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LSVDDVVSDSDHHQNRYQFDRHSPEYRSQFKAITEEMHTTCPMAWSDTYGGHWVAAGSHEVFELARCPAV SNDHDVNNQRRGYKGISIPTASRINGVRGGILEMDDPEHRIYRTVLNPYLSPAAVKRWEPFIDEVTRACL DERIEQGSIDFVDDLANIVPAVLTLAILGIPLEKWNLYSEPVHAAVYTPEHSPDIQRVTEMHRQMGLDMV TNMIEIRDNPRPGLVNALVQMRIDGQPAPDLEILGNLGLVIGGGFDTTTALTAHALEWLSEHHDERERLW RNRDTLIDSATEEFLRYFTPAPGDGRTFSDDLEFFGIHFKEGERLWISWAMANREPQVFPDPDELVLDRR GNRHFSFGIGVHRCVGSNVARTVFKSMLSAVADRMPDYRCDPDGRSTTRPSASSRACASCPQRSPRAARS ARAWTRLSRSCNASATNRNSRGPSPSANKPRSSTDAPPASRHKIASGSGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0317 | cyp188A3 | - | 100% (470) | cytochrome P450 188A3 Cyp188A3 |
| M. ulcerans Agy99 | MUL_3863 | cyp108B4 | 2e-31 | 29.35% (310) | cytochrome P450 108B4 Cyp108B4 |
| M. ulcerans Agy99 | MUL_4077 | cyp142A3 | 9e-31 | 28.57% (315) | cytochrome P450 142A3 Cyp142A3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 1e-32 | 28.25% (400) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_2498 | - | 1e-177 | 72.80% (397) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 1e-32 | 28.25% (400) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 8e-24 | 26.10% (318) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3825 | - | 7e-32 | 29.53% (298) | cytochrome P450 |
| M. marinum M | MMAR_4717 | cyp188A3 | 0.0 | 98.22% (394) | cytochrome P450 188A3 Cyp188A3 |
| M. avium 104 | MAV_0940 | - | 0.0 | 84.01% (394) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4803 | - | 1e-177 | 71.07% (394) | cytochrome P450 superfamily protein |
| M. thermoresistible (build 8) | TH_2693 | - | 0.0 | 72.59% (394) | PUTATIVE cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_4160 | - | 1e-177 | 73.05% (397) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0317|M.ulcerans_Agy99 -----------------MSVDDVVS---DSDHHQNRYQFDRHSPEYRSQF
MMAR_4717|M.marinum_M -----------------MSVDDVVS---DSDHQKNRYQFDRHSPEYRSQF
MAV_0940|M.avium_104 -----------------MSVDDGVN---DSDRKKNRYHFDRHSPDYRSRF
Mflv_2498|M.gilvum_PYR-GCK --MTNYTEIAASKESRLLSVDDVVDGTADDSRRKNTYYFDRHTPEYRLQF
Mvan_4160|M.vanbaalenii_PYR-1 -----------------MSVDDVVSGTADDSRKQNRYYFDRHTPEYRLQF
MSMEG_4803|M.smegmatis_MC2_155 -----------------MSIQDVTT---DDDREKITYHFDRHTPEYRLQF
TH_2693|M.thermoresistible__bu -----------------LSVDDIIT---DAERKKHRYHFDRHTPEYRLQF
Mb0789c|M.bovis_AF2122/97 ---------------------------MTVRVGDPELVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv ---------------------------MTVRVGDPELVLDPYDYDFHEDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAB_3825|M.abscessus_ATCC_1997 -----------------------MATALSEIEEAGRVLADPAAYADELRL
.
MUL_0317|M.ulcerans_Agy99 KAITEEMHTTCPMA--WSDTYGGHWVAAGSHEVFELARCPAVSNDHDVNN
MMAR_4717|M.marinum_M KAITEEMHTTCPMA--WSDTYGGHWVAAGSHEVFELARCPAVSNDHDVNN
MAV_0940|M.avium_104 KAITEEMHAKCPMA--WTDTYGGHWVAAGSHEVFELARCPAVSNDHDING
Mflv_2498|M.gilvum_PYR-GCK DKITEEMHAKCPMA--WSETYNGHWVAADSKHVFELARCPAVSNHHDISG
Mvan_4160|M.vanbaalenii_PYR-1 EKITEEMQTKCPMA--WSDTYGGHWVAADSKHVFELARCPVVSNHHDISG
MSMEG_4803|M.smegmatis_MC2_155 EKITEEMHSRCPVA--WTETYDGHWVAAGSNEVFELARCPVVSNHHDISG
TH_2693|M.thermoresistible__bu EKITEEMHAKCPMA--WTDTYGGHWVAADSKHVFELARCPVVSNHHDITG
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLY--RNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSL
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLY--RNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSL
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQ--LPG-MPLTVFSSFSDCDEALRHPLSASDRLKATL
MAB_3825|M.abscessus_ATCC_1997 HAAMTLLRREQPVTKVITDDYRPFWAVTKHDDIMAVERDNALWINEPRPL
: *: . .
MUL_0317|M.ulcerans_Agy99 QRRGYKGISIPTASRINGVRGGILEMDDPEHRIYRTVLNPYLSPAAVKRW
MMAR_4717|M.marinum_M QRRGYKGISIPTASRINGVRGGILEMDDPEHRIYRTVLNPYLSPAAVKRW
MAV_0940|M.avium_104 ERRGYKGISIPTASRVSAVRGGILEMDDPEHRIYRTVLNPYLSPAAVKRW
Mflv_2498|M.gilvum_PYR-GCK ETP-FQGITIPKASRATVVRGGILEMDEPEHSAYRGALNPYLSPAAIKRW
Mvan_4160|M.vanbaalenii_PYR-1 ETP-FQGITIPKASRATVVRGGILEMDEPEHSAYRGALNPYLSPAAIKRW
MSMEG_4803|M.smegmatis_MC2_155 ETP-FQGITIPKASRATVVRGGILEMDEPEHSAYRGALNPYLSPAAIKRW
TH_2693|M.thermoresistible__bu ETP-FQGITIPKASRATVVRGGILEMDEPEHSIYRGALNPYLSPAAIKRW
Mb0789c|M.bovis_AF2122/97 DPSSRTS----EAYRVMS----MLAMDDPAHLRMRTLVSKGFTPRRIREL
Rv0766c|M.tuberculosis_H37Rv DPSSRTS----EAYRVMS----MLAMDDPAHLRMRTLVSKGFTPRRIREL
MLBr_02088|M.leprae_Br4923 AQQAIAAGAEPRPFYASS----FMFLDPPDHTRLRKLVSKAFAPKVVQAL
MAB_3825|M.abscessus_ATCC_1997 LMNLEQEAELDKQAAMGIELKTLVHIDDPKHRVLRAIGADWFRPKAMRDM
:: :* * * * : * ::
MUL_0317|M.ulcerans_Agy99 EPFIDEVTRACLDERIEQG-SIDFVDDLANIVPAVLTLAILGIPLEKWNL
MMAR_4717|M.marinum_M EPFIDEVTRACLDERIEQG-SIDFVDDLANIVPAVLTLAILGIPLEKWNL
MAV_0940|M.avium_104 EPFIDEVTRAALDEKIEEG-SIDFVDDLANIVPAVLTLAMLGIPLKKWKM
Mflv_2498|M.gilvum_PYR-GCK EPFIDEITRAALDEHIESG-RIDFVDHLANVVPAVFTLAMMGIELKKWNV
Mvan_4160|M.vanbaalenii_PYR-1 EPFIHEITRAALDEHIESG-RIDFVDHLANVVPAVFTLAMMGIKLDKWNV
MSMEG_4803|M.smegmatis_MC2_155 EPFVDEITRAAIDEHISSG-RIDFVEHLANVVPAVFTLAMMGIELKKWNV
TH_2693|M.thermoresistible__bu EPFVHEITRAAIDEKIESG-EIDFVEDLANVVPAVFTLAMMGIELKKWKV
Mb0789c|M.bovis_AF2122/97 EPQVLELARIHLDSALQTE-SFDFVAEFAGKLPMDVISELIGVPDTDRAR
Rv0766c|M.tuberculosis_H37Rv EPQVLELARIHLDSALQTE-SFDFVAEFAGKLPMDVISELIGVPDTDRAR
MLBr_02088|M.leprae_Br4923 EGDIAALVDSLLDKGAAAG-QFDVIADLAFPLAVAVICRLLGVPYEDAPE
MAB_3825|M.abscessus_ATCC_1997 KLRTDELANRYVNKLLEAGGSCDFAQDIAVHFPLYVIMSLLGIPESDFDR
: :. ::. *. .:* .. . ::*: .
MUL_0317|M.ulcerans_Agy99 YSEPVHAAVYTPEH----SPDIQRVTEMHRQMGLDMVTN----MIEIRDN
MMAR_4717|M.marinum_M YSEPVHAAVYTPEH----SPDIQRVTEMHRQMGLDMVTN----MIEIRDN
MAV_0940|M.avium_104 YSEPVHAAVYTPEH----SPDIERVTAMHREMGLDMVNN----MLEIREN
Mflv_2498|M.gilvum_PYR-GCK YSEPTHASVYTPEH----APEREKINEQHREMGIDLINN----MMEIREN
Mvan_4160|M.vanbaalenii_PYR-1 YSEPTHASVYTPEH----APEREKINEQHRAMGLDLITN----MMEIREN
MSMEG_4803|M.smegmatis_MC2_155 YSEPTHASVYTPEH----APEREKINEQHREMGIDLINN----MMEIRQN
TH_2693|M.thermoresistible__bu YSEPTHASVYTPEH----APEREKVNEMHREMGIDLINN----MMEIREN
Mb0789c|M.bovis_AF2122/97 IRALADAVLHRED---GVADVPP----PAMAASIELMRYYADLIAEFRRR
Rv0766c|M.tuberculosis_H37Rv IRALADAVLHRED---GVADVPP----PAMAASIELMRYYADLIAEFRRR
MLBr_02088|M.leprae_Br4923 FGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGT
MAB_3825|M.abscessus_ATCC_1997 MLKLTQELFGGDDS----EFQRGTTPEEQLMALLDFFGYFSGLTASRRQH
. : : : *
MUL_0317|M.ulcerans_Agy99 PRPGLVNALVQMRIDGQPAPDLEILGNLGLVIGGGFDTTTALTAHALEWL
MMAR_4717|M.marinum_M PRPGLVNALVQMRIDGQPAPDLEILGNLGLVIGGGFDTTTALTAHALEWL
MAV_0940|M.avium_104 PRPGIVNALLQMRIDGEPAPDLEILGNLGLVIGGGFDTTTALTAHSLEWL
Mflv_2498|M.gilvum_PYR-GCK PRPGLVNALLQLRIDGEPAPDMEILGNLGLIIGGGFDTTTALTAHALEWL
Mvan_4160|M.vanbaalenii_PYR-1 PRPGLVNALLQLRIDGEPAPDIEILGNLGLIIGGGFDTTTALTAHALEWL
MSMEG_4803|M.smegmatis_MC2_155 PRPGLVNALLQLRIDGEPAPDMEILGNLGLIIGGGFDTTTALTAHALEWL
TH_2693|M.thermoresistible__bu PRPGLVNALLQLRIDGEPAPDMEILGNLGLIIGGGFDTTTALTAHALEWL
Mb0789c|M.bovis_AF2122/97 PANNLTSALLAAELDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWA
Rv0766c|M.tuberculosis_H37Rv PANNLTSALLAAELDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWA
MLBr_02088|M.leprae_Br4923 PGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAM
MAB_3825|M.abscessus_ATCC_1997 PTDDLASTIANARVDGELLSDVDTASYYTIIATAGHDTTSATIAGGLEAL
* .: . : .*: .: : . :: .* :** * .:
MUL_0317|M.ulcerans_Agy99 SEHHDERERLWRNRDTLIDSATEEFLRYFTPAPGDGRTFSDDLEFFGIHF
MMAR_4717|M.marinum_M SEHPDERERLWRNRDTLIDSATEEFLRYFTPAPGDGRTFSDDVEFDGIHF
MAV_0940|M.avium_104 SEHPEQRQLLSDERKTLLDPATEEFLRYFTPAPGDGRTFSEDFELDGTVF
Mflv_2498|M.gilvum_PYR-GCK GEHPDERERLSRERATLLAPATEEFLRFFTPAPGDGRTFSEDVEVAGQRF
Mvan_4160|M.vanbaalenii_PYR-1 GEHPDQRQRLSSERATLLDPATEEFLRFFTPAPGDGRTFADDVEVEGQRF
MSMEG_4803|M.smegmatis_MC2_155 GEHPDERERLSRERDTLLNPATEEFLRFFTPAPGDGRTFAEDAEVAGYKF
TH_2693|M.thermoresistible__bu GEHPDERERLSRERDTLLNPATEEFLRFFTPAPGDGRTFAEDVEVLGTQF
Mb0789c|M.bovis_AF2122/97 AHHPGQLARVFAD-HSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
Rv0766c|M.tuberculosis_H37Rv AHHPGQLARVFAD-HSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
MLBr_02088|M.leprae_Br4923 LRNPSQWKALSSN-PQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTL
MAB_3825|M.abscessus_ATCC_1997 LEHPDQLARLREN-PGLMPLAVDEMIRWVTPVKEFMRTATADTEIRGVPI
.: : : : .:* :*: .. *. : * . :
MUL_0317|M.ulcerans_Agy99 KEGERLWISWAMANREPQVFPDPDELVLDRRG-NRHFSFGIGVHRCVGSN
MMAR_4717|M.marinum_M KEGERLWISWAMANRDPQVFPDPDELVLDRRG-NRHFSFGIGVHRCIGSN
MAV_0940|M.avium_104 KEGERLWISWAMANRDPAVFHDPDEVILDRKG-NRHFSFGLGIHRCIGSN
Mflv_2498|M.gilvum_PYR-GCK KQYERLWLSWAMANRDPAVFDEPNKVVLDRKG-NRHFSFGIGVHRCVGSN
Mvan_4160|M.vanbaalenii_PYR-1 KKFERLWLSWAMANRDASVFDRPNEVVLDRKG-NRHFSFGIGVHRCVGSN
MSMEG_4803|M.smegmatis_MC2_155 KQYERLWLSWAMANRDPSVFDKPNEVILDRKG-NRHFSFGIGVHRCVGSN
TH_2693|M.thermoresistible__bu KKYERLWLSWAMANRDPAVFERPNEIILDRKG-NRHFSFGIGVHRCVGSN
Mb0789c|M.bovis_AF2122/97 PEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGAH
Rv0766c|M.tuberculosis_H37Rv PEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGAH
MLBr_02088|M.leprae_Br4923 TEGDTMVLLLAAANRDPAVYSRPDEFDPDRPS-SRHLAFAVGSHFCLGAA
MAB_3825|M.abscessus_ATCC_1997 TEGESVLLSYPSGNRDEDIFTDPFTFDIARDP-NKHLAFGFGVHFCLGAA
: : : : .**: :: * * : .:*. * * *:*:
MUL_0317|M.ulcerans_Agy99 VARTVFKSMLSAVADRMPDYRCDPDGRSTTRPSASSRACASCPQRSPRAA
MMAR_4717|M.marinum_M VARTVFKSMLSAVADRMPDYRCDPDGAVHYETIGVIQGMRKLPATFTPGR
MAV_0940|M.avium_104 VARTVFKSMLIAVLDRMPDYRCDPEGTVHYETIGVIQGMRKLPATFTPGR
Mflv_2498|M.gilvum_PYR-GCK VARTVFKSMLTAVLDRMPDYVCDPEGTVHYDSIGVIQGMRNLPATFTPGK
Mvan_4160|M.vanbaalenii_PYR-1 VARTLFKSMVTAVLDRMPDYVCDPEGTVHYDTIGVIQGMRNLPATFTPGK
MSMEG_4803|M.smegmatis_MC2_155 VARTVFKSMLTAVLDRMPDYVCDPEGTVHYDTIGVIQGMRNLPATFTPSR
TH_2693|M.thermoresistible__bu VARTVFKSMLTAVLDRMPDYVCDPEGTMHYDTIGVIQGMRHLPAKFTPGK
Mb0789c|M.bovis_AF2122/97 LARMEARVALGALLRRIRNYEVDDD-NVVRVHSSNVRGFAHLPISVQAR-
Rv0766c|M.tuberculosis_H37Rv LARMEARVALGALLRRIRNYEVDDD-NVVRVHSSNVRGFAHLPISVQAR-
MLBr_02088|M.leprae_Br4923 LARLEATVTLSAISARFPQVQLAGE-LVYKPN-VAMRGMSALPVQV----
MAB_3825|M.abscessus_ATCC_1997 LARMEVNSFFSALLPRLESIEVDGN--IERTSTIFVGGIKHLPIRYTLR-
:** . *: *: . : . *
MUL_0317|M.ulcerans_Agy99 RSAR----AWTRLSRSCNASATNRNSRGPSPSANKPRSSTDAPPASRHKI
MMAR_4717|M.marinum_M KAGAGLDETLAKLQRICDEQELAR-------------------PVTERKQ
MAV_0940|M.avium_104 RIGAGLDETLEKLQRICDEQELAR-------------------PITERKE
Mflv_2498|M.gilvum_PYR-GCK PLGPGLDETIEKLQRICNEQELAR-------------------PITERKE
Mvan_4160|M.vanbaalenii_PYR-1 RLGPGLDETLEKLQRICDEQELAR-------------------PITERKE
MSMEG_4803|M.smegmatis_MC2_155 PLGPGLDETLEKLQRICNEEELAR-------------------PITERKE
TH_2693|M.thermoresistible__bu PLGPKLDETLDRLQQICDEQELAR-------------------PITERKE
Mb0789c|M.bovis_AF2122/97 --------------------------------------------------
Rv0766c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02088|M.leprae_Br4923 --------------------------------------------------
MAB_3825|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_0317|M.ulcerans_Agy99 ASGSGR
MMAR_4717|M.marinum_M AAVID-
MAV_0940|M.avium_104 AAVID-
Mflv_2498|M.gilvum_PYR-GCK AAVID-
Mvan_4160|M.vanbaalenii_PYR-1 AAVID-
MSMEG_4803|M.smegmatis_MC2_155 RAVID-
TH_2693|M.thermoresistible__bu PAVITW
Mb0789c|M.bovis_AF2122/97 ------
Rv0766c|M.tuberculosis_H37Rv ------
MLBr_02088|M.leprae_Br4923 ------
MAB_3825|M.abscessus_ATCC_1997 ------