For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSVEVAGSDSRKALQFHFDRHAPEYRERFLDVTQEMHQRCPIAWTDTYGGHWVAAGGDAVFELARCPHVS NDHDVNNERRGYRGVTIPLTTESDQIRGGMLEMDDPEHRIYRSLLNPYLSPAAVSRWQPFIDDVVRACLD ERIESGRIDFVDDLANVVPAVLTLAMLGVPLRKWTMYNEPVHAMVYTPPDSPEAAKVHDMWVSVVVDLFA NLTEIREHPRPGIINALAQLRIDGEPAPDMEIIGMLTLLIGGGFDTTTALTAHALEWLSEHPDQRARLHG ELDVLLNPATEEFLRYFTPAPGDARTISADMELDGIRFAEGERLWLSWAMANRDPSLFDNPNELMLARKA NRHFSFGIGVHRCIGSNVARTVFKSMLTAVLERMPDYRCDRVNTVHYDTIGIIQGMRNLPADFTPGKRRG PGLDETLDRLQSVCDSQGLARPITEYKEQARIHE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1397 | - | - | 100% (454) | cytochrome P450 superfamily protein |
| M. avium 104 | MAV_0940 | - | 0.0 | 70.64% (453) | cytochrome P450 superfamily protein |
| M. avium 104 | MAV_2159 | - | 1e-63 | 36.34% (388) | cytochrome P450 superfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 3e-35 | 29.55% (352) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_1259 | - | 0.0 | 74.72% (443) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 3e-35 | 29.55% (352) | cytochrome P450 124 CYP124 |
| M. leprae Br4923 | MLBr_02088 | - | 7e-25 | 26.85% (324) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3825 | - | 2e-39 | 30.00% (320) | cytochrome P450 |
| M. marinum M | MMAR_4717 | cyp188A3 | 0.0 | 69.42% (448) | cytochrome P450 188A3 Cyp188A3 |
| M. smegmatis MC2 155 | MSMEG_4803 | - | 0.0 | 66.82% (449) | cytochrome P450 superfamily protein |
| M. thermoresistible (build 8) | TH_2693 | - | 0.0 | 68.78% (442) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0317 | cyp188A3 | 1e-167 | 68.80% (391) | cytochrome P450 188A3 Cyp188A3 |
| M. vanbaalenii PYR-1 | Mvan_4880 | - | 0.0 | 68.55% (442) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1397|M.avium_104 ---------MSVEVAGSDSRKALQFHFDRHAPEYRERFLDVTQ----EMH
Mflv_1259|M.gilvum_PYR-GCK -----------------MNPETLRYDFDRHRPDYRDRFLDITH----EMH
Mvan_4880|M.vanbaalenii_PYR-1 -----------MADQLDRRREARSFHFDRHTPQYRDRFQEITA----QMQ
MMAR_4717|M.marinum_M --------MSVDDVVSDSDHQKNRYQFDRHSPEYRSQFKAITE----EMH
MUL_0317|M.ulcerans_Agy99 --------MSVDDVVSDSDHHQNRYQFDRHSPEYRSQFKAITE----EMH
MSMEG_4803|M.smegmatis_MC2_155 --------MSIQDVTTDDDREKITYHFDRHTPEYRLQFEKITE----EMH
TH_2693|M.thermoresistible__bu --------LSVDDIITDAERKKHRYHFDRHTPEYRLQFEKITE----EMH
Mb2289|M.bovis_AF2122/97 ---MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATLR
Rv2266|M.tuberculosis_H37Rv ---MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATLR
MAB_3825|M.abscessus_ATCC_1997 ---------MATALSEIEEAGRVLADPAAYADELRLHAAMTLLR----RE
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
:
MAV_1397|M.avium_104 QRCPIAWTDTYGGHWVAAGGDAVFELARCPHVSND--HDVNNERRGYRGV
Mflv_1259|M.gilvum_PYR-GCK QQCPLAWTDTYDGHWVAASSDAVFELARCPFVSND--HDVNNERRGYKGI
Mvan_4880|M.vanbaalenii_PYR-1 ARCPLAWTDTYGGHWVAAGNREVFELARCPHVSND--NDIDGTRRGYTGI
MMAR_4717|M.marinum_M TTCPMAWSDTYGGHWVAAGSHEVFELARCPAVSND--HDVNNQRRGYKGI
MUL_0317|M.ulcerans_Agy99 TTCPMAWSDTYGGHWVAAGSHEVFELARCPAVSND--HDVNNQRRGYKGI
MSMEG_4803|M.smegmatis_MC2_155 SRCPVAWTETYDGHWVAAGSNEVFELARCPVVSNH--HDISGETP-FQGI
TH_2693|M.thermoresistible__bu AKCPMAWTDTYGGHWVAADSKHVFELARCPVVSNH--HDITGETP-FQGI
Mb2289|M.bovis_AF2122/97 REAPISFWPTIELPGFVAG-NGHWALTKYDDVFYA--SRHPDIFSSYPNI
Rv2266|M.tuberculosis_H37Rv REAPISFWPTIELPGFVAG-NGHWALTKYDDVFYA--SRHPDIFSSYPNI
MAB_3825|M.abscessus_ATCC_1997 QPVTKVITDDYRPFWAVTKHDDIMAVERDNALWIN--EPRPLLMNLEQEA
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
.
MAV_1397|M.avium_104 TIPLTT-ESDQIRGGMLEMDDPEHRIYRSLLNPYLSPAAVSRWQPFIDDV
Mflv_1259|M.gilvum_PYR-GCK SIPRML-EAEGFRGGMLEMDDPEHRHYRTALNPYLSPAAVKRWEPFVDEI
Mvan_4880|M.vanbaalenii_PYR-1 NIPRGD-YSVAFRGGMLEMDDPEHREYRSPLNGYLSPAAVRRWVPVVDEL
MMAR_4717|M.marinum_M SIPTAS-RINGVRGGILEMDDPEHRIYRTVLNPYLSPAAVKRWEPFIDEV
MUL_0317|M.ulcerans_Agy99 SIPTAS-RINGVRGGILEMDDPEHRIYRTVLNPYLSPAAVKRWEPFIDEV
MSMEG_4803|M.smegmatis_MC2_155 TIPKAS-RATVVRGGILEMDEPEHSAYRGALNPYLSPAAIKRWEPFVDEI
TH_2693|M.thermoresistible__bu TIPKAS-RATVVRGGILEMDEPEHSIYRGALNPYLSPAAIKRWEPFVHEI
Mb2289|M.bovis_AF2122/97 TINDQTPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAAVRDR
Rv2266|M.tuberculosis_H37Rv TINDQTPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAAVRDR
MAB_3825|M.abscessus_ATCC_1997 ELDKQAAMGIELK-TLVHIDDPKHRVLRAIGADWFRPKAMRDMKLRTDEL
MLBr_02088|M.leprae_Br4923 AIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAAL
: :: :* * * * : * .:
MAV_1397|M.avium_104 VRACLDERIESG---RIDFVDDLANVVPAVLTLAMLGVPLRKWT--MYNE
Mflv_1259|M.gilvum_PYR-GCK VCACLDDRIESG---RIDFVDDLANVVPAVLTLAMLGVPLQKWE--MYNE
Mvan_4880|M.vanbaalenii_PYR-1 VKACLDEKIEDG---RIDFVDDLANIVPAVLTLGLLGVPLKDWE--IYCE
MMAR_4717|M.marinum_M TRACLDERIEQG---SIDFVDDLANIVPAVLTLAILGIPLEKWN--LYSE
MUL_0317|M.ulcerans_Agy99 TRACLDERIEQG---SIDFVDDLANIVPAVLTLAILGIPLEKWN--LYSE
MSMEG_4803|M.smegmatis_MC2_155 TRAAIDEHISSG---RIDFVEHLANVVPAVFTLAMMGIELKKWN--VYSE
TH_2693|M.thermoresistible__bu TRAAIDEKIESG---EIDFVEDLANVVPAVFTLAMMGIELKKWK--VYSE
Mb2289|M.bovis_AF2122/97 AHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQRIFHWT
Rv2266|M.tuberculosis_H37Rv AHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQRIFHWT
MAB_3825|M.abscessus_ATCC_1997 ANRYVNKLLEAG--GSCDFAQDIAVHFPLYVIMSLLGIPESDFDRMLKLT
MLBr_02088|M.leprae_Br4923 VDSLLDKGAAAG---QFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVS
. :.. . *. .:* .. . ::*: .
MAV_1397|M.avium_104 PVHAMVYTPPD----SPEAAKVHDMWVSVVVD--LFANLTEIREHPRPGI
Mflv_1259|M.gilvum_PYR-GCK PAHASVYTPPD----SPDAERVRELYMAMGID--LFTNLMEIRDNPRPGI
Mvan_4880|M.vanbaalenii_PYR-1 PAHASVYTPAD----SPDFPRVADLAIASAMG--MMHHVAEIRQTPRPGL
MMAR_4717|M.marinum_M PVHAAVYTPEH----SPDIQRVTEMHRQMGLD--MVTNMIEIRDNPRPGL
MUL_0317|M.ulcerans_Agy99 PVHAAVYTPEH----SPDIQRVTEMHRQMGLD--MVTNMIEIRDNPRPGL
MSMEG_4803|M.smegmatis_MC2_155 PTHASVYTPEH----APEREKINEQHREMGID--LINNMMEIRQNPRPGL
TH_2693|M.thermoresistible__bu PTHASVYTPEH----APEREKVNEMHREMGID--LINNMMEIRENPRPGL
Mb2289|M.bovis_AF2122/97 NVILGFGDPDL----ATDFDEFMQVSADIGAY--ATALAEDRRVNHHDDL
Rv2266|M.tuberculosis_H37Rv NVILGFGDPDL----ATDFDEFMQVSADIGAY--ATALAEDRRVNHHDDL
MAB_3825|M.abscessus_ATCC_1997 QELFGGDDSEF----QRGTTPEEQLMALLDFFGYFSGLTASRRQHPTDDL
MLBr_02088|M.leprae_Br4923 ALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGEDL
. * .:
MAV_1397|M.avium_104 INALAQLRIDGEPAPDMEIIGMLTLLIGGGFDTTTALTAHALEWLSEHPD
Mflv_1259|M.gilvum_PYR-GCK INALATLRIDGEAPPDIELIGMLNLLIGGGFDTTTALTAHALEWLSEHPD
Mvan_4880|M.vanbaalenii_PYR-1 IDALVRTRIDGQPAPDTEIMGMLMLLIGGGFDTTTALTAHALEWLSQHPD
MMAR_4717|M.marinum_M VNALVQMRIDGQPAPDLEILGNLGLVIGGGFDTTTALTAHALEWLSEHPD
MUL_0317|M.ulcerans_Agy99 VNALVQMRIDGQPAPDLEILGNLGLVIGGGFDTTTALTAHALEWLSEHHD
MSMEG_4803|M.smegmatis_MC2_155 VNALLQLRIDGEPAPDMEILGNLGLIIGGGFDTTTALTAHALEWLGEHPD
TH_2693|M.thermoresistible__bu VNALLQLRIDGEPAPDMEILGNLGLIIGGGFDTTTALTAHALEWLGEHPD
Mb2289|M.bovis_AF2122/97 TSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALSRYPE
Rv2266|M.tuberculosis_H37Rv TSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALSRYPE
MAB_3825|M.abscessus_ATCC_1997 ASTIANARVDGELLSDVDTASYYTIIATAGHDTTSATIAGGLEALLEHPD
MLBr_02088|M.leprae_Br4923 ISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLRNPS
. : .*: .. : . :: .* :** : .: : . .
MAV_1397|M.avium_104 QRARLHGELDVLLNPATEEFLRYFTPAPGDARTISADMELDGIRFAEGER
Mflv_1259|M.gilvum_PYR-GCK ERARLSADRDTLLNPATEEFLRYFTPAPGDARTIAEDVAVNGVELREGQR
Mvan_4880|M.vanbaalenii_PYR-1 ERERLSRDRDTLLDPATEEFLRYFTPAPGDGRTVAEDIEVDGVVLKEGER
MMAR_4717|M.marinum_M ERERLWRNRDTLIDSATEEFLRYFTPAPGDGRTFSDDVEFDGIHFKEGER
MUL_0317|M.ulcerans_Agy99 ERERLWRNRDTLIDSATEEFLRYFTPAPGDGRTFSDDLEFFGIHFKEGER
MSMEG_4803|M.smegmatis_MC2_155 ERERLSRERDTLLNPATEEFLRFFTPAPGDGRTFAEDAEVAGYKFKQYER
TH_2693|M.thermoresistible__bu ERERLSRERDTLLNPATEEFLRFFTPAPGDGRTFAEDVEVLGTQFKKYER
Mb2289|M.bovis_AF2122/97 QRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDK
Rv2266|M.tuberculosis_H37Rv QRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDK
MAB_3825|M.abscessus_ATCC_1997 QLARLREN-PGLMPLAVDEMIRWVTPVKEFMRTATADTEIRGVPITEGES
MLBr_02088|M.leprae_Br4923 QWKALSSN-PQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEGDT
: : ..:* :*: .. *. : * . : :
MAV_1397|M.avium_104 LWLSWAMANRDPSLFDNPNELMLARKANRHFSFGIG-VHRCIGSNVARTV
Mflv_1259|M.gilvum_PYR-GCK LWLSWAMANRDPAVFTDPDQIVLDRKGNRHFSFGLG-VHRCIGSNVARTV
Mvan_4880|M.vanbaalenii_PYR-1 LWLSWAMANRDPALFQNPDEVVLDRKGNRHFSFGLG-VHRCIGSNVARTV
MMAR_4717|M.marinum_M LWISWAMANRDPQVFPDPDELVLDRRGNRHFSFGIG-VHRCIGSNVARTV
MUL_0317|M.ulcerans_Agy99 LWISWAMANREPQVFPDPDELVLDRRGNRHFSFGIG-VHRCVGSNVARTV
MSMEG_4803|M.smegmatis_MC2_155 LWLSWAMANRDPSVFDKPNEVILDRKGNRHFSFGIG-VHRCVGSNVARTV
TH_2693|M.thermoresistible__bu LWLSWAMANRDPAVFERPNEIILDRKGNRHFSFGIG-VHRCVGSNVARTV
Mb2289|M.bovis_AF2122/97 VSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGANLARRE
Rv2266|M.tuberculosis_H37Rv VSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGANLARRE
MAB_3825|M.abscessus_ATCC_1997 VLLSYPSGNRDEDIFTDPFTFDIARDPNKHLAFGFG-VHFCLGAALARME
MLBr_02088|M.leprae_Br4923 MVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFAVG-SHFCLGAALARLE
: : .**: : * . * . *:.*. * * *:*: :**
MAV_1397|M.avium_104 FKSMLTAVLERMPDYRCDRVNTVHYDTIGIIQGMRNLPADFTPGKRRGPG
Mflv_1259|M.gilvum_PYR-GCK FKSMLTAVLDRMPDYRCLPKETVHYDSIGVIQGMRHLPAEFTPGPRRGAG
Mvan_4880|M.vanbaalenii_PYR-1 FKSMLTAVLDRMPDFQCDAAGAVHYETIGVIQGMQHLPAAFTPGPRLGPG
MMAR_4717|M.marinum_M FKSMLSAVADRMPDYRCDPDGAVHYETIGVIQGMRKLPATFTPGRKAGAG
MUL_0317|M.ulcerans_Agy99 FKSMLSAVADRMPDYRCDPDGRSTTRPSASSRACASCPQRSPRAARSAR-
MSMEG_4803|M.smegmatis_MC2_155 FKSMLTAVLDRMPDYVCDPEGTVHYDTIGVIQGMRNLPATFTPSRPLGPG
TH_2693|M.thermoresistible__bu FKSMLTAVLDRMPDYVCDPEGTMHYDTIGVIQGMRHLPAKFTPGKPLGPK
Mb2289|M.bovis_AF2122/97 IRVAFDELRRQMPDVVATEEPARLLS--QFIHGIKTLPVTWS--------
Rv2266|M.tuberculosis_H37Rv IRVAFDELRRQMPDVVATEEPARLLS--QFIHGIKTLPVTWS--------
MAB_3825|M.abscessus_ATCC_1997 VNSFFSALLPRLESIEVDGN--IERTSTIFVGGIKHLPIRYTLR------
MLBr_02088|M.leprae_Br4923 ATVTLSAISARFPQVQLAGELVYKPN--VAMRGMSALPVQV---------
: : :: . . *
MAV_1397|M.avium_104 LDETLDRLQSVCDSQGLAR-------------------PITEYKEQARIH
Mflv_1259|M.gilvum_PYR-GCK VAETVARLQKICDEQGLAR-------------------PITELKDAARIE
Mvan_4880|M.vanbaalenii_PYR-1 LEATLEKLQRVCDEQQLAA-------------------PITVHKAAAVI-
MMAR_4717|M.marinum_M LDETLAKLQRICDEQELAR-------------------PVTERKQAAVID
MUL_0317|M.ulcerans_Agy99 ---AWTRLSRSCNASATNRNSRGPSPSANKPRSSTDAPPASRHKIASGSG
MSMEG_4803|M.smegmatis_MC2_155 LDETLEKLQRICNEEELAR-------------------PITERKERAVID
TH_2693|M.thermoresistible__bu LDETLDRLQQICDEQELAR-------------------PITERKEPAVIT
Mb2289|M.bovis_AF2122/97 --------------------------------------------------
Rv2266|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3825|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02088|M.leprae_Br4923 --------------------------------------------------
MAV_1397|M.avium_104 E--
Mflv_1259|M.gilvum_PYR-GCK EAV
Mvan_4880|M.vanbaalenii_PYR-1 ---
MMAR_4717|M.marinum_M ---
MUL_0317|M.ulcerans_Agy99 R--
MSMEG_4803|M.smegmatis_MC2_155 ---
TH_2693|M.thermoresistible__bu W--
Mb2289|M.bovis_AF2122/97 ---
Rv2266|M.tuberculosis_H37Rv ---
MAB_3825|M.abscessus_ATCC_1997 ---
MLBr_02088|M.leprae_Br4923 ---