For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VNPETLRYDFDRHRPDYRDRFLDITHEMHQQCPLAWTDTYDGHWVAASSDAVFELARCPFVSNDHDVNNE RRGYKGISIPRMLEAEGFRGGMLEMDDPEHRHYRTALNPYLSPAAVKRWEPFVDEIVCACLDDRIESGRI DFVDDLANVVPAVLTLAMLGVPLQKWEMYNEPAHASVYTPPDSPDAERVRELYMAMGIDLFTNLMEIRDN PRPGIINALATLRIDGEAPPDIELIGMLNLLIGGGFDTTTALTAHALEWLSEHPDERARLSADRDTLLNP ATEEFLRYFTPAPGDARTIAEDVAVNGVELREGQRLWLSWAMANRDPAVFTDPDQIVLDRKGNRHFSFGL GVHRCIGSNVARTVFKSMLTAVLDRMPDYRCLPKETVHYDSIGVIQGMRHLPAEFTPGPRRGAGVAETVA RLQKICDEQGLARPITELKDAARIEEAV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1259 | - | - | 100% (448) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_1854 | - | 0.0 | 71.95% (435) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_2498 | - | 0.0 | 69.63% (438) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 1e-36 | 30.05% (406) | cytochrome P450 123 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 1e-36 | 30.05% (406) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 6e-27 | 28.45% (341) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3825 | - | 1e-36 | 27.82% (381) | cytochrome P450 |
| M. marinum M | MMAR_4717 | cyp188A3 | 0.0 | 72.21% (439) | cytochrome P450 188A3 Cyp188A3 |
| M. avium 104 | MAV_1397 | - | 0.0 | 74.72% (443) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4803 | - | 0.0 | 68.33% (442) | cytochrome P450 superfamily protein |
| M. thermoresistible (build 8) | TH_2693 | - | 0.0 | 70.55% (438) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0317 | cyp188A3 | 1e-172 | 72.15% (377) | cytochrome P450 188A3 Cyp188A3 |
| M. vanbaalenii PYR-1 | Mvan_4880 | - | 0.0 | 71.20% (441) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1259|M.gilvum_PYR-GCK -----------------------------MNPETLRYDFDRHRPDYRDRF
MAV_1397|M.avium_104 ---------------------MSVEVAGSDSRKALQFHFDRHAPEYRERF
Mvan_4880|M.vanbaalenii_PYR-1 -----------------------MADQLDRRREARSFHFDRHTPQYRDRF
MMAR_4717|M.marinum_M --------------------MSVDDVVSDSDHQKNRYQFDRHSPEYRSQF
MUL_0317|M.ulcerans_Agy99 --------------------MSVDDVVSDSDHHQNRYQFDRHSPEYRSQF
MSMEG_4803|M.smegmatis_MC2_155 --------------------MSIQDVTTDDDREKITYHFDRHTPEYRLQF
TH_2693|M.thermoresistible__bu --------------------LSVDDIITDAERKKHRYHFDRHTPEYRLQF
Mb0789c|M.bovis_AF2122/97 ---------------------------MTVRVGDPELVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv ---------------------------MTVRVGDPELVLDPYDYDFHEDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAB_3825|M.abscessus_ATCC_1997 -----------------------MATALSEIEEAGRVLADPAAYADELRL
.
Mflv_1259|M.gilvum_PYR-GCK LDITHEMHQQCPLA--WTDTYDGHWVAASSDAVFELARCPFVSNDHDVNN
MAV_1397|M.avium_104 LDVTQEMHQRCPIA--WTDTYGGHWVAAGGDAVFELARCPHVSNDHDVNN
Mvan_4880|M.vanbaalenii_PYR-1 QEITAQMQARCPLA--WTDTYGGHWVAAGNREVFELARCPHVSNDNDIDG
MMAR_4717|M.marinum_M KAITEEMHTTCPMA--WSDTYGGHWVAAGSHEVFELARCPAVSNDHDVNN
MUL_0317|M.ulcerans_Agy99 KAITEEMHTTCPMA--WSDTYGGHWVAAGSHEVFELARCPAVSNDHDVNN
MSMEG_4803|M.smegmatis_MC2_155 EKITEEMHSRCPVA--WTETYDGHWVAAGSNEVFELARCPVVSNHHDISG
TH_2693|M.thermoresistible__bu EKITEEMHAKCPMA--WTDTYGGHWVAADSKHVFELARCPVVSNHHDITG
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLY--RNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSL
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLY--RNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSL
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQ--LPG-MPLTVFSSFSDCDEALRHPLSASDRLKATL
MAB_3825|M.abscessus_ATCC_1997 HAAMTLLRREQPVTKVITDDYRPFWAVTKHDDIMAVERDNALWINEPRPL
: *: .
Mflv_1259|M.gilvum_PYR-GCK ERRGYKGISIPRMLEAEGFRGGMLEMDDPEHRHYRTALNPYLSPAAVKRW
MAV_1397|M.avium_104 ERRGYRGVTIPLTTESDQIRGGMLEMDDPEHRIYRSLLNPYLSPAAVSRW
Mvan_4880|M.vanbaalenii_PYR-1 TRRGYTGINIPRGDYSVAFRGGMLEMDDPEHREYRSPLNGYLSPAAVRRW
MMAR_4717|M.marinum_M QRRGYKGISIPTASRINGVRGGILEMDDPEHRIYRTVLNPYLSPAAVKRW
MUL_0317|M.ulcerans_Agy99 QRRGYKGISIPTASRINGVRGGILEMDDPEHRIYRTVLNPYLSPAAVKRW
MSMEG_4803|M.smegmatis_MC2_155 ETP-FQGITIPKASRATVVRGGILEMDEPEHSAYRGALNPYLSPAAIKRW
TH_2693|M.thermoresistible__bu ETP-FQGITIPKASRATVVRGGILEMDEPEHSIYRGALNPYLSPAAIKRW
Mb0789c|M.bovis_AF2122/97 DPSSRTS----EAYRVM----SMLAMDDPAHLRMRTLVSKGFTPRRIREL
Rv0766c|M.tuberculosis_H37Rv DPSSRTS----EAYRVM----SMLAMDDPAHLRMRTLVSKGFTPRRIREL
MLBr_02088|M.leprae_Br4923 AQQAIAAGAEPRPFYAS----SFMFLDPPDHTRLRKLVSKAFAPKVVQAL
MAB_3825|M.abscessus_ATCC_1997 LMNLEQEAELDKQAAMGIELKTLVHIDDPKHRVLRAIGADWFRPKAMRDM
:: :* * * * : * :
Mflv_1259|M.gilvum_PYR-GCK EPFVDEIVCACLDDRIESG-RIDFVDDLANVVPAVLTLAMLGVPLQKWEM
MAV_1397|M.avium_104 QPFIDDVVRACLDERIESG-RIDFVDDLANVVPAVLTLAMLGVPLRKWTM
Mvan_4880|M.vanbaalenii_PYR-1 VPVVDELVKACLDEKIEDG-RIDFVDDLANIVPAVLTLGLLGVPLKDWEI
MMAR_4717|M.marinum_M EPFIDEVTRACLDERIEQG-SIDFVDDLANIVPAVLTLAILGIPLEKWNL
MUL_0317|M.ulcerans_Agy99 EPFIDEVTRACLDERIEQG-SIDFVDDLANIVPAVLTLAILGIPLEKWNL
MSMEG_4803|M.smegmatis_MC2_155 EPFVDEITRAAIDEHISSG-RIDFVEHLANVVPAVFTLAMMGIELKKWNV
TH_2693|M.thermoresistible__bu EPFVHEITRAAIDEKIESG-EIDFVEDLANVVPAVFTLAMMGIELKKWKV
Mb0789c|M.bovis_AF2122/97 EPQVLELARIHLDSALQTE-SFDFVAEFAGKLPMDVISELIGVPDTDRAR
Rv0766c|M.tuberculosis_H37Rv EPQVLELARIHLDSALQTE-SFDFVAEFAGKLPMDVISELIGVPDTDRAR
MLBr_02088|M.leprae_Br4923 EGDIAALVDSLLDKGAAAG-QFDVIADLAFPLAVAVICRLLGVPYEDAPE
MAB_3825|M.abscessus_ATCC_1997 KLRTDELANRYVNKLLEAGGSCDFAQDIAVHFPLYVIMSLLGIPESDFDR
:. ::. *. .:* .. . ::*: .
Mflv_1259|M.gilvum_PYR-GCK YNEPAHASVYTPP-------DSPDA-ERVRELYMAMGIDLFTNLMEIRDN
MAV_1397|M.avium_104 YNEPVHAMVYTPP-------DSPEA-AKVHDMWVSVVVDLFANLTEIREH
Mvan_4880|M.vanbaalenii_PYR-1 YCEPAHASVYTPA-------DSPDF-PRVADLAIASAMGMMHHVAEIRQT
MMAR_4717|M.marinum_M YSEPVHAAVYTPE-------HSPDI-QRVTEMHRQMGLDMVTNMIEIRDN
MUL_0317|M.ulcerans_Agy99 YSEPVHAAVYTPE-------HSPDI-QRVTEMHRQMGLDMVTNMIEIRDN
MSMEG_4803|M.smegmatis_MC2_155 YSEPTHASVYTPE-------HAPER-EKINEQHREMGIDLINNMMEIRQN
TH_2693|M.thermoresistible__bu YSEPTHASVYTPE-------HAPER-EKVNEMHREMGIDLINNMMEIREN
Mb0789c|M.bovis_AF2122/97 IRALADAVLHRED---GVADVPP----PAMAASIELMRYYADLIAEFRRR
Rv0766c|M.tuberculosis_H37Rv IRALADAVLHRED---GVADVPP----PAMAASIELMRYYADLIAEFRRR
MLBr_02088|M.leprae_Br4923 FGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGT
MAB_3825|M.abscessus_ATCC_1997 MLKLTQELFGGDD----SEFQRGTTPEEQLMALLDFFGYFSGLTASRRQH
. *
Mflv_1259|M.gilvum_PYR-GCK PRPGIINALATLRIDGEAPPDIELIGMLNLLIGGGFDTTTALTAHALEWL
MAV_1397|M.avium_104 PRPGIINALAQLRIDGEPAPDMEIIGMLTLLIGGGFDTTTALTAHALEWL
Mvan_4880|M.vanbaalenii_PYR-1 PRPGLIDALVRTRIDGQPAPDTEIMGMLMLLIGGGFDTTTALTAHALEWL
MMAR_4717|M.marinum_M PRPGLVNALVQMRIDGQPAPDLEILGNLGLVIGGGFDTTTALTAHALEWL
MUL_0317|M.ulcerans_Agy99 PRPGLVNALVQMRIDGQPAPDLEILGNLGLVIGGGFDTTTALTAHALEWL
MSMEG_4803|M.smegmatis_MC2_155 PRPGLVNALLQLRIDGEPAPDMEILGNLGLIIGGGFDTTTALTAHALEWL
TH_2693|M.thermoresistible__bu PRPGLVNALLQLRIDGEPAPDMEILGNLGLIIGGGFDTTTALTAHALEWL
Mb0789c|M.bovis_AF2122/97 PANNLTSALLAAELDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWA
Rv0766c|M.tuberculosis_H37Rv PANNLTSALLAAELDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWA
MLBr_02088|M.leprae_Br4923 PGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAM
MAB_3825|M.abscessus_ATCC_1997 PTDDLASTIANARVDGELLSDVDTASYYTIIATAGHDTTSATIAGGLEAL
* .: . : .*: .: : . :: .* :** * .:
Mflv_1259|M.gilvum_PYR-GCK SEHPDERARLSADRDTLLNPATEEFLRYFTPAPGDARTIAEDVAVNGVEL
MAV_1397|M.avium_104 SEHPDQRARLHGELDVLLNPATEEFLRYFTPAPGDARTISADMELDGIRF
Mvan_4880|M.vanbaalenii_PYR-1 SQHPDERERLSRDRDTLLDPATEEFLRYFTPAPGDGRTVAEDIEVDGVVL
MMAR_4717|M.marinum_M SEHPDERERLWRNRDTLIDSATEEFLRYFTPAPGDGRTFSDDVEFDGIHF
MUL_0317|M.ulcerans_Agy99 SEHHDERERLWRNRDTLIDSATEEFLRYFTPAPGDGRTFSDDLEFFGIHF
MSMEG_4803|M.smegmatis_MC2_155 GEHPDERERLSRERDTLLNPATEEFLRFFTPAPGDGRTFAEDAEVAGYKF
TH_2693|M.thermoresistible__bu GEHPDERERLSRERDTLLNPATEEFLRFFTPAPGDGRTFAEDVEVLGTQF
Mb0789c|M.bovis_AF2122/97 AHHPGQLARVFAD-HSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
Rv0766c|M.tuberculosis_H37Rv AHHPGQLARVFAD-HSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
MLBr_02088|M.leprae_Br4923 LRNPSQWKALSSN-PQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTL
MAB_3825|M.abscessus_ATCC_1997 LEHPDQLARLREN-PGLMPLAVDEMIRWVTPVKEFMRTATADTEIRGVPI
.: .: : : .:* :*: .. *. : * . :
Mflv_1259|M.gilvum_PYR-GCK REGQRLWLSWAMANRDPAVFTDPDQIVLDRKG-NRHFSFGLGVHRCIGSN
MAV_1397|M.avium_104 AEGERLWLSWAMANRDPSLFDNPNELMLARKA-NRHFSFGIGVHRCIGSN
Mvan_4880|M.vanbaalenii_PYR-1 KEGERLWLSWAMANRDPALFQNPDEVVLDRKG-NRHFSFGLGVHRCIGSN
MMAR_4717|M.marinum_M KEGERLWISWAMANRDPQVFPDPDELVLDRRG-NRHFSFGIGVHRCIGSN
MUL_0317|M.ulcerans_Agy99 KEGERLWISWAMANREPQVFPDPDELVLDRRG-NRHFSFGIGVHRCVGSN
MSMEG_4803|M.smegmatis_MC2_155 KQYERLWLSWAMANRDPSVFDKPNEVILDRKG-NRHFSFGIGVHRCVGSN
TH_2693|M.thermoresistible__bu KKYERLWLSWAMANRDPAVFERPNEIILDRKG-NRHFSFGIGVHRCVGSN
Mb0789c|M.bovis_AF2122/97 PEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGAH
Rv0766c|M.tuberculosis_H37Rv PEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGAH
MLBr_02088|M.leprae_Br4923 TEGDTMVLLLAAANRDPAVYSRPDEFDPDRPS-SRHLAFAVGSHFCLGAA
MAB_3825|M.abscessus_ATCC_1997 TEGESVLLSYPSGNRDEDIFTDPFTFDIARDP-NKHLAFGFGVHFCLGAA
: : : : .**: :: * * : .:*. * * *:*:
Mflv_1259|M.gilvum_PYR-GCK VARTVFKSMLTAVLDRMPDYRCLPKETVHYDSIGVIQGMRHLPAEFTPGP
MAV_1397|M.avium_104 VARTVFKSMLTAVLERMPDYRCDRVNTVHYDTIGIIQGMRNLPADFTPGK
Mvan_4880|M.vanbaalenii_PYR-1 VARTVFKSMLTAVLDRMPDFQCDAAGAVHYETIGVIQGMQHLPAAFTPGP
MMAR_4717|M.marinum_M VARTVFKSMLSAVADRMPDYRCDPDGAVHYETIGVIQGMRKLPATFTPGR
MUL_0317|M.ulcerans_Agy99 VARTVFKSMLSAVADRMPDYRCDPDGRSTTRPSASSRACASCPQRSPRAA
MSMEG_4803|M.smegmatis_MC2_155 VARTVFKSMLTAVLDRMPDYVCDPEGTVHYDTIGVIQGMRNLPATFTPSR
TH_2693|M.thermoresistible__bu VARTVFKSMLTAVLDRMPDYVCDPEGTMHYDTIGVIQGMRHLPAKFTPGK
Mb0789c|M.bovis_AF2122/97 LARMEARVALGALLRRIRNYEVDDD-NVVRVHSSNVRGFAHLPISVQAR-
Rv0766c|M.tuberculosis_H37Rv LARMEARVALGALLRRIRNYEVDDD-NVVRVHSSNVRGFAHLPISVQAR-
MLBr_02088|M.leprae_Br4923 LARLEATVTLSAISARFPQVQLAGE-LVYKPN-VAMRGMSALPVQV----
MAB_3825|M.abscessus_ATCC_1997 LARMEVNSFFSALLPRLESIEVDGN--IERTSTIFVGGIKHLPIRYTLR-
:** : *: *: . . *
Mflv_1259|M.gilvum_PYR-GCK RRGAGVAETVARLQKICDEQGLAR-------------------PITELKD
MAV_1397|M.avium_104 RRGPGLDETLDRLQSVCDSQGLAR-------------------PITEYKE
Mvan_4880|M.vanbaalenii_PYR-1 RLGPGLEATLEKLQRVCDEQQLAA-------------------PITVHKA
MMAR_4717|M.marinum_M KAGAGLDETLAKLQRICDEQELAR-------------------PVTERKQ
MUL_0317|M.ulcerans_Agy99 RSAR----AWTRLSRSCNASATNRNSRGPSPSANKPRSSTDAPPASRHKI
MSMEG_4803|M.smegmatis_MC2_155 PLGPGLDETLEKLQRICNEEELAR-------------------PITERKE
TH_2693|M.thermoresistible__bu PLGPKLDETLDRLQQICDEQELAR-------------------PITERKE
Mb0789c|M.bovis_AF2122/97 --------------------------------------------------
Rv0766c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02088|M.leprae_Br4923 --------------------------------------------------
MAB_3825|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1259|M.gilvum_PYR-GCK AARIEEAV
MAV_1397|M.avium_104 QARIHE--
Mvan_4880|M.vanbaalenii_PYR-1 AAVI----
MMAR_4717|M.marinum_M AAVID---
MUL_0317|M.ulcerans_Agy99 ASGSGR--
MSMEG_4803|M.smegmatis_MC2_155 RAVID---
TH_2693|M.thermoresistible__bu PAVITW--
Mb0789c|M.bovis_AF2122/97 --------
Rv0766c|M.tuberculosis_H37Rv --------
MLBr_02088|M.leprae_Br4923 --------
MAB_3825|M.abscessus_ATCC_1997 --------