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MTVVDRLRYDGKRALIVGGATGMGAAAAKSAAELGAEIIVMDYAPVGYDAAQTLSVDLRDPASIDSAVER LGGPVHAVFSAAGVADGPDLMKINFIGHRHLIDRLLANDQLPSGSAVCFISSVAGMGWENDLPRLTEFLA TPDYGAAQDWVSAHEAEGIIHYGFSKKAINAYVATRAYPLLKRGIRINAICPGPTDTPLAQANADLWLTF AQDYRDETGSKVHTPEQMGDVMVFLNSAAAFGISGITLLVDYGHTMSSLTGAYPPGKPIIDLIMGRVPMP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4326 | - | - | 100% (280) | short-chain type dehydrogenase/reductase |
| M. marinum M | MMAR_4773 | - | 7e-37 | 36.60% (265) | dehydrogenase/reductase |
| M. marinum M | MMAR_4765 | - | 8e-11 | 26.35% (277) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 1e-11 | 26.84% (272) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2405 | - | 4e-31 | 36.58% (257) | 3-alpha-hydroxysteroid dehydrogenase |
| M. tuberculosis H37Rv | Rv2857c | - | 1e-11 | 26.84% (272) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 3e-09 | 24.07% (216) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_0073c | - | 5e-11 | 25.68% (292) | putative short chain dehydrogenase/reductase |
| M. avium 104 | MAV_1264 | - | 1e-138 | 83.57% (280) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_4862 | - | 5e-27 | 31.66% (259) | 3-alpha-hydroxysteroid dehydrogenase |
| M. thermoresistible (build 8) | TH_3168 | - | 1e-107 | 71.21% (257) | PUTATIVE short-chain type dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_0136 | - | 1e-161 | 99.64% (280) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_2008 | - | 2e-28 | 31.30% (262) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2882c|M.bovis_AF2122/97 --------------------------------------------------
Rv2857c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4326|M.marinum_M --------------------------------------------------
MUL_0136|M.ulcerans_Agy99 --------------------------------------------------
MAV_1264|M.avium_104 --------------------------------------------------
TH_3168|M.thermoresistible__bu --------------------------------------------------
Mflv_2405|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4862|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2008|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0073c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mb2882c|M.bovis_AF2122/97 --------------------------------------------------
Rv2857c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4326|M.marinum_M --------------------------------------------------
MUL_0136|M.ulcerans_Agy99 --------------------------------------------------
MAV_1264|M.avium_104 --------------------------------------------------
TH_3168|M.thermoresistible__bu --------------------------------------------------
Mflv_2405|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4862|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2008|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0073c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mb2882c|M.bovis_AF2122/97 --------------------------------------------------
Rv2857c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4326|M.marinum_M --------------------------------------------------
MUL_0136|M.ulcerans_Agy99 --------------------------------------------------
MAV_1264|M.avium_104 --------------------------------------------------
TH_3168|M.thermoresistible__bu --------------------------------------------------
Mflv_2405|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4862|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2008|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0073c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
Mb2882c|M.bovis_AF2122/97 --------------------------------------------------
Rv2857c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4326|M.marinum_M --------------------------------------------------
MUL_0136|M.ulcerans_Agy99 --------------------------------------------------
MAV_1264|M.avium_104 --------------------------------------------------
TH_3168|M.thermoresistible__bu --------------------------------------------------
Mflv_2405|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4862|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2008|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0073c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
Mb2882c|M.bovis_AF2122/97 ---MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVVGDVDVEAG
Rv2857c|M.tuberculosis_H37Rv ---MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVVGDVDVEAG
MMAR_4326|M.marinum_M --MTVVDRLRYDGKRALIVGGATGMGAAAAKSAAELGAEIIVMDYAP--V
MUL_0136|M.ulcerans_Agy99 -MMTVVDRLRYDGKRALIVGGATGMGAAAAKSAAELGAEVIVMDYAP--V
MAV_1264|M.avium_104 --MTIVDRLRYDGKRALVVGGATGMGAAAAKSAAELGAEVIVLDYAP--V
TH_3168|M.thermoresistible__bu ------------------------MGAAAARIVRDLGATVTVMDYAP--V
Mflv_2405|M.gilvum_PYR-GCK --------MRYDGRHVVVTGCASGIGAQAARLLRDLGARVTGLDVRAPED
MSMEG_4862|M.smegmatis_MC2_155 -MAALDALVRYDGRHVVVTGCSSGIGAKVTDQLRCLGARVTGLDLRAPDS
Mvan_2008|M.vanbaalenii_PYR-1 --------MQVEKRRIVVVGAGSGIGAAVAAHFHDNGDHVLAVDLRP--N
MAB_0073c|M.abscessus_ATCC_199 -------MTRLGGRVAVVTGAGKGMGRTHCERLAEEGSDVIAIDLPGSDD
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVES--A
:* * : *
Mb2882c|M.bovis_AF2122/97 GAAADELSGLFVPTDVCDEDAVNGLFDGAAETYGRIDIAFNN--------
Rv2857c|M.tuberculosis_H37Rv GAAADELSGLFVPTDVCDEDAVNGLFDGAAETYGRIDIAFNN--------
MMAR_4326|M.marinum_M GYDAAQTLSVDLRDPASIDSAVERLGGPVHAVFSAAGVADGP----DLMK
MUL_0136|M.ulcerans_Agy99 GYDAAQTLSVDLRDPASIDSAVERLGGPVHAVFSAAGVADGP----DLMK
MAV_1264|M.avium_104 TYDVAKSIQVDLRDPASIDAALEQLDGPVHAVFSAAGIAEGTT---DLMA
TH_3168|M.thermoresistible__bu TYDTDRVIEMDLRDPGSIDHAVDELSGPVDAVFSAAGIADGP----DLMR
Mflv_2405|M.gilvum_PYR-GCK VSALTDFISVDLADQDSVRAAAAAVDGAVDALFNVAGVSSGIGDPLLVLR
MSMEG_4862|M.smegmatis_MC2_155 GAGPDAFREMDLADPDSVDAAAAAIDGPVHALFNVAGVSSGIGDPLLVVR
Mvan_2008|M.vanbaalenii_PYR-1 DTPAAAHAQCDLRDPQSIAGLLDDIGADWDVLAHVAGVPGTAP-ADDVLT
MAB_0073c|M.abscessus_ATCC_199 LAQTAAAVEEHGRRCVWAFADVRDAAALTEAIDTGVRMLGRLD-------
MLBr_02565|M.leprae_Br4923 AEALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHAD--------
Mb2882c|M.bovis_AF2122/97 ---AGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMVLAGKG
Rv2857c|M.tuberculosis_H37Rv ---AGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMVLAGKG
MMAR_4326|M.marinum_M INFIGHRHLIDRLLANDQLPSGSAVCFISSVAGMGWENDLPRLTEFLATP
MUL_0136|M.ulcerans_Agy99 INFIGHRHLIDRLLANDQLPSGSAVCFISSVAGMGWENDLPRLTEFLATP
MAV_1264|M.avium_104 INFLGHRYLIERLLERNQLPSGSAICFISSVAGMGWENDLDLLNEFLATP
TH_3168|M.thermoresistible__bu TNFIGHRHLLDRLFADGRLGRGSAICFISSVAGMGWENDLDRLLDFLSTT
Mflv_2405|M.gilvum_PYR-GCK INFLGMRQFTESLLDR--MPAGGAVTNVSSLAASAYRENAHVTAGLLATR
MSMEG_4862|M.smegmatis_MC2_155 INFLGTRQFTEALVDR--IADGGSITSVSSLAASAYRENRAVTAGLVSTG
Mvan_2008|M.vanbaalenii_PYR-1 VNYLGMRKMVEGMLPR--MRRGGSVVAVASIAGIGWEQRLDELSELLAAT
MAB_0073c|M.abscessus_ATCC_199 -IVVANAGVYDGLAPSCELTEDSWRRALDVNLTGAWHTVKAGAAHLLDGG
MLBr_02565|M.leprae_Br4923 ILVNNAGITRDKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGG
: : : :
Mb2882c|M.bovis_AF2122/97 SIVNTASFVAVMGSATSQISYTASKGGVLAMSRELG-VQFARQGIRVNAL
Rv2857c|M.tuberculosis_H37Rv SIVNTASFVAVMGSATSQISYTASKGGVLAMSRELG-VQFARQGIRVNAL
MMAR_4326|M.marinum_M DYGAAQDWVSAHE-AEGIIHYGFSKKAINAYVATRA-YPLLKRGIRINAI
MUL_0136|M.ulcerans_Agy99 DYGAAQDWVSAHE-AEGIIHYGFSKKAINAYVATRA-YPLLKRGIRINAI
MAV_1264|M.avium_104 DFATAQEWVKAHE-PEGIIHYGFSKKVVNAYVATQG-YPLLKKGIRINAI
TH_3168|M.thermoresistible__bu DYRSADAWVKEHE-GDGFIHYGFSKQVVNAYVATWA-FELLKQGVRINAI
Mflv_2405|M.gilvum_PYR-GCK SVDEGLRWCADHPEALADGGYRQSKEAIILYGMQRV-TDLGARGIRVNCT
MSMEG_4862|M.smegmatis_MC2_155 SVDEGLRWCAENPDALADGGYRLSKEAIILYGMSKA-VELGARGIRVNCT
Mvan_2008|M.vanbaalenii_PYR-1 DPEAVAAWQSRQD--PSYPVYTTSKQAVILYAKRLAGTALSRYGVRVNTV
MAB_0073c|M.abscessus_ATCC_199 SVIIISSTNGLKG-TANTAHYTASKHAVVGLARTAA-NELGPQGIRVNTV
MLBr_02565|M.leprae_Br4923 RVIVLSSMAGIAG-NRGQTNYATAKAGVIGLTQALA-PGLAEKGITINAV
* :* : : *: :*
Mb2882c|M.bovis_AF2122/97 CPGPVNT------PLLQELFAKNPERAARRMVHVPLGRFAEPD------E
Rv2857c|M.tuberculosis_H37Rv CPGPVNT------PLLQELFAKNPERAARRMVHVPLGRFAEPD------E
MMAR_4326|M.marinum_M CPGPTDT------PLAQANADLWL-TFAQDYRDETGSKVHTPE------Q
MUL_0136|M.ulcerans_Agy99 CPGPTDT------PLAQANADLWL-TFAQDYRDETGSKVHTPE------Q
MAV_1264|M.avium_104 CPGPTDT------PLAQANADLWL-TFAQDYRDETGSKVHTPE------Q
TH_3168|M.thermoresistible__bu CPGPTDT------PLARANADLWL-TFAQDYRDATGVGVHQPE------Q
Mflv_2405|M.gilvum_PYR-GCK APGVTET------PILDQLRSAYG-QQYLDSFTAPLGRVSTPE------E
MSMEG_4862|M.smegmatis_MC2_155 GPGVTDT------PILDQLRSAYG-QQYLDSFTTPLGRNSEPD------E
Mvan_2008|M.vanbaalenii_PYR-1 SPGPVET------PILADFEQTMG-KEILDMLRDTYGRHGTVD------D
MAB_0073c|M.abscessus_ATCC_199 HPGAVSTGMILNPAVIARLRPDLEHPTVEDAAEALAARTLLPVPWVEAVD
MLBr_02565|M.leprae_Br4923 APGFIET--------QMTAAIPLATREVGRRLNSLLQGGLPVD-------
** .*
Mb2882c|M.bovis_AF2122/97 IAAAVAFLASDDASFITASTFLVDGGISSAYVTPL---------------
Rv2857c|M.tuberculosis_H37Rv IAAAVAFLASDDASFITASTFLVDGGISSAYVTPL---------------
MMAR_4326|M.marinum_M MGDVMVFLNSAAAFGISGITLLVDYGHTMSSLTGAYPPGKPIIDLIMGRV
MUL_0136|M.ulcerans_Agy99 MGDVMVFLNSAAAFGISGITLLVDYGHTMSSLTGAYPPGKPIIDLIMGRV
MAV_1264|M.avium_104 MGDVMAFLNSAAAFGINGITLLVDYGHTMASLTGAYPPGKPIIDIIMGRV
TH_3168|M.thermoresistible__bu MGSAMAFLNSPAASGISGITLLVDSGHAMSSLTNAFPPGKPIMDLITGRA
Mflv_2405|M.gilvum_PYR-GCK QAAVLVFLGSRAAGYISGQVLWTDGGILGRRIASQMFDEPLTQGN-----
MSMEG_4862|M.smegmatis_MC2_155 QAALLVFLGSAAASYVTGQVIWADGGIIAQRETALIESTRATQES-----
Mvan_2008|M.vanbaalenii_PYR-1 IVPVIAFLASDAAQWINGQDVHVDSGFVTSMTAGTPIAL-----------
MAB_0073c|M.abscessus_ATCC_199 ISNAVVFLASDEARYITGTQLVVDAGLTQKA-------------------
MLBr_02565|M.leprae_Br4923 VAETIAYFAIPASNAVTGNVIRVCGQAMLGA-------------------
:.:: : :.. . .
Mb2882c|M.bovis_AF2122/97 ---
Rv2857c|M.tuberculosis_H37Rv ---
MMAR_4326|M.marinum_M PMP
MUL_0136|M.ulcerans_Agy99 PMP
MAV_1264|M.avium_104 KL-
TH_3168|M.thermoresistible__bu KL-
Mflv_2405|M.gilvum_PYR-GCK ---
MSMEG_4862|M.smegmatis_MC2_155 ---
Mvan_2008|M.vanbaalenii_PYR-1 ---
MAB_0073c|M.abscessus_ATCC_199 ---
MLBr_02565|M.leprae_Br4923 ---