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RVAVVTGGASGMGEATCHELGRRGMKIAVLDVDEHAAQRVTDDLRTGGATALGVGADVTDRAAVEQAFAK VRSELGPVTVLVTSAGMFGFSPFLDITAESWSRIIDVNLTGTFHCCQVALPDMVAANWGRIVMISSSSAQ RGSPFAAHYAASKGAVITLTKSLAREYAPHGITVNNIPPSGIETPMQHQGQAAGYLPSNEQIAANIPLGY LGTGADIAAAVGFLTSDEARYITGQVLGVNGGAVMLTVRIR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3962 | - | - | 100% (252) | NAD-dependent epimerase/dehydratase:Short-chain dehydrogenase/reductase SDR |
| M. avium 104 | MAV_1395 | - | 5e-73 | 56.56% (244) | 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase |
| M. avium 104 | MAV_0942 | - | 6e-63 | 51.03% (243) | 3-oxoacyl-(acyl-carrier-protein) reductase, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1519 | fabG1 | 2e-32 | 36.44% (247) | 3-oxoacyl- |
| M. gilvum PYR-GCK | Mflv_2469 | - | 1e-105 | 75.92% (245) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1483 | fabG1 | 2e-32 | 36.44% (247) | 3-oxoacyl- |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 1e-34 | 38.06% (247) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0073c | - | 2e-32 | 34.63% (257) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_4715 | - | 4e-62 | 51.44% (243) | 3-oxoacyl- |
| M. smegmatis MC2 155 | MSMEG_0294 | fabG | 1e-111 | 81.63% (245) | 3-oxoacyl-(acyl-carrier-protein) reductase |
| M. thermoresistible (build 8) | TH_0026 | - | 3e-69 | 78.21% (156) | 3-oxoacyl-(acyl-carrier-protein) reductase, putative |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 6e-62 | 53.33% (240) | 3-oxoacyl- |
| M. vanbaalenii PYR-1 | Mvan_4185 | - | 1e-107 | 76.73% (245) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1519|M.bovis_AF2122/97 MTATATEG------AKPPFVSRSVLVTGGNRGIGLAIAQRLAADGHKVAV
Rv1483|M.tuberculosis_H37Rv MTATATEG------AKPPFVSRSVLVTGGNRGIGLAIAQRLAADGHKVAV
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
MAV_3962|M.avium_104 --------------------MRVAVVTGGASGMGEATCHELGRRGMKIAV
MSMEG_0294|M.smegmatis_MC2_155 -------------------MNRVAVVTGGASGMGEATCHELGRRGHKVAV
Mflv_2469|M.gilvum_PYR-GCK ------------------MSSRVAVVTGGASGMGESTCHELGRRGHKVAV
Mvan_4185|M.vanbaalenii_PYR-1 -------------------MTRVAVVTGGASGMGEATCHELGRRGCKVAV
TH_0026|M.thermoresistible__bu --------------------------------------------------
MMAR_4715|M.marinum_M ----------MK----------TAVVTGGASGIGLAIARRLRADGIDVAT
MUL_0315|M.ulcerans_Agy99 ----------MRPDSSPSWCTITSVVTGGASGIGLAIARRLSADGTDVAT
MAB_0073c|M.abscessus_ATCC_199 ---------------MTRLGGRVAVVTGAGKGMGRTHCERLAEEGSDVIA
Mb1519|M.bovis_AF2122/97 THR-GSGAPKG-----------LFGVECDVTDSDAVDRAFTAVEEHQGPV
Rv1483|M.tuberculosis_H37Rv THR-GSGAPKG-----------LFGVECDVTDSDAVDRAFTAVEEHQGPV
MLBr_01807|M.leprae_Br4923 THR-ASVVPDW-----------FFGVECDVTDNDAIGAAFKAVEEHQGPV
MAV_3962|M.avium_104 LDV-DEHAAQRVTDDLRTGGATALGVGADVTDRAAVEQAFAKVRSELGPV
MSMEG_0294|M.smegmatis_MC2_155 LDV-DVDAAQRVTDHLRSEGVTAFAVGADVTDRAAVEEAFAKVRSELGAV
Mflv_2469|M.gilvum_PYR-GCK LDL-NGEAAQRVAEELRADGVTALGIAADVTDRAAVEDAFAKVRTELGPV
Mvan_4185|M.vanbaalenii_PYR-1 LDL-DGQAAQRVAEELRGDGVPALGVAADVTDRAAVEDAFAKVRTELGPV
TH_0026|M.thermoresistible__bu --------------------------------------------------
MMAR_4715|M.marinum_M LDL-KTPDGE-------------LAFSADVTNRSQVDAALTAIRQRLGPV
MUL_0315|M.ulcerans_Agy99 LDL-KTPDGG-------------LAFSADVTNRSQVDAALAAIRQRLGPV
MAB_0073c|M.abscessus_ATCC_199 IDLPGSDDLAQTAAAVEEHGRRCVWAFADVRDAAALTEAIDTGVRMLGRL
Mb1519|M.bovis_AF2122/97 EVLVSNAGLSA-DAFLMRMTEEKFEKVINANLTGAFRVAQRASRSMQRNK
Rv1483|M.tuberculosis_H37Rv EVLVSNAGLSA-DAFLMRMTEEKFEKVINANLTGAFRVAQRASRSMQRNK
MLBr_01807|M.leprae_Br4923 EVLVANAGITS-DMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQR
MAV_3962|M.avium_104 TVLVTSAGMFG-FSPFLDITAESWSRIIDVNLTGTFHCCQVALPDMVAAN
MSMEG_0294|M.smegmatis_MC2_155 GILVTSAGMFG-YASFADITEQSWAQMIDVNLSGTFRCCQVALPDMVDAG
Mflv_2469|M.gilvum_PYR-GCK HILVTSAGLVD-FAPFLDISPQLWQRLIDVNLNGTFHCAQAAIPDMLAAG
Mvan_4185|M.vanbaalenii_PYR-1 HILVTSAGLVD-FAPFLEISPDRWQRLIEVNLNGTFHCAQVAIPDMLAAG
TH_0026|M.thermoresistible__bu ---------VD-FAPFTEISRQAWQRLIDVNLTGTFHCCQVAIPDMVAAG
MMAR_4715|M.marinum_M TILVNAAGLDG-FKRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVAAG
MUL_0315|M.ulcerans_Agy99 TILVNAAGLDG-FKRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVAAG
MAB_0073c|M.abscessus_ATCC_199 DIVVANAGVYDGLAPSCELTEDSWRRALDVNLTGAWHTVKAGAAHLLDG-
:: : : : ::.**.*.:: : :
Mb1519|M.bovis_AF2122/97 FGRMIFIGSVSGSWGIGNQANYAASKAGVIGMARSIARELSKANVTANVV
Rv1483|M.tuberculosis_H37Rv FGRMIFIGSVSGSWGIGNQANYAASKAGVIGMARSIARELSKANVTANVV
MLBr_01807|M.leprae_Br4923 FGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSITANVV
MAV_3962|M.avium_104 WGRIVMISSSSAQRGSPFAAHYAASKGAVITLTKSLAREYAPHGITVNNI
MSMEG_0294|M.smegmatis_MC2_155 WGRIVLISSSSAQRGTPFAAHYAASKGALLTLTKSLAREYAKHGITVNNI
Mflv_2469|M.gilvum_PYR-GCK WGRIVMISSSSAQRGSPGMAHYAASKGALISLTRSLAREYGAAGITVNNI
Mvan_4185|M.vanbaalenii_PYR-1 WGRIVMISSSSAQRGSPGMAHYAASKGALISFTRSLAREYGPAGITVNNV
TH_0026|M.thermoresistible__bu WGRIVMISSSSAQRGSPKMAHYAAAKGALISLTKSLAREYGPLGITVNNI
MMAR_4715|M.marinum_M WGRIVNISSSSTHSGTPYMTHYVAAKSAVNGLTKALALEYGPSGITVNAV
MUL_0315|M.ulcerans_Agy99 WGRIVNISSSSTHSGTPYMTHYVAAKSAVNGLTKALALEYGPSGITVNAV
MAB_0073c|M.abscessus_ATCC_199 -GSVIIISSTNGLKGTANTAHYTASKHAVVGLARTAANELGPQGIRVNTV
* : :.* * ::*.*:* .: :::: * * . .: .* :
Mb1519|M.bovis_AF2122/97 APGYIDTDMTRALDER----------IQQGALQFIPAKRVG-----TPAE
Rv1483|M.tuberculosis_H37Rv APGYIDTDMTRALDER----------IQQGALQFIPAKRVG-----TPAE
MLBr_01807|M.leprae_Br4923 APGFIDTEMTRAMDSK----------YQEAALQAIPLGRIG-----AVEE
MAV_3962|M.avium_104 PPSGIETPMQHQGQAAGYL------PSNEQIAANIPLGYLG-----TGAD
MSMEG_0294|M.smegmatis_MC2_155 PPSGIETPMQHASQAAGYL------PPNETIAANIPLGRLG-----APAD
Mflv_2469|M.gilvum_PYR-GCK PPSGIETPMQLQSQAAGFL------PPNEQMAASIPVGHLG-----TGDD
Mvan_4185|M.vanbaalenii_PYR-1 PPSGIETPMQHQSQAAGFL------PPNEQMAASIPVGHLG-----TGDD
TH_0026|M.thermoresistible__bu PPSGIETPMQHRSQAAGHL------PPNEQMAASIPVGHLG-----TGDD
MMAR_4715|M.marinum_M PPGFIDTPMLRNAAAQGHL------GDIEQNIARTPVRRIG-----KPED
MUL_0315|M.ulcerans_Agy99 PPGFIDTPMLRNAAAQGHL------GDIEQNIARTPVRRIG-----KPED
MAB_0073c|M.abscessus_ATCC_199 HPGAVSTGMILNPAVIARLRPDLEHPTVEDAAEALAARTLLPVPWVEAVD
*. :.* * : . : :
Mb1519|M.bovis_AF2122/97 VAGVVSFLASEDASYISGAVIPVDGGMGMGH----
Rv1483|M.tuberculosis_H37Rv VAGVVSFLASEDASYISGAVIPVDGGMGMGH----
MLBr_01807|M.leprae_Br4923 IAGAVSFLASEDAGYISGAVIPVDGGLGMGH----
MAV_3962|M.avium_104 IAAAVGFLTSDEARYITGQVLGVNGGAVMLTVRIR
MSMEG_0294|M.smegmatis_MC2_155 IAAAVGFLCSEEAGFITGQTLGVNGGSVM------
Mflv_2469|M.gilvum_PYR-GCK IAAAVGFLCSEQAGFITGQTLGVNGGSVMA-----
Mvan_4185|M.vanbaalenii_PYR-1 IAAAVGFLCSEEAGFITGQTLGVNGGSVMA-----
TH_0026|M.thermoresistible__bu IAAAVGFLCSEAAGFITGQVLGVNGGSVL------
MMAR_4715|M.marinum_M IAAACAFLVSEEAGYITGQILGVNGGRNT------
MUL_0315|M.ulcerans_Agy99 IAAACAFLVSEEAGYITGQILGVNGGRNT------
MAB_0073c|M.abscessus_ATCC_199 ISNAVVFLASDEARYITGTQLVVDAGLTQKA----
:: . ** *: * :*:* : *:.*