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MARTDHDRWDLATSVGATATMVAAQRALSSDANLIDDPYAAPLVRAVGIDVYVRLVDGEIQPGTSEFDPH RMAKGMACRTRFYDDFFLDAARAGVGQAVILASGLDARAYRLPWPAGTVVYEVDMPDVIEFKTLTLADLG AQPTAQRRTVAIDLRDDWAAALREEGFDTQAPAAWSAEGLLVYLPEQAQDALFDNITALSAPGSRLAFDF VPDTAVFADPRWRAHHERMSELGFEVDFNDLVYHGERSHIVDHLSGRGWRVTSRTIAELHAANGFAYAAD DVAAAFADVTYSSAVLGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0778 | - | - | 100% (298) | methyltransferase, putative, family protein |
| M. avium 104 | MAV_4442 | - | 1e-95 | 58.86% (299) | methyltransferase, putative, family protein |
| M. avium 104 | MAV_4435 | - | 9e-91 | 57.10% (303) | methyltransferase, putative, family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0853 | - | 1e-127 | 72.58% (299) | hypothetical protein Mb0853 |
| M. gilvum PYR-GCK | Mflv_5025 | - | 3e-86 | 56.11% (303) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv0830 | - | 1e-127 | 72.58% (299) | hypothetical protein Rv0830 |
| M. leprae Br4923 | MLBr_02640 | - | 1e-57 | 46.79% (280) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_3787 | - | 3e-77 | 53.09% (307) | hypothetical protein MAB_3787 |
| M. marinum M | MMAR_4850 | - | 1e-134 | 77.33% (300) | O-methyltransferase |
| M. smegmatis MC2 155 | MSMEG_1482 | - | 4e-88 | 56.69% (314) | methyltransferase |
| M. thermoresistible (build 8) | TH_2706 | - | 3e-82 | 54.82% (301) | PUTATIVE putative methyltransferase |
| M. ulcerans Agy99 | MUL_0450 | - | 1e-130 | 75.33% (300) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1344 | - | 3e-81 | 57.14% (280) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0853|M.bovis_AF2122/97 MVRADRDRWDLATSVGATATMVAAQRALAADPRYALIDDPYAAPLVRAVG
Rv0830|M.tuberculosis_H37Rv MVRADRDRWDLATSVGATATMVAAQRALAADPRYALIDDPYAAPLVRAVG
MMAR_4850|M.marinum_M MVRTDRDRWDLATSVGATATMVAAQRALAADPQYALIDDPYAAPLVRAVG
MUL_0450|M.ulcerans_Agy99 MVRTDRDRWDLATSVGATATMVAAQRALAADPQYALIDDPYAAPLVRAVD
MAV_0778|M.avium_104 MARTDHDRWDLATSVGATATMVAAQRALSSDAN--LIDDPYAAPLVRAVG
Mflv_5025|M.gilvum_PYR-GCK MARTPDDSWDLASSVGATATMVAAGRAVASADPDPLINDPYAEPLVRAVG
Mvan_1344|M.vanbaalenii_PYR-1 MARTADDSWDPASSVGATATMVAAGRAAASADPDPLINDPYAEPLVRAVG
MAB_3787|M.abscessus_ATCC_1997 MARTDDDSWDLASSVGATATMVAAQRALASHVPNPLINDPYAEPLVRAVG
TH_2706|M.thermoresistible__bu MARSESDTWDLTSGVGVTATMVAAARALASREPEPLIDDPFAAPLVRAVG
MSMEG_1482|M.smegmatis_MC2_155 MARTENDTWDLASSVGATATMVAAARALATNADEPAIDDPFAAPLVRAVG
MLBr_02640|M.leprae_Br4923 -MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTNTG
*: * ** :.**.**.**** ** : * **:* ** ..
Mb0853|M.bovis_AF2122/97 M-DVYTRLVDWQIPVEGDSEFDPQ-----RMATGMACRTRFFDQFFLDAT
Rv0830|M.tuberculosis_H37Rv M-DVYTRLVDWQIPVEGDSEFDPQ-----RMATGMACRTRFFDQFFLDAT
MMAR_4850|M.marinum_M I-DVYTRLVNGQIPVDVESGFDPA-----RMAEAMACRTRFYDQFFVEAT
MUL_0450|M.ulcerans_Agy99 I-DVYTRLVNGQIPVDVESGFDPA-----RMPEAMACRTRFYDQFFVDAT
MAV_0778|M.avium_104 I-DVYVRLVDGEIQP-GTSEFDPH-----RMAKGMACRTRFYDDFFLDAA
Mflv_5025|M.gilvum_PYR-GCK L-DFFTRMLDGELDLSVFPDSSPE--RAQAMIDGMAVRTRFFDDCCLAAA
Mvan_1344|M.vanbaalenii_PYR-1 L-SFFTKMLDGELDLSQFADGSPE--RVQAMIDGMAVRTRFFDDCCGTST
MAB_3787|M.abscessus_ATCC_1997 I-EYFTKLASGAFDPEQMAGLVQLGITADGMANGMASRTWYYDTAFESST
TH_2706|M.thermoresistible__bu V-EFFTRLVDGDLELPADTAEERA--AAQVLTEVMAVRTRFFDDFFTDAT
MSMEG_1482|M.smegmatis_MC2_155 V-DFFTKLVDDNFDLTALDPEAAEG--LTRFANGMAARTRFFDDFFLDAA
MLBr_02640|M.leprae_Br4923 AGALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNNAV
: : . : : * ** ::* :.
Mb0853|M.bovis_AF2122/97 HSGIGQFVILASGLDARAYRLAWPVGSIVYEVDMPEVIEFKTATLSDLGA
Rv0830|M.tuberculosis_H37Rv HSGIGQFVILASGLDARAYRLAWPVGSIVYEVDMPEVIEFKTATLSDLGA
MMAR_4850|M.marinum_M RSGISQVVILASGLDARAYRLDWPAGTVVYEVDMPEVIEFKTLTLADLGA
MUL_0450|M.ulcerans_Agy99 RSGISQVVILASGLDARAYRLGWPAGTVVHEVDMPQVIEFKTLTLADLGA
MAV_0778|M.avium_104 RAGVGQAVILASGLDARAYRLPWPAGTVVYEVDMPDVIEFKTLTLADLGA
Mflv_5025|M.gilvum_PYR-GCK SAGVRQVVILAAGLDARTYRLPWPDGTVVYELDQPDVIAFKTQTLRNLGA
Mvan_1344|M.vanbaalenii_PYR-1 TAGITQVVILASGLDARAYRLGWPAGTVVYELDQPAVIEFKTRTLAGLGA
MAB_3787|M.abscessus_ATCC_1997 AAGVRQAVILASGLDTRAYRLTWPAGTTVYELDQPEVITFKTDTLAELGA
TH_2706|M.thermoresistible__bu RVGARQAVILASGLDARAYRLTWPDGTVVYEIDQPEVIAFKTRTLAELGA
MSMEG_1482|M.smegmatis_MC2_155 RAGVRQFVILASGLDARAYRLPWPAGSVVFEIDQPDVIEFKTKALADLGA
MLBr_02640|M.leprae_Br4923 IDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAEHGV
* * ****:***:*:*** ** *: *.*:* * *: :*: :* *.
Mb0853|M.bovis_AF2122/97 EPATERRTVAVDLRDDWATALQTAGFDPKVPAAWSAEGLLVYLPVEAQDA
Rv0830|M.tuberculosis_H37Rv EPATERRTVAVDLRDDWATALQTAGFDPKVPAAWSAEGLLVYLPVEAQDA
MMAR_4850|M.marinum_M EPTAERRTVAVDLRDDWAAALQAAGFDKDVPSAWSAEGLLVYLPDDAQDA
MUL_0450|M.ulcerans_Agy99 KPTAERRTVAVDLRDDWAAVLQAAGFDKDVPSAWSAEGLLVYLPDDAQGA
MAV_0778|M.avium_104 QPTAQRRTVAIDLRDDWAAALREEGFDTQAPAAWSAEGLLVYLPEQAQDA
Mflv_5025|M.gilvum_PYR-GCK EPAATQRPVPVDLREDWPAALRAAGFDATRPTAWLAEGLLIYLPPEAQDA
Mvan_1344|M.vanbaalenii_PYR-1 HPTATHRPVPIDLREDWPAALHAAGFDASRPTAWLAEGLLIYLPPEAQDQ
MAB_3787|M.abscessus_ATCC_1997 SPSAERRTVAIDLREDWPAALQAAGFDPEQPTVWSAEGLLIYLPPEAQDR
TH_2706|M.thermoresistible__bu PPTAPHRPVAVDLRDDWPAALTAAGFDPTVATAWSAEGLLRYLPPDAQDR
MSMEG_1482|M.smegmatis_MC2_155 LPTTDRRAVAVDLRFDWPAALTEAGFDPAEPTAWIAEGLLGYLPPEAQDR
MLBr_02640|M.leprae_Br4923 TPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPATAQDG
*:: :* *.:*** **...* *** :.* ***** *** **.
Mb0853|M.bovis_AF2122/97 LFDNITALSAPGSRLAFEFVPDTAIFA----DERWRNYHNRMSELGFD--
Rv0830|M.tuberculosis_H37Rv LFDNITALSAPGSRLAFEFVPDTAIFA----DERWRNYHNRMSELGFD--
MMAR_4850|M.marinum_M LFDNITALSATGSRLAFEFVPDTAVFN----DERWRSHHARMSELGFE--
MUL_0450|M.ulcerans_Agy99 LFDNVTALSATGSRLAFEFVPDTAVFN----DERWRSHHARMSELGFE--
MAV_0778|M.avium_104 LFDNITALSAPGSRLAFDFVPDTAVFA----DPRWRAHHERMSELGFE--
Mflv_5025|M.gilvum_PYR-GCK LFDTVTALSAPGSTLATEYVPGIVDFD----GAKARALSEPLREHGLD--
Mvan_1344|M.vanbaalenii_PYR-1 LFDRITALSAPGSTIATEYAPGIIDFD----DEKARAMSAPMREMGLD--
MAB_3787|M.abscessus_ATCC_1997 LFASITELSAPGSRLVCEQVPGLETAD----FSKARELTRQFAGETLD--
TH_2706|M.thermoresistible__bu LFDHITDLSAPGSRLATEDHPGPGAGL----GEKADELGRRWREHGFE--
MSMEG_1482|M.smegmatis_MC2_155 LLDQIAELSAPGSRVAVEEIPAIEEEDHEEIAARMKDFSDRWRAHGFD--
MLBr_02640|M.leprae_Br4923 LFTEIGGLSAVGSRIAVETSPLHGDEWR---EQMQLRFRRVSDALGFEQA
*: : *** ** :. : * ::
Mb0853|M.bovis_AF2122/97 IDLNELVYHGQ-RGHVLDYLTRDGWQTSALTVTQLYEANGFAYPDD-ELA
Rv0830|M.tuberculosis_H37Rv IDLNELVYHGQ-RGHVLDYLTRDGWQTSALTVTQLYEANGFAYPDD-ELA
MMAR_4850|M.marinum_M IDFNDLVYHGQ-RSHVIDHLARDGWQSASHTAKELHAANGFDYPDD-DIA
MUL_0450|M.ulcerans_Agy99 IDFNDLVYHGQ-RSHVIDHLARDGWQSASHTAKELHAANGLDYPDD-DIA
MAV_0778|M.avium_104 VDFNDLVYHGE-RSHIVDHLSGRGWRVTSRTIAELHAANGFAYAAD-DVA
Mflv_5025|M.gilvum_PYR-GCK IDMPSLVYTGA-RTPVMDHLRGAGWQVSGTARAELFARFGRPLPQDADGT
Mvan_1344|M.vanbaalenii_PYR-1 IDMPSLVYAGT-RSHVMDYLAGQGWEVTGVPRRELFTRYGRPLPPEAGDT
MAB_3787|M.abscessus_ATCC_1997 LDLESLVYTQE-RQMAADWLAEHGWTVITEENDELYARLN-LDPPNPLLR
TH_2706|M.thermoresistible__bu VQLSELFHPGE-RTPVVDYLRGRGWDARARPRAEVFAGYGREFPDS-AAL
MSMEG_1482|M.smegmatis_MC2_155 LDFTELVFLGD-RADVSSYLQGHGWKTTSMTSDELLVHNGLPRVDD---D
MLBr_02640|M.leprae_Br4923 VDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWGDGVPMAD
::. .*.. * . * ** : .
Mb0853|M.bovis_AF2122/97 TAFADLTYSSATLMR------
Rv0830|M.tuberculosis_H37Rv TAFADLTYSSATLMR------
MMAR_4850|M.marinum_M AVFADITYTSAVLGR------
MUL_0450|M.ulcerans_Agy99 AVFADITYTSAVLGR------
MAV_0778|M.avium_104 AAFADVTYSSAVLGG------
Mflv_5025|M.gilvum_PYR-GCK DPLGEIVYVSATLAADA----
Mvan_1344|M.vanbaalenii_PYR-1 DPLGEIVYVSAHRPQ------
MAB_3787|M.abscessus_ATCC_1997 SIFPNIVYVDATLG-------
TH_2706|M.thermoresistible__bu AAMRDSSAVTAVRPVVRAGMR
MSMEG_1482|M.smegmatis_MC2_155 AQIGSVVYVTATR--------
MLBr_02640|M.leprae_Br4923 DKDAFAEFVTAHRL-------
*