For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MAKTIVITGASDGIGRAAARILRDAGHTIVVVGRSLEKTKAIADELGCRHHIGDFARLEDVRRLAGELLE QYPVIDVLCNNAGGIMADRRTTVDGHEMTLQVNHLAPFLLTTLVLPRLISSKATVIATSSSVNRRGRIRL DDLEGERRYSATGAYSAAKLANILFTKELHRRYADAGVTAVSFEPGPVASNFGADSTLLMRLIYHSVANR FLLSPTRGADTLAWLADSRPDVDWSSGLHYRKRKPVKPSRLADDAALGRQLWKQSELMVQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1829 | - | - | 100% (270) | retinol dehydrogenase 14 |
| M. avium 104 | MAV_1610 | - | 1e-63 | 51.13% (266) | NAD dependent epimerase/dehydratase family protein |
| M. avium 104 | MAV_4710 | - | 8e-30 | 35.82% (282) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0447c | - | 3e-31 | 35.21% (284) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0143 | - | 9e-27 | 34.15% (284) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0439c | - | 4e-31 | 35.21% (284) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00315 | - | 1e-26 | 36.82% (220) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0646c | - | 2e-32 | 36.32% (223) | short chain dehydrogenase |
| M. marinum M | MMAR_3998 | - | 1e-58 | 47.19% (267) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0863 | - | 5e-34 | 36.81% (288) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4179 | - | 9e-27 | 35.24% (210) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3862 | - | 6e-57 | 46.07% (267) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0762 | - | 1e-30 | 35.74% (277) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0863|M.smegmatis_MC2_155 MSADT----KWTEADVPDQSGRVAIVTGSNTGLGYETARALAAKGAHVVI
TH_4179|M.thermoresistible__bu MTG------KWTARDVPDQTGRTAVITGANTGLGFETAKVLAEKGAHVVL
Mb0447c|M.bovis_AF2122/97 MTANDNKTRKWSAADVPDQSGRVVVVTGANTGIGYHTAAVFADRGAHVVL
Rv0439c|M.tuberculosis_H37Rv MTANDNKTRKWSAADVPDQSGRVVVVTGANTGIGYHTAAVFADRGAHVVL
MLBr_00315|M.leprae_Br4923 -------MAKWTTADIPDQTGRVAVITGANTGLGYQTALALAEHGAHVVL
MAB_0646c|M.abscessus_ATCC_199 MSRS---TTKWSTTDIPDQTGRIAIVTGANTGLGLETAKALAAHGAHVVL
Mflv_0143|M.gilvum_PYR-GCK MTDWTN----WNVADIPDQTGRTAVITGANTGLGFETAKALAEKGARVVI
Mvan_0762|M.vanbaalenii_PYR-1 MTDWT-------TADIPDQTGRTAVITGANTGLGFETAKALAAGGARVVL
MMAR_3998|M.marinum_M ------------------MTGKTIVITGASDGIGAAAARRLTQNGEKVVV
MUL_3862|M.ulcerans_Agy99 ------------------MTGKTIVITGASDGIGAGAARRLTQNGEKVVV
MAV_1829|M.avium_104 -------------------MAKTIVITGASDGIGRAAARILRDAGHTIVV
.: ::**:. *:* :* : * :*:
MSMEG_0863|M.smegmatis_MC2_155 AVRNLDKGRDAVDRIMASTPKADLKLQKLDVGSLDSVRTAADELKGAYPH
TH_4179|M.thermoresistible__bu AVRDPDKGRRAADRITAAAPHADVTVRQLDLTSLDNIRRAADDLRAGYPR
Mb0447c|M.bovis_AF2122/97 AVRNLEKGNAARARIMAARPGAHVTLQQLDLCSLDSVRAAADALRTAYPR
Rv0439c|M.tuberculosis_H37Rv AVRNLEKGNAARARIMAARPGAHVTLQQLDLCSLDSVRAAADALRTAYPR
MLBr_00315|M.leprae_Br4923 AVRNLDKGKDAAARITATSAQNNVALQELDLASLESVRAAAKQLRSDYDH
MAB_0646c|M.abscessus_ATCC_199 AVRNAEKGKAAAEAITAAHSNADVTLQSLDLSSLESVRRASDELKGRYDK
Mflv_0143|M.gilvum_PYR-GCK AVRNTDKGAQAAARIRG-----DVDVQELDLTSLSSIRTAAEALKARFDK
Mvan_0762|M.vanbaalenii_PYR-1 AVRDTEKGAQAAAKMAG-----DVDVQQLDLTSLASIRSAADALKSRFDH
MMAR_3998|M.marinum_M VGRSESKTTAVAAQLRAD-------YFVADFADLSQVRALADKIRSEYPR
MUL_3862|M.ulcerans_Agy99 VGRSESKTTAVAAQLRAD-------YFVADFADLSQVRALADKIRSEYPR
MAV_1829|M.avium_104 VGRSLEKTKAIADELGCR-------HHIGDFARLEDVRRLAGELLEQYPV
. *. .* : *. * .:* : : :
MSMEG_0863|M.smegmatis_MC2_155 IDLLINNAGVMYPPKQTTVDGFELQFGTNHLGPFALTGLLIDHLLPVEGS
TH_4179|M.thermoresistible__bu IDLLINNAGVMYPPRQTTRDGFELQFGTNHLGHFALTGQLLDNILPVDGS
Mb0447c|M.bovis_AF2122/97 IDVLINNAGVMWTPKQVTKDGFELQFGTNHLGHFALTGLVLDHMLPVPGS
Rv0439c|M.tuberculosis_H37Rv IDVLINNAGVMWTPKQVTKDGFELQFGTNHLGHFALTGLVLDHMLPVPGS
MLBr_00315|M.leprae_Br4923 IDLLINNAGVMWTPKSTTKDGFELQFGTNHLGHFAFTGLLLDRLLPIVGS
MAB_0646c|M.abscessus_ATCC_199 IDLLINNAGVMWTEKSSTADGFELQFGTNHLGHYALTGLLLERLLPVEGS
Mflv_0143|M.gilvum_PYR-GCK IDLLINNAGVMTTPKGTTADGFELQFGTNHLGHFALTGLLFDNILDIPGS
Mvan_0762|M.vanbaalenii_PYR-1 IDLLINNAGVMTTPKGTTADGFELQFGTNHLGHFAFTGLLLDKLLDVDGA
MMAR_3998|M.marinum_M IDVLANNAGAMCHEIQFTADGYEKTYQVNYLSPFLLTTLLLDVLVQSR-A
MUL_3862|M.ulcerans_Agy99 IDVLANNAGAMCHEFQLTADAYEKTYQVNYLSSFLLTTLRLDVLVQSR-A
MAV_1829|M.avium_104 IDVLCNNAGGIMADRRTTVDGHEMTLQVNHLAPFLLTTLVLPRLISSK-A
**:* **** : * *..* .*:*. : :* : :: :
MSMEG_0863|M.smegmatis_MC2_155 RVVAVASVAHRIRAKIHFEDLQWERRYNRVEAYGQSKLANLLFAYELQRR
TH_4179|M.thermoresistible__bu RVVTVASIAHRNMADIHFDDLQWERGYHRVAAYGQSKLANLMFAYELQRR
Mb0447c|M.bovis_AF2122/97 RVVTVSSQGHRIHAAIHFDDLQWERRYNRVAAYGQAKLANLLFTYELQRR
Rv0439c|M.tuberculosis_H37Rv RVVTVSSQGHRIHAAIHFDDLQWERRYNRVAAYGQAKLANLLFTYELQRR
MLBr_00315|M.leprae_Br4923 RVITVSSLSHRLFADIHFNDLQWECNYNRVAAYGQSKLANLLFTYELQRR
MAB_0646c|M.abscessus_ATCC_199 RVVTVSSIGHRIRADIHFDDLQWERDYDRVAAYGQSKLANLLFTYELQRR
Mflv_0143|M.gilvum_PYR-GCK RIVTVSSNGHKMGGAIHWDDLQWERSYNRMGAYTQSKLANLLFTYELQRR
Mvan_0762|M.vanbaalenii_PYR-1 RIVTVSSNGHKMGGAIHWDDLQWERSYSRMGAYSQSKLANLLFTYELQRR
MMAR_3998|M.marinum_M TVVNTTSSSQRLLPKVTLAELESTAQRRPSVAYALTKLAIVLFTRELHRR
MUL_3862|M.ulcerans_Agy99 TVVNTTSSSQRLLPKVTLAELENTAQRRPSVAYALTKLAIVLFTRELHRR
MAV_1829|M.avium_104 TVIATSSSVNRRG-RIRLDDLEGERRYSATGAYSAAKLANILFTKELHRR
:: .:* :: : :*: ** :*** ::*: **:**
MSMEG_0863|M.smegmatis_MC2_155 LAAAGKPTISVAAHPGLSNTELMRHIPGTGLPGYHQIAS-LFSNSPLMGA
TH_4179|M.thermoresistible__bu LSAKNAPTISVAAHPGVSNTELTRYIPGARLPGVSLLAG-LLTNSPAVGA
Mb0447c|M.bovis_AF2122/97 LGEAGKSTIAVAAHPGGSNTELTRNLPRLIRPVATVLGP-LLFQSPEMGA
Rv0439c|M.tuberculosis_H37Rv LGEAGKSTIAVAAHPGGSNTELTRNLPRLIRPVATVLGP-LLFQSPEMGA
MLBr_00315|M.leprae_Br4923 LATR-QTTIAVAAHPGGSRTELTRTLPALIAPIFSVAEL-FLTQDAATGA
MAB_0646c|M.abscessus_ATCC_199 LAG--TNTVALAAHPGGSNTELARNSPLWVRAVFDVVAP-VLVQGADMGA
Mflv_0143|M.gilvum_PYR-GCK LAPR-GKTIAVAAHPGTSTTELARNLPRPVERAFLAAAPVLFAQTADRGA
Mvan_0762|M.vanbaalenii_PYR-1 LAPR-GKTIAVAAHPGTSSTELGRNLPAALQPALNRLAP-LLAQSPAAGA
MMAR_3998|M.marinum_M YHAKGLSAATFHPGYVDSNFGEASGSRALAFMKYHVPLVARLTSTAEQGA
MUL_3862|M.ulcerans_Agy99 YHAKGLSAATFHPGYVDSNFGEASGSRALAFMKYHVPLVTRFTSTAEQGA
MAV_1829|M.avium_104 YADAGVTAVSFEPGPVASNFGADS--TLLMRLIYHS-VANRFLLSPTRGA
: :. . * : . **
MSMEG_0863|M.smegmatis_MC2_155 LATLRAATDPGVKGGQYYGPDGFREVRGHPELVKSSSQSRDPELQRRLWA
TH_4179|M.thermoresistible__bu LATLRAATDPEVKGGQYYGPDGFQEIRGHPVLVGSSAKSRDEDIQRRLWT
Mb0447c|M.bovis_AF2122/97 LPTLRAATDPTTQGGQYYGPDGFGEQRGHPKVVQSSAQSHDKDLQRRLWT
Rv0439c|M.tuberculosis_H37Rv LPTLRAATDPTTQGGQYYGPDGFGEQRGHPKVVQSSAQSHDKDLQRRLWT
MLBr_00315|M.leprae_Br4923 LPTLRAATDAAVLGGQYFGPDGFAEIRGHPKVVASNGKSHDVDRQLRLWA
MAB_0646c|M.abscessus_ATCC_199 LPTLRAATDPAALGGQYYGPDGFMEQRGNPKVVASSEQSYNLDLQRRLWS
Mflv_0143|M.gilvum_PYR-GCK LPTLRAAADPGVLGGQYYGPDGLGQQRGAPVVVASSAQSYDVDQQRRLWE
Mvan_0762|M.vanbaalenii_PYR-1 LPTLRAATDPSVLGGQYYGPDGIGQQRGNPVVVASSNQSYDMALQRRLWT
MMAR_3998|M.marinum_M EQLVWLASSAAGTDWTSG------EYYSRHKIAKANRAAYDPRLASELWD
MUL_3862|M.ulcerans_Agy99 EQLVWLASSAAGTDWTSG------EYYSRHKIARANRAAYDPRLASELWD
MAV_1829|M.avium_104 DTLAWLADSRPDVDWSSG------LHYRKRKPVKPSRLADDAALGRQLWK
* . . . .. : : .**
MSMEG_0863|M.smegmatis_MC2_155 VSEELTGVSYPV------------------------
TH_4179|M.thermoresistible__bu VSEELTGVTFPV------------------------
Mb0447c|M.bovis_AF2122/97 VSEELTGVSFGV------------------------
Rv0439c|M.tuberculosis_H37Rv VSEELTGVSFGV------------------------
MLBr_00315|M.leprae_Br4923 VSEELTGVVYPVG-----------------------
MAB_0646c|M.abscessus_ATCC_199 VSEELTDVVFPVK-----------------------
Mflv_0143|M.gilvum_PYR-GCK ISEELTKVTFPDL-----------------------
Mvan_0762|M.vanbaalenii_PYR-1 VSEELTGVTFPVPVLS--------------------
MMAR_3998|M.marinum_M RTLAKLR-----------------------------
MUL_3862|M.ulcerans_Agy99 RTLAKLRREARPATSGIHQIVKSIMPLTMSPLSRSV
MAV_1829|M.avium_104 QSELMVQ-----------------------------
: