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M. avium 104 MAV_0944 (-)

annotation: aldehyde dehydrogenase (NAD) family protein
coordinates: 884926 - 886497
length: 523

VTATTSGGTGMPAQDTAEPVTGSSATAATADAAPAAHVDRRLLIDGRLVTAGTTFPSINPATGAVIGHAP
DAGTAEAEAAIAAARRAFDGTGWATDVELRIRCLDQLHRALLEHADELRELTIAEVGATRALTHGAQLDE
PIGIVRFYADLLRSYPFTEDLGEKESRGLRHHRWVEKEAAGVVGAIIAYNYPNQLALAKLAPALAAGCTV
VLKGAPDTPLVTLALGELIANHTDIPAGVVNVLSSSDPAAGVALTTSPDVDVITFTGSTAVGREIMAAAS
QTVKRVFLELGGKSAAIILDDADFAGAALFAAFSMVTHAGQGCALTSRLLVPRSHHDEIVELIAQNFAKV
RHGDPADPKTYMGPLINERQRDKVDGMVRRAVAAGATLVTGGKRLDPGFFYAPTLLTNVDPDSEIAQEEI
FGPVLVVIAFDDDDDAVRIANNSIYGLAGAVFSGDQERALAVARRIRTGSFSINGGNYFGADSPFGGFKQ
SGVGREMGVAGLEEFLERKTFAVVAGPAEGALA

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. avium 104 MAV_0944 - - 100% (523) aldehyde dehydrogenase (NAD) family protein
M. avium 104 MAV_0713 - e-144 53.89% (475) aldehyde dehydrogenase (NAD) family protein
M. avium 104 MAV_1275 - e-128 52.17% (483) aldehyde dehydrogenase family protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0791 aldA 1e-145 54.60% (478) aldehyde dehydrogenase NAD dependant AldA
M. gilvum PYR-GCK Mflv_2502 - 0.0 77.35% (499) aldehyde dehydrogenase
M. tuberculosis H37Rv Rv0768 aldA 1e-145 54.60% (478) aldehyde dehydrogenase NAD dependent AldA
M. leprae Br4923 MLBr_02573 gabD1 2e-53 33.48% (460) succinic semialdehyde dehydrogenase
M. abscessus ATCC 19977 MAB_1218 - 1e-140 53.22% (481) aldehyde dehydrogenase AldA
M. marinum M MMAR_4714 - 0.0 87.01% (508) NAD-dependent aldehyde dehydrogenase
M. smegmatis MC2 155 MSMEG_4799 - 0.0 77.37% (486) aldehyde dehydrogenase (NAD) family protein
M. thermoresistible (build 8) TH_2504 - 0.0 81.17% (478) PUTATIVE aldehyde dehydrogenase
M. ulcerans Agy99 MUL_0477 aldA 1e-140 53.56% (478) NAD-dependent aldehyde dehydrogenase, AldA
M. vanbaalenii PYR-1 Mvan_4156 - 0.0 75.75% (503) aldehyde dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mb0791|M.bovis_AF2122/97            ------------MALWGD-------------------GISALLIDGKLSD
Rv0768|M.tuberculosis_H37Rv         ------------MALWGD-------------------GISALLIDGKLSD
MUL_0477|M.ulcerans_Agy99           ------------MALLAD-------------------GVSSLFIDGKRCE
MAB_1218|M.abscessus_ATCC_1997      ------------MTVLSD-------------------GDSELFIDGKLLP
MAV_0944|M.avium_104                MTATTSGGTGMPAQDTAEPVTGSSATAATADAAPAAHVDRRLLIDGRLVT
MMAR_4714|M.marinum_M               ----------MSSQDTAQTIA--DARSGVAEAPAASRAQRRLLIGGRLIS
Mflv_2502|M.gilvum_PYR-GCK          ------------MQETVTIPD-----ATSGTETADRRAARRLLIGGQLVD
Mvan_4156|M.vanbaalenii_PYR-1       ------------MQETATISD-----ERSGAGQAAQRAERHLLIGGQLLE
MSMEG_4799|M.smegmatis_MC2_155      ------------MQETSTIA-------------AGQRADRKLLIGGELRE
TH_2504|M.thermoresistible__bu      -----------MMRETSTLPG-----EEQRSNGAGQHVDRRLLIDGQLLT
MLBr_02573|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb0791|M.bovis_AF2122/97            GRAGTFPTVNPATEEVLGVAADADAEDMGRAIEAARRAFDSTDWSRNTEL
Rv0768|M.tuberculosis_H37Rv         GRAGTFPTVNPATEEVLGVAADADAEDMGRAIEAARRAFDSTDWSRNTEL
MUL_0477|M.ulcerans_Agy99           GAAGTFATVNPATEETLGVAADAVAGDMDRAIEAARRAFDDTDWSRNTEL
MAB_1218|M.abscessus_ATCC_1997      GGAGRFPTVNPATEEVLGTAADADSDDMSDAIEAARRAFDDSGWSRDVAL
MAV_0944|M.avium_104                AGT-TFPSINPATGAVIGHAPDAGTAEAEAAIAAARRAFDGTGWATDVEL
MMAR_4714|M.marinum_M               TDR-TFPSVNPATGAVLGCAPDAGVPEAEAAVAAARRAFDTTEWSTDVEL
Mflv_2502|M.gilvum_PYR-GCK          TER-TFASLNPATGDVLGYAPDASVADAEAAVAAARAAFDTGDWATDTEL
Mvan_4156|M.vanbaalenii_PYR-1       TER-TFPSLNPATGEVLGYAPDATVADAEAAVAAARRAFDAGVWATDTEL
MSMEG_4799|M.smegmatis_MC2_155      TSR-TFPSVNPATAEVLGYAPDATVADAEAAVAAARTAFDTTSWSTDTEF
TH_2504|M.thermoresistible__bu      TAR-TFPSLNPATGQVLGYAPDATVAEAQAAVAAARRAFDTTDWATNVEL
MLBr_02573|M.leprae_Br4923          ---MSIATINPATGETVKTFTPTTQDEVEDAIARAYARFDN-YRHTTFTQ
                                         :.::****  .:   . :   :   *:  *   **          

Mb0791|M.bovis_AF2122/97            RVRCVRQLRDAMQQHVEELRELTISEVGAPRMLTASAQLEGPVGDLSFAA
Rv0768|M.tuberculosis_H37Rv         RVRCVRQLRDAMQQHVEELRELTISEVGAPRMLTASAQLEGPVGDLSFAA
MUL_0477|M.ulcerans_Agy99           RVRCVRQLRDAMREHIEELRALTISEVGAPRMLTAAAQLEGPVNDLAFSA
MAB_1218|M.abscessus_ATCC_1997      RVHCIRQLRDGMKTHIEELRELTIAEVGAPRMLTAGAQLEGPVDDLQFAA
MAV_0944|M.avium_104                RIRCLDQLHRALLEHADELRELTIAEVGATRALTHGAQLDEPIGIVRFYA
MMAR_4714|M.marinum_M               RIRCLDQLHRALVDHAEELRELTIAEVGATHALTQGAQLDEPIGIVRFYA
Mflv_2502|M.gilvum_PYR-GCK          RIRCLEQLHAALVEHRDELAALTIAEVGATPALCQGAQLDQPIEIVRYYA
Mvan_4156|M.vanbaalenii_PYR-1       RIRCLEQFHAALVEHRDELAALTVAEVGATPALCQGAQLDQPIEIVRYYA
MSMEG_4799|M.smegmatis_MC2_155      RVHCLEQFHRALLEHRDELAALTTAEVGATAALCAGAQLDQPIDIVRYYA
TH_2504|M.thermoresistible__bu      RIRCLDQLHRALVEHRDELADLTVAEVGATPALCAGAQLDQPIAIVRYYA
MLBr_02573|M.leprae_Br4923          RAKWANATADLLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKG-FRYYA
                                    * :        :  . ::   *   *:* .        :. .   . : *

Mb0791|M.bovis_AF2122/97            DTAESYPWKQDLGEASPLGIATRRTLAREAVGVVGAITPWNFPHQINLAK
Rv0768|M.tuberculosis_H37Rv         DTAESYPWKQDLGEASPLGIATRRTLAREAVGVVGAITPWNFPHQINLAK
MUL_0477|M.ulcerans_Agy99           DTAESYSWKQDLGAAAPMGIPTRRTVVREAVGVVGAITPWNFPHQINLAK
MAB_1218|M.abscessus_ATCC_1997      DTAESFDWTSDLGVASPMGIKTRRTLAREAVGVVGAVTPWNFPHQINLAK
MAV_0944|M.avium_104                DLLRSYPFTEDLGEKESRGLRHHRWVEKEAAGVVGAIIAYNYPNQLALAK
MMAR_4714|M.marinum_M               DLLSRYEFSEDLGEKESRGMRHHRWVEKEAAGVVAAIIAYNYPNQLALAK
Mflv_2502|M.gilvum_PYR-GCK          DLLKTYPLTEDLGNIESRGMQHHRWVEKEAGGVVAAIIAYNYPNQLALAK
Mvan_4156|M.vanbaalenii_PYR-1       DLLKTYPLTEDLGNIESRGMQHHRWVEKEAGGVVAAIIAYNYPNQLALAK
MSMEG_4799|M.smegmatis_MC2_155      ELLATYPLTEDLGNIESRGMQHHRWVEKEAAGVVAAIIAYNYPNQLALAK
TH_2504|M.thermoresistible__bu      DLLRRYPMTEDLGNAEIRGMQHHRWVEKEAAGVVAAIIAYNYPNQLALAK
MLBr_02573|M.leprae_Br4923          EKAETLLADEPAEAAAVG--ASKALARYQPLGVVLAVMPWNFPLWQTVRF
                                    :        .            :     :. *** *: .:*:*    :  

Mb0791|M.bovis_AF2122/97            LGPALAAGNTVVLKPAPDTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHA
Rv0768|M.tuberculosis_H37Rv         LGPALAAGNTVVLKPAPDTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHA
MUL_0477|M.ulcerans_Agy99           LGPALAAGNTVVLKPAPDTPWCAAVLGELIADCTDIPPGVVNIVTSSEHG
MAB_1218|M.abscessus_ATCC_1997      VGPALAAGNTLVLKPAPDTPWCAAVLGRIIAEHTDFPPGVVNIVTSSDHR
MAV_0944|M.avium_104                LAPALAAGCTVVLKGAPDTPLVTLALGELIANHTDIPAGVVNVLSSSDPA
MMAR_4714|M.marinum_M               LAPALAAGCTVVLKGAPDTPLVTLALGELIANHTDIPAGVVNVLSSSDPA
Mflv_2502|M.gilvum_PYR-GCK          LAPALAAGCTVVLKSAPDTPLITLALGELIAEHTDIPPGVVNVLSGADPQ
Mvan_4156|M.vanbaalenii_PYR-1       LAPALAAGCTVVLKSAPDTPLVTLALGELIAKHTDIPAGVVNVLSGADPA
MSMEG_4799|M.smegmatis_MC2_155      LAPALAAGCTVVLKAAPDTPLITLALGELIAHHTDIPPGVVNVISGADPE
TH_2504|M.thermoresistible__bu      LGPALAAGCTVVLKGAPDTPLVTLALGELIAEHTDIPAGVVNVLSGADPD
MLBr_02573|M.leprae_Br4923          AAPALMAGNVGLLKHASNVPQCALYLADVIARG-GFPEDCFQTLLISANG
                                     .*** ** . :** *.:.*  :  *. :*.   .:* . .: :  :   

Mb0791|M.bovis_AF2122/97            LGALLAKDPRVDMISFTGSTATGRAVMADAAATIKKVFLELGGKSAFVVL
Rv0768|M.tuberculosis_H37Rv         LGALLAKDPRVDMISFTGSTATGRAVMADAAATIKKVFLELGGKSAFVVL
MUL_0477|M.ulcerans_Agy99           LGALLAKDPRVDMVSFTGSTATGRSVMADGAATIKRMFLELGGKSAFIVL
MAB_1218|M.abscessus_ATCC_1997      IGAQLSTDPRVDMVSFTGSTATGRAVMTDAAATVKKVFLELGGKSAFIVL
MAV_0944|M.avium_104                AGVALTTSPDVDVITFTGSTAVGREIMAAASQTVKRVFLELGGKSAAIIL
MMAR_4714|M.marinum_M               VGEVLTTSPDVDVVTFTGSTATGRRIMAAASQTVKRVFLELGGKSAVIML
Mflv_2502|M.gilvum_PYR-GCK          VGAALTTSPDVDMVTFTGSTPTGRAIMAAASGTLKKVFLELGGKSAAIVL
Mvan_4156|M.vanbaalenii_PYR-1       VGAALTTSPDVDMVTFTGSTPTGRAIMAAASGTLKKVFLELGGKSAAIVL
MSMEG_4799|M.smegmatis_MC2_155      VGAVLTTSPDVDMVTFTGSTPTGRRIMAAASETLKKVFLELGGKSAAIIL
TH_2504|M.thermoresistible__bu      VGAALTTSPDVDMVTFTGSTQTGRRIMAAASETLKKVFLELGGKSAAIVL
MLBr_02573|M.leprae_Br4923          VEAILR-DPRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVM
                                        *  .* *   ::***  .*: : : ..  :*  .*****... :::

Mb0791|M.bovis_AF2122/97            DD---ADLAAASAVSAFSACMHAGQGCAITTRLVVPRARYEEAVAIAAAT
Rv0768|M.tuberculosis_H37Rv         DD---ADLAAASAVSAFSACMHAGQGCAITTRLVVPRARYEEAVAIAAAT
MUL_0477|M.ulcerans_Agy99           DD---ADLAAASSVSAFTASMHAGQGCAITTRLVVPRARYDEAVAIAAGT
MAB_1218|M.abscessus_ATCC_1997      DDLDEAALGSACSVAAFTAAMHAGQGCAITTRLVVPRERYDDAVAAAAAT
MAV_0944|M.avium_104                DD---ADFAGAALFAAFSMVTHAGQGCALTSRLLVPRSHHDEIVELIAQN
MMAR_4714|M.marinum_M               DD---ADFAGAAMFAAFSMVTHAGQGCALTSRLLVPRAHHDEIVELIAQN
Mflv_2502|M.gilvum_PYR-GCK          DD---ADFSTAALFSAFSMVTHAGQGCALTSRLLVPRKHKDEIVELVKNN
Mvan_4156|M.vanbaalenii_PYR-1       DD---ADFNTAAMFSAFSMVTHAGQGCALTSRLLVPKKHKDELVELVKNN
MSMEG_4799|M.smegmatis_MC2_155      DD---ADFNTAALFSAFSMVTHAGQGCALTSRLLVPAAHKDEIVELIKNN
TH_2504|M.thermoresistible__bu      DD---ADFTMAALFTAFSMVTHAGQGCALTSRLLVPRTHHDEIVVLVKNN
MLBr_02573|M.leprae_Br4923          PS---ADLDAAVATAVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKFVAR
                                     .   * :  *   :.     : **.*  :.*::.     :: *      

Mb0791|M.bovis_AF2122/97            MSSIRPGDPNDPGTVCGPLISARQRDRVQGYLDLAVAEGGRFACGGARPA
Rv0768|M.tuberculosis_H37Rv         MSSIRPGDPNDPGTVCGPLISARQRDRVQGYLDLAVAEGGRFACGGARPA
MUL_0477|M.ulcerans_Agy99           MSSIKPGDPDDARTVCGPLISQRQRDRVEGYLDLAIAEGGTFACGGGRPA
MAB_1218|M.abscessus_ATCC_1997      MGSLKPGDPAKPGTICGPVISARQRDRVQSYLDLAVAEGGSFACGGGRPE
MAV_0944|M.avium_104                FAKVRHGDPADPKTYMGPLINERQRDKVDGMVRRAVAAGATLVTGGKR--
MMAR_4714|M.marinum_M               FARVRHGDPADPKTYMGPLINERQRDKVDAMVGRAVAAGATLVTGGKR--
Mflv_2502|M.gilvum_PYR-GCK          FGLVRLGDPADPSTYMGPLISEKQRDKVDGMVKRAVEAGATLVTGGEK--
Mvan_4156|M.vanbaalenii_PYR-1       FGLVRYGDPTAAGTYMGPLISEKQRDKVDGMVKRAVEAGATLVTGGEK--
MSMEG_4799|M.smegmatis_MC2_155      FAMVRYGDPADPKTYMGPLISEKQRDKVDGMVKRAVAAGATLVTGGEK--
TH_2504|M.thermoresistible__bu      FGLVKYGDPTDPQTYMGPLISEKQRDKVHGMVQRAVAAGATLVTGGQK--
MLBr_02573|M.leprae_Br4923          METLRVGDPTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGGKRP-
                                    :  :: ***  . *  **: .   * :*.  :  *   *. :  ** :  

Mb0791|M.bovis_AF2122/97            DREVGFYIEPTVIAGLTNDARVAREEIFGPVLTVIAHDGDDDAVRIANDS
Rv0768|M.tuberculosis_H37Rv         DREVGFYIEPTVIAGLTNDARVAREEIFGPVLTVIAHDGDDDAVRIANDS
MUL_0477|M.ulcerans_Agy99           GRQVGYFIEPTVIAGLTTDARPAREEIFGPVLTVLAHDGDDDAVRIANDS
MAB_1218|M.abscessus_ATCC_1997      GKDRGFFIEPTVVAGLTNAARVAREEIFGPVLVVIAHDGDEDAVRIANDS
MAV_0944|M.avium_104                -LDPGFFYAPTLLTNVDPDSEIAQEEIFGPVLVVIAFDDDDDAVRIANNS
MMAR_4714|M.marinum_M               -LDPGFFYAPTLLTNVDPDSEIAQDEVFGPVLVVIAFDDDDDAVRIANNS
Mflv_2502|M.gilvum_PYR-GCK          -VDPGYFYTPTLLADVDPDSEIAQEEVFGPVLTVIAYEDDDDAVRIANNS
Mvan_4156|M.vanbaalenii_PYR-1       -VDPGYFYTPTLLADVDPDSEIAQEEVFGPVLVVIAYEDDDDAVRIANNS
MSMEG_4799|M.smegmatis_MC2_155      -VDPGYFYTPTLLADVDPDSEIAQEEVFGPVLAVISYTDDDDAVRIANNS
TH_2504|M.thermoresistible__bu      -VDPGFFYQPTLLTGVDPDSEIAQEEVFGPVLAVIAYDDDDDAVRIANNS
MLBr_02573|M.leprae_Br4923          -DRPGWFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANAT
                                        *::  **:::.:        :*:****  * .  . :**:.*** :

Mb0791|M.bovis_AF2122/97            PYGLSGTVYGADPQRAARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGI
Rv0768|M.tuberculosis_H37Rv         PYGLSGTVYGADPQRAARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGI
MUL_0477|M.ulcerans_Agy99           PYGLSGTVYGGDPQRAADVAARLRVGAVNVNGGVWYCADAPFGGYKQSGI
MAB_1218|M.abscessus_ATCC_1997      PYGLSGTVFGDDDERSARVASRLRVGTVNVNGGVWYSADAPFGGYKQSGN
MAV_0944|M.avium_104                IYGLAGAVFSGDQERALAVARRIRTGSFSINGGNYFGADSPFGGFKQSGV
MMAR_4714|M.marinum_M               IYGLAGAVFSRDQERALALARRIRTGSFSINGGNYFGADSPFGGFKQSGV
Mflv_2502|M.gilvum_PYR-GCK          IYGLSGAVFG-SQDRALGVARRIRTGTFSINGGNYFSPDSPFGGYKQSGI
Mvan_4156|M.vanbaalenii_PYR-1       IYGLSGAVFG-SQDRALAVARRIRTGTFSINGGNYFAPDSPFGGYKQSGI
MSMEG_4799|M.smegmatis_MC2_155      IYGLSGAVFG-SQERALAVSRRIRTGTFSINGGNYFSPDSPFGGYKQSGI
TH_2504|M.thermoresistible__bu      IYGLSGAVFG-SEERAIAVARRIRTGTFSINGGNYFSPDVPFGGYKQSGI
MLBr_02573|M.leprae_Br4923          PFGLGSNAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGY
                                     :**.. .:  . ..   .  .: .* . :**     .: **** *:** 

Mb0791|M.bovis_AF2122/97            GREMGLLGFEEYLEAKLIATAAN----------
Rv0768|M.tuberculosis_H37Rv         GREMGLLGFEEYLEAKLIATAAN----------
MUL_0477|M.ulcerans_Agy99           GREMGLAGFEEYLETKLIATAAN----------
MAB_1218|M.abscessus_ATCC_1997      GREMGVAGFEEYLETKVIATAVK----------
MAV_0944|M.avium_104                GREMGVAGLEEFLERKTFAVVAGPAEGALA---
MMAR_4714|M.marinum_M               GREMGVAGLEEFLERKTFAVPVMPAVPAGEARA
Mflv_2502|M.gilvum_PYR-GCK          GREMGRAGLEEFLESKTFATVAG----------
Mvan_4156|M.vanbaalenii_PYR-1       GREMGRAGLEEFLESKTYAVVVPEAGGQA----
MSMEG_4799|M.smegmatis_MC2_155      GREMGTAGLEEFLESKTFATVVA----------
TH_2504|M.thermoresistible__bu      GREMGVAGLEEFLESKTFARVLTEVPA------
MLBr_02573|M.leprae_Br4923          GRELSTHGIREFCNIKTVWIA------------
                                    ***:.  *:.*: : *

species	id	gene	e-value	identity (len)	annotation
M. avium 104	MAV_0944	-	-	100% (523)	aldehyde dehydrogenase (NAD) family protein
M. avium 104	MAV_0713	-	e-144	53.89% (475)	aldehyde dehydrogenase (NAD) family protein
M. avium 104	MAV_1275	-	e-128	52.17% (483)	aldehyde dehydrogenase family protein