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DLEYTPEQQQLRAEIRATLQTVMTPERVAAVSEQMDGGPAVRECVRALAAANLLGVGWPKEYGGRGFSAI EQFIFAEEARRVSAPIPLVTLNTVGPTLMHYGTDEQKRRFLPAILDGTVEFAIGYSEPGAGSDLASVHTT AVRVGDEYVINGQKMFTSGAAYADYIWLAVRTDPDAKKHKGISILIVPTSSPGFSWQPLHTMPGISTFYT FYDDVRVPVSALVGAENQGWQLITTQLNFERAALGNLGALEPLFDKTLDWALSTELDGGRVIDQPWVRSA LARVEAQVAAYKLVNLRVNAAMTKGALNMGEASAAKVFGTELTQQVARELLEVLDGNGVRRGAEAPLRGA LESAYRQAVINTFGGGANEIQRDIIAMAALGMPRAPRDLRAAN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1338 | - | - | 100% (394) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_0652 | - | e-107 | 51.53% (392) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_0618 | - | 4e-98 | 49.49% (390) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3534 | fadE26 | 1e-109 | 52.12% (401) | acyl-CoA dehydrogenase FADE26 |
| M. gilvum PYR-GCK | Mflv_1551 | - | 1e-107 | 51.52% (394) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3504 | fadE26 | 1e-109 | 52.12% (401) | acyl-CoA dehydrogenase FADE26 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 9e-31 | 28.64% (391) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4158 | - | 1e-108 | 51.15% (393) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4992 | fadE26 | 1e-108 | 51.65% (395) | acyl-CoA dehydrogenase FadE26 |
| M. smegmatis MC2 155 | MSMEG_5906 | - | 1e-111 | 53.05% (394) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4647 | - | 1e-174 | 74.49% (392) | PUTATIVE putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4067 | fadE26 | 1e-107 | 51.39% (395) | acyl-CoA dehydrogenase FadE26 |
| M. vanbaalenii PYR-1 | Mvan_5206 | - | 1e-108 | 51.78% (394) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1338|M.avium_104 ---MDLEYTPEQQQLRAEIRATLQTVMTPERVAAVS---EQMDGGPAVRE
TH_4647|M.thermoresistible__bu ---MDFDYTPEQEALRRDFRRRLEAVMTPERRAAIA---GQLEGGPAVAE
Mb3534|M.bovis_AF2122/97 ---MRISYTPQQEELRRELRSYFATLMTPERREALSSVQGEYGVGNVYRE
Rv3504|M.tuberculosis_H37Rv ---MRISYTPQQEELRRELRSYFATLMTPERREALSSVQGEYGVGNVYRE
MMAR_4992|M.marinum_M ---MRISYTPEQEELRRELRSYFTTLMTPERREALSSVQGEYGTGNVYRE
MUL_4067|M.ulcerans_Agy99 ---MRISYTPEQEELRRELRSYFTTLMTPERREALSSVQGEYGTGNVYRE
MAB_4158|M.abscessus_ATCC_1997 ---MHIAYTPEQEELRRELRAYFDKLLTPERREALASNQGEYGSGNVYRE
Mflv_1551|M.gilvum_PYR-GCK ---MRIGYTPEQEELRRELRSYFTKLMTPERAEALAASDGEMGRGNVYRE
Mvan_5206|M.vanbaalenii_PYR-1 ---MRIGYTPEQEELRRELRAYFTKLMTPERAEALAASDGEMGRGNVYRE
MSMEG_5906|M.smegmatis_MC2_155 ---MRIGYTPEQEELRRELRAYFSKLMTPERVEALSSSEGEMGRGNVYRE
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
: * : . : : . . . *
MAV_1338|M.avium_104 CVRALAAANLLGVGWPKEYGGRGFSAIEQFIFAEEARRVSAPIPLV-TLN
TH_4647|M.thermoresistible__bu CRRALGEAGLLGVSWPVEYGGGGLSALEQYIFAEEARRVNAPLPMI-TLN
Mb3534|M.bovis_AF2122/97 TIAQMGRDGWLALGWPKEYGGQGRSAMDQLIFTDEAAIAGAPVPFL-TIN
Rv3504|M.tuberculosis_H37Rv TIAQMGRDGWLALGWPKEYGGQGRSAMDQLIFTDEAAIAGAPVPFL-TIN
MMAR_4992|M.marinum_M TVAQMGKDGWLTLNWPKEYGGQDRSPMDSLIFTDEAAIAGAPVPFL-TIN
MUL_4067|M.ulcerans_Agy99 TVAQMGKNGWLTLNWPKEYGGQDRSPMDSLIFTDEAAIAGAPVPFL-TIN
MAB_4158|M.abscessus_ATCC_1997 TVEQMGADGWLALGWPKEFGGQDRSVMDQLIFTDEAAIAGAPVPFL-TIN
Mflv_1551|M.gilvum_PYR-GCK TVAQMGKDGWLTLSWPEEFGGQARPPMDGLIFNDEAAIANVPVPFL-TIN
Mvan_5206|M.vanbaalenii_PYR-1 TVAQMGKDGWLTLSWPKEFGGQARPPMDGLIFNDEAAIANVPVPFL-TIN
MSMEG_5906|M.smegmatis_MC2_155 TVAQMGKDGWLTLSWPKEFGGQARPPMDGLIFTDEAAIAGAPVPFL-TIN
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
: . : * *:** : *. :*. .... .:: ::*
MAV_1338|M.avium_104 TVGPT-LMHYGTDEQKRRFLPAILDGTVEFAIGYSEPGAGSDLASVHTTA
TH_4647|M.thermoresistible__bu TVGPT-LMQFGTEEQKQKFLPAILRGTVDFAIGYSEPGAGSDLASLRTTA
Mb3534|M.bovis_AF2122/97 SVAPT-IMAYGTDEQKRFFLPRIAAGDLHFSIGYSEPGAGTDLANLRTTA
Rv3504|M.tuberculosis_H37Rv SVAPT-IMAYGTDEQKRFFLPRIAAGDLHFSIGYSEPGAGTDLANLRTTA
MMAR_4992|M.marinum_M SVAPT-IMAFGTDEQKKFFLPKIAAGDLHFSIGYSEPGAGTDLANLRTTA
MUL_4067|M.ulcerans_Agy99 SVAPT-IMAFGTDEQKKFFLPKIAAGDLHFSIGYSEPGAGTDLANLRTTA
MAB_4158|M.abscessus_ATCC_1997 SVAPT-IMHFGTDEQKKFFLPKIAAGKLHFSIGYSEPGAGTDLASLRTSA
Mflv_1551|M.gilvum_PYR-GCK SVAPT-IMHFGTEEQKKFFLPRIAKGDLHFSIGYSEPGAGTDLASLRTTA
Mvan_5206|M.vanbaalenii_PYR-1 SVAPT-IMAFGTEEQKKFFLPKIAAGDLHFSIGYSEPGAGTDLAALRTTA
MSMEG_5906|M.smegmatis_MC2_155 SVAPT-IMAFGTEEQKKFFLPKIASGELHFSIGYSEPGAGTDLASLRTTA
MLBr_00737|M.leprae_Br4923 KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
.:.. :: *::* *: .** : : . ** **:* * ::* *
MAV_1338|M.avium_104 VRVGDEYVINGQKMFTSGAAYADYIWLAVRTDPD---AKKHKGISILIVP
TH_4647|M.thermoresistible__bu VRDGDEWVIDGSKMFTSGAEYADYIWLAARTDPE---ARKHKGITLFIVP
Mb3534|M.bovis_AF2122/97 VRDGDDYVVNGQKMWTSLIQYADYVWLAVRTNPESSGAKKHRGISVLIVP
Rv3504|M.tuberculosis_H37Rv VRDGDDYVVNGQKMWTSLIQYADYVWLAVRTNPESSGAKKHRGISVLIVP
MMAR_4992|M.marinum_M VRDGDDYVINGQKMWTSLIAYADWVWLAVRTNPE---AKKHRGISMLVVP
MUL_4067|M.ulcerans_Agy99 VRDGDDYLINGQKMWTSLIAYADWVCLAVRTNPE---AKKHRGISMLVVP
MAB_4158|M.abscessus_ATCC_1997 VRDGDDYIVNGQKMWTSLIEYADYIWLAVRTNTE---VKKHRGISMLIVP
Mflv_1551|M.gilvum_PYR-GCK VHDGDDYVINGQKMWTSLIAYADYVWLAVRTNTE---AKKHRGISMLIVP
Mvan_5206|M.vanbaalenii_PYR-1 VRDGDDYVINGQKMWTSLIAYADYVWLAVRTNPE---AKKHRGISMLIVP
MSMEG_5906|M.smegmatis_MC2_155 VRDGDDYVINGQKMWTSLIAYADYVWLAVRTNPE---AKKHRGISMLIVP
MLBr_00737|M.leprae_Br4923 KADGDDWILNGFKCWITNGGKSTWYTVMAVTDPD----KGANGISAFIVH
**:::::* * : : : : : . *:.: : .**: ::*
MAV_1338|M.avium_104 TSSPGFSWQPLHT---MPGISTFYTFYDDVRVPVSALVGAENQGWQLITT
TH_4647|M.thermoresistible__bu TDSPGFSWKPLHT---MPGVSTYYTFYDDVRVPDDNIVGNLNEGWKLVTN
Mb3534|M.bovis_AF2122/97 TTAEGFSWTPVHT---MAGPDTSATYYSDVRVPVANRVGEENAGWKLVTN
Rv3504|M.tuberculosis_H37Rv TTAEGFSWTPVHT---MAGPDTSATYYSDVRVPVANRVGEENAGWKLVTN
MMAR_4992|M.marinum_M TTAEGFSWTPVHT---MAGPDTSATYYTDVRVPVTNLIGEENAGWKLVTN
MUL_4067|M.ulcerans_Agy99 TTAEGFSWTPVHT---MAGPDTSATYYTDVRVPVTNLIGEENAGWKLVTN
MAB_4158|M.abscessus_ATCC_1997 TTAEGFSYTKVHT---MAGPGTSATYYQDVRVPVTSRVGEENAGWKLVTN
Mflv_1551|M.gilvum_PYR-GCK TTAEGFSWTPVHT---VSGVDTSATYYQDVRVPKSALVGEENGGWKLVTN
Mvan_5206|M.vanbaalenii_PYR-1 TTAEGFSWTPVHT---MSGVDTSATYYQDVRVPVSSLVGEENAGWKLVTN
MSMEG_5906|M.smegmatis_MC2_155 TTAEGFSWTPVHT---MSGVDTSATYYQDVRVPVTNLVGEENQGWKLVTN
MLBr_00737|M.leprae_Br4923 KDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALA
. *** .. : * * :: . *:* :* . *::
MAV_1338|M.avium_104 QLNFERAALGNLGA-LEPLFDKTLDWALST-ELDGGRVIDQPWVRSALAR
TH_4647|M.thermoresistible__bu QLNLERAALGNLGA-LEPLFEKTLQWARTT-PADGGHIIDIPWVQQVLAR
Mb3534|M.bovis_AF2122/97 QLNHERVALVSPAP-IFGCLREVREWAQNTKDAGGTRLIDSEWVQLNLAR
Rv3504|M.tuberculosis_H37Rv QLNHERVALVSPAP-IFGCLREVREWAQNTKDAGGTRLIDSEWVQLNLAR
MMAR_4992|M.marinum_M QLNHERVALVSSAP-ISMALREVREWAQNTKDAGGARLIDSEWVQLNLAR
MUL_4067|M.ulcerans_Agy99 QLNHERVALVSSAP-ISMALREVREWAQNTKDAGGARLIDSEWVQLNLAR
MAB_4158|M.abscessus_ATCC_1997 QLNHERVALVSSAP-IITALREVREWAQNTKGPGG-RIIDAEWVQLNLAR
Mflv_1551|M.gilvum_PYR-GCK QLNHERVALVSAQP-IFVALNGVREWAQNTKDVHGNRVIDSEWVQLNLAR
Mvan_5206|M.vanbaalenii_PYR-1 QLNHERVALVSAQP-IFVALNGVREWAQNTKDVHGKRLIDSEWVQLNLAR
MSMEG_5906|M.smegmatis_MC2_155 QLNHERVALVSAQP-IYVALNGVREWAQNTKDVHGKRLIDSEWVQLNLAR
MLBr_00737|M.leprae_Br4923 TLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLAD
*: * :: : . . * : :: **
MAV_1338|M.avium_104 VEAQVAAYKLVNLRVNAA---MTKGALNM-GEASAAKVFGTELTQQVARE
TH_4647|M.thermoresistible__bu VEAQVSAYRLMNLRVNAS---MSSGGLGM-AEASAAKVFGTELTQRVARE
Mb3534|M.bovis_AF2122/97 VHAKAEVLKLINWELASSQSGPKDAGPSP-ADASAAKVFGTELATEAYRL
Rv3504|M.tuberculosis_H37Rv VHAKAEVLKLINWELASSQSGPKDAGPSP-ADASAAKVFGTELATEAYRL
MMAR_4992|M.marinum_M VHAKVEVLKLINWELASN-----DAAPSP-ADASAAKVFGTELATEAYRL
MUL_4067|M.ulcerans_Agy99 VHAKVEVLKLINWELASN-----DAAPSP-ADASAAKVFGTELATEAYRL
MAB_4158|M.abscessus_ATCC_1997 VHAKAEYLKLINWELAST----TDAAPSP-ADASATKVFGTELATEAYRL
Mflv_1551|M.gilvum_PYR-GCK VHAKAEVLKLINWELASS----TDTAPSP-ADASAAKVFGTELATEAYRL
Mvan_5206|M.vanbaalenii_PYR-1 VHAKAEVLKLINWELASA----TDAAPSP-ADASAAKVYGTELATEAYRL
MSMEG_5906|M.smegmatis_MC2_155 VHAKAEVLKLINWELAS-----TEAAPSP-ADASAAKVYGTELATEAYRL
MLBr_00737|M.leprae_Br4923 MAMKVEAARLIVYAAAAR---AERGEPDLGFISAASKCFASDIAMEVTTD
: :. :*: : . ::*:* :.:::: ..
MAV_1338|M.avium_104 LLEVLDGNGVRRG--AEAPLRGALESAYRQAVINTFGGGANEIQRDIIAM
TH_4647|M.thermoresistible__bu LLEVLGADGTRKG--ADAPLRGELEHAYRLAVINTFGGGANELQRDIIAM
Mb3534|M.bovis_AF2122/97 LMEVLGTAATLRQNSPGALLRGRVERMHRACLILTFGGGTNEVQRDIIGM
Rv3504|M.tuberculosis_H37Rv LMEVLGTAATLRQNSPGALLRGRVERMHRACLILTFGGGTNEVQRDIIGM
MMAR_4992|M.marinum_M LMEVLGTAATLRQDSPGALLHGRVERMHRACLILTFGGGTNEVQRDIIGM
MUL_4067|M.ulcerans_Agy99 LMEVLGTAATLRQDSPGALLRGRVERMHRACLILTFGGGTNEVQRDIIGM
MAB_4158|M.abscessus_ATCC_1997 LMEVLGTAATLRQDSPGAQLRGRVERMHRACLILTFGGGTNEVQRDIIAM
Mflv_1551|M.gilvum_PYR-GCK LMEVLGTAATLRTNSPGAVLRGRIERMHRSCLILTFGGGTNEIQRDIIGM
Mvan_5206|M.vanbaalenii_PYR-1 LMEVLGTAATLRTNSPGALLRGRIERMHRSCLILTFGGGTNEIQRDIIGM
MSMEG_5906|M.smegmatis_MC2_155 LMEVLGTSATLRGDTRGALLRGRVERFHRSALILTFGGGTNEIQRDIIGM
MLBr_00737|M.leprae_Br4923 AVQLFGG--------AGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSR
::::. :* * . * : *:*::** ::.
MAV_1338|M.avium_104 AALGMPRAPRDLRAAN-
TH_4647|M.thermoresistible__bu AGLGMPRAPRDLRATAS
Mb3534|M.bovis_AF2122/97 VALGLPRANR-------
Rv3504|M.tuberculosis_H37Rv VALGLPRANR-------
MMAR_4992|M.marinum_M VALGLPRANR-------
MUL_4067|M.ulcerans_Agy99 VALGLPRANR-------
MAB_4158|M.abscessus_ATCC_1997 TALGQPAASR-------
Mflv_1551|M.gilvum_PYR-GCK VALGLPRVNR-------
Mvan_5206|M.vanbaalenii_PYR-1 VALGLPRVNR-------
MSMEG_5906|M.smegmatis_MC2_155 VALGLPRVNR-------
MLBr_00737|M.leprae_Br4923 ALLR-------------
. *