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PESVPMVELAASYVAGKWITGSHAETFDVTSPSTGEVLGTVGVASHGEVDAAVAGARDALPGWAATSPAY RGAALGRLADALSARKGELADLTTAEIGSPRSWSTFGQVLTAVGVLKAYAAITADYPFAATRRSMTGGTV LVRQVPVGVVGAIVPWNTPLFIAALKIGPALAAGCTVVLKPAPDAPLEFGVLTEAIEQAEIPDGVVNVVN GGAATGELLTKHVGVDKVSFTGSTAVGARIAASCGSRIRRYSLELGGKSAAIVLPDAEPEKTVPGLVSGV MGNNGQLCAALTRILLPRSRYGEYVAALTDAVGGLTVGDPTDRATDVGPVINEAARDKIEGFLRRARDEG ATVLVGGERADGPGWFVTPALVEATNDMEIAREEVFGPVGVVIAYDDAGSDDAAEAVAIANDSRYGLVGA VWSSDEERAAAVAARLQVGSVAVNSTAVLDFASPFGGFKQSGVGREGGPEGIAGFIEYQSVIR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1944 | - | - | 100% (484) | betaine-aldehyde dehydrogenase |
| M. avium 104 | MAV_2647 | - | 0.0 | 82.64% (484) | betaine-aldehyde dehydrogenase |
| M. avium 104 | MAV_3969 | - | e-117 | 48.18% (467) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 3e-84 | 41.60% (488) | aldehyde dehydrogenase NAD dependant AldA |
| M. gilvum PYR-GCK | Mflv_0428 | - | 1e-108 | 44.42% (475) | betaine-aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 1e-101 | 42.23% (476) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 3e-57 | 33.11% (456) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4484 | - | 1e-100 | 43.37% (475) | aldehyde dehydrogenase |
| M. marinum M | MMAR_3965 | - | 1e-116 | 46.85% (476) | NAD-dependent aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0309 | - | 1e-103 | 42.32% (475) | aldehyde dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_3080 | - | 1e-113 | 46.32% (475) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_1122 | - | 8e-99 | 42.44% (476) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0240 | - | 1e-108 | 44.84% (475) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0428|M.gilvum_PYR-GCK ---MTQS----TAFRTEWDKLFIGGKWVEPASSEVIEVRSPATGDVVGKV
Mvan_0240|M.vanbaalenii_PYR-1 ---MTQS----TTFRTEWDKLFIGGKWVEPATSDVIEVHSPATGELVGKV
MSMEG_0309|M.smegmatis_MC2_155 MTAMTQTAPAATAATTNWDKLFIGGQWVEPSSSEIIEVFSPATGEKVGQA
Rv0223c|M.tuberculosis_H37Rv ----------MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKV
MUL_1122|M.ulcerans_Agy99 -----------MGEKTEYDKLFIGGRWTEPSTSEVIEVHCPATGEYVGKV
MAB_4484|M.abscessus_ATCC_1997 --------------MTNYDKLFIGGVWTEPATDQVIEVISPATGQKVGQC
MMAR_3965|M.marinum_M --------MTADSTHRSFHELFIGGRWCKPTIAEPITVISPHSEEPIGRA
TH_3080|M.thermoresistible__bu -------------VHP--EELFIGGEWATPSSAQRIEVISPHTEEPVAAV
MAV_1944|M.avium_104 --------MPESVPMVELAASYVAGKWITGSHAETFDVTSPSTGEVLGTV
Mb0791|M.bovis_AF2122/97 ----------MALWGDGISALLIDGKLSD-GRAGTFPTVNPATEEVLGVA
MLBr_02573|M.leprae_Br4923 ---------------------------------MSIATINPATGETVKTF
: . * : : :
Mflv_0428|M.gilvum_PYR-GCK PLASAADVDAACAAAREAFDNGPWPQMSPTERAEVLGRAVKLMEERADEL
Mvan_0240|M.vanbaalenii_PYR-1 PLASAADVDAACAAAREAFDNGPWPHMSPAERGEILGRAVKIMEERADEL
MSMEG_0309|M.smegmatis_MC2_155 PLATKADVDAACAAARKAFDEGPWPRMTPQEREAVLAKATALIEESADEF
Rv0223c|M.tuberculosis_H37Rv PMAAAADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLF
MUL_1122|M.ulcerans_Agy99 PLAAAADVDAAVAAARAAFDNGPWPSTPPKERATVIANALKLLEERKDHF
MAB_4484|M.abscessus_ATCC_1997 PLASPADVDAAVSAARRAFDNGPWPRLTPHERQAVLQKAVSLLESRKDEI
MMAR_3965|M.marinum_M PAAGPDEVEAAVAAARRAFDYGPWPRLDPDERIRKVEELAAIYASHLDDM
TH_3080|M.thermoresistible__bu AAACPDDVDRAVAAARAAFDTGPWPRMDPAERVAVIRGLAERYGERRSEL
MAV_1944|M.avium_104 GVASHGEVDAAVAGARDALPG--WAATSPAYRGAALGRLADALSARKGEL
Mb0791|M.bovis_AF2122/97 ADADAEDMGRAIEAARRAFDSTDWSRN-TELRVRCVRQLRDAMQQHVEEL
MLBr_02573|M.leprae_Br4923 TPTTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQS
: :: * * : : *
Mflv_0428|M.gilvum_PYR-GCK KFLLAAETGQPPTIVDMMQYGAAMSSFQFYAG-AADKFTWQDIRDGVYG-
Mvan_0240|M.vanbaalenii_PYR-1 KFLLAAETGQPPTIVDMMQYGAAMSSFQFYAG-AADKFTWQDIRDGVYG-
MSMEG_0309|M.smegmatis_MC2_155 KTLLKLETGQPQTIVDMMQYGAAMSTLQFYAS-AADKFAWKDIRDGIYG-
Rv0223c|M.tuberculosis_H37Rv TKLLAAETGQPPTIIETMHWMGSMGAMNYFAG-AADKVTWTETRTGSYG-
MUL_1122|M.ulcerans_Agy99 AKLFADETGQPPMTVETMHWMGSIGALNFFAGPAVDQVRWKEIRNGSYG-
MAB_4484|M.abscessus_ATCC_1997 CKAIADETGAPPMVIETLQWMGGFGAIQYYAN-AADAVKWKELRNGAYG-
MMAR_3965|M.marinum_M ADLITAEMGSPHSFSRLGQAAGAAGLMQLALA-AGRNFPWVERRQGIRG-
TH_3080|M.thermoresistible__bu AELITAQIGAPISFAQRAQVGLPWTMMSAFCT-LAENHPWQQTRAGMYGA
MAV_1944|M.avium_104 ADLTTAEIGSPRSWSTFGQVLTAVGVLKAYAA-ITADYPFAATRRSMTGG
Mb0791|M.bovis_AF2122/97 RELTISEVGAPRMLTASAQLEGPVGDLSFAAD-TAESYPWKQDLGEASPL
MLBr_02573|M.leprae_Br4923 AALMTLEMG-KTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVGA
: * . :
Mflv_0428|M.gilvum_PYR-GCK ----QTLVVREPVGVVGAVTAWNVPFFLAANKLGPALLAGCTVVLKPAAE
Mvan_0240|M.vanbaalenii_PYR-1 ----QTLVVREPVGVVGAVTAWNVPFFLAANKLGPALLAGCTVVLKPAAE
MSMEG_0309|M.smegmatis_MC2_155 ----QTLVLKEPVGVVGAVVAWNVPFFLAANKLGPALLAGCTIVLKPAAE
Rv0223c|M.tuberculosis_H37Rv ----QSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAE
MUL_1122|M.ulcerans_Agy99 ----QTIVHREPIGVVGAIVAWNVPLFLAINKLGPAPLAGCTVVLKPAAE
MAB_4484|M.abscessus_ATCC_1997 ----QTLVTREPAGVVAAIAAWNVPLFLALNKIGPAFLAGCAVVLKPAAE
MMAR_3965|M.marinum_M ----QAHLRRAPVGVVGAIVPWNVPQFLIMPKLIPALIAGCTVIIKPAPE
TH_3080|M.thermoresistible__bu ----DVHVRREPVGVVAAIVPWNMPQFLIVTKLIPALLAGCTVVLKPAPE
MAV_1944|M.avium_104 ----TVLVRQVPVGVVGAIVPWNTPLFIAALKIGPALAAGCTVVLKPAPD
Mb0791|M.bovis_AF2122/97 GIATRRTLAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPD
MLBr_02573|M.leprae_Br4923 S---KALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASN
. *** *: .** * ** ** . ::* *.:
Mflv_0428|M.gilvum_PYR-GCK TPLSVFAMAEMFVEAG-LPEGVLSIVPGG-PETGQALTANPNLDKYTFTG
Mvan_0240|M.vanbaalenii_PYR-1 TPLSVFAMAEMFVEAG-LPEGVLSIVPGG-PETGQALTANPNLDKYTFTG
MSMEG_0309|M.smegmatis_MC2_155 TPLTTNLMAQKFLEAG-LPEGVLSVVPGG-PETGRALTDNPALDKFTFTG
Rv0223c|M.tuberculosis_H37Rv TPLTANALAEVFAEVG-LPEGVLSVVPGG-IETGQALTSNPDIDMFTFTG
MUL_1122|M.ulcerans_Agy99 TPLTANALAEVFAEAG-LPEGVLSVVPGG-VETGQALTSNPGVDLFTFTG
MAB_4484|M.abscessus_ATCC_1997 TPLSSFILAEVFAEAG-VPEGVLSVVPGG-AETGRALTNNPDVDVFSFTG
MMAR_3965|M.marinum_M TPLDALWLAEMIEQIE-LPEGVVSVLPGG-PSVGEALVRHPGVDKIAFTG
TH_3080|M.thermoresistible__bu SPLDALLLAELIADSG-IPSGVVNVLPGP-AGVGERLVRHPGVDKVSFTG
MAV_1944|M.avium_104 APLEFGVLTEAIEQAE-IPDGVVNVVNGG-AATGELLTKHVGVDKVSFTG
Mb0791|M.bovis_AF2122/97 TPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFTG
MLBr_02573|M.leprae_Br4923 VPQCALYLADVIARGG-FPEDCFQTLLIS-ANGVEAILRDPRVAAATLTG
* : : : .* . .. : : . : ::**
Mflv_0428|M.gilvum_PYR-GCK SSGVGKEIAKIAADKLKPCTLELGGKSAAIILEDADLDSTLPMLVFSGLM
Mvan_0240|M.vanbaalenii_PYR-1 SSGVGKEIAKIAADKLKPCTLELGGKSAAIILEDADLDSTLPMLVFSGLM
MSMEG_0309|M.smegmatis_MC2_155 SSAVGKEIGKIAAEKLKPCTLELGGKSAAIILEDADLDSTLPMLLFSGLM
Rv0223c|M.tuberculosis_H37Rv SSAVGREVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVM
MUL_1122|M.ulcerans_Agy99 SSAVGKEIGRRAAEMLKPCTLELGGKSAAILLEDVDLSTAVPMMVFSGIM
MAB_4484|M.abscessus_ATCC_1997 STAVGKEIAEIAAKNLKKVTLELGGKSAAIVLEDADLAAALPMLVFSGLM
MMAR_3965|M.marinum_M SSATGRRIAALCGEGLKRVSLELGGKSAAIILDDADIGKTVAGLKTAGLM
TH_3080|M.thermoresistible__bu STAAGRAVAAAAAAGLKRVSLELGGKSAAVVLSDADPAAVATAVRSASLS
MAV_1944|M.avium_104 STAVGARIAASCGSRIRRYSLELGGKSAAIVLPDAEPEKTVPGLVSGVMG
Mb0791|M.bovis_AF2122/97 STATGRAVMADAAATIKKVFLELGGKSAFVVLDDADLAAASAVSAFSACM
MLBr_02573|M.leprae_Br4923 SEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQ
* .* : .. :: *****... ::: ..: . . .
Mflv_0428|M.gilvum_PYR-GCK NSGQACVGQTRILAPRSRYDEVIEKLGEAVRNMAPGLPDNPAAMIGPLIS
Mvan_0240|M.vanbaalenii_PYR-1 NSGQACVGQTRILAPRSRYDEVVEKLAAAAAGMAPGLPDNPAAMIGPLIS
MSMEG_0309|M.smegmatis_MC2_155 NSGQACVGQTRILAPRSRYDEVVEKVAAGVAAMQVGVPDDPAAMVGPLIS
Rv0223c|M.tuberculosis_H37Rv NAGQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLIS
MUL_1122|M.ulcerans_Agy99 NTGQACVGQTRILAPRSRYEEIVEAVSAFVQTLPVGPPSDPAAQIGSLIS
MAB_4484|M.abscessus_ATCC_1997 NAGQGCVNQTRVLAPRSRYDEVVDGIVGMVSLMGVGLPDDPATQVGPLIT
MMAR_3965|M.marinum_M NNGQACVAQTRILVSERRHDEVVDALADMMSALQVGDPADEKTDVGPLVA
TH_3080|M.thermoresistible__bu NSGQICNALTRILMPAGRAAEFTDALAAEMESLVIGDPTDAETQIGPLVA
MAV_1944|M.avium_104 NNGQLCAALTRILLPRSRYGEYVAALTDAVGGLTVGDPTDRATDVGPVIN
Mb0791|M.bovis_AF2122/97 HAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLIS
MLBr_02573|M.leprae_Br4923 NNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLAT
: ** * .*.: * : * * : : *.:
Mflv_0428|M.gilvum_PYR-GCK EKQRDRVEGYIKKGIEEGARVITGG-GRPEGLDSGWFVEPTVFADVDNSM
Mvan_0240|M.vanbaalenii_PYR-1 EKQRDRVEGYIKKGIEEGARVVTGG-GRPEGLDSGWYVQPTVFADVDNSM
MSMEG_0309|M.smegmatis_MC2_155 EKQRERVEGYIKKGIEEGARLVTGG-GRPEGLDSGWFVQPTVFADVDNSM
Rv0223c|M.tuberculosis_H37Rv EKQRTRVEGYIAKGIEEGARLVCGG-GRPEGLDNGFFIQPTVFADVDNKM
MUL_1122|M.ulcerans_Agy99 EKQRARVEGYIAKGIEEGARLVSGG-GRPESLDNGFFVQPTVFADVDNKM
MAB_4484|M.abscessus_ATCC_1997 EKQRTRVEGYIAKGIAEGARLAYGG-KRPEGLDGGYFVQPTIFADVDNSM
MMAR_3965|M.marinum_M QRQQRRVRDYIRSGQQEGARIVLGGQDSPQ--DRGWYVRPTLFTDATNDM
TH_3080|M.thermoresistible__bu RRQQERVRGYIEAGCAEGARLVTGGPGLPAGVDRGWYVQPTLFADADNSM
MAV_1944|M.avium_104 EAARDKIEGFLRRARDEGATVLVGG-ERADG--PGWFVTP-ALVEATNDM
Mb0791|M.bovis_AF2122/97 ARQRDRVQGYLDLAVAEGGRFACGG-ARPADREVGFYIEPTVIAGLTNDA
MLBr_02573|M.leprae_Br4923 ESGRAQVEQQVDAAAAAGAVIRCGG-KRPDR--PGWFYPPTVITDITKDM
: ::. : . *. . ** . *:: * :. :.
Mflv_0428|M.gilvum_PYR-GCK TIAQEEIFGPVLSVIPYEDE-----DDAVRIANDSVYGLAGSVYTTDNDR
Mvan_0240|M.vanbaalenii_PYR-1 TIAQEEIFGPVLAVIPYEDE-----DDAVRIANDSVYGLAGSVYTTDNDR
MSMEG_0309|M.smegmatis_MC2_155 TIAQEEIFGPVLVVIPFEDE-----DDAVRIANDSVYGLAGSVYTTDHAK
Rv0223c|M.tuberculosis_H37Rv TIAQEEIFGPVLAIIPYDTE-----EDAIAIANDSVYGLAGSVWTTDVPK
MUL_1122|M.ulcerans_Agy99 TIAQEEIFGPVLVVIPYDTK-----EDAIKIANDSVYGLAGSVWTSNVPK
MAB_4484|M.abscessus_ATCC_1997 TIAQEEIFGPVLSIIAYDSV-----DEAVKIANDSNYGLAGSVWTTDVQK
MMAR_3965|M.marinum_M CIAREEIFGPVLTVLTYRDE-----QDAIRIANDSDYGLAGSVWTADTAH
TH_3080|M.thermoresistible__bu RIAREEIFGPVLTVIPYPDE-----DAAVAIANDSDYGLAGSVFTADTER
MAV_1944|M.avium_104 EIAREEVFGPVGVVIAYDDAGSDDAAEAVAIANDSRYGLVGAVWSSDEER
Mb0791|M.bovis_AF2122/97 RVAREEIFGPVLTVIAHDGD-----DDAVRIANDSPYGLSGTVYGADPQR
MLBr_02573|M.leprae_Br4923 ALYTDEVFGPVASVYCATNI-----DDAIEIANATPFGLGSNAWTQNESE
: :*:**** : *: *** : :** . .: : .
Mflv_0428|M.gilvum_PYR-GCK ALKIARRIRTGTYAVNM-YAFDPCAPFGGYKNSGIGRENGWEGIEAYCEQ
Mvan_0240|M.vanbaalenii_PYR-1 ALKIARRIRTGTYAVNM-YAFDPCAPFGGFKNSGIGRENGWEGIEAYCEP
MSMEG_0309|M.smegmatis_MC2_155 GVEIASKVRTGTYGINM-YAFDPGAPFGGYKNSGIGRECGPEGIAGYCES
Rv0223c|M.tuberculosis_H37Rv GIKISQQIRTGTYGINW-YAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQ
MUL_1122|M.ulcerans_Agy99 GIEISEKIRTGTYAINW-YAFDPCCPFGGYKNSGIGRENGPEGVEHFTQQ
MAB_4484|M.abscessus_ATCC_1997 GLEVAAQIRTGTYGINW-YAFDPSCPFGGYKQSGIGRENGPEGIEEYCEL
MMAR_3965|M.marinum_M GLEIAAAVRTGTYGINM-YTLDISAPFGGFKQSGIGREFGPEGLAEYVEL
TH_3080|M.thermoresistible__bu GLAIAARIRTGTFGVNQGYTMDPFAPFGGVKGSGYGRELGPEGIDAYTDV
MAV_1944|M.avium_104 AAAVAARLQVGSVAVNSTAVLDFASPFGGFKQSGVGREGGPEGIAGFIEY
Mb0791|M.bovis_AF2122/97 AARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGIGREMGLLGFEEYLEA
MLBr_02573|M.leprae_Br4923 QRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNI
. : .* :* **** * ** *** . *. : :
Mflv_0428|M.gilvum_PYR-GCK KSILLPFGYTPPAS------
Mvan_0240|M.vanbaalenii_PYR-1 KSILLPFGYTPAT-------
MSMEG_0309|M.smegmatis_MC2_155 KSVLLPFGYTPE--------
Rv0223c|M.tuberculosis_H37Rv KSVLLPMGYTVA--------
MUL_1122|M.ulcerans_Agy99 KSVLMPMGYTLES-------
MAB_4484|M.abscessus_ATCC_1997 KSVLLPMGYTLESI------
MMAR_3965|M.marinum_M QTVLCSGKMPPLRGFEEPAG
TH_3080|M.thermoresistible__bu KSISVAPASTT---------
MAV_1944|M.avium_104 QSVIR---------------
Mb0791|M.bovis_AF2122/97 KLIATAAN------------
MLBr_02573|M.leprae_Br4923 KTVWIA--------------
: :