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NGHAISADSHVTEPIELYAERVDARFKDRVPTISNQDGWRMLHAEGMAPRKLMTASELELAVVAGPDPEQ RLREQRQDGVVGEVVYPNWALQTCFVGDPELQNAICKAYNDWAHDALMTTDWSLPVAMIPMANIDDAIAE AQRAASLGFRALSLPARVEQREYNSEDNDPFWACASELGLPLTFHSGTGYDPRLVRGQGANVINYVLGAQ LDGPRVLLHLAAGGVLDRFPTLRIVAVETGASWLGWVMTQADAVYADHAFFAKKKLSAPPSEFIRRQCHA TFMVDPVAVQNRNITGVECLIWGNDYPHPEGTWPQSATQAAPQFDGVPDEEVDAIVGGNAAAVFGFDRTR L*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0475 | - | - | 100% (352) | amidohydrolase family protein |
| M. avium 104 | MAV_1917 | - | 1e-39 | 29.92% (361) | amidohydrolase 2 |
| M. avium 104 | MAV_2629 | - | 8e-36 | 31.51% (292) | amidohydrolase 2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_2419 | - | 3e-26 | 25.78% (353) | amidohydrolase 2 |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0299 | - | 7e-10 | 24.55% (224) | putative amidohydrolase (aminocarboxymuconate-semialdehyde |
| M. marinum M | MMAR_4820 | - | 2e-36 | 31.27% (371) | hypothetical protein MMAR_4820 |
| M. smegmatis MC2 155 | MSMEG_4837 | - | 2e-29 | 25.87% (375) | amidohydrolase 2 |
| M. thermoresistible (build 8) | TH_2277 | - | 5e-25 | 25.78% (353) | amidohydrolase family protein |
| M. ulcerans Agy99 | MUL_0389 | - | 2e-35 | 31.00% (371) | hypothetical protein MUL_0389 |
| M. vanbaalenii PYR-1 | Mvan_4275 | - | 1e-26 | 22.55% (377) | amidohydrolase 2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2419|M.gilvum_PYR-GCK MSTPTVPSPAHPPTLYPPEGFGAPKHRHGHSTGAVT--GLPADTVIFSAD
TH_2277|M.thermoresistible__bu MSTPTL--------VYPAEGYGAPKNRRGRAPRDVTELGLPAGTEVFSAD
MMAR_4820|M.marinum_M ----------------------------------------MDRYTVISAD
MUL_0389|M.ulcerans_Agy99 ----------------------------------------MDRYTVISAD
MAV_0475|M.avium_104 -----------------------------------------MNGHAISAD
MSMEG_4837|M.smegmatis_MC2_155 --------------------------------------MNKDDMILISVD
Mvan_4275|M.vanbaalenii_PYR-1 --------------------------------------MQTDDLILVSID
MAB_0299|M.abscessus_ATCC_1997 -------------------------------------------MTSVRID
. *
Mflv_2419|M.gilvum_PYR-GCK NHISVADDIFYERFPEELKGAAPRIWYEDGAYMVGMKGKAWTGGDFGRVL
TH_2277|M.thermoresistible__bu NHISVAEDIFYERFPDDLKGAAPRIWYEDGAYMVGMKGKSWVGGDFGRVL
MMAR_4820|M.marinum_M CHAGADLLDYREYLEAKYQD------EFDDWAKTFVNPFG-------DLS
MUL_0389|M.ulcerans_Agy99 CHAGADLFDYREYLEAKYQD------EFDDWAKTFVNPFG-------DLS
MAV_0475|M.avium_104 SHVTEPIELYAERVDARFKDRVPTISNQDGWRMLHAEGMAPRKLMTASEL
MSMEG_4837|M.smegmatis_MC2_155 DHIIEPPDMFKNHLPAKYRDEAPRLVHNPDGSDTWQFRDTVIPNVALNAV
Mvan_4275|M.vanbaalenii_PYR-1 DHVVEPPDMFLRHVPAKYREEAPIVVTDDKGVDQWMYQGRPQGVSGLNAV
MAB_0299|M.abscessus_ATCC_1997 IHAHLWSDEYLSLLDGYGRP------ATDVHRGLGAGATR----------
* : . :
Mflv_2419|M.gilvum_PYR-GCK MQYDDLAG-----------AASNNIEARIRELKEDGIDKELAFPN-----
TH_2277|M.thermoresistible__bu MQYDDLAG-----------AATNNIEARVQELAEDGITRELAFPN-----
MMAR_4820|M.marinum_M EPDAEHNW---------------DSDRRNAELDSDGVAGEVIFPNTVPPF
MUL_0389|M.ulcerans_Agy99 EPDAEHNW---------------DSDRRNAELDSDGVAGEVIFPNTVPPF
MAV_0475|M.avium_104 ELAVVAGP---------------DPEQRLREQRQDGVVGEVVYPN-----
MSMEG_4837|M.smegmatis_MC2_155 AGRPKEEYGLEPQGLDEIRKGCYDPNERVKDMNAGGVLATMNFPSFPG--
Mvan_4275|M.vanbaalenii_PYR-1 VSWPAEEWGRDPAGFAEMRPGVYDVHERVRDMNRNGILASMCFPTFTG--
MAB_0299|M.abscessus_ATCC_1997 ----------------------DDLDGRFELMDEAGVDLQILTAT-----
: . * *: : ..
Mflv_2419|M.gilvum_PYR-GCK ------AVLALFHYPDKALRERVFRIYNEHIADLQE-RSNGHFYGVGLIN
TH_2277|M.thermoresistible__bu ------AVLALFHYPDKALRERVFRIYNEHIADLQD-RSNGHFYGVGLIN
MMAR_4820|M.marinum_M FPQGSLAAPPPSTARDLELRWAGLRAHNRWLADFCS-LSPERRAGVGQIL
MUL_0389|M.ulcerans_Agy99 FPQGSLAAPAPSTARDLELRWAGLRAHNRWLADFCS-LSPERRAGVGQIL
MAV_0475|M.avium_104 ------WALQTCFVGDPELQNAICKAYNDWAHDAL--MTTDWSLPVAMIP
MSMEG_4837|M.smegmatis_MC2_155 ------FAARLFATDDEEFSLALVQAYNDWHIDEWCASNPGRFIPMAIPA
Mvan_4275|M.vanbaalenii_PYR-1 ------FSARHLNMHREEATLVMVSAYNDWHIDEWAGSYPDRFIPIAILP
MAB_0299|M.abscessus_ATCC_1997 --------PASPHFEDQAAAVASARFINDEYAKLSS-EYPGRFGALASLP
* . :.
Mflv_2419|M.gilvum_PYR-GCK WWDPKGTRSTLEE-LKSLGLKTFLLPLNPGKDDEGNIYDYGSTSMDAVWD
TH_2277|M.thermoresistible__bu WWDPKGTRSTLEQ-LKSLGLKTFLLPLNPGKDDDGNIYDYGSRAMDPVWD
MMAR_4820|M.marinum_M LGDVDEAVAEVAQ-IAKLGLRGGVLLPGVAPGTGIPALYA--EHWEPLWA
MUL_0389|M.ulcerans_Agy99 LGDVDEAVAEVAQ-IAKLGLPGGVLLPGVAPGTGIPALYA--EHWEPLWA
MAV_0475|M.avium_104 MANIDDAIAEAQR-AASLGFRALSLPARVEQ----REYNS--EDNDPFWA
MSMEG_4837|M.smegmatis_MC2_155 IWNPGLAAAEVRR-VAEKGVHSLTFTENPSTLGYPSFHDL--EYWRPLWQ
Mvan_4275|M.vanbaalenii_PYR-1 TWNVEAMCAEIRR-VAAKGCRAVTMPELPHLEGLPSYHDD--DYWGPVFR
MAB_0299|M.abscessus_ATCC_1997 LPHVPAALEELARAIDELGMYGASITTSVLG---RSIADP---IFDPLYA
. . * : ..:
Mflv_2419|M.gilvum_PYR-GCK EIEAAGLPVSHHIGETPPKTPCQNNSVVVGMMVNVDSFR--EQFAKYVFS
TH_2277|M.thermoresistible__bu EIEEAGLPVTHHIGETPPKTPCEHNSVVVGMMVNVDSFR--EQFSKYVFS
MMAR_4820|M.marinum_M ACAQAGLVINHHGGN-AGPSPIDGWGSSLAVWVYESHWWAHRALWHLIFS
MUL_0389|M.ulcerans_Agy99 ACAQAGLVINHHGGN-AGPSPIDGWGSSLAVLVYESHWWAHRALLHLIFS
MAV_0475|M.avium_104 CASELGLPLTFHSGTGYDPRLVRGQGANVINYVLGAQLDGPRVLLHLAAG
MSMEG_4837|M.smegmatis_MC2_155 ALVDTETVMNVHIGS-SGKLAITAPDAPMDVMITLQPMNIVQAAADLLWS
Mvan_4275|M.vanbaalenii_PYR-1 TLSEENVVMCLHIGT-GFGAISMAPNAPIDNLIILATQVSAMCAQDLLWG
MAB_0299|M.abscessus_ATCC_1997 ELNRRRAVLFVHPAGCGAESSLITDHS--LTWSIGAPIEDTVAIMHLIVA
: * . . .
Mflv_2419|M.gilvum_PYR-GCK GILDRHPSLKIGWFEGGIAWVPTALQDAEHMLASY----------RHMFN
TH_2277|M.thermoresistible__bu GILDRHPGLRIGWFEGGIAWVPTALQDAEHLLASY----------RHMFN
MMAR_4820|M.marinum_M GVLDRYPDLTVVLTEQGTGWIPATLDSLDVAAARYRRPNSAIARFAGPTA
MUL_0389|M.ulcerans_Agy99 GVLDRYPDLTVVLTEQGTGWIPATLDSLDVAAARYRRPNSAIARFAGPTA
MAV_0475|M.avium_104 GVLDRFPTLRIVAVETGASWLGWVMTQADAVYADH----------AFFAK
MSMEG_4837|M.smegmatis_MC2_155 APIKEFPTLKIALSEGGTGWIPYFLDRVDRTFEMH----------STWTH
Mvan_4275|M.vanbaalenii_PYR-1 PAMRNYPDLKFAFSEGGIGWIPFYLDRSDRHYTN-----------QKWLR
MAB_0299|M.abscessus_ATCC_1997 GVPSRYPDMKIVTCHLG-GALPMVLERAHRQVTEW----------EATQC
..* : . . * . : : .
Mflv_2419|M.gilvum_PYR-GCK HELQHDVN-HYWANHMSASFMVDPLGLQLIDRIGVDNVMWSSDYPHNEST
TH_2277|M.thermoresistible__bu HELQHDIR-HYWDNHMSASFMVDPLGLELIDRIGVDNVFWSSDYPHNEST
MMAR_4820|M.marinum_M GSLPLQPSQYWARQCYVGASFLRPVECAQRHRIGVDRIMWGSDYPHMEGT
MUL_0389|M.ulcerans_Agy99 GSLPLQPSQYWARQCYVGASFLRPVECAQRHRIGVDRIMWASDYPHMEGT
MAV_0475|M.avium_104 KKLSAPPSEFIRRQCHA-TFMVDPVAVQNRNITGVECLIWGNDYPHPEGT
MSMEG_4837|M.smegmatis_MC2_155 QNFGGKLPSEVFREHFMTCFISDPVGVKNRHMIGIDNICWEMDYPHSDSM
Mvan_4275|M.vanbaalenii_PYR-1 RDFGDKLPSDVFREHSLACYVTDKTSLKLRHEIGIDIIAWECDYPHSDCF
MAB_0299|M.abscessus_ATCC_1997 PEAPRDAARRLWYDTVG--HDHTPALRAAVASLGVDRLIFGSDFPYQAGP
. : *:: : : *:*:
Mflv_2419|M.gilvum_PYR-GCK FGYSEKSLATVVD--AVGPEAAVKIVSSNVQRFLGL--------------
TH_2277|M.thermoresistible__bu YGYSEKSLAAVVQ--AVGPENAVKIVSTNIQRFLGIAE------------
MMAR_4820|M.marinum_M APYSREALRHTFS--DVDPDEVAAMVGGNAAAVYGFDLQALAPLAARIGP
MUL_0389|M.ulcerans_Agy99 APYSREALRHTFS--DVDPDEVAAMVGGNAAAVYGFDLQALAPLAARIGP
MAV_0475|M.avium_104 WPQSATQAAPQFD--GVPDEEVDAIVGGNAAAVFGFDRTRL---------
MSMEG_4837|M.smegmatis_MC2_155 WPGAPEELSAVFDTYDVPDDEINKITHENAMRLYHFDPFAHVPKEQATVG
Mvan_4275|M.vanbaalenii_PYR-1 WPDAPEKVLAELNAAGASDSDINKITWENSCRFFSWDPFKLTPKEQATAG
MAB_0299|M.abscessus_ATCC_1997 RYVS----SATYIEEGLSAEDASAILDHNGAELLGLTGV-----------
: . : * .
Mflv_2419|M.gilvum_PYR-GCK -----------------------------------------
TH_2277|M.thermoresistible__bu -----------------------------------------
MMAR_4820|M.marinum_M TVTEVAEPLAAIPADASSTAFEPDPIRAW------------
MUL_0389|M.ulcerans_Agy99 TVTEVAEPLAAIPADASSTAFEPDPIRAW------------
MAV_0475|M.avium_104 -----------------------------------------
MSMEG_4837|M.smegmatis_MC2_155 ALRKAAEGHDVSIRALSKKDKTGASFADFQANAKAVSGARD
Mvan_4275|M.vanbaalenii_PYR-1 ALRAKATDVDTSIRPR-------AEWARLYNEKQQFAQA--
MAB_0299|M.abscessus_ATCC_1997 -----------------------------------------