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MSPTVRLAQGVVSGAEDGGVYRFLGMPYAAPPVGDLRWAPPAPPASWAGVRDATRYGNAAIQTVDTGFDP GAPQSEDCLYLNVWTSTLDVGARRPVMVWIHGGGFLNGASSMDLWQGQHLARRGVTVVSLNYRLGAFGFL AHPQAGGNFGLLDWVAALSWVAENIATFGGDPANVTIFGQSAGGAATRALLHTPSARGLFHRAVIQSAGY EDYAVVGSPSYQRVTDASERLFEQLGSADIDELRRLPAEQVRQASFDQCGVNPPPGQVHTPANLVWYPTV DGRVMEEDFSGWPADVPVMIGCTEHEGRFFVQPTMLYAHPELDPAQVYTQDTLEHMARALGGERAGDILA HYAASGLSAYEALAELITIGVWHEPALASVERFAALGRRAYHYRFARVSPGARTSGLLAKHSAEIPYLFG GLTPAGSYDEVDAAVSDAVQHAWVEFARTGVPRTPDGTDFPSYDTTSRQVVVFDDTTEVRPLDANPVTDM IHTLRAAPTRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0492 | - | - | 100% (501) | para-nitrobenzyl esterase |
| M. avium 104 | MAV_1226 | - | 3e-57 | 33.53% (501) | carboxylesterase superfamily protein |
| M. avium 104 | MAV_2466 | - | 3e-52 | 33.84% (523) | LppT protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2071c | lipT | 3e-52 | 33.94% (498) | carboxylesterase LipT |
| M. gilvum PYR-GCK | Mflv_3419 | - | 2e-67 | 35.53% (515) | carboxylesterase, type B |
| M. tuberculosis H37Rv | Rv2045c | lipT | 3e-52 | 33.94% (498) | carboxylesterase LipT |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3452c | - | 2e-59 | 35.53% (515) | carboxylesterase LipT |
| M. marinum M | MMAR_4363 | - | 5e-65 | 35.63% (522) | carboxylesterase |
| M. smegmatis MC2 155 | MSMEG_1432 | - | 2e-65 | 38.08% (478) | acetylcholinesterase |
| M. thermoresistible (build 8) | TH_3679 | - | 1e-64 | 34.85% (505) | PUTATIVE Carboxylesterase, type B |
| M. ulcerans Agy99 | MUL_2261 | lipT | 4e-51 | 33.40% (503) | carboxylesterase, LipT |
| M. vanbaalenii PYR-1 | Mvan_3172 | - | 1e-63 | 35.51% (521) | carboxylesterase, type B |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3419|M.gilvum_PYR-GCK ------------------MTAEATPR----SSA---PVVDTSTGPVRGLD
Mvan_3172|M.vanbaalenii_PYR-1 ------------------MTADATTR----SSAGGRPVVETTNGPVRGVD
TH_3679|M.thermoresistible__bu --------MPSTTPPDDRTPDDAPTRPAPAHSAVGSPVVDTVHGPVRGRD
MMAR_4363|M.marinum_M ------------------MTSDIRRM------ASDGYVVETAYGPVRGAE
Mb2071c|M.bovis_AF2122/97 ---------MALESATVGSMHERTVR------------ARTATGIVEGFT
Rv2045c|M.tuberculosis_H37Rv ---------MALESATVGSMHERTVR------------ARTATGIVEGFT
MUL_2261|M.ulcerans_Agy99 -------------------MHERTVR------------ARTATGVVEGFT
MAB_3452c|M.abscessus_ATCC_199 -------------------MAKKPIR------------INTVNGTVEGFT
MAV_0492|M.avium_104 --------------------MSPTVR--------------LAQGVVSGAE
MSMEG_1432|M.smegmatis_MC2_155 MRRARQVSALLFGLVIVLNAAVVGCRAAEAPVATDPVVVHTASGTVRGLV
* * *
Mflv_3419|M.gilvum_PYR-GCK DGI--------IKSWKGVPYAAAPVGELRWRAPEPPPAWTEPRDATRVGP
Mvan_3172|M.vanbaalenii_PYR-1 DGS--------VKSWKAVRYAAAPVGELRWRAPEPPQAWSEPVDAGRVGP
TH_3679|M.thermoresistible__bu DGV--------VKVWRGIRYAAAPVGGLRWRAPEPPQPWREPMDAIRVGP
MMAR_4363|M.marinum_M DGIAAAGSGVRTKSWKGIRYGAPPVGELRFRAPQPPQPWTEIADATAFGP
Mb2071c|M.bovis_AF2122/97 RDG--------VHRWRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTFAN
Rv2045c|M.tuberculosis_H37Rv RDG--------VHRWRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTFAN
MUL_2261|M.ulcerans_Agy99 RDG--------VHRWRSIPYARAPIGLLRFRAPRPPQPWSGVRHCHGFTH
MAB_3452c|M.abscessus_ATCC_199 RGG--------VHRFRGIPYAEPPVGPLRLRAPRPALPWTGVRTCRAWGA
MAV_0492|M.avium_104 DGG--------VYRFLGMPYAAPPVGDLRWAPPAPPASWAGVRDATRYGN
MSMEG_1432|M.smegmatis_MC2_155 AEG--------HRLFAGIPYAAPPVGSLRFAAPEPAASWPGERDATRPGP
: .: *. .*:* ** .* *. .* .
Mflv_3419|M.gilvum_PYR-GCK VCPQP-TDPKIPLDLGAPQGEDFLSLNVWAPSGTQPGDRKPVMVWVHGGA
Mvan_3172|M.vanbaalenii_PYR-1 VCPQP-TDPRIPIDLGAPQGEDFLTLNIWAPSGTQPGDAKPVMVWIHGGA
TH_3679|M.thermoresistible__bu ACPQP-ADPRIPLDLGAAIGEDCLNLNVWASSDTEPGDRKPVLVWVHGGA
MMAR_4363|M.marinum_M VCPQP-VLANMPIDLGAPQDEDCLRLNIWAPANTAPGAAKPVMVWLHGGA
Mb2071c|M.bovis_AF2122/97 CAPQQRRYTVMGIGRYQTRSEDCLTLNVVTPEEPATQP-LPVMVFIHGGG
Rv2045c|M.tuberculosis_H37Rv CAPQQRRYTVMGIGRYQTRSEDCLTLNVVTPEEPATQP-LPVMVFIHGGG
MUL_2261|M.ulcerans_Agy99 CSPQQRRYTMLGLGKYQPMSEDCLTLNVVAPEAPTHRP-LPVMVFIHGGG
MAB_3452c|M.abscessus_ATCC_199 ASIQQHRYAIILPGKPQKLSEDCLTLNVVAPEGPVSGP-LPVMFFIHGGG
MAV_0492|M.avium_104 AAIQT---VDTGFDPGAPQSEDCLYLNVWTS-TLDVGARRPVMVWIHGGG
MSMEG_1432|M.smegmatis_MC2_155 RCVQD---PDADLEHGDNSGEDCLTLNVWTP--PVGKDLRPVMVWIHGGG
. * .** * **: :. **:.::***.
Mflv_3419|M.gilvum_PYR-GCK YVLGSASQPLYHGRAMAGAGDVIVVTVNYRLGALGFLELSTLD-DSGRFA
Mvan_3172|M.vanbaalenii_PYR-1 YILGSASQPLYHGGTLASGGDAVVVTVNYRLGALGFLELSTLGADPERFA
TH_3679|M.thermoresistible__bu YVIGAASQPLYHGRELVRRGDVVLVTLNYRLGAFGFLELTALSSGRRRFD
MMAR_4363|M.marinum_M YMLGSASQALYDGRRLASSGEVIVVTVNYRLGALGFLDLSSLSHAGRSFD
Mb2071c|M.bovis_AF2122/97 YILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPQITLD
Rv2045c|M.tuberculosis_H37Rv YILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPQITLD
MUL_2261|M.ulcerans_Agy99 YILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPDIAID
MAB_3452c|M.abscessus_ATCC_199 YFLGSSATPLYDGASLARRG-CVYVSVNYRLGGLGCVDLSSLSDDKHTID
MAV_0492|M.avium_104 FLNGASSMDLWQGQHLARRG-VTVVSLNYRLGAFGFLAHPQAG-------
MSMEG_1432|M.smegmatis_MC2_155 FVNGSS--DVYDASRLASRGDIVVVTVNYRLGTLGFLAHPALEAPG--EV
:. *:: ::.. :. * *::***** :* : .
Mflv_3419|M.gilvum_PYR-GCK SNLGLRDVLAALGWVRDNIAAFGGDPGRVTVFGESAGGGIVTSLLGSPAA
Mvan_3172|M.vanbaalenii_PYR-1 TNLGLRDVLAALEWVRDNIAAFGGDPGRVTVFGESAGGGIVASLLASPAA
TH_3679|M.thermoresistible__bu TNVGLRDVLFALAWVRDNIAAFGGDPDRVTLFGESAGGGIVTTLLGSPAA
MMAR_4363|M.marinum_M SNVGLRDVLAALHWVRENIAAFGGDPANITLFGESAGAGLVTTLLVTPAA
Mb2071c|M.bovis_AF2122/97 SNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLAVPAA
Rv2045c|M.tuberculosis_H37Rv SNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLAVPAA
MUL_2261|M.ulcerans_Agy99 GNLYLRDLVMALQWIQDNIAEFGGDPDNVTIFGESAGAHITATLLAVPAA
MAB_3452c|M.abscessus_ATCC_199 SNLYLRDLVLALQWVHDNIGAFGGDPNNVTIFGESAGSHAVNTLLAVPSA
MAV_0492|M.avium_104 GNFGLLDWVAALSWVAENIATFGGDPANVTIFGQSAGGAATRALLHTPSA
MSMEG_1432|M.smegmatis_MC2_155 GNYGIADQQAALRWVRDNIAAFGGDPQRVTLAGESAGGTSVCDHLVAPGS
* : * ** *: :**. ***** .:*: *:***. . * *.:
Mflv_3419|M.gilvum_PYR-GCK AGLFHAAIAQSS-----PATSMYDVGRARRVATRFLEVIGVDRADMS-AL
Mvan_3172|M.vanbaalenii_PYR-1 AGLFSAAIAQSA-----PVTSTYELGRAQRVAERFLDVLGARPDDLH-RL
TH_3679|M.thermoresistible__bu AGLFHRAIAQSS-----PATSCYGTERAIDVAEQFLGHLGLSPRDVD-RL
MMAR_4363|M.marinum_M RGLFSRAIAQSS-----PATSVYDRERAQRVAVHLLDKLGVAASDVD-KL
Mb2071c|M.bovis_AF2122/97 KGLFARAISESP-----AAGMVRSREVAAEFAARFANLIGARTQDAANAL
Rv2045c|M.tuberculosis_H37Rv KGLFARAISESP-----AAGMVRSREVAAEFAARFANLIGARTQDAANAL
MUL_2261|M.ulcerans_Agy99 KGLFARAISESP-----AAGMVRPREIAAEFATRFARLLGARKHDAASAL
MAB_3452c|M.abscessus_ATCC_199 AGLFHRAICQST-----ASGLVVSAEDAAVNARQFAKYLGASDSNAAATV
MAV_0492|M.avium_104 RGLFHRAVIQSAGYEDYAVVGSPSYQRVTDASERLFEQLGSADIDELRRL
MSMEG_1432|M.smegmatis_MC2_155 AGLFDAVVLMSA-----PCQVQADLPTAEQRSVAYAAEAGCPDPASAGDC
*** .: *. . . : *
Mflv_3419|M.gilvum_PYR-GCK TTAPISALVEASRTVFN-EVPVRTPGTLAFAPTIDGDLLPDYPVNLARNG
Mvan_3172|M.vanbaalenii_PYR-1 SEAPIDVLVEASRTVFD-EVPVRTPGTLAFAPTVDGDLLPDYPVNLARQG
TH_3679|M.thermoresistible__bu PDVPVAAIVEVSKHVFD-DVPARRPGTLAFAPIVDGDIVPDYPVALARAG
MMAR_4363|M.marinum_M TQLPTAAIVAASTEVFN-EVPVRNPGTLAFVPIVDGDVLTDYPVKVAQEG
Mb2071c|M.bovis_AF2122/97 MQASPAQLVEAQHHLIR-QGMRKRLGAFPIGPVFGDDYLPMDPVEAMRSG
Rv2045c|M.tuberculosis_H37Rv MQASPAQLVEAQHHLIR-QGMRKRLGAFPIGPVFGDDYLPMDPVEAMRSG
MUL_2261|M.ulcerans_Agy99 MRATAAQLVQTQHRLID-QGMQKRLGAFPIGPTFGDDCLPLDPVEAMRAG
MAB_3452c|M.abscessus_ATCC_199 LAAKPKDLVKALFRLIG-SAKHVPGLSLRIGPSIDGDVLPQDPIEAMERG
MAV_0492|M.avium_104 PAEQVRQASFDQCGVNPPPGQVHTPANLVWYPTVDGRVMEED-----FSG
MSMEG_1432|M.smegmatis_MC2_155 LRALPVDRLRKPVWYFN------IGSDQMTTPVTGTAMLPRAPLR--SLG
* . : *
Mflv_3419|M.gilvum_PYR-GCK KTHPVPLLIGTNKNEAALFRY----MKSPLMPVAPESVRAMFAEISAEQP
Mvan_3172|M.vanbaalenii_PYR-1 RTHPVPLIIGTNKNEAALFRY----MKSPLMPIAPASIKAMFAEIAAEQP
TH_3679|M.thermoresistible__bu RTLPVPLVIGTNKDEASLFRW----MKSPLLPITPDAIKKMFADIAAEQP
MMAR_4363|M.marinum_M RSHPVPLLIGTNKHEAALFRL----MRSPLMPITPRAITSMFTQIAAEQP
Mb2071c|M.bovis_AF2122/97 RVHAVPLIVGTNAEEGRLFTR----FLG-MLPTNEPMVEELLSGMKPA--
Rv2045c|M.tuberculosis_H37Rv RVHAVPLIVGTNAEEGRLFTR----FLG-MLPTNEPMVEELLSGMKPA--
MUL_2261|M.ulcerans_Agy99 QSHKVPLIVGTNADEGRLFTR----FLK-MLPTNKAMIDELLADTEPA--
MAB_3452c|M.abscessus_ATCC_199 ESHRVPLIIGYNAEEATLFTK----VLK-ILPITPEALEHSLSKGGPD--
MAV_0492|M.avium_104 WPADVPVMIGCTEHEGRFFVQPTMLYAHPELDPAQVYTQDTLEHMARALG
MSMEG_1432|M.smegmatis_MC2_155 EAPDVPVLIGTTRDEFTLFVALR--YLRQDQRFTPEEYPELLRQTFGA--
**:::* . .* :* :
Mflv_3419|M.gilvum_PYR-GCK TLQLPSEDHLRGIYRG-RGKNHALGLTSDLGFRMPSIWFADGHRAVAPVY
Mvan_3172|M.vanbaalenii_PYR-1 GLQLPSEDILKGTYRG-RGKTKGLGLTSDLGFRMPSLWFADGHRAVAPVY
TH_3679|M.thermoresistible__bu GLRLPTETQISAAYRRQRGKRLGVGVASDIGFRMPSVWFAEGHTAVAPTY
MMAR_4363|M.marinum_M DLQLPTEEEIGLAYSRLRRRARPLSIATDVGFRMPSVWLAEGHSRVAPVY
Mb2071c|M.bovis_AF2122/97 -----DRERITAAYPNYPAPSACIQLGGDFAFSSAAWQIAEAHGANAPTY
Rv2045c|M.tuberculosis_H37Rv -----DRERITAAYPNYPAPSACIQLGGDFAFSSAAWQIAEAHGANAPTY
MUL_2261|M.ulcerans_Agy99 -----TRERITAAYPNYPESAACIQLGGDFAFNAAAWQIAEAQGVHAPTY
MAB_3452c|M.abscessus_ATCC_199 -----FVRRIIEGYDGYPSQQALLQLAGDLAFGSAAWRVAEAHGRYAPTY
MAV_0492|M.avium_104 GERAGDILAHYAASGLSAYEALAELITIGVWHEPALASVERFAALGRRAY
MSMEG_1432|M.smegmatis_MC2_155 ------DADAVGAHYPLERYGGAAQAYSAAVTDSAFSCVAEQMADELPGT
. .
Mflv_3419|M.gilvum_PYR-GCK LYRFDFATPLLRVARLHAAHATELPFVWGNLGSGRKDPTFALGGRKSGTA
Mvan_3172|M.vanbaalenii_PYR-1 LYRFDFHTPLLRLVRLHAAHATELPFVWGNLVAGRRDPTFALGGRKSGAA
TH_3679|M.thermoresistible__bu LYRFDWSTPTLRLLRLGAAHATELPYVFGNLDTP-KDPTFTLGGRRTGRQ
MMAR_4363|M.marinum_M LYRFDYSTPLLKLLLVRAAHATELPYVWGNLGGP-QDPTLRLGGAKTAKA
Mb2071c|M.bovis_AF2122/97 LYRYDYAPRTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADRRAALR
Rv2045c|M.tuberculosis_H37Rv LYRYDYAPRTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADRRAALR
MUL_2261|M.ulcerans_Agy99 LYRYDYAPRTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADRRHALR
MAB_3452c|M.abscessus_ATCC_199 FYRYDYTTRALRRYGLGPTHAIELLAVFGTYRTVAGPFLAGRADRAVARS
MAV_0492|M.avium_104 HYRFARVSPGARTSGLLAKHSAEIPYLFG-------GLTPAGSYDEVDAA
MSMEG_1432|M.smegmatis_MC2_155 VYAYEFADRDAPAPEVMRTLPFPVGASHSLELRYLFDVGGAPPLNPRQQA
* : . . : .
Mflv_3419|M.gilvum_PYR-GCK VSQRMQSRWTNFAANGDPSAPG-APTWRPYDAS------RATLVIDKHDS
Mvan_3172|M.vanbaalenii_PYR-1 VSERMRARWVSFAAHGAPTGPAGEPVWRPYGADD-----RATLVIDKQDT
TH_3679|M.thermoresistible__bu VSQRIRTRWINFAVHGRPDGPPGEPRWHAYDRAE-----RPCLLIDRRDR
MMAR_4363|M.marinum_M VSKRMRTRWINFATQDNPAGPAGEPDWPAYQDGD-----RACLVIDKSDR
Mb2071c|M.bovis_AF2122/97 VSNEVQRRWRCFSQIGVP-----GDDWPAYTQDD-----RAVLVFDRRCR
Rv2045c|M.tuberculosis_H37Rv VSNEVQRRWRCFSQIGVP-----GDDWPAYTQDD-----RAVLVFDRRCR
MUL_2261|M.ulcerans_Agy99 VSDEVIRRWRSFSQTGTP-----GEDWPAYTHTR-----RAVMVIDRKSR
MAB_3452c|M.abscessus_ATCC_199 VSDEMQRRWLAFAHTGVP-----GDGWPAHTVPD-----RQVLIIDNPSR
MAV_0492|M.avium_104 VSDAVQHAWVEFARTGVPRTP-DGTDFPSYDTTS-----RQVVVFDDTTE
MSMEG_1432|M.smegmatis_MC2_155 LADQMIGYWSQFVRTGDPAAE-DQPEWPAYSASESSGRQWMSLRPDGSRM
::. : * * . * : .: : *
Mflv_3419|M.gilvum_PYR-GCK VVDDLDAHVRRAWGDDVLSFL--
Mvan_3172|M.vanbaalenii_PYR-1 VVDDLDADVRRAWGDDVLSFL--
TH_3679|M.thermoresistible__bu VVRDVDEPIRLTWGSEVLSFR--
MMAR_4363|M.marinum_M VARDIDAPIRAAWGREVVGFR--
Mb2071c|M.bovis_AF2122/97 IEFDPHQHRRIAWDGFSLAN---
Rv2045c|M.tuberculosis_H37Rv IEFDPHQHRRIAWDGFSLAN---
MUL_2261|M.ulcerans_Agy99 VEIDPHRHRRLAWDGFSLAR---
MAB_3452c|M.abscessus_ATCC_199 LEADPDADRRPLWQDVTSIV---
MAV_0492|M.avium_104 VRPLDANPVTDMIHTLRAAPTRR
MSMEG_1432|M.smegmatis_MC2_155 ASDFGEEHQCPFWVGLKEK----