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MRVLDELSYDPYDVEIDVDPYPTYRRLRDEAPVYFNGRFGFWALSRFADVEAALRDVDNLSNAKGDILEV VKAEPKMPLGVFINEDPPLHTVHRLLVSRAFTPRKMRAIEDQIRTFCAACLDPLTSGDRFDFTLDLGAEM PMRVIGMLIGIPEELQRSVRKVAGQRLRNKPGEPLPVNKDNYFNGNMFRDYVEWRAQNPSDDLVTELLNV EFEDVTGTTRKLSSEELLVFLGVIANAGTETVGRLFGWLGKLLGEHPDQRRALVADPSLIPGAVEEVLRY EPPVHNIARYVSADVDYHGQTIPAGSALLLMTGAANRDERRFDDPDRFDIRRSPNHLSFGRGAHFCLGAS LARVEGRVALEEILKRWPDWTVDMGNAVRAPTATVRGWDSMPAIVG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6622 | - | - | 100% (396) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_3693 | - | e-131 | 57.69% (390) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_4887 | - | e-130 | 55.78% (389) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 1e-66 | 38.89% (396) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_1266 | - | 0.0 | 83.59% (390) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 1e-66 | 38.89% (396) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-47 | 33.08% (393) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 1e-65 | 38.69% (398) | cytochrome P450 |
| M. marinum M | MMAR_4753 | cyp189A7 | 1e-138 | 57.80% (391) | cytochrome P450 189A7 Cyp189A7 |
| M. avium 104 | MAV_1389 | - | 1e-159 | 67.18% (390) | NikQ protein |
| M. thermoresistible (build 8) | TH_2671 | - | 0.0 | 82.71% (399) | PUTATIVE cytochrome P450 monooxygenase |
| M. ulcerans Agy99 | MUL_0324 | cyp189A7 | 1e-137 | 57.54% (391) | cytochrome P450 189A7 Cyp189A7 |
| M. vanbaalenii PYR-1 | Mvan_3187 | - | 1e-134 | 58.33% (396) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0789c|M.bovis_AF2122/97 --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
MSMEG_6622|M.smegmatis_MC2_155 ----------------------------MRVLDE--LSYDPYDVEIDVDP
Mflv_1266|M.gilvum_PYR-GCK -------------------------------MSG--LYYDPYNVEIDVLP
TH_2671|M.thermoresistible__bu ----------------------------MRVLGGSRLYYDPYDIEIDRDP
MAV_1389|M.avium_104 -------------------------------MTG--LYYDPWNREIDADP
MMAR_4753|M.marinum_M ----------------------------MTVTAASDVYFDPYDVELNADP
MUL_0324|M.ulcerans_Agy99 ----------------------------MTVTAASDVYFDPYDVELNADP
Mvan_3187|M.vanbaalenii_PYR-1 --------------------------------MADDLYYDPYDQGIVADP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: : *
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVSMDK
MSMEG_6622|M.smegmatis_MC2_155 YPTYRRLRDEAPVYFNGRFGFWALSRFADVEAALRDVDNLSNAKGDILEV
Mflv_1266|M.gilvum_PYR-GCK YPVYKRLRDEAPLYYNEKFDFWALSRFAEVDSALKDVDNLSNAKGDILEV
TH_2671|M.thermoresistible__bu YPTYRVLRDEVPLYYNDKFDFWALSRYADVEAALRDVENLSSAKGDILEV
MAV_1389|M.avium_104 YPIYKMLRNEAPLYYNERHDFWGLSRYDDVDAALRDPLRLSSAKGDILDV
MMAR_4753|M.marinum_M YPMFRRLREEAPLYYNAQHGFYALSRFADVDRAIVDYQTFSSARGAILEI
MUL_0324|M.ulcerans_Agy99 YPMFRRLREEAPLYYNAQHGFYALSRFADVDRAIVDYQTFSSARGAILEF
Mvan_3187|M.vanbaalenii_PYR-1 YPTYARLRDEAPLYYNGRYDFWALSRHADVEKALQDWSTFSNSRSDILEL
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
:* : * : *: : .* . : .: . *. :
Mb0789c|M.bovis_AF2122/97 SSRTSEAYR----VMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
Rv0766c|M.tuberculosis_H37Rv SSRTSEAYR----VMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
MAB_1216c|M.abscessus_ATCC_199 ASFGPHAKL----VMSFLAMDDPEHLRLRALVSKGFTPRRIRELEGQVVA
MSMEG_6622|M.smegmatis_MC2_155 VKAEPKMP-----LGVFINEDPPLHTVHRLLVSRAFTPRKMRAIEDQIRT
Mflv_1266|M.gilvum_PYR-GCK VKAEPVMP-----DGVFINEDPPVHTVHRLLVSRAFTPRKMKAIEEQVRA
TH_2671|M.thermoresistible__bu VKAEPVMP-----LGVFIHEDPPLHTVHRLLVSRAFTPRKMAAIEDQVRA
MAV_1389|M.avium_104 VKADPVMP-----PGVFINEDPPLHTIHRALVARAFTPKKMRTLEDKIRA
MMAR_4753|M.marinum_M IKANIDIP-----AGVLVFEDPPVHDVHRKLLSRMFTPRKINDLEPKIRE
MUL_0324|M.ulcerans_Agy99 IKANIDIP-----AGVLVFEDPPVHDVHRKLLSRMFTPRKINDLEPKIRE
Mvan_3187|M.vanbaalenii_PYR-1 IKSDFDMP-----KGVMMFEDPPEHTMLRGLMSRVFTPRRMAEIEDQIRR
MLBr_02088|M.leprae_Br4923 QAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAA
:: * * * * *::: *:*: : :* .:
Mb0789c|M.bovis_AF2122/97 LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIRAL
Rv0766c|M.tuberculosis_H37Rv LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIRAL
MAB_1216c|M.abscessus_ATCC_199 LARTHLDRALANASDRSFDFIAEYAGKLPMDVISELMGVPESDRARIREL
MSMEG_6622|M.smegmatis_MC2_155 FCAACLDPLTSGDR---FDFTLDLGAEMPMRVIGMLIGIPEELQRSVRKV
Mflv_1266|M.gilvum_PYR-GCK FCQACLDPLQGGDR---FDFTLDLGAEMPMRVIGMLVGMPDSLQRSVRKA
TH_2671|M.thermoresistible__bu FCAACLDPLNAGDR---FDFTRDLGAEMPMRVIGMLVGMPDSLQREVRSV
MAV_1389|M.avium_104 FCVASLDMVADSDR---FDFVEDLGAELPMRTIGMLLGIPDADQPSVREH
MMAR_4753|M.marinum_M FCARSLDPLIGSGR---FDFVADLGAQMPMRVIGMLLGVPEEDQEAARDF
MUL_0324|M.ulcerans_Agy99 FCARSLDPLIGSGR---FDFVADLGAQMPMRVIGMLLGVPEEDQEAARDF
Mvan_3187|M.vanbaalenii_PYR-1 YCVNCLDPLVGSDG---FDVIAELAAMMPMRVIGMLLGIPESEQVSVRDA
MLBr_02088|M.leprae_Br4923 LVDSLLDKGAAAGQ---FDVIADLAFPLAVAVICRLLGVPYEDAPEFGRV
** **. : . :.: .* *:*:*
Mb0789c|M.bovis_AF2122/97 ADAVLHRED-------GVADVPPPAMAASIELMRYYADLIAEFRRRPANN
Rv0766c|M.tuberculosis_H37Rv ADAVLHRED-------GVADVPPPAMAASIELMRYYADLIAEFRRRPANN
MAB_1216c|M.abscessus_ATCC_199 ADGVMHRED-------GLADVPPEAIQASFDLMTYYIEMVRERRRRPTED
MSMEG_6622|M.smegmatis_MC2_155 AGQRLRNKP-------GEP--LPVN-KDNYFNGNMFRDYVEWRAQNPSDD
Mflv_1266|M.gilvum_PYR-GCK AGARLRNKP-------GEP--LPVK-KDNYFNGNMFRDYVAWRKDNPSDD
TH_2671|M.thermoresistible__bu AGRRLRNQP-------GRP--LPVS-RDNYFNGDMFRDYVAWRERHPSDD
MAV_1389|M.avium_104 ARATLHNDT-------GGP--MPIR-KDHYFDGDMFSDYVEWRKQNPSDD
MMAR_4753|M.marinum_M ATAQLRTEA-------GKP--MKAS-ADGMVSGDFFAHYIDWRAEHPSSD
MUL_0324|M.ulcerans_Agy99 ATAQLRTEA-------GKP--MKAS-ADGMVSGDFFAHYIDWRAEHPSSD
Mvan_3187|M.vanbaalenii_PYR-1 NDANLRTRP-------GAP--MKVADPDRIADGRIYSDYVEWRAANPSDD
MLBr_02088|M.leprae_Br4923 SALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGED
:: . . : * .:
Mb0789c|M.bovis_AF2122/97 LTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYW
Rv0766c|M.tuberculosis_H37Rv LTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYW
MAB_1216c|M.abscessus_ATCC_199 LTSALLQAEIDGD-----RLTDEEVLAFLFLMVIAGNETTTKLLANAVYW
MSMEG_6622|M.smegmatis_MC2_155 LVTELLNVEFEDVTGTTRKLSSEELLVFLGVIANAGTETVGRLFGWLGKL
Mflv_1266|M.gilvum_PYR-GCK LVTELLNVEFEDVDGSRRKLRDEELLVFLGVIANAGSETVGRLFGWLGKV
TH_2671|M.thermoresistible__bu LVTELLNVEFEDVSGTVRRLRTEELLVFLGVIANAGTETVGRLFGWLGKL
MAV_1389|M.avium_104 LITELLSVDFEDQSGTVRRLTTPELLIFLAVIAGAGVETTGRLFGWMGKV
MMAR_4753|M.marinum_M IMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAGKV
MUL_0324|M.ulcerans_Agy99 IMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAGKV
Mvan_3187|M.vanbaalenii_PYR-1 LMTALLNVEFTDEAGVHRKLTRKEVLHYTQVVAGAGNETTGRLIGWLAKV
MLBr_02088|M.leprae_Br4923 LISRLIELDESGD-----QLTEEEIIATCGLLLVAGHETTVNLIANAVLA
: : *: : . :* *:: :: ** **. .*:.
Mb0789c|M.bovis_AF2122/97 AAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
Rv0766c|M.tuberculosis_H37Rv AAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
MAB_1216c|M.abscessus_ATCC_199 GHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAEDITVYDTKI
MSMEG_6622|M.smegmatis_MC2_155 LGEHPDQRRALVADPSLIPGAVEEVLRYEPPVHNIARYVSADVDYHGQTI
Mflv_1266|M.gilvum_PYR-GCK LADHPDARRELAADPSLIPGAIEEILRMEPPVHNIARYVAKDVTYHGQTV
TH_2671|M.thermoresistible__bu LGEHPDQRRELARDPALIPGAVEEVLRYESPVHNIARYVANDVEYHGQTV
MAV_1389|M.avium_104 LADHPDQRKELAEDRSLIPAAVEELLRYEPPGPSVARYVTEDVEFHGQTV
MMAR_4753|M.marinum_M LAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGESV
MUL_0324|M.ulcerans_Agy99 LAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGQSV
Mvan_3187|M.vanbaalenii_PYR-1 LAEHPQQRREIVEDRSLLGRAVDETLRFEPTGPHVARYLARDFEYDGTTV
MLBr_02088|M.leprae_Br4923 MLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTL
:* : : ::* ** :.. :.* : *. .:
Mb0789c|M.bovis_AF2122/97 PEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCLGA
Rv0766c|M.tuberculosis_H37Rv PEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCLGA
MAB_1216c|M.abscessus_ATCC_199 PAGDILLLLPGSANRDDRVFD-DADQYRIGREIGAKLVSFGSGAHFCLGA
MSMEG_6622|M.smegmatis_MC2_155 PAGSALLLMTGAANRDERRFD-DPDRFDIRRSP--NHLSFGRGAHFCLGA
Mflv_1266|M.gilvum_PYR-GCK PAGSALLLMAGAANRDERRFD-NPDVFDIRRSP--NHLTFGRGAHFCLGT
TH_2671|M.thermoresistible__bu PAGSALLLMAGAANRDERRFE-DPDRFDIHRSSG-SHLAFGRGTHFCLGA
MAV_1389|M.avium_104 PSGSAMLLMLSSANRDERRFD-HPDRFDIHRKPG-RHLTFGRGVHFCLGA
MMAR_4753|M.marinum_M PEGSIMMMLIGAANRDHRQFPPDGDVFDIRREPH-QHLTFSVGTHYCLGS
MUL_0324|M.ulcerans_Agy99 PEGSIMMMLIGAANRDHRQFRPDGDVFNIRREPH-QHLTFSVGTHYCLGS
Mvan_3187|M.vanbaalenii_PYR-1 PAGSAILLLFGAANRDERRYR-NPDTFDIHRDNI-SHLTFGKGLHYCLGA
MLBr_02088|M.leprae_Br4923 TEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPSS-RHLAFAVGSHFCLGA
. *. :::: .:**** : * : * ::*. * *:***:
Mb0789c|M.bovis_AF2122/97 HLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR-
Rv0766c|M.tuberculosis_H37Rv HLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR-
MAB_1216c|M.abscessus_ATCC_199 HLARMEAKVALTELFTRISGYEIDERNSVRVHSSNVRGFAHLPMTVQLRE
MSMEG_6622|M.smegmatis_MC2_155 SLARVEGRVALEEILKRWPDWTVDMGNAVRAPTATVRGWDSMPAIVG---
Mflv_1266|M.gilvum_PYR-GCK SLARLEGRIALEEILKRWPDWTFDEDNAHRAPTATVRGWDSMPAIVG---
TH_2671|M.thermoresistible__bu SLARLEGRVALEEILKRWPDWTIDADNAVRAPTATVRGWDSMPAVLG---
MAV_1389|M.avium_104 PLARLEGRIGLEEVLNRWPEWEIDMDNARRSRTSTVRGWDSMPAIVT---
MMAR_4753|M.marinum_M ALARLEGRIALEEILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD---
MUL_0324|M.ulcerans_Agy99 ALARLEGRIALEDILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD---
Mvan_3187|M.vanbaalenii_PYR-1 NLARLEGRVALDELLNRWPEWNIDYDTARLAPTSTVRGWEHLRMLVG---
MLBr_02088|M.leprae_Br4923 ALARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQV----
***:*. : * : * . . :** : .
Mb0789c|M.bovis_AF2122/97 --
Rv0766c|M.tuberculosis_H37Rv --
MAB_1216c|M.abscessus_ATCC_199 GR
MSMEG_6622|M.smegmatis_MC2_155 --
Mflv_1266|M.gilvum_PYR-GCK --
TH_2671|M.thermoresistible__bu --
MAV_1389|M.avium_104 --
MMAR_4753|M.marinum_M --
MUL_0324|M.ulcerans_Agy99 --
Mvan_3187|M.vanbaalenii_PYR-1 --
MLBr_02088|M.leprae_Br4923 --