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ITEPATAFSRVFRGYDPAAVDAYVEALLAKQKLLIDEVQNLRAQRNESGDQLAALRIEVACLKDEVAHLS DTSPTPYAIQHRMTKMLRRTLEEISRMQAEAQAEAESMIAAAAAQVEASHREHQELLADMAAQREALETE REEAKKELEAELATMRAEARASIDEARREAERECARLLAEAKQKADDLDERARRTVEEANQQRIMILEEL MDVARDLQGLPASLESAYQERTSPSEASVVVPLDPKNQAPGPAVAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1300 | - | - | 100% (257) | hypothetical protein MAV_1300 |
| M. avium 104 | MAV_3650 | - | 1e-71 | 56.00% (250) | hypothetical protein MAV_3650 |
| M. avium 104 | MAV_2345 | - | 1e-09 | 25.49% (255) | Wag31 protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1709 | - | 3e-38 | 35.38% (277) | coiled-coil structural protein |
| M. gilvum PYR-GCK | Mflv_2996 | - | 1e-06 | 25.29% (257) | DivIVA family protein |
| M. tuberculosis H37Rv | Rv1682 | - | 3e-38 | 35.38% (277) | coiled-coil structural protein |
| M. leprae Br4923 | MLBr_01120 | - | 1e-05 | 28.18% (181) | hypothetical protein MLBr_01120 |
| M. abscessus ATCC 19977 | MAB_1531c | - | 4e-44 | 37.41% (286) | hypothetical protein MAB_1531c |
| M. marinum M | MMAR_3185 | wag31 | 2e-06 | 26.19% (252) | secreted antigen Wag31 |
| M. smegmatis MC2 155 | MSMEG_1950 | - | 9e-07 | 24.31% (144) | hypothetical protein MSMEG_1950 |
| M. thermoresistible (build 8) | TH_1226 | - | 2e-06 | 29.53% (149) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3493 | wag31 | 2e-06 | 26.19% (252) | secreted antigen Wag31 |
| M. vanbaalenii PYR-1 | Mvan_4435 | - | 5e-06 | 28.48% (151) | hypothetical protein Mvan_4435 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1709|M.bovis_AF2122/97 --------------------------------------------------
Rv1682|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1531c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1300|M.avium_104 --------------------------------------------------
MLBr_01120|M.leprae_Br4923 MKLHRLALTNYRGTARREIEFPDRGVILVCGANEIGKSSMIEALDLLLEF
Mvan_4435|M.vanbaalenii_PYR-1 MKLHRLALTNYRGITHRDIEFPDRGVVVVSGPNEAGKSSMLEALDLLLES
MMAR_3185|M.marinum_M --------------------------------------------------
MUL_3493|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2996|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1950|M.smegmatis_MC2_155 --------------------------------------------------
TH_1226|M.thermoresistible__bu --------------------------------------------------
Mb1709|M.bovis_AF2122/97 --------------------------------------------------
Rv1682|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1531c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1300|M.avium_104 --------------------------------------------------
MLBr_01120|M.leprae_Br4923 RDRSTKKEVKQVKPANADIGSEVCAEISSGTYRFVYRKRFNKKCETALTV
Mvan_4435|M.vanbaalenii_PYR-1 KDRSSKKEVKQVKPTHADVGAEVTAEISAGPYRFVYRKRFHKRPETELTV
MMAR_3185|M.marinum_M --------------------------------------------------
MUL_3493|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2996|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1950|M.smegmatis_MC2_155 --------------------------------------------------
TH_1226|M.thermoresistible__bu --------------------------------------------------
Mb1709|M.bovis_AF2122/97 --------------------------------------------------
Rv1682|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1531c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1300|M.avium_104 --------------------------------------------------
MLBr_01120|M.leprae_Br4923 LAPHREQLTGDEAHERVRAMLAETVDNDLWHAQRVLQAASTAAVDLSGCD
Mvan_4435|M.vanbaalenii_PYR-1 LTPRREQLTGDEAHERVRAILAESVDLDLWQAQRVLQSAPTSAADLSGCN
MMAR_3185|M.marinum_M --------------------------------------------------
MUL_3493|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2996|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1950|M.smegmatis_MC2_155 --------------------------------------------------
TH_1226|M.thermoresistible__bu --------------------------------------------------
Mb1709|M.bovis_AF2122/97 --------------------------------------------------
Rv1682|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1531c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1300|M.avium_104 --------------------------------------------------
MLBr_01120|M.leprae_Br4923 ALSRALDLAAGDHAELSGT-----EPLLIERIEAEYRRYFTSTGRPTGEW
Mvan_4435|M.vanbaalenii_PYR-1 ALSRALDVVAGEVDDVSATGAGNVESLLVDRVEEEYRRYFTSTGRATGEW
MMAR_3185|M.marinum_M --------------------------------------------------
MUL_3493|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2996|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1950|M.smegmatis_MC2_155 --------------------------------------------------
TH_1226|M.thermoresistible__bu --------------------------------------------------
Mb1709|M.bovis_AF2122/97 --------------------------------------------------
Rv1682|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1531c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1300|M.avium_104 --------------------------------------------------
MLBr_01120|M.leprae_Br4923 AVAISRLSDAETAVGECAAAVAEVDDRVRRHAVLTERVAGLAQQRFAAGP
Mvan_4435|M.vanbaalenii_PYR-1 AAATARLRAADEEVARCAAAMAEVDEAVRRHAALTTDMAQLAVETASAAE
MMAR_3185|M.marinum_M --------------------------------------------------
MUL_3493|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2996|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1950|M.smegmatis_MC2_155 --------------------------------------------------
TH_1226|M.thermoresistible__bu --------------------------------------------------
Mb1709|M.bovis_AF2122/97 --------------------------------------------------
Rv1682|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1531c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1300|M.avium_104 --------------------------------------------------
MLBr_01120|M.leprae_Br4923 RLAVAQAAADKVAVLTRQAREAELVAAAATATNAAAVAAHTSRLRLLAEI
Mvan_4435|M.vanbaalenii_PYR-1 RLQSARNAAAAVAVLQGELDQATARAEAARSVHAASKAALAQRRRARADL
MMAR_3185|M.marinum_M --------------------------------------------------
MUL_3493|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2996|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1950|M.smegmatis_MC2_155 --------------------------------------------------
TH_1226|M.thermoresistible__bu --------------------------------------------------
Mb1709|M.bovis_AF2122/97 --------------------------------------------------
Rv1682|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1531c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1300|M.avium_104 --------------------------------------------------
MLBr_01120|M.leprae_Br4923 DTRAVVLAATQDEAQEAVDAVSTMRADAEASDAAVEESTEALMAAQQRAD
Mvan_4435|M.vanbaalenii_PYR-1 DERSATVTSLQTESDTAADELDTANEMQVAAEEAAGKARSALAACQERVD
MMAR_3185|M.marinum_M --------------------------------------------------
MUL_3493|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2996|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1950|M.smegmatis_MC2_155 --------------------------------------------------
TH_1226|M.thermoresistible__bu --------------------------------------------------
Mb1709|M.bovis_AF2122/97 --------------------------------------------------
Rv1682|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1531c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1300|M.avium_104 --------------------------------------------------
MLBr_01120|M.leprae_Br4923 IARSTVDQLVDRQEADRLSTRLAKIDAIQGERDLICAELSAVTLTEQLLQ
Mvan_4435|M.vanbaalenii_PYR-1 AARVAVQRLADREEADRLTGRIATIERHGRELEAVQRDLTAITLTDALLA
MMAR_3185|M.marinum_M --------------------------------------------------
MUL_3493|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2996|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1950|M.smegmatis_MC2_155 --------------------------------------------------
TH_1226|M.thermoresistible__bu --------------------------------------------------
Mb1709|M.bovis_AF2122/97 -------------MLPQRPNCTKLFRPRRGVSERYRVTTAHNGSAPRFQR
Rv1682|M.tuberculosis_H37Rv -------------MLPQRPNCTKLFRPRRGVSERYRVTTAHNGSAPRFQR
MAB_1531c|M.abscessus_ATCC_199 -----------------------------------MTTTTLNESTRNFTR
MAV_1300|M.avium_104 ---------------------------------------MITEPATAFSR
MLBr_01120|M.leprae_Br4923 RIENAAAIVDRTGEQLKLISAAVEFTATADIEISVGQQRVSLEAGQSWST
Mvan_4435|M.vanbaalenii_PYR-1 DIETAAAAVERATAAVEQTSAHIEVTAAADVEVRIGDADMTLRAGDTWAA
MMAR_3185|M.marinum_M --------------------------------MPLTPADVHNVAFSKPPI
MUL_3493|M.ulcerans_Agy99 --------------------------------MPLTPADVHNVAFSKPPI
Mflv_2996|M.gilvum_PYR-GCK --------------------------------MPLTPADVHNVAFSKPPI
MSMEG_1950|M.smegmatis_MC2_155 ----------------------------------MTQHSKSDQARKSFID
TH_1226|M.thermoresistible__bu ---------------------------------MTAGCVVPRGDVLELID
Mb1709|M.bovis_AF2122/97 TRSGYDPVAVNHYIAELVLRQQAQHCEIETLKA-----------------
Rv1682|M.tuberculosis_H37Rv TRSGYDPVAVNHYIAELVLRQQAQHCEIETLKA-----------------
MAB_1531c|M.abscessus_ATCC_199 TRNGYDPIEVNEYISRLTIMHQSGLNDVETLKSRLEDATK----------
MAV_1300|M.avium_104 VFRGYDPAAVDAYVEALLAKQKLLIDEVQNLRAQRNESGDQLAAL-----
MLBr_01120|M.leprae_Br4923 TATGPTEVEVLGVLTACVIPGATALDAQSKYVAAQEELSVALADGGVVDL
Mvan_4435|M.vanbaalenii_PYR-1 AVGTATGIDLPGVLSVQVIPGASAAATAAALDTAAARLADALRAAGVDDV
MMAR_3185|M.marinum_M GKRGYNEDEVDAFLDLVENELTRLIEENSDLRQR----------------
MUL_3493|M.ulcerans_Agy99 GKRGYNEDEVDAFLDLVENELTRLIEENSDLRQR----------------
Mflv_2996|M.gilvum_PYR-GCK GKRGYNEDEVDAFLDLVENELSRLIEENSDLRQR----------------
MSMEG_1950|M.smegmatis_MC2_155 SVKGTAKEVVGAVTGNDSLTAEGQLEKTQAKERR----------------
TH_1226|M.thermoresistible__bu DIKDAIPGELDDAQDVLDARDTLLREAKEHSESMVS--------------
:
Mb1709|M.bovis_AF2122/97 -------------------------------EIASLKDENAALKDTSP--
Rv1682|M.tuberculosis_H37Rv -------------------------------EIASLKDENAALKDTSP--
MAB_1531c|M.abscessus_ATCC_199 -------------------------------QISSLKDEVTTLSDTSP--
MAV_1300|M.avium_104 -----------------------------RIEVACLKDEVAHLSDTSP--
MLBr_01120|M.leprae_Br4923 AAARCANQRRRELQSSLDQLSAALAGVCGDDQIDQLRARLEQLRDGYPGE
Mvan_4435|M.vanbaalenii_PYR-1 EAARALDRRRHELSAAGRQIRAILEALAADDSVDQLRARLADLQARTPAE
MMAR_3185|M.marinum_M --------------------------------IAELDQELAAGAGGGAAV
MUL_3493|M.ulcerans_Agy99 --------------------------------IAELDQELAAGAGGGAAV
Mflv_2996|M.gilvum_PYR-GCK --------------------------------ISELDHELGQARAGGAA-
MSMEG_1950|M.smegmatis_MC2_155 --------------------------------------------------
TH_1226|M.thermoresistible__bu --------------------------------------------------
Mb1709|M.bovis_AF2122/97 --------------------------------------------------
Rv1682|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1531c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1300|M.avium_104 --------------------------------------------------
MLBr_01120|M.leprae_Br4923 PDLLAVDIG------SARAELEAAETVRAAVDFEREVCRRTAAAANCRLV
Mvan_4435|M.vanbaalenii_PYR-1 EGLFDTDTRGSLDPAAQRLELVEATAAHQQAIRDCETHRKVAEEAAKLSA
MMAR_3185|M.marinum_M T-------------------------------------------------
MUL_3493|M.ulcerans_Agy99 T-------------------------------------------------
Mflv_2996|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1950|M.smegmatis_MC2_155 --------------------------------------------------
TH_1226|M.thermoresistible__bu --------------------------------------------------
Mb1709|M.bovis_AF2122/97 ------------------SAQAVTDRMAKMLRLAVDEVFQMQSEARAEAA
Rv1682|M.tuberculosis_H37Rv ------------------SAQAVTDRMAKMLRLAVDEVFQMQSEARAEAA
MAB_1531c|M.abscessus_ATCC_199 ------------------SAHAMTDRMAKMLRIAVDEVAEMQNEARTESA
MAV_1300|M.avium_104 ------------------TPYAIQHRMTKMLRRTLEEISRMQAEAQAEAE
MLBr_01120|M.leprae_Br4923 ETSARANFLLKKAETQRAELDQDIDQLAQQRASVSDEDLASAAEAGLRAV
Mvan_4435|M.vanbaalenii_PYR-1 KRGLHAARLLEKLQAAQAELAAAGARLAEQRAATSDDELAVKAEADAEAA
MMAR_3185|M.marinum_M -----------------AQPTQAMPVYEPEPEPAK------------PAA
MUL_3493|M.ulcerans_Agy99 -----------------AQPTQAMPVYEPEPEPAK------------PAA
Mflv_2996|M.gilvum_PYR-GCK -----------------AQPTQTIPAYEPEPEPAPEPEPEPVYEAPAPAA
MSMEG_1950|M.smegmatis_MC2_155 -----------------------------------------------EAG
TH_1226|M.thermoresistible__bu -------------------------------------------TATAEAE
:
Mb1709|M.bovis_AF2122/97 TLVSAARDEAEAVRTQKR-----EMLADMNARQRALESEHADVMRRAREE
Rv1682|M.tuberculosis_H37Rv TLVSAARDEAEAVRTQKR-----EMLADMNARQRALESEHADVMRRAREE
MAB_1531c|M.abscessus_ATCC_199 ALIASAKADAEAMRTKHK-----ELLADMAARQSALETEYTEVMARAREE
MAV_1300|M.avium_104 SMIAAAAAQVEASHREHQ-----ELLADMAAQREALETE-----------
MLBr_01120|M.leprae_Br4923 QIAEQRVAKLTEELVAAEPEAVTAELVAATAAAESLRDQHEDAAGALREI
Mvan_4435|M.vanbaalenii_PYR-1 AAAEAAVARVGAELAGHEPEAVAAALVDAERAAAEVGARHHEVGEALREI
MMAR_3185|M.marinum_M PVASAATNEEQAMKAARVLS---LAQDTADRLTSTAKAESDKMLSDARAN
MUL_3493|M.ulcerans_Agy99 PVASAATNEEQAMKAARVLS---LAQDTADRLTSTAKAESDKMLSDARAN
Mflv_2996|M.gilvum_PYR-GCK QQAAPAT-EDQHLRAAKVLS---LAQDTADRLTSSAKAESEKMLADARAQ
MSMEG_1950|M.smegmatis_MC2_155 RAAAVADAEARQARAEEA-----QAQADGAQKRAAVAAEAAVVENDVR--
TH_1226|M.thermoresistible__bu SLVSHARAEADRLLAEAK--------AQADRMVAEARQHSERMVTEAREE
.
Mb1709|M.bovis_AF2122/97 AEQL-------------VAQATAEVERMRVIDARRREKAEQELDAEIIRL
Rv1682|M.tuberculosis_H37Rv AEQL-------------VAQATAEVERMRVIDARRREKAEQELDAEIIRL
MAB_1531c|M.abscessus_ATCC_199 ANQI-------------VAQAVSESERLRAAEAKRREKAETELDEELTKL
MAV_1300|M.avium_104 -----------------------------------REEAKKELEAELATM
MLBr_01120|M.leprae_Br4923 SIELSVFGTEGRQGKLDTAEAEREHAISQHTQIGRRARAAQLLRSVMARH
Mvan_4435|M.vanbaalenii_PYR-1 AAQLKVYGTEGRKGGLDAAETERGRAEAEFVRVQRRARAAELLRSVMGRH
MMAR_3185|M.marinum_M ADQILS------------------------EARHTAETTVTEARQRADGM
MUL_3493|M.ulcerans_Agy99 ADQILS------------------------EARHTAETTVTEARQRADGM
Mflv_2996|M.gilvum_PYR-GCK ADQLVT------------------------EARQTAETTVTEARQRADAM
MSMEG_1950|M.smegmatis_MC2_155 -----------------------------------AQQDAQKREAEAAAR
TH_1226|M.thermoresistible__bu ASRIVA------------------------TAKREYEATTGRAKSEADRL
Mb1709|M.bovis_AF2122/97 RTDAQFQIDDQLQATQQECEKRLGEAKIEADRRLHVAD-EQIEHGLSEAR
Rv1682|M.tuberculosis_H37Rv RTDAQFQIDDQLQATQQECEKRLGEAKIEADRRLHVAD-EQIEHGLSEAR
MAB_1531c|M.abscessus_ATCC_199 RTDTQSAVDEQRRSIQGECEKRLADAKDEADRRLRLAD-EQIERRLDQAR
MAV_1300|M.avium_104 RAEARASIDEARREAERECARLLAEAKQKAD--------DLDER----AR
MLBr_01120|M.leprae_Br4923 RDTTRLRYVEPYRTELQRLGRPVFGPTFEVDIDSDLRIRSRTLDGITVPF
Mvan_4435|M.vanbaalenii_PYR-1 RDAMRQRYVDPFRGEVERLGRIVFGDSFEVDVDSSLCIGNRTLSGRTVPY
MMAR_3185|M.marinum_M LADAQARSESQLRQAQEKADALQADAERKHS----------EIMGTINQQ
MUL_3493|M.ulcerans_Agy99 LADAQARSESQLRQAQEKADALQADAERKHS----------EIMGTINQQ
Mflv_2996|M.gilvum_PYR-GCK LADAQSRSETQLRQAQEKADALQADAERKHS----------EIMGTINQQ
MSMEG_1950|M.smegmatis_MC2_155 RDAERQK---TQADIDAQREVQLADAAERSD--------------VAVAR
TH_1226|M.thermoresistible__bu IESGNLAYEKAVQEGIKEQQRLVSQTEIVQT--------------ANAEA
. .
Mb1709|M.bovis_AF2122/97 RTLEEISQRRVGILEQLAR--IHAQLENIPALLESAR-----HSETEPLQ
Rv1682|M.tuberculosis_H37Rv RTLEEISQRRVGILEQLAR--IHAQLENIPALLESAR-----HSETEPLQ
MAB_1531c|M.abscessus_ATCC_199 RSVEEIGQQRISILEQLMG--VHGRLESIPSALESAYRD---RDNSKSIV
MAV_1300|M.avium_104 RTVEEANQQRIMILEELMD--VARDLQGLPASLESAYQERTSPSEASVVV
MLBr_01120|M.leprae_Br4923 ESLSGGAKEQLGILARFAGATLVAKEDNVPVVVDDALGFTDPDRLAKMGE
Mvan_4435|M.vanbaalenii_PYR-1 ESLSGGAKEQLGIVARLAGAALVAKEDSVPVVIDDALGFTDTERLTKMAE
MMAR_3185|M.marinum_M RTVLEGRLEQLRTFEREYRTRLKTYLESQLEELGQRGSAAPVDSSAD-AG
MUL_3493|M.ulcerans_Agy99 RTVLEGRLEQLRTFEREYRTRLKTYLESQLEELGQRGSAAPVDSSAD-AG
Mflv_2996|M.gilvum_PYR-GCK RTVLEGRLEQLRTFEREYRTRLKTYLESQLEELGTRGSAAPVDTGANNDG
MSMEG_1950|M.smegmatis_MC2_155 QEAAEAAADHQDAVKESAD--VRARADRMRQEADKLTEEADLPGDEK---
TH_1226|M.thermoresistible__bu SRLIDSAHAEADRLRGECDIYVDSKLAEFEEFLNGTLRSVNRGRHQLRTA
. . :
Mb1709|M.bovis_AF2122/97 SING-AVAELRAI----------------------
Rv1682|M.tuberculosis_H37Rv SING-AVAELRAI----------------------
MAB_1531c|M.abscessus_ATCC_199 MVPSKRVLDQKVIEG--------------------
MAV_1300|M.avium_104 PLDPKNQAPGPAVAS--------------------
MLBr_01120|M.leprae_Br4923 MFDTVGAHGQVIVLTCSPDRYDGFTGAHRIDLNV-
Mvan_4435|M.vanbaalenii_PYR-1 VFDAVAGDGQVIILTCSPQRYAGVRTAQHIELIAG
MMAR_3185|M.marinum_M GFEQFNRGNN-------------------------
MUL_3493|M.ulcerans_Agy99 GFEQFNRGNN-------------------------
Mflv_2996|M.gilvum_PYR-GCK GVNQFNRGNN-------------------------
MSMEG_1950|M.smegmatis_MC2_155 -----------------------------------
TH_1226|M.thermoresistible__bu AGTHDYVTR--------------------------