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DYDLGDDAAQLRSHLRELVANHIPADFLGACTENPQDLATTETFCKLLAAEGLLALAWPKEHGGGGGSVW QQTVLREEMWAQHEPRGPQYMGINWVGPALMRYGTEEQKTKHLAAIAAGDVIWCQGFSEPEAGTDLVSLR TRAVADGDGWRITGQKVWTSYALMASWCVLAACTDPDAPKHKRLTLFLIPMDRPGFTVRPIPSMLGPHHL NEMFLDDVPAYPGDVLGEVGDGWRVMREALAYERVGIARYARCESLLERMRGRLGDEWEQLPESIRARWV RALVDLRVARLLAYRAVSLQDDPASGAAASAARIATTTCDQQVAELLFDVLGPTALDAGSGAPLHGAIED HWRYAQAATVASGTIEVQKMLVARDVLGGHR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1629 | - | - | 100% (382) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1268 | - | 4e-56 | 34.43% (395) | acyl-CoA dehydrogenase domain-containing protein |
| M. avium 104 | MAV_1338 | - | 1e-52 | 34.62% (390) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1969c | fadE17 | 3e-57 | 34.25% (400) | acyl-CoA dehydrogenase FADE17 |
| M. gilvum PYR-GCK | Mflv_1792 | - | 1e-127 | 56.88% (385) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1934c | fadE17 | 3e-57 | 34.25% (400) | acyl-CoA dehydrogenase FADE17 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-25 | 25.71% (389) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0597 | - | 3e-56 | 34.02% (391) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_3981 | fadE17_2 | 0.0 | 85.45% (385) | acyl-CoA dehydrogenase FadE17_2 |
| M. smegmatis MC2 155 | MSMEG_5622 | - | 1e-126 | 55.99% (384) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3217 | - | 1e-122 | 54.71% (393) | PUTATIVE putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_3842 | fadE17_2 | 0.0 | 84.94% (385) | acyl-CoA dehydrogenase FadE17_2 |
| M. vanbaalenii PYR-1 | Mvan_4958 | - | 1e-125 | 56.22% (386) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1969c|M.bovis_AF2122/97 ---MDVSYPPEAEAF--------RDRIREFVAEHLPPGWPGPGAL--PPH
Rv1934c|M.tuberculosis_H37Rv ---MDVSYPPEAEAF--------RDRIREFVAEHLPPGWPGPGAL--PPH
MAB_0597|M.abscessus_ATCC_1997 MVESQVSPAPAGEPMSEMSDDQVRTEIREWLAENLVGEFAELKGLGGPGS
MMAR_3981|M.marinum_M ---MDYDLGDDARQL--------RDRLRRLISEHIPDDFLG-----ACTT
MUL_3842|M.ulcerans_Agy99 ---MDYDLGDDARQL--------RDRLRRLISEHIPDDFLG-----ACTT
MAV_1629|M.avium_104 ---MDYDLGDDAAQL--------RSHLRELVANHIPADFLG-----ACTE
MSMEG_5622|M.smegmatis_MC2_155 ---MDFDLGEDANRL--------RGELRALIDAHVPADFLG-----AFTD
TH_3217|M.thermoresistible__bu -MTLNFDMGADAARL--------RGELRQLIAEHVPAGYLG-----AFTD
Mflv_1792|M.gilvum_PYR-GCK ---MDFDMGKGAADL--------RRELRALVGEHVPEHFLG-----AFTD
Mvan_4958|M.vanbaalenii_PYR-1 ---MDFDMGKRASDL--------RRELRDLVNERVPERFLG-----AFTD
MLBr_00737|M.leprae_Br4923 --MVGWSGNPLFDLFKLP---EEHNELRATIRALAEKEIAP-----HAAD
. : : .:* :
Mb1969c|M.bovis_AF2122/97 EREEFAR--HWRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAG
Rv1934c|M.tuberculosis_H37Rv EREEFAR--HWRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAG
MAB_0597|M.abscessus_ATCC_1997 EHEAFEERLAWNRHLAAAGWTCLGWPVEHGGRGATVSQRVIFYEEYARAE
MMAR_3981|M.marinum_M DPQDLATTESFCKLLAAEDLLALAWPKEHGGGGGSIWQQTVLREEMWARH
MUL_3842|M.ulcerans_Agy99 DPQDLATTESFCKLLAAEDLLALAWPEEHGGGGGSIWQQTVLREEMWARH
MAV_1629|M.avium_104 NPQDLATTETFCKLLAAEGLLALAWPKEHGGGGGSVWQQTVLREEMWAQH
MSMEG_5622|M.smegmatis_MC2_155 DPADLAVAQQFCRTLAERQLLCMSWPREFGGGDASVWEQTVVREEMWAHH
TH_3217|M.thermoresistible__bu DPADLEVAQQFCRTLAERNLLCLSWPSEYGGGDASVWEQTVVREEMWAHH
Mflv_1792|M.gilvum_PYR-GCK DPADLDTAQRFCRMLAERNLLCMAWPEEFGGSGASVWEQTVVREEMWAHH
Mvan_4958|M.vanbaalenii_PYR-1 DPADLETAQAFCRTLAERNLLCLAWPEEFGGGGASVWEQTVVREEMWAHH
MLBr_00737|M.leprae_Br4923 VDQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVD
* .: * *.** . :. **
Mb1969c|M.bovis_AF2122/97 APERAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPE
Rv1934c|M.tuberculosis_H37Rv APERAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPE
MAB_0597|M.abscessus_ATCC_1997 APHKVN--HLGEELLGPTLIAYGTPEQQQRFLPAIRDVTELWCQGYSEPG
MMAR_3981|M.marinum_M EPRGPQ--YMGINWVGPAIMRYGTPAQKTQHLSAIAAGEVVWCQGFSEPE
MUL_3842|M.ulcerans_Agy99 EPRGPQ--YMGINWVGPAIMRYGTPAQKTRHLSAIAAGEVVWCQGFSEPE
MAV_1629|M.avium_104 EPRGPQ--YMGINWVGPALMRYGTEEQKTKHLAAIAAGDVIWCQGFSEPE
MSMEG_5622|M.smegmatis_MC2_155 EPRGAQ--YMGVNWVGPIIMRYGTEEQQRKHLPPIANGEVIWCQGFSEPE
TH_3217|M.thermoresistible__bu EPRGAQ--YMGVNWVGPIIMRHGTEEQQRTHLPPIARGEVIWCQGFSEPE
Mflv_1792|M.gilvum_PYR-GCK EPRGAQ--YMGVNWVGPIIMRHGTEEQQRRHLPPIAAGEVIWCQGFSEPE
Mvan_4958|M.vanbaalenii_PYR-1 EPRGAQ--YMGVNWVGPIIMRHGTEAQQLRHLPPIAAGEVIWCQGFSEPE
MLBr_00737|M.leprae_Br4923 ASASLIPAVNKLGTMG--LILRGSEELKKQVLPSLAAEGAMASYALSERE
. :* :: *: : *. : . . **
Mb1969c|M.bovis_AF2122/97 AGSDLASVRTRGVLDGDE---WVINGHKIWTSAGTTANWIFLLARTDPS-
Rv1934c|M.tuberculosis_H37Rv AGSDLASVRTRGVLDGDE---WVINGHKIWTSAGTTANWIFLLARTDPS-
MAB_0597|M.abscessus_ATCC_1997 AGSDLANVSTSAVLDGGD---WVINGQKVWTSLALQSQWCFVVARTEPG-
MMAR_3981|M.marinum_M AGTDLASLRTRAVPEAPDGPGWRITGQKVWTSYAQMASWCVLAACTHPD-
MUL_3842|M.ulcerans_Agy99 AGTDLASLRTRAVPEAPDGPGWRITGQKVWTSYAQMASWCVLAACTHPD-
MAV_1629|M.avium_104 AGTDLVSLRTRAV---ADGDGWRITGQKVWTSYALMASWCVLAACTDPD-
MSMEG_5622|M.smegmatis_MC2_155 AGSDLASLRTSARRVDD---GWRINGQKIWTSYATMAQWCFLLARTSKG-
TH_3217|M.thermoresistible__bu AGSDLASLRTFARRAGDNPTGWLVNGQKIWTSYATMAQWCFLLARTTRVG
Mflv_1792|M.gilvum_PYR-GCK AGSDLASLRTYAR--ADGD-GWLVSGQKIWTSYATMAQWCFLLARTSRLG
Mvan_4958|M.vanbaalenii_PYR-1 AGSDLASLRTYARRAEDGD-GWLVSGQKIWTSYATMAQWCFLLARTSRVG
MLBr_00737|M.leprae_Br4923 AGSDAASMRTRAKADGDD---WILNGFKCWITNGGKSTWYTVMAVTDPD-
**:* ..: * . * :.* * * : . : * : * *
Mb1969c|M.bovis_AF2122/97 ----AAKHRGLSFLLVPMDQPGVVVRPIVNAAGH--SSFSEVFLTDARTS
Rv1934c|M.tuberculosis_H37Rv ----AAKHRGLSFLLVPMDQPGVVVRPIVNAAGH--SSFSEVFLTDARTS
MAB_0597|M.abscessus_ATCC_1997 ----SSRHKGLSYLLVPLDQPGVEIRPIIQLTGT--SEFNEVFFDNARTS
MMAR_3981|M.marinum_M ----APKPKRLTLFLLPMDRPGFTVRPIPSMLGP--HHLNEMFLDEVPAS
MUL_3842|M.ulcerans_Agy99 ----ARKPKRLTLFLLPMDRPGFTVRPIPSMLGP--HHLNEMFLDEVPAS
MAV_1629|M.avium_104 ----APKHKRLTLFLIPMDRPGFTVRPIPSMLGP--HHLNEMFLDDVPAY
MSMEG_5622|M.smegmatis_MC2_155 ----EKKQQGLTIFLVSMDDPAITVRPIRTMMGP--HHLNEVFFDDLEVT
TH_3217|M.thermoresistible__bu DGGVQRKQQGLTVFLVPMDRPGIQVRPIRTMMGP--HHLNEVFFDDVPVT
Mflv_1792|M.gilvum_PYR-GCK EGATQKKQQGLTIFLVPMDDPAITVRPIRTMLGP--HHLNEVFFDDLRVT
Mvan_4958|M.vanbaalenii_PYR-1 EGATQKKQQGLTIFLVPMDDPAITVRPIRTMLGP--HHLNEVFFDDLRVT
MLBr_00737|M.leprae_Br4923 -----KGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIP
. :: ::: * .. : * * .*::: .
Mb1969c|M.bovis_AF2122/97 AGNVVGRVGDGWSTAMTLLGFERGSHIATAAIDFERDLQRLCELARDRGL
Rv1934c|M.tuberculosis_H37Rv AGNVVGRVGDGWSTAMTLLGFERGSHIATAAIDFERDLQRLCELARDRGL
MAB_0597|M.abscessus_ATCC_1997 ADLVVGEPGDGWRVAMGTLTFERGVSTLGNQITYARELSRLAELAKSNGA
MMAR_3981|M.marinum_M PTDVLGEPGDGWRVMREALAFER--VGIARYARCESLLDRMRTELGDDWA
MUL_3842|M.ulcerans_Agy99 PSDVLGEPGDGWRVMREALAFER--VGIARYARCESLLDRMRTELGDDWA
MAV_1629|M.avium_104 PGDVLGEVGDGWRVMREALAYER--VGIARYARCESLLERMRGRLGDEWE
MSMEG_5622|M.smegmatis_MC2_155 EADVLGTVDEGWKIVQDVVSFER--VGIARYARCERLLQAAPDVLGDAWD
TH_3217|M.thermoresistible__bu EADVLGTVDDGWSIVQDVMSFER--VGIARYARCERLLALAPQVLGEHWD
Mflv_1792|M.gilvum_PYR-GCK EADVLGTVDQGWSIVQDVMSFER--VGIARYARCERLLAAAPTVLGERWD
Mvan_4958|M.vanbaalenii_PYR-1 EADVLGTVDAGWSIVQDVMAFER--VGIARYARCERLLAAAPGVLGDRWD
MLBr_00737|M.leprae_Br4923 GDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQ
::* . *: : . * * .
Mb1969c|M.bovis_AF2122/97 HTDPRVRDGLAWCYARVQIMRYRGYRDLTLALTGRPPGAEAAITKVIWSE
Rv1934c|M.tuberculosis_H37Rv HTDPRVRDGLAWCYARVQIMRYRGYRDLTLALTGRPPGAEAAITKVIWSE
MAB_0597|M.abscessus_ATCC_1997 ADDPAIRERLAQAYVGMRTMR-----AYALATMDEERPGQDNVSKLLWAN
MMAR_3981|M.marinum_M RLPESIRVRWVRALADLRVARLLAYRAVALRDD-PTAGAAASAARIVTTT
MUL_3842|M.ulcerans_Agy99 RLPESSRVRWVRALADLRVARLLAYRAVALRDD-PTSGAAASAARIVTTT
MAV_1629|M.avium_104 QLPESIRARWVRALVDLRVARLLAYRAVSLQDD-PASGAAASAARIATTT
MSMEG_5622|M.smegmatis_MC2_155 QLPAELRGRWTRMLTHCRRARLMAYRVVAMQATGRVNPGDSAAYRIAVTR
TH_3217|M.thermoresistible__bu ALPAELHGRWARMLTHCRRARLLAYRVVALQAGGQVRPGDAAAYRIAVTR
Mflv_1792|M.gilvum_PYR-GCK SLPTELRGRWIRMLTHCRRARLLAYRVVALQSSGRIAPGDAAAYRIAVTK
Mvan_4958|M.vanbaalenii_PYR-1 SLPAELRGRWIGMLTHCRRARLLAYRVVALQSSGRITPGDASAYRIAVTK
MLBr_00737|M.leprae_Br4923 FGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLG-FISAA
: . . :
Mb1969c|M.bovis_AF2122/97 YFRRYTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDELLYA
Rv1934c|M.tuberculosis_H37Rv YFRRYTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDELLYA
MAB_0597|M.abscessus_ATCC_1997 WHRDLGELAMEIIG------------TSTLLTNAGEMDE---WQRLFLFS
MMAR_3981|M.marinum_M CDQQVAELLLDVLGPAALDS----GTTAPLHGAI---------EDHWRYA
MUL_3842|M.ulcerans_Agy99 CDQQVAELLLDVLGPAALDS----GATAPLHGAI---------EDHWRYA
MAV_1629|M.avium_104 CDQQVAELLFDVLGPTALDA----GSGAPLHGAI---------EDHWRYA
MSMEG_5622|M.smegmatis_MC2_155 LDQESAEVLMEIAAALPRGG---DQRTEYFRAEV---------EDHWRYS
TH_3217|M.thermoresistible__bu LDQDSAEVLMELVAALPPGDSADRQAAEYFRAEV---------EDHWRYS
Mflv_1792|M.gilvum_PYR-GCK LDQDSAEVLMDIAAEVRHDD----ERAAWFLGEV---------DDHWRYS
Mvan_4958|M.vanbaalenii_PYR-1 LDQDSAEVLMDIAAEVRRDD----HRAQWFLGEV---------EDHWRYS
MLBr_00737|M.leprae_Br4923 SKCFASDIAMEVTTDAVQLFG-----GAGYTSDFP-------VERFMRDA
:: .:: :
Mb1969c|M.bovis_AF2122/97 RAATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC---
Rv1934c|M.tuberculosis_H37Rv RAATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC---
MAB_0597|M.abscessus_ATCC_1997 RADTIYGGSNEIQRNIISERVLGLPREAR--------
MMAR_3981|M.marinum_M QAATVASGTIEVQRMLVARDVLGEHR-----------
MUL_3842|M.ulcerans_Agy99 QAATVASGTIEVQRMLVARDVLGEHR-----------
MAV_1629|M.avium_104 QAATVASGTIEVQKMLVARDVLGGHR-----------
MSMEG_5622|M.smegmatis_MC2_155 QASTVSSGSIEMQRILLSRTMFAG--AAR--------
TH_3217|M.thermoresistible__bu QASTVSSGSIEMQRILLSRAMLATGKAPR--------
Mflv_1792|M.gilvum_PYR-GCK QASTVSSGSIEMQRILLSRAMLTADARSKSASVGAPR
Mvan_4958|M.vanbaalenii_PYR-1 QASTVSSGSIEMQRILLSRAMLSAGAAK---------
MLBr_00737|M.leprae_Br4923 KITQIYEGTNQIQRVVMSRALLR--------------
: : *: ::*: ::.. ::