus_ATCC_199 ----------------------------------
Mb0177|M.bovis_AF2122/97 PGPPAPPGPGPQLPAPFINPGGTGGSGVTGGSEN
MLBr_02591|M.leprae_Br4923 QDSSAPHEPREQLSAPLINPGGTGGSGGAGGSRN