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M. tuberculosis H37Rv Rv1144 (-)

annotation: PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE
coordinates: 1271156 - 1271908
length: 250

MKTKDAVAVVTGGASGLGLATTKRLLDAGAQVVVVDLRGDDVVGGLGDRARFAQADVTDEAAVSNALELA
DSLGPVRVVVNCAGTGNAIRVLSRDGVFPLAAFRKIVDINLVGTFNVLRLGAERIAKTEPIGEERGVIIN
TASVAAFDGQIGQAAYSASKGGVVGMTLPIARDLASKLIRVVTIAPGLFDTPLLASLPAEAKASLGQQVP
HPSRLGNPDEYGALVLHIIENPMLNGEVIRLDGAIRMAPR

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv1144 - - 100% (250) PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE
M. tuberculosis H37Rv Rv1350 fabG 2e-23 33.20% (247) 3-ketoacyl-(acyl-carrier-protein) reductase
M. tuberculosis H37Rv Rv2857c - 1e-21 31.87% (251) short chain dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1176 - 1e-136 100.00% (250) short-chain type dehydrogenase/reductase
M. gilvum PYR-GCK Mflv_2127 - 1e-104 74.40% (250) short-chain dehydrogenase/reductase SDR
M. leprae Br4923 MLBr_01807 fabG1 1e-23 30.58% (242) 3-oxoacyl-
M. abscessus ATCC 19977 MAB_0368 - 1e-62 51.18% (254) Short-chain dehydrogenase/reductas
M. marinum M MMAR_4307 - 1e-120 86.96% (253) short-chain type dehydrogenase/reductase
M. avium 104 MAV_1285 - 1e-113 81.10% (254) 3-hydroxyacyl-CoA dehydrogenase
M. smegmatis MC2 155 MSMEG_5183 - 1e-111 79.84% (253) 3-hydroxyacyl-CoA dehydrogenase
M. thermoresistible (build 8) TH_1987 - 1e-110 78.49% (251) 3-Hydroxyacyl-CoA dehydrogenase
M. ulcerans Agy99 MUL_0987 - 1e-120 86.96% (253) short-chain type dehydrogenase/reductase
M. vanbaalenii PYR-1 Mvan_4577 - 1e-104 74.40% (250) short-chain dehydrogenase/reductase SDR

CLUSTAL 2.0.9 multiple sequence alignment


Rv1144|M.tuberculosis_H37Rv         ----------------MKTKDAVAVVTGGASGLGLATTKRLLDAGAQVVV
Mb1176|M.bovis_AF2122/97            ----------------MKTKDAVAVVTGGASGLGLATTKRLLDAGAQVVV
MMAR_4307|M.marinum_M               ----------------MEIRDAVAVVTGGASGLGLATTKRLLDAGAQVVV
MUL_0987|M.ulcerans_Agy99           ----------------MEIRDAVAVVTGGASGLGLATTKRLLDAGAQVVV
Mflv_2127|M.gilvum_PYR-GCK          ----------------MEIKDAAAVVTGGASGLGLATTKRLLDRGASVVV
Mvan_4577|M.vanbaalenii_PYR-1       ----------------MEIKDAVAVVTGGASGLGLATTKRLLDRGASVVV
MAV_1285|M.avium_104                ----------------MEIKDAVAVVTGGASGLGLATTKRLLDRGAQVVV
TH_1987|M.thermoresistible__bu      ----------------VEIKDSVAVVTGGASGLGLATTKRLLDRGAQVVV
MSMEG_5183|M.smegmatis_MC2_155      ----------------MEIKDAVAVVTGGASGLGLATTKRLLDAGAQVVV
MAB_0368|M.abscessus_ATCC_1997      ----------------MDINGVSAIVTGGASGLGAATARLLAAQGAKVVI
MLBr_01807|M.leprae_Br4923          MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
                                                        .   :****  *:* *.:: *   *  *.:

Rv1144|M.tuberculosis_H37Rv         VDLR---GDDVVGGLGDRARFAQADVTDEAAVSNALELADSLG-PVRVVV
Mb1176|M.bovis_AF2122/97            VDLR---GDDVVGGLGDRARFAQADVTDEAAVSNALELADSLG-PVRVVV
MMAR_4307|M.marinum_M               LDIR---GEDVVADLGDRARFAAADVTDEAAVASALDLAETMG-TLRIVV
MUL_0987|M.ulcerans_Agy99           LDIR---GEDVVADLGDRARFAAADVTDEAAVASALDLAETMG-TLRIVV
Mflv_2127|M.gilvum_PYR-GCK          IDLK---GEDVVAELGPRAKFVEANVTDPEQVAAALDAAEEFG-PLRINV
Mvan_4577|M.vanbaalenii_PYR-1       MDLR---GEEAVKELDARAKFVETNVTDPEQVAAALDAAEEMG-PLRIDV
MAV_1285|M.avium_104                IDLR---GEDAVRELGDRARFVQADVTDEAAVGKALDTAESMG-PLRINV
TH_1987|M.thermoresistible__bu      LDLK---GEDAVKALGDRARFVETNVTDEAAVAKALDVAEEMG-PVRINV
MSMEG_5183|M.smegmatis_MC2_155      IDLK---GEEVVAELGDRAKFVATDVTDEAGVTEALNVAESLG-PVRINV
MAB_0368|M.abscessus_ATCC_1997      ADVQDEKGEALAKELGG--AFVHTDVTSEADGIAAVDAAKELG-PVRVLI
MLBr_01807|M.leprae_Br4923          THRA--------SVVPDWFFGVECDVTDNDAIGAAFKAVEEHQGPVEVLV
                                     .            :      .  :**.      *.. ..    .:.: :

Rv1144|M.tuberculosis_H37Rv         NCAGTGNAIRVLSRDGVFP----LAAFRKIVDINLVGTFNVLRLGAERIA
Mb1176|M.bovis_AF2122/97            NCAGTGNAIRVLSRDGVFP----LAAFRKIVDINLVGTFNVLRLGAERIA
MMAR_4307|M.marinum_M               NCAGTGNAIRVLSRDGVFP----LAAFRKIVDINLVGSFNVLRLAAERIA
MUL_0987|M.ulcerans_Agy99           NCAGTGNAIRVLSRDGVFS----LAAFRKIVDINLVGSFNVLRLAAERIA
Mflv_2127|M.gilvum_PYR-GCK          NCAGIGNAIKTLSKDGPFP----LDGFTKVIQVNLIGTFNVLRLAAERMA
Mvan_4577|M.vanbaalenii_PYR-1       NCAGIGNAAKTLSKDGPFP----LDAFKKVVEVNLIGTFNVIRLAAERIA
MAV_1285|M.avium_104                NCAGIGNAIKTLSKDGPFP----LDAFKKVVGVNLIGTFNVLRLAAERIA
TH_1987|M.thermoresistible__bu      NCAGIGNAIKTLSKNGPFP----LDEFTKVIQVNLIGTFNVLRLAAERIA
MSMEG_5183|M.smegmatis_MC2_155      NCAGIGNAIKTLSKNGPFP----LDGFRKVVEVNLIGTFNVIRLSAERIA
MAB_0368|M.abscessus_ATCC_1997      NCAGVGWPGRTIGKDGQYASAHSLDIFSKVIGINLIGSFNLIRLAATAIS
MLBr_01807|M.leprae_Br4923          ANAGITSDMLIMRMS--------EEQFQKVIDVNLTGVFRVAKLASRNMI
                                      **       :  .           * *:: :** * *.: :*.:  : 

Rv1144|M.tuberculosis_H37Rv         KTEPIG----EERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIAR
Mb1176|M.bovis_AF2122/97            KTEPIG----EERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIAR
MMAR_4307|M.marinum_M               KTEPVGP-NAEERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIAR
MUL_0987|M.ulcerans_Agy99           KTEPVGP-NAEERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIAR
Mflv_2127|M.gilvum_PYR-GCK          KQEPING----ERGVIINTASVAAFEGQIGQAAYSASKGGVVGMTLPIAR
Mvan_4577|M.vanbaalenii_PYR-1       KQEPING----ERGVIINTASVAAFEGQIGQAAYSASKGGVVGMTLPIAR
MAV_1285|M.avium_104                KTEPIGPGTSPERGVIINTASVAAFEGQIGQAAYSASKGGVVGMTLPIAR
TH_1987|M.thermoresistible__bu      KTEPLKG---EERGVIINTASVAAFEGQIGQAAYSASKGGVVGMTLPIAR
MSMEG_5183|M.smegmatis_MC2_155      KTEPIGP-NGEERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIAR
MAB_0368|M.abscessus_ATCC_1997      QEEPVDEFG--ERGAIVNTASVAAFDGQIGQAAYSASKGGIVGMTLPIAR
MLBr_01807|M.leprae_Br4923          KQ---------RFGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLAR
                                    :          . *  :  .**..:.*  *** *:***.*::**: .:**

Rv1144|M.tuberculosis_H37Rv         DLASKLIRVVTIAPGLFDTPLLAS--LPAEAKASLGQQVPHPSRLGNPDE
Mb1176|M.bovis_AF2122/97            DLASKLIRVVTIAPGLFDTPLLAS--LPAEAKASLGQQVPHPSRLGNPDE
MMAR_4307|M.marinum_M               DLASHRIRVMTIAPGLFDTPLLAS--LPEEARASLGKQVPHPSRLGSPDE
MUL_0987|M.ulcerans_Agy99           DLASHRIRVMTIAPGLFDTPLLAS--LPEEARASLGKQVPHPSRLGNPDE
Mflv_2127|M.gilvum_PYR-GCK          DLSREFIRVCTIAPGLFKTPLLGS--LPEEAQASLGKQVPHPARLGDPDE
Mvan_4577|M.vanbaalenii_PYR-1       DLSRELIRVCTIAPGLFKTPLLGS--LPEEAQASLGKQVPHPARLGDPDE
MAV_1285|M.avium_104                DLARELIRVVTIAPGLFKTPLLGS--LPEEAQASLGKQVPHPARLGDPDE
TH_1987|M.thermoresistible__bu      DLARELIRVVTIAPGLFKTPLLGS--LPEEAQKSLGQQVPHPARLGDPDE
MSMEG_5183|M.smegmatis_MC2_155      DLSRELIRVVTIAPGLFKTPLLGS--LPEEAQKSLGAQVPHPARLGDPDE
MAB_0368|M.abscessus_ATCC_1997      DLSVVGIRVNTIAPGLIDTPIYGEGESAQQFKDRLAPNVLYPQRLGNPEE
MLBr_01807|M.leprae_Br4923          ELGSRSITANVVAPGFIDTEMTRA--MDSKYQEAALQAIPLGRIGAVEEI
                                    :*.   * . .:***::.* :        : :      :      .  : 

Rv1144|M.tuberculosis_H37Rv         YGALVLHIIENP-MLNGEVIRLDGAIRMAPR
Mb1176|M.bovis_AF2122/97            YGALVLHIIENP-MLNGEVIRLDGAIRMAPR
MMAR_4307|M.marinum_M               YGALAVHIIENP-MLNGEVIRLDGAIRMAPR
MUL_0987|M.ulcerans_Agy99           YGALAVHIIENP-MLNGEVIRLDGAIRMAPR
Mflv_2127|M.gilvum_PYR-GCK          YGALAVHIVENP-MLNGETIRLDGAIRMAPR
Mvan_4577|M.vanbaalenii_PYR-1       YGALAVHIVENP-MLNGETIRLDGAIRMAPR
MAV_1285|M.avium_104                YGALAVHIVENP-MLNGEVIRLDGAIRMAPR
TH_1987|M.thermoresistible__bu      YGALAVHIVENP-MLNGEVIRLDGAIRMAPR
MSMEG_5183|M.smegmatis_MC2_155      YGALAQHIIENP-MLNGEVIRLDGAIRMAPR
MAB_0368|M.abscessus_ATCC_1997      FASLALELVTNS-YMNAETIRIDGGARLQPK
MLBr_01807|M.leprae_Br4923          AGAVSFLASEDAGYISGAVIPVDGGLGMGH-
                                     .::      :.  :.. .* :**.  :

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv1144	-	-	100% (250)	PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE
M. tuberculosis H37Rv	Rv1350	fabG	2e-23	33.20% (247)	3-ketoacyl-(acyl-carrier-protein) reductase
M. tuberculosis H37Rv	Rv2857c	-	1e-21	31.87% (251)	short chain dehydrogenase