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SGGGSRRTSVRVAAALLAGLMVGSAVLTYLSYTAAFTSTDTVTVSSPRAGLVMEKGAKVKYRGIQVGKVT DISYSGNQARLKLAIDSGEMGFIPSNATVRIAGNTIFGAKSVEFIPPKTPSPKPLSPNAHVAASQVQLEV NTLFQSLIDLLHKIDPLETNATLSALSEGLRGHGDDLGALLSGLNTLTRQANPKLPALQEDFRKAAVVAN VYADAAGDLNTVFDNLPTINKTIVDQKDNLNDTLLATIGLSNNAYETLAPAEQNFIDAINRLRAPLKVTS DYSPVFGCLFKGIARGVKEFAPLIGVRKAGLFTSSSFVLGAPSYTYPESLPIVNASGGPNCRGLPDIPTK QTGGSFYRAPFLVTDNALIPYQPFTELQVDAPSTLQFLFNGAFAERDDF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3499c | mce4A | - | 100% (400) | MCE-FAMILY PROTEIN MCE4A |
| M. tuberculosis H37Rv | Rv1966 | mce3A | 1e-50 | 34.02% (341) | MCE-family protein MCE3A |
| M. tuberculosis H37Rv | Rv0589 | mce2A | 3e-48 | 32.12% (386) | MCE-family protein MCE2A |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3529c | mce4A | 0.0 | 100.00% (400) | MCE-family protein MCE4A |
| M. gilvum PYR-GCK | Mflv_1556 | - | 1e-154 | 66.75% (400) | virulence factor Mce family protein |
| M. leprae Br4923 | MLBr_02589 | mce1A | 3e-41 | 27.87% (427) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 1e-131 | 58.23% (395) | MCE-family protein |
| M. marinum M | MMAR_4987 | mce4A | 0.0 | 85.50% (400) | MCE-family protein Mce4A |
| M. avium 104 | MAV_0657 | - | 0.0 | 84.90% (384) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_5900 | - | 1e-157 | 67.25% (400) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_1937 | mce4 | 1e-156 | 66.50% (400) | MCE-FAMILY PROTEIN MCE4A |
| M. ulcerans Agy99 | MUL_4062 | mce4A | 0.0 | 85.50% (400) | MCE-family protein Mce4A |
| M. vanbaalenii PYR-1 | Mvan_5202 | - | 1e-153 | 67.00% (400) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1556|M.gilvum_PYR-GCK ----MSDGDAKRSHVRIAAAILAALVLAAVVFTYLSYTAAFTPTDKVTVL
Mvan_5202|M.vanbaalenii_PYR-1 ----MADGNAKRSHVRIAAAILAALVLAAAVFTYLSYTAAFTPTDKVTVL
MSMEG_5900|M.smegmatis_MC2_155 ----MSNGNAKRSHVRIAAAVLALIVLAAVVFTYLSYTAAFTPTDKVTVT
TH_1937|M.thermoresistible__bu ----MADTGSRRLHVRIAAAILAAVIVAFVVFTYLAYSAAFVRTDTVTVT
Rv3499c|M.tuberculosis_H37Rv ----MSGGGSRRTSVRVAAALLAGLMVGSAVLTYLSYTAAFTSTDTVTVS
Mb3529c|M.bovis_AF2122/97 ----MSGGGSRRTSVRVAAALLAGLMVGSAVLTYLSYTAAFTSTDTVTVS
MMAR_4987|M.marinum_M ----MAGGGSRRTSARVAAALLASLLVAGIALTYLSYTSAFTPTDTVVVS
MUL_4062|M.ulcerans_Agy99 ----MAGGGSRRTSARVAAALLASLLVAGIALTYLSYTSAFTPTDTVVVS
MAV_0657|M.avium_104 --------------------MLAGLMVAFAVLTYLSYTAAFAPIDTVTVS
MAB_4153c|M.abscessus_ATCC_199 ----MSDTSTRR-AVRLAGTVLASVLVLLTVLTYLAYNDAFADTKPITVV
MLBr_02589|M.leprae_Br4923 MTSSTKINASRKPPYKLAGVGLLVVAVVIFGLVYGQFRGNFTPKSKLTML
* : : :.* : *. . :.:
Mflv_1556|M.gilvum_PYR-GCK SPRAGLVMDVDAKVKYRGIQVGKVESIEYAGNA----AKLTLAINRGDMR
Mvan_5202|M.vanbaalenii_PYR-1 SPRAGLVMDVDAKVKYRGIQVGKVESIEYAGDA----AKLTLAINRGDLR
MSMEG_5900|M.smegmatis_MC2_155 APRAGLVMERDAKVKYRGIQIGKVTDIEYAGRE----AKLTLSLNRGEMQ
TH_1937|M.thermoresistible__bu APRAGLVMERGAKVKYRGLQVGKVDDIEYTGDD----AKLTLAINRDQMR
Rv3499c|M.tuberculosis_H37Rv SPRAGLVMEKGAKVKYRGIQVGKVTDISYSGNQ----ARLKLAIDSGEMG
Mb3529c|M.bovis_AF2122/97 SPRAGLVMEKGAKVKYRGIQVGKVTDISYSGNQ----ARLKLAIDSGEMG
MMAR_4987|M.marinum_M SPRAGLVMEKGAKVKYRGIQVGAVEDIYYSGDQ----ARLKLAIRSAEMH
MUL_4062|M.ulcerans_Agy99 SPRAGLVMEKGAKVKYRGIQVGTVEDIYYSGDQ----ARLKLAIRSAEMH
MAV_0657|M.avium_104 APRAGLVMEQGAKVKYRGIQIGKVEAIEYSGDQ----ARLTLGINSKDMH
MAB_4153c|M.abscessus_ATCC_199 SPRAGLVMEEGGKVKFHGLQIGKVTSISYANDQ----AKLELAVNAKDLR
MLBr_02589|M.leprae_Br4923 ADRAGLVMDRGSKITYNGVKIGRVADISETVRNGRPVAEFTLDVYPRYLS
: ******: ..*:.:.*:::* * * : *.: * : :
Mflv_1556|M.gilvum_PYR-GCK YIPGDAPVRIGGTTIFGAKSVEFLAPEDPSGQPLRPGAEVKADDVQLEVN
Mvan_5202|M.vanbaalenii_PYR-1 YIPADAPVRIGGTTIFGAKSVEFLPPEYPNGQALSPGAEVKADSVQLEVN
MSMEG_5900|M.smegmatis_MC2_155 YIPSNATVRIAGNTIFGAKSVEFLPPEKATDTPLRPGTSVPAQDVQLEVN
TH_1937|M.thermoresistible__bu FIPSNAPVQIAGNTIFGAKSVEFLPPERPEPTALRPGAHVSAGDVQLEVN
Rv3499c|M.tuberculosis_H37Rv FIPSNATVRIAGNTIFGAKSVEFIPPKTPSPKPLSPNAHVAASQVQLEVN
Mb3529c|M.bovis_AF2122/97 FIPSNATVRIAGNTIFGAKSVEFIPPKTPSPKPLSPNAHVAASQVQLEVN
MMAR_4987|M.marinum_M FIPSNATVHIAGNTIFGAKSVEFIPPKTPSPTSLHPNAKVTASEVQLEVN
MUL_4062|M.ulcerans_Agy99 FIPSNATVHIAGNTIFGAKSVEFIPPKTPSPTSLHPNAKVTASEVQLEVN
MAV_0657|M.avium_104 FIPSNATVHIAGNTIFGAKAVEFIPPQTPSPTSLRPDAHVAATSVQLEVN
MAB_4153c|M.abscessus_ATCC_199 LIPSNATVRIAGTTVFGAKSVEFLAPQKPSDSSLRPGATVTAEAVALEVN
MLBr_02589|M.leprae_Br4923 LIPANVNADIKATTVFGGKYVSLTTPEHPSQKRLTPQTVIDARSVTTEIN
**.:. . * ..*:**.* *.: .*: . * * : : * * *:*
Mflv_1556|M.gilvum_PYR-GCK TLFQTLTDLLQKIDPIKLNGTLSALGEGMRGHGDDVGALLSGLNYYTSQL
Mvan_5202|M.vanbaalenii_PYR-1 TLFQTLTDLLDKIDPIELNATLSALGEGLRGNGDDVGALLSGLNYYVGQL
MSMEG_5900|M.smegmatis_MC2_155 TLFQTLSDLLDKIDPVSLNGTLTALGEGLRGHGDDLGATLAGLNTLLGQL
TH_1937|M.thermoresistible__bu TLFQTLMEVLNQVDPIELNATLTALAEGLRGNGDNLGAALVGANELAARL
Rv3499c|M.tuberculosis_H37Rv TLFQSLIDLLHKIDPLETNATLSALSEGLRGHGDDLGALLSGLNTLTRQA
Mb3529c|M.bovis_AF2122/97 TLFQSLIDLLHKIDPLETNATLSALSEGLRGHGDDLGALLSGLNTLTRQA
MMAR_4987|M.marinum_M TLFQSLIDLLHKIDPVELNGTLSALSEGLRGHGDDLGALLSGLNTLTRQA
MUL_4062|M.ulcerans_Agy99 TLFQSLIDLLHKIDPVELNGTLSALSEGLRGHGDDLGALLSGLNTLTRQA
MAV_0657|M.avium_104 TLFQSLIDLLHKIDPVELNGTLSAFSEGLRGHGDDLGGILSGLNTLTRQA
MAB_4153c|M.abscessus_ATCC_199 TVFENLTRLLGKIDPVNLNATLTAVGEGLRGNGDNFGQGLVELDQYLDQL
MLBr_02589|M.leprae_Br4923 TLFQTITLIAEKVDPIKLNLTLSAAAQSLAGLGERFGQSIVNGNSVLDDV
*:*:.: : ::**:. * **:* .:.: * *: .* : :
Mflv_1556|M.gilvum_PYR-GCK NPKLPALQEDLRRTAVVADIYGDAGPDLARILDNAPAISQTIVDEQDNLN
Mvan_5202|M.vanbaalenii_PYR-1 NPKLPALQEDLRRTAVVADIYGDAGPDLVRVLDNAPAISKTIVDEQDNLN
MSMEG_5900|M.smegmatis_MC2_155 NPKLPTLQDDFSKAAVVAGIYGDAGPDIATVLDNVPGVNQTIIDEQANLN
TH_1937|M.thermoresistible__bu NPKMPTLQEDFRRTAAVGAVYSDAGPDIVTIIDNAPTLSATITERENDLN
Rv3499c|M.tuberculosis_H37Rv NPKLPALQEDFRKAAVVANVYADAAGDLNTVFDNLPTINKTIVDQKDNLN
Mb3529c|M.bovis_AF2122/97 NPKLPALQEDFRKAAVVANVYADAAGDLNTVFDNLPTINKTIVDQKDNLN
MMAR_4987|M.marinum_M NPKLPTLQEDFRKAAIVTNTYADAAPDLNTVFDSLPTINKTVVDKQNDLD
MUL_4062|M.ulcerans_Agy99 NPKLPTLQEDFRKAAIVTNTYADAAPDLNTVFDSLPTINKTVVDKQNDLD
MAV_0657|M.avium_104 NPKLPALQEDFRRTAVVSNVYADAAPDLNTVFDNLPTINKTVVDQQKNLD
MAB_4153c|M.abscessus_ATCC_199 NPKLPALQQDFRQAGQVGQIYGDAAPDIVRILDNLPALSRTVVDQQQDLK
MLBr_02589|M.leprae_Br4923 NSQLPQARHDIQQLASLGDTYANSASDFFDFLNNSIVTSRTINQQQKDLD
*.::* :.*: : . : *.::. *: .::. . *: :.: :*.
Mflv_1556|M.gilvum_PYR-GCK AALLAATGLANNGTATFEPAADDYIAAVQRLRAPLKVAGEYSPVIGCTLR
Mvan_5202|M.vanbaalenii_PYR-1 AALLAATGLANNGTATFEPAADDYIAAVQRLRAPLKVAGEYSPVIGCTLK
MSMEG_5900|M.smegmatis_MC2_155 ATLLAATGLANNGTATLQPAADDYIAAVQRLRAPLKVAGDYSPEFGCILE
TH_1937|M.thermoresistible__bu ATLLAATGLSDTAVATLEPGAEDYIAAIQRLRAPLKVTADYSPQYGCLLQ
Rv3499c|M.tuberculosis_H37Rv DTLLATIGLSNNAYETLAPAEQNFIDAINRLRAPLKVTSDYSPVFGCLFK
Mb3529c|M.bovis_AF2122/97 DTLLATIGLSNNAYETLAPAEQNFIDAINRLRAPLKVTSDYSPVFGCLFK
MMAR_4987|M.marinum_M TTLLAAIGLANNGYETLAPAEQDFIAAINRLRAPVKVAHDYSPEFGCLFK
MUL_4062|M.ulcerans_Agy99 TTLLATIGLANNGYETLAPAEQDFIAAINRLRAPVKVAHDYSPEFGCLFK
MAV_0657|M.avium_104 TTLLATIGLANNAYDTLAPAEQDFIDTINRVRAPLKVAADYSPEFGCLFA
MAB_4153c|M.abscessus_ATCC_199 ATLLAAIGLGNNGYETLAPAEKDLTAALQRLRAPATLLGRYSPEIPCTLQ
MLBr_02589|M.leprae_Br4923 QVLLAAVGFGNTGADIFSRSGPYLARGAADLVPTAQLLDTYSPAIFCTLR
.***: *:.:.. : . : .. : *** * :
Mflv_1556|M.gilvum_PYR-GCK GTAAAIERFAPIIG------GIRPGLFVSSNFLP----------------
Mvan_5202|M.vanbaalenii_PYR-1 GTANAIDRFAPIIG------GIRPGLFVSSNFLP----------------
MSMEG_5900|M.smegmatis_MC2_155 GTANAVDRFAPIIG------GIRPGLYVASNFLP----------------
TH_1937|M.thermoresistible__bu AIDRAIREFAPVIG------GTRPGLFTSSNFLL----------------
Rv3499c|M.tuberculosis_H37Rv GIARGVKEFAPLIG------VRKAGLFTSSSFVL----------------
Mb3529c|M.bovis_AF2122/97 GIARGVKEFAPLIG------VRKAGLFTSSSFVL----------------
MMAR_4987|M.marinum_M GIGRGIKEFAPLIG------VRKAGLFTSSSFVL----------------
MUL_4062|M.ulcerans_Agy99 GIGRGIKEFAPLIG------VRKAGLFTSSSFVL----------------
MAV_0657|M.avium_104 GIERGIKEFAPLLG------VRKAGLFTSSSFVL----------------
MAB_4153c|M.abscessus_ATCC_199 AISKALVTFTPLIG------GVRPGLFLTNSFPL----------------
MLBr_02589|M.leprae_Br4923 NYHDIEPKVTSFLGGNGYSINDHVELLSGLGFLLNPTSAISIIGAGVLSQ
.:..:* : * .*
Mflv_1556|M.gilvum_PYR-GCK --------------GSPAYTYPESLPIVNASGGPNCRGLPDVPSKQYGGS
Mvan_5202|M.vanbaalenii_PYR-1 --------------GSPAYTYPESLPIVNASGGPNCRGLPDVPSKQYGGS
MSMEG_5900|M.smegmatis_MC2_155 --------------GSPGYTYPESLPIVNASGGPNCRGLPDVPSKQYGGS
TH_1937|M.thermoresistible__bu --------------GSPSYTYPESLPIVNAKGGPNCRGLPDMPGKQGGGS
Rv3499c|M.tuberculosis_H37Rv --------------GAPSYTYPESLPIVNASGGPNCRGLPDIPTKQTGGS
Mb3529c|M.bovis_AF2122/97 --------------GAPSYTYPESLPIVNASGGPNCRGLPDIPTKQTGGS
MMAR_4987|M.marinum_M --------------GSPSYTYPESLPIVNASGGPNCRGLPDIPTKQTGGS
MUL_4062|M.ulcerans_Agy99 --------------GSPSYTYPESLPIVNASGGPNCRGLPDIPTKQTGGS
MAV_0657|M.avium_104 --------------GAPSYTYPESLPIVNASGGPNCRGLPDIPTKQTGGS
MAB_4153c|M.abscessus_ATCC_199 --------------GAPVYTYPDSLPIVNASGGPNCRGLPNIPTKMQNGS
MLBr_02589|M.leprae_Br4923 GLLAPLGLAGVVNGAANPYIYPENLPRVNARGGP--GGAPGCWQHITR-D
.: * **:.** *** *** * *. : .
Mflv_1556|M.gilvum_PYR-GCK WYRTPFLVTDNAYVPYQPNTELQFDAPSTLQFLFNGAYAERDDF-
Mvan_5202|M.vanbaalenii_PYR-1 WYHTPFLVTDNAYVPYQPNTELQFDAPSTLQFLFNGAYAERDDF-
MSMEG_5900|M.smegmatis_MC2_155 WYRSPFLVTDNAYVPYQPNTELQFDAPATLQFLFNGAFAERDDF-
TH_1937|M.thermoresistible__bu WYKAPFLVTDNAYIPYQPFTELQLDAPSTLQFLFNGAFAERDDW-
Rv3499c|M.tuberculosis_H37Rv FYRAPFLVTDNALIPYQPFTELQVDAPSTLQFLFNGAFAERDDF-
Mb3529c|M.bovis_AF2122/97 FYRAPFLVTDNALIPYQPFTELQVDAPSTLQFLFNGAFAERDDF-
MMAR_4987|M.marinum_M FYRAPFLVTDNANIPYEPFTEVQVDAPSTLQFLFHGTFAERDDF-
MUL_4062|M.ulcerans_Agy99 FYRAPFLVTDNANIPYEPFTEVQVDAPSTLQFVFHGTFAERDDF-
MAV_0657|M.avium_104 FYRAPFLVTDNANIPYEPFTELQVDAPSTLQFLFHGAFAERDDF-
MAB_4153c|M.abscessus_ATCC_199 WFRSPFLVTDNAYIPYKPLEELQVNAPDTLQYLYNGAFAKRSEF-
MLBr_02589|M.leprae_Br4923 LWPTPELVMDTGNS-IAPYNHLDSGSPYAIEYVWGRQVGDNTINP
: :* ** *.. * .:: .:* :::::: ...