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SSASRATVPSAYLHPRFQGQEPPGFPGRFTVAWNENYGGFWFLSSYDAVSQTARNGDTFAHKYEPNAADG VDYQGEMGVPRPEGQPALGLGEVDGPYHQALRHALAPFFSPGAVEKLKPFMEQSAHWFLDQQITTGQMDL VLDYASPVPAILTMKLMGLPYDNWHLYANLFHSVMAVSQDSDEYATAIAKVPAMMHEVLDYAATRRAKPE EDLTSFLIRFEFDGHRLTDEQLLNILWNLIGGGVDTTTSQTALTLLHLGTHPDLRQQLIDHPELYRTATD EFLRYFSVNQTLSRTVTHDVVLAGQRLRKNDRVVISWLSANHDENEFDRPDEIILDRSPNRHVAFGLGPH RCIGSHLARLMSEVMVRAVLDRIPDYQVDVENVHQYLGNPSMTGLGQLPVTFAPGKSRKTLLPW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2159 | - | - | 100% (415) | cytochrome P450 superfamily protein |
| M. avium 104 | MAV_1397 | - | 1e-63 | 36.34% (388) | cytochrome P450 superfamily protein |
| M. avium 104 | MAV_0940 | - | 1e-63 | 36.10% (385) | cytochrome P450 superfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 6e-36 | 28.77% (365) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_1854 | - | 2e-65 | 37.47% (387) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 6e-36 | 28.77% (365) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 9e-35 | 30.94% (320) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0101 | - | 5e-34 | 28.11% (338) | cytochrome P450 |
| M. marinum M | MMAR_4717 | cyp188A3 | 8e-62 | 34.91% (381) | cytochrome P450 188A3 Cyp188A3 |
| M. smegmatis MC2 155 | MSMEG_4803 | - | 2e-63 | 34.88% (387) | cytochrome P450 superfamily protein |
| M. thermoresistible (build 8) | TH_3303 | - | 5e-78 | 41.05% (380) | PUTATIVE putative cytochrome P450 superfamily protein |
| M. ulcerans Agy99 | MUL_0317 | cyp188A3 | 7e-56 | 34.18% (354) | cytochrome P450 188A3 Cyp188A3 |
| M. vanbaalenii PYR-1 | Mvan_4160 | - | 6e-67 | 37.24% (384) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4717|M.marinum_M -----------------MSVDDVVS---DSDHQKNRYQFDRHSPEYRSQF
MUL_0317|M.ulcerans_Agy99 -----------------MSVDDVVS---DSDHHQNRYQFDRHSPEYRSQF
MSMEG_4803|M.smegmatis_MC2_155 -----------------MSIQDVTT---DDDREKITYHFDRHTPEYRLQF
Mvan_4160|M.vanbaalenii_PYR-1 -----------------MSVDDVVSGTADDSRKQNRYYFDRHTPEYRLQF
Mflv_1854|M.gilvum_PYR-GCK -----------------MSDQ-------PDRRDGRGFHFDRHTPQYRDRF
TH_3303|M.thermoresistible__bu -----------------MTTFDTRP----------TVDFDHHSPEYAQNS
MAV_2159|M.avium_104 -----------------MSSASRAT-----------VPSAYLHPRFQG--
Mb0789c|M.bovis_AF2122/97 ---------------------------MTVRVGDPELVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv ---------------------------MTVRVGDPELVLDPYDYDFHEDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAB_0101|M.abscessus_ATCC_1997 -----------------MTTCPFTPGFDFTDPDLIQHRIPAEEFAYLRKT
MMAR_4717|M.marinum_M KAITEEMHTTCPMAWSDTYGGHWVAAGSHEVFELARCP-AVSNDHDVNNQ
MUL_0317|M.ulcerans_Agy99 KAITEEMHTTCPMAWSDTYGGHWVAAGSHEVFELARCP-AVSNDHDVNNQ
MSMEG_4803|M.smegmatis_MC2_155 EKITEEMHSRCPVAWTETYDGHWVAAGSNEVFELARCP-VVSNHHDISGE
Mvan_4160|M.vanbaalenii_PYR-1 EKITEEMQTKCPMAWSDTYGGHWVAADSKHVFELARCP-VVSNHHDISGE
Mflv_1854|M.gilvum_PYR-GCK QEITAAMHARCPLAWTDTYGGHWVAAGNRAVFELARCP-HVSNDHDVTGE
TH_3303|M.thermoresistible__bu AAINAELRAKCPVAHTDAHGGFWVISRYDDVVAAAKNDEVFASGYTVNGV
MAV_2159|M.avium_104 -QEPPGFPGRFTVAWNENYGGFWFLSSYDAVSQTARNGDTFAHKYEPNAA
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEE-RNFWAVSRHHDVLQGFRDSTALSNAYGVSLD
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEE-RNFWAVSRHHDVLQGFRDSTALSNAYGVSLD
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG--MPLTVFSSFSDCDEALRHPLSASDRLKATLA
MAB_0101|M.abscessus_ATCC_1997 EPIWWNAQPRGVAGFDDD--GYWVVTKHADVKEVSRLNEVFSNSVNTTVV
: : : .
MMAR_4717|M.marinum_M RRGYKGISIPTASRINGVRGGILEMDDPEHRIYRTVLNPYLSPAAVKRWE
MUL_0317|M.ulcerans_Agy99 RRGYKGISIPTASRINGVRGGILEMDDPEHRIYRTVLNPYLSPAAVKRWE
MSMEG_4803|M.smegmatis_MC2_155 TP-FQGITIPKASRATVVRGGILEMDEPEHSAYRGALNPYLSPAAIKRWE
Mvan_4160|M.vanbaalenii_PYR-1 TP-FQGITIPKASRATVVRGGILEMDEPEHSAYRGALNPYLSPAAIKRWE
Mflv_1854|M.gilvum_PYR-GCK RKGYQGINIPRGDTSVNFRAGMLEMDDPEHREYRSPLNGYLSPAAVQRWV
TH_3303|M.thermoresistible__bu SP--LGVTIPPSP----VPMCPIEMDPPEYLPYRKLLNPFFSPGESKKWE
MAV_2159|M.avium_104 DGVDYQGEMGVPRPEGQPALGLGEVDGPYHQALRHALAPFFSPGAVEKLK
Mb0789c|M.bovis_AF2122/97 PS----SRTS----EAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELE
Rv0766c|M.tuberculosis_H37Rv PS----SRTS----EAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELE
MLBr_02088|M.leprae_Br4923 QQ----AIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALE
MAB_0101|M.abscessus_ATCC_1997 RYN---EDITAEQLEIQRENLLIDMDEPKHRILRRIVSPLFTPKAVNGLH
:* * : * : ::* .
MMAR_4717|M.marinum_M PFIDEVTRACLDERIEQGSIDFVDDLANIVPAVLTLAILGIPLEKWNLYS
MUL_0317|M.ulcerans_Agy99 PFIDEVTRACLDERIEQGSIDFVDDLANIVPAVLTLAILGIPLEKWNLYS
MSMEG_4803|M.smegmatis_MC2_155 PFVDEITRAAIDEHISSGRIDFVEHLANVVPAVFTLAMMGIELKKWNVYS
Mvan_4160|M.vanbaalenii_PYR-1 PFIHEITRAALDEHIESGRIDFVDHLANVVPAVFTLAMMGIKLDKWNVYS
Mflv_1854|M.gilvum_PYR-GCK PVVDELVRACLDDKIEQGRIDFVDDLANIVPAVLTLGLFGVPLKHWEIYC
TH_3303|M.thermoresistible__bu PRIAHWVDVCLDQVIEKGSFDLVDDLANPVPSLFTCEFLGLPIEKWNDFA
MAV_2159|M.avium_104 PFMEQSAHWFLDQQITTGQMDLVLDYASPVPAILTMKLMGLPYDNWHLYA
Mb0789c|M.bovis_AF2122/97 PQVLELARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDRARIR
Rv0766c|M.tuberculosis_H37Rv PQVLELARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDRARIR
MLBr_02088|M.leprae_Br4923 GDIAALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFG
MAB_0101|M.abscessus_ATCC_1997 ARLVERAHGIVEEAAEKSSGNFVSDIASVLPMHAIADLVGIPESDRQQVL
: . ::. :.: . * :. :.*: .
MMAR_4717|M.marinum_M EPVHAAVYTPEHSPDIQRVTE--------MHRQMGLDMVTNMIEIRDNPR
MUL_0317|M.ulcerans_Agy99 EPVHAAVYTPEHSPDIQRVTE--------MHRQMGLDMVTNMIEIRDNPR
MSMEG_4803|M.smegmatis_MC2_155 EPTHASVYTPEHAPEREKINE--------QHREMGIDLINNMMEIRQNPR
Mvan_4160|M.vanbaalenii_PYR-1 EPTHASVYTPEHAPEREKINE--------QHRAMGLDLITNMMEIRENPR
Mflv_1854|M.gilvum_PYR-GCK EPAHASVYTPAESPEYRRVTE--------LAVASAMEMMRHVAEIRETPR
TH_3303|M.thermoresistible__bu SVQHEIIYTPPE--EQEDILR--------RYMELCGEVFQLITERRQNPT
MAV_2159|M.avium_104 NLFHSVMAVSQDSDEYATAIA--------KVPAMMHEVLDYAATRRAKPE
Mb0789c|M.bovis_AF2122/97 ALADAVLHRED---GVADVPP----PAMAASIELMRYYADLIAEFRRRPA
Rv0766c|M.tuberculosis_H37Rv ALADAVLHRED---GVADVPP----PAMAASIELMRYYADLIAEFRRRPA
MLBr_02088|M.leprae_Br4923 RVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPG
MAB_0101|M.abscessus_ATCC_1997 DWTNQMFAYDDPAIGRDTATT--------ATVSMLGYAYAMAEERQLNPQ
. : *
MMAR_4717|M.marinum_M -PGLVNALVQMRIDGQPAPDLEILGNLGLVIGGGFDTTTALTAHALEWLS
MUL_0317|M.ulcerans_Agy99 -PGLVNALVQMRIDGQPAPDLEILGNLGLVIGGGFDTTTALTAHALEWLS
MSMEG_4803|M.smegmatis_MC2_155 -PGLVNALLQLRIDGEPAPDMEILGNLGLIIGGGFDTTTALTAHALEWLG
Mvan_4160|M.vanbaalenii_PYR-1 -PGLVNALLQLRIDGEPAPDIEILGNLGLIIGGGFDTTTALTAHALEWLG
Mflv_1854|M.gilvum_PYR-GCK -PGLIDALIRTRINGAPPPDIEIMGMLMLLIGGGFDTTTALTAHSLEWLS
TH_3303|M.thermoresistible__bu GEGLIDFLVTAEIDGEPIPDDKVFSMVNLVIAGGFDTTTAVTVSSLVYLA
MAV_2159|M.avium_104 -EDLTSFLIRFEFDGHRLTDEQLLNILWNLIGGGVDTTTSQTALTLLHLG
Mb0789c|M.bovis_AF2122/97 -NNLTSALLAAELDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWAA
Rv0766c|M.tuberculosis_H37Rv -NNLTSALLAAELDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWAA
MLBr_02088|M.leprae_Br4923 -EDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAML
MAB_0101|M.abscessus_ATCC_1997 -DDILTGLVRGAYDDRPLTPLEFAYFVIQLMVAGNETSRNAITHGVLAFA
.: *: .. . :. :: .* :*: . :
MMAR_4717|M.marinum_M EHPDERERLWRNRDTLIDSATEEFLRYFTPAPGDGRTFSDDVEFDGIHFK
MUL_0317|M.ulcerans_Agy99 EHHDERERLWRNRDTLIDSATEEFLRYFTPAPGDGRTFSDDLEFFGIHFK
MSMEG_4803|M.smegmatis_MC2_155 EHPDERERLSRERDTLLNPATEEFLRFFTPAPGDGRTFAEDAEVAGYKFK
Mvan_4160|M.vanbaalenii_PYR-1 EHPDQRQRLSSERATLLDPATEEFLRFFTPAPGDGRTFADDVEVEGQRFK
Mflv_1854|M.gilvum_PYR-GCK GHPDERERLSRDRDTLLDPATEEFLRYFTPAPGDGRTLAADVEVDGVVLK
TH_3303|M.thermoresistible__bu EHPEDRQRLIDNPD-LLPRAIEEFLRAFTPQQALARTVTKPVTVAGVELQ
MAV_2159|M.avium_104 THPDLRQQLIDHPE-LYRTATDEFLRYFSVNQTLSRTVTHDVVLAGQRLR
Mb0789c|M.bovis_AF2122/97 HHPGQLARVFADHS-RIPMWVEETLRYDTSSQILARTVAHDLTLYDTTIP
Rv0766c|M.tuberculosis_H37Rv HHPGQLARVFADHS-RIPMWVEETLRYDTSSQILARTVAHDLTLYDTTIP
MLBr_02088|M.leprae_Br4923 RNPSQWKALSSNPQ-RAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLT
MAB_0101|M.abscessus_ATCC_1997 DNPAQWRLYRERRP---STAADEIIRWASPIIAFQRTALQDVELGGVQIR
: :* :* . *. . :
MMAR_4717|M.marinum_M EGERLWISWAMANRDPQVFPDPDELVLDRRG-NRHFSFG-IGVHRCIGSN
MUL_0317|M.ulcerans_Agy99 EGERLWISWAMANREPQVFPDPDELVLDRRG-NRHFSFG-IGVHRCVGSN
MSMEG_4803|M.smegmatis_MC2_155 QYERLWLSWAMANRDPSVFDKPNEVILDRKG-NRHFSFG-IGVHRCVGSN
Mvan_4160|M.vanbaalenii_PYR-1 KFERLWLSWAMANRDASVFDRPNEVVLDRKG-NRHFSFG-IGVHRCVGSN
Mflv_1854|M.gilvum_PYR-GCK EGERLWLSWAMANRDPGLFDHPDEVILDRKG-NRHFSFG-LGVHRCIGSN
TH_3303|M.thermoresistible__bu PGERVLLSWASANQDETAFERPEEIILDRFP-NRHTTFG-IGIHRCLGSH
MAV_2159|M.avium_104 KNDRVVISWLSANHDENEFDRPDEIILDRSP-NRHVAFG-LGPHRCIGSH
Mb0789c|M.bovis_AF2122/97 EGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFG-SGAHFCLGAH
Rv0766c|M.tuberculosis_H37Rv EGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFG-SGAHFCLGAH
MLBr_02088|M.leprae_Br4923 EGDTMVLLLAAANRDPAVYSRPDEFDPDRPS-SRHLAFA-VGSHFCLGAA
MAB_0101|M.abscessus_ATCC_1997 KDQRVGMFYASANFDEDVFDDPFAFNIERDP-NPHLAFGGHGIHYCLGAN
: : : ** : : * * :*. * * *:*:
MMAR_4717|M.marinum_M VARTVFKSMLSAVADRMPDYRCDPDGAVHYETIGVIQGMRKLPATFTPGR
MUL_0317|M.ulcerans_Agy99 VARTVFKSMLSAVADRMPDYRCDPDGRSTTRPSASSRACASCPQRSPRAA
MSMEG_4803|M.smegmatis_MC2_155 VARTVFKSMLTAVLDRMPDYVCDPEGTVHYDTIGVIQGMRNLPATFTPSR
Mvan_4160|M.vanbaalenii_PYR-1 VARTLFKSMVTAVLDRMPDYVCDPEGTVHYDTIGVIQGMRNLPATFTPGK
Mflv_1854|M.gilvum_PYR-GCK VARTVFKSMLTAVLDRMPDFHCDPAGAVHYETIGVIQGMKHLPATFTPGP
TH_3303|M.thermoresistible__bu VARIELETMIRRVLDRMPDYHVDLAAARRYPSIGIINGWINAPATFTPG-
MAV_2159|M.avium_104 LARLMSEVMVRAVLDRIPDYQVDVENVHQYLGNPSMTGLGQLPVTFAPGK
Mb0789c|M.bovis_AF2122/97 LARMEARVALGALLRRIRNYEVD-DDNVVRVHSSNVRGFAHLPISVQAR-
Rv0766c|M.tuberculosis_H37Rv LARMEARVALGALLRRIRNYEVD-DDNVVRVHSSNVRGFAHLPISVQAR-
MLBr_02088|M.leprae_Br4923 LARLEATVTLSAISARFPQVQLA-GELVYKPN-VAMRGMSALPVQV----
MAB_0101|M.abscessus_ATCC_1997 LARLEIGIMFDALADRLPDLMPT--GAPTRFRSGWINGVVALPANYHGSG
:** . : *: : . *
MMAR_4717|M.marinum_M KAGAGLDETLAKLQRICDEQELAR-------------------PVTERKQ
MUL_0317|M.ulcerans_Agy99 RSAR----AWTRLSRSCNASATNRNSRGPSPSANKPRSSTDAPPASRHKI
MSMEG_4803|M.smegmatis_MC2_155 PLGPGLDETLEKLQRICNEEELAR-------------------PITERKE
Mvan_4160|M.vanbaalenii_PYR-1 RLGPGLDETLEKLQRICDEQELAR-------------------PITERKE
Mflv_1854|M.gilvum_PYR-GCK RLGPGLDATLERLQRVCDDQRLAA-------------------PITERRE
TH_3303|M.thermoresistible__bu -------------QRLRDEKLPGA--------------------------
MAV_2159|M.avium_104 ----------------SRKTLLPW--------------------------
Mb0789c|M.bovis_AF2122/97 --------------------------------------------------
Rv0766c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02088|M.leprae_Br4923 --------------------------------------------------
MAB_0101|M.abscessus_ATCC_1997 PRG-----------------------------------------------
MMAR_4717|M.marinum_M AAVID-
MUL_0317|M.ulcerans_Agy99 ASGSGR
MSMEG_4803|M.smegmatis_MC2_155 RAVID-
Mvan_4160|M.vanbaalenii_PYR-1 AAVID-
Mflv_1854|M.gilvum_PYR-GCK AAVL--
TH_3303|M.thermoresistible__bu ------
MAV_2159|M.avium_104 ------
Mb0789c|M.bovis_AF2122/97 ------
Rv0766c|M.tuberculosis_H37Rv ------
MLBr_02088|M.leprae_Br4923 ------
MAB_0101|M.abscessus_ATCC_1997 ------