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M. avium 104 MAV_1812 (-)

annotation: 3-hydroxyacyl-CoA dehydrogenase type-2
coordinates: 1807816 - 1808595
length: 259

TIKQFEGASAIVSGGAGGLGEATVRRLHADGLGVVIADLAAEKGKALADELGNRAEFVSTNVTSEDSVLA
AIEAANQLGRLRYAVVAHGGFGVAQRIVQRDGSPADMGGFTKTIDLYLNGTYNVARLVAASIAAAEPREN
GERGALVLTASIAGYEGQIGQTAYAAAKAGVIGLTIAAARDLSSAGIRVNTIAPGTMKTPIMESVGEEAL
AKFAANIPFPKRLGTPDEFADAAAFLLTNGYINGEVMRLDGAQRFTPK*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. avium 104 MAV_1812 - - 100% (259) 3-hydroxyacyl-CoA dehydrogenase type-2
M. avium 104 MAV_2552 - e-127 87.64% (259) 3-hydroxyacyl-CoA dehydrogenase type-2
M. avium 104 MAV_1285 - 3e-54 46.12% (258) 3-hydroxyacyl-CoA dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1176 - 5e-53 46.61% (251) short-chain type dehydrogenase/reductase
M. gilvum PYR-GCK Mflv_2127 - 2e-59 49.02% (255) short-chain dehydrogenase/reductase SDR
M. tuberculosis H37Rv Rv1144 - 5e-53 46.61% (251) short-chain type dehydrogenase/reductase
M. leprae Br4923 MLBr_01807 fabG1 6e-22 30.52% (249) 3-oxoacyl-
M. abscessus ATCC 19977 MAB_0368 - 6e-59 50.19% (259) Short-chain dehydrogenase/reductas
M. marinum M MMAR_4307 - 1e-54 45.14% (257) short-chain type dehydrogenase/reductase
M. smegmatis MC2 155 MSMEG_4871 - 4e-74 56.86% (255) 3-hydroxyacyl-CoA dehydrogenase type-2
M. thermoresistible (build 8) TH_3346 - 2e-71 55.69% (255) PUTATIVE short-chain dehydrogenase/reductase SDR
M. ulcerans Agy99 MUL_0987 - 1e-54 45.14% (257) short-chain type dehydrogenase/reductase
M. vanbaalenii PYR-1 Mvan_4251 - 7e-72 56.08% (255) short-chain dehydrogenase/reductase SDR

CLUSTAL 2.0.9 multiple sequence alignment


TH_3346|M.thermoresistible__bu      ----------------MQIAGSAALVVGGAGGLGEATVRRLHAAGAKVVV
Mvan_4251|M.vanbaalenii_PYR-1       ----------------MQIAGSSALVVGGAGGLGEATVRRLHDAGAKVVI
MSMEG_4871|M.smegmatis_MC2_155      ----------------MQIAGTSALVVGGTGGLGEATVRRLHGAGAKVVV
MAV_1812|M.avium_104                -------------MTIKQFEGASAIVSGGAGGLGEATVRRLHADGLGVVI
MMAR_4307|M.marinum_M               ----------------MEIRDAVAVVTGGASGLGLATTKRLLDAGAQVVV
MUL_0987|M.ulcerans_Agy99           ----------------MEIRDAVAVVTGGASGLGLATTKRLLDAGAQVVV
Mb1176|M.bovis_AF2122/97            ----------------MKTKDAVAVVTGGASGLGLATTKRLLDAGAQVVV
Rv1144|M.tuberculosis_H37Rv         ----------------MKTKDAVAVVTGGASGLGLATTKRLLDAGAQVVV
Mflv_2127|M.gilvum_PYR-GCK          ----------------MEIKDAAAVVTGGASGLGLATTKRLLDRGASVVV
MAB_0368|M.abscessus_ATCC_1997      ----------------MDINGVSAIVTGGASGLGAATARLLAAQGAKVVI
MLBr_01807|M.leprae_Br4923          MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
                                                        .   :* **  *:* *..: *   *  *.:

TH_3346|M.thermoresistible__bu      ADLADERGGELEKELG--VRYVRTDATSEQDVLAAIAEAESLG-PLRISV
Mvan_4251|M.vanbaalenii_PYR-1       ADLADDKGRQLESELG--VRYVRTDATSEESVNAAITEAESLG-PLRISV
MSMEG_4871|M.smegmatis_MC2_155      ADVADDKGAALEKELG--IRYVRTDATSEESVLAAIAEAESLA-PLRISV
MAV_1812|M.avium_104                ADLAAEKGKALADELGNRAEFVSTNVTSEDSVLAAIEAANQLG-RLRYAV
MMAR_4307|M.marinum_M               LDIR---GEDVVADLGDRARFAAADVTDEAAVASALDLAETMG-TLRIVV
MUL_0987|M.ulcerans_Agy99           LDIR---GEDVVADLGDRARFAAADVTDEAAVASALDLAETMG-TLRIVV
Mb1176|M.bovis_AF2122/97            VDLR---GDDVVGGLGDRARFAQADVTDEAAVSNALELADSLG-PVRVVV
Rv1144|M.tuberculosis_H37Rv         VDLR---GDDVVGGLGDRARFAQADVTDEAAVSNALELADSLG-PVRVVV
Mflv_2127|M.gilvum_PYR-GCK          IDLK---GEDVVAELGPRAKFVEANVTDPEQVAAALDAAEEFG-PLRINV
MAB_0368|M.abscessus_ATCC_1997      ADVQDEKGEALAKELGG--AFVHTDVTSEADGIAAVDAAKELG-PVRVLI
MLBr_01807|M.leprae_Br4923          THRAS--------VVPDWFFGVECDVTDNDAIGAAFKAVEEHQGPVEVLV
                                     .            :      .  :.*.      *.  ..     :.  :

TH_3346|M.thermoresistible__bu      DTHGGPAGGGRLVGKDGSPLG---LEAFETTIKYYLTAVFNIMRLTAAAI
Mvan_4251|M.vanbaalenii_PYR-1       DTHGGPAGGGRLVGKDGSPLS---MEAFETTIKFYLTAVFNIMRLSAAAI
MSMEG_4871|M.smegmatis_MC2_155      DTHGGPASGGRLVGKDGSPLD---LDGFKKTIEFYLTAVFNVMRLTAAAI
MAV_1812|M.avium_104                VAHGGFGVAQRIVQRDGSPAD---MGGFTKTIDLYLNGTYNVARLVAASI
MMAR_4307|M.marinum_M               NCAG-TGNAIRVLSRDGVFP----LAAFRKIVDINLVGSFNVLRLAAERI
MUL_0987|M.ulcerans_Agy99           NCAG-TGNAIRVLSRDGVFS----LAAFRKIVDINLVGSFNVLRLAAERI
Mb1176|M.bovis_AF2122/97            NCAG-TGNAIRVLSRDGVFP----LAAFRKIVDINLVGTFNVLRLGAERI
Rv1144|M.tuberculosis_H37Rv         NCAG-TGNAIRVLSRDGVFP----LAAFRKIVDINLVGTFNVLRLGAERI
Mflv_2127|M.gilvum_PYR-GCK          NCAG-IGNAIKTLSKDGPFP----LDGFTKVIQVNLIGTFNVLRLAAERM
MAB_0368|M.abscessus_ATCC_1997      NCAG-VGWPGRTIGKDGQYASAHSLDIFSKVIGINLIGSFNLIRLAATAI
MLBr_01807|M.leprae_Br4923          ANAGITSDMLIMRMSE---------EQFQKVIDVNLTGVFRVAKLASRNM
                                       *  .        :           * . :   * . :.: :* :  :

TH_3346|M.thermoresistible__bu      GRTEPLE--EGGRGVIVNTASIAGYEGQIGQLPYAAAKGGVIGMTLNAAR
Mvan_4251|M.vanbaalenii_PYR-1       AKTEPLE--EGGRGVIVNTASVAGYEGQIGQLPYSAAKGGVIGMTLVAAR
MSMEG_4871|M.smegmatis_MC2_155      ARTEPLE--EGGRGVIVNTASIAGYEGQIGQLPYAAAKGGVLGMTLVAAR
MAV_1812|M.avium_104                AAAEPRE--NGERGALVLTASIAGYEGQIGQTAYAAAKAGVIGLTIAAAR
MMAR_4307|M.marinum_M               AKTEPVGPNAEERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIAR
MUL_0987|M.ulcerans_Agy99           AKTEPVGPNAEERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIAR
Mb1176|M.bovis_AF2122/97            AKTEPIG---EERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIAR
Rv1144|M.tuberculosis_H37Rv         AKTEPIG---EERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIAR
Mflv_2127|M.gilvum_PYR-GCK          AKQEPIN---GERGVIINTASVAAFEGQIGQAAYSASKGGVVGMTLPIAR
MAB_0368|M.abscessus_ATCC_1997      SQEEPVD-EFGERGAIVNTASVAAFDGQIGQAAYSASKGGIVGMTLPIAR
MLBr_01807|M.leprae_Br4923          IKQ--------RFGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLAR
                                                 *  :  .*:.. .*  **  *:*:*.*::*::   **

TH_3346|M.thermoresistible__bu      DLSPLGIRVVTIAPGTINTPAYGQ--HADQLEAYWGPQVPFPKRMGRSTE
Mvan_4251|M.vanbaalenii_PYR-1       DLSPLGIRVVTIAPGTINTPAYGK--AADQLEQYWGPQVPFPKRMGRSTE
MSMEG_4871|M.smegmatis_MC2_155      DLSPLGIRVVTIAPGTINTPAYGQ--AADQLEEYWGPQVPFPKRMGRSTE
MAV_1812|M.avium_104                DLSSAGIRVNTIAPGTMKTPIMES--VGEEALAKFAANIPFPKRLGTPDE
MMAR_4307|M.marinum_M               DLASHRIRVMTIAPGLFDTPLLAS--LPEEARASLGKQVPHPSRLGSPDE
MUL_0987|M.ulcerans_Agy99           DLASHRIRVMTIAPGLFDTPLLAS--LPEEARASLGKQVPHPSRLGNPDE
Mb1176|M.bovis_AF2122/97            DLASKLIRVVTIAPGLFDTPLLAS--LPAEAKASLGQQVPHPSRLGNPDE
Rv1144|M.tuberculosis_H37Rv         DLASKLIRVVTIAPGLFDTPLLAS--LPAEAKASLGQQVPHPSRLGNPDE
Mflv_2127|M.gilvum_PYR-GCK          DLSREFIRVCTIAPGLFKTPLLGS--LPEEAQASLGKQVPHPARLGDPDE
MAB_0368|M.abscessus_ATCC_1997      DLSVVGIRVNTIAPGLIDTPIYGEGESAQQFKDRLAPNVLYPQRLGNPEE
MLBr_01807|M.leprae_Br4923          ELGSRSITANVVAPGFIDTEMTRA---MDSKYQEAALQAIPLGRIGAVEE
                                    :*.   * . .:*** :.*          .     . :     *:*   *

TH_3346|M.thermoresistible__bu      YAQLAQSIIEN--DYLNGEIIRLDGALRFPPK
Mvan_4251|M.vanbaalenii_PYR-1       YAQLAQSVIEN--DYLNGEVIRLDGALRFPPK
MSMEG_4871|M.smegmatis_MC2_155      YAQLAQSIVEN--DYLNGEVIRLDGALRFPPK
MAV_1812|M.avium_104                FADAAAFLLTN--GYINGEVMRLDGAQRFTPK
MMAR_4307|M.marinum_M               YGALAVHIIEN--PMLNGEVIRLDGAIRMAPR
MUL_0987|M.ulcerans_Agy99           YGALAVHIIEN--PMLNGEVIRLDGAIRMAPR
Mb1176|M.bovis_AF2122/97            YGALVLHIIEN--PMLNGEVIRLDGAIRMAPR
Rv1144|M.tuberculosis_H37Rv         YGALVLHIIEN--PMLNGEVIRLDGAIRMAPR
Mflv_2127|M.gilvum_PYR-GCK          YGALAVHIVEN--PMLNGETIRLDGAIRMAPR
MAB_0368|M.abscessus_ATCC_1997      FASLALELVTN--SYMNAETIRIDGGARLQPK
MLBr_01807|M.leprae_Br4923          IAGAVSFLASEDAGYISGAVIPVDGGLGMGH-
                                     .  .  :  :    :..  : :**.  :

species	id	gene	e-value	identity (len)	annotation
M. avium 104	MAV_1812	-	-	100% (259)	3-hydroxyacyl-CoA dehydrogenase type-2
M. avium 104	MAV_2552	-	e-127	87.64% (259)	3-hydroxyacyl-CoA dehydrogenase type-2
M. avium 104	MAV_1285	-	3e-54	46.12% (258)	3-hydroxyacyl-CoA dehydrogenase