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MANADCIVIQGSNMAECHPVGFQWVEEARARGARVIHVDPRFTRTSAVSDRHIPIRAGSDVVLLGALINH VLTNDLWFSEYVVAYTNAATVINENFRDTEDLGGLFSGFDPETGQYDTSSWAYEEEDDGRSGGEIESPGG GHTHGATATHSAAGDEHGSGGPPLAHARVRRDETLQHPRTVFQILKRHYARYTPEMVKDVCGISREDFDY LARSIVENSGRERTTCFAYAVGWTQHTLGAQFIRTATILQLLMGNVGRPGSGIMALRGHATIQGSTDIPT LFNLLPGYLPMPKAGVHDTLADYLDAVGSKKQKGFWANADAYTVSLLKAWWGEAATADNDWAYDYLPRLT GPHGTYQTVMGMLADEVEGYFLLGQNPAVGSAHGRMQRLGMSHLKWLVVRDFNLIESATWWKDGPEIASG ELKTEEIETEVFFLPAATHVEKAGSFTQTQRLVQWRHQAVEPPGQCQSELQFFYELGKRIRQRLAGSTDE RDRPLLDLTWDYPTDEHGDPDGEAVLAEINGYRVGEPADPLASYTELRADGSTAAGCWIYTGVYANAVNQ AARRVPNGGASPSQSEWGWAWPADRRVLYNRASADPDGKPWSERKRYIWWDPDQRRWVGYDVPDFVVDRA PGARPDPELGGPDALAGDDPFIMQADGKGWLFAPKGVVDGPLPTHYEPQESPVANALYPQQRNPARITFA RKDNLSAPSAGEPGSDVYPYVFTTYRLTEHHTAGGMSRWLPYLSELQPEMFCEVSPELAAERGLQPYGWA TIISPRAAIEARVLVTKRVAPLVINGHTVHQIGLPYHWGVGGDAVVSGDAANDLLGVTLDPNVQIQESKA GSCDIRPGRRPRGEELLRLIADYQSRSGVTAETGNVRVDDAVWERGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0422 | - | - | 100% (887) | formate dehydrogenase, alpha subunit |
| M. avium 104 | MAV_4535 | - | 2e-12 | 24.26% (371) | nitrate reductase NarB |
| M. avium 104 | MAV_2075 | - | 7e-10 | 33.33% (90) | FdhF protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2924c | fdhF | 3e-06 | 31.25% (80) | formate dehydrogenase H |
| M. gilvum PYR-GCK | Mflv_3016 | - | 2e-09 | 41.89% (74) | molybdopterin oxidoreductase |
| M. tuberculosis H37Rv | Rv2900c | fdhF | 3e-06 | 31.25% (80) | formate dehydrogenase H |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2438 | - | 7e-10 | 34.52% (84) | oxidoreductase |
| M. marinum M | MMAR_5195 | - | 0.0 | 61.57% (864) | formate dehydrogenase, beta subunit, selenocysteine-containing |
| M. smegmatis MC2 155 | MSMEG_2837 | - | 4e-14 | 24.66% (369) | nitrate reductase NarB |
| M. thermoresistible (build 8) | TH_1885 | narX | 2e-06 | 22.15% (325) | PROBABLE NITRATE REDUCTASE NARX |
| M. ulcerans Agy99 | MUL_1474 | fdhF | 4e-10 | 33.33% (90) | formate dehydrogenase H FdhF |
| M. vanbaalenii PYR-1 | Mvan_3491 | - | 1e-10 | 35.37% (82) | molybdopterin oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0422|M.avium_104 --------------------------------------------------
MMAR_5195|M.marinum_M --------------------------------------------------
Mflv_3016|M.gilvum_PYR-GCK ------MTRTACSYCGVGCGISVETRTDP-ASGVPVIARVSGDKLHPTNF
Mvan_3491|M.vanbaalenii_PYR-1 ------MTRTACSYCGVGCGISVETRTDP-ATGVPVIARVTGDKLHPSNF
MAB_2438|M.abscessus_ATCC_1997 ------------------------MRTDAHAAGPVTVATVEGDVLHPSNQ
MUL_1474|M.ulcerans_Agy99 MAPNKDAVKTVCAYCGVGCGIVLQTTTDP-QTGKRRVAKSTGDKSHPANL
Mb2924c|M.bovis_AF2122/97 --------------------------------------------------
Rv2900c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155 --------------------------------------------------
TH_1885|M.thermoresistible__bu ------------------------------VTSPPRVGGPIEDLLQRSGR
MAV_0422|M.avium_104 --------------------------------------------------
MMAR_5195|M.marinum_M --------------------------------------------------
Mflv_3016|M.gilvum_PYR-GCK GRLCTKGATHAEMMAATDGRLTTALVRPSRDADPVALDVDDAVAEAGSRL
Mvan_3491|M.vanbaalenii_PYR-1 GRLCTKGATHAEMMAATDGRLTTALLRPSRDAEPVATDVDDALAEAGARL
MAB_2438|M.abscessus_ATCC_1997 GRLCTKGATHAQLMAA-DGRMTTAHLRSIRGQQPIPAPLAAATAEAGRRL
MUL_1474|M.ulcerans_Agy99 GRLCTKGTTTADLLAA-PGRMESAHLRAHRAGHLESIPIDDAITQCAMRL
Mb2924c|M.bovis_AF2122/97 --------------------------------------------------
Rv2900c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155 --------------------------------------------------
TH_1885|M.thermoresistible__bu FFTPGDVSDDGRIVHRRGGREGDVFYRDRWSHDKVVRSTHGVNCTGSCSW
MAV_0422|M.avium_104 --------------------------------------------------
MMAR_5195|M.marinum_M --------------------------------------------------
Mflv_3016|M.gilvum_PYR-GCK RAIVDEHGPDAVALYVSGQMSIEAQYLATKLAKGFLRTVHIESNSRLCMA
Mvan_3491|M.vanbaalenii_PYR-1 RAILDEHGPDAVALYVSGQMSIEAQYLATKLAKGFLRTVHIESNSRLCMA
MAB_2438|M.abscessus_ATCC_1997 REILDNHGPDAIALYVSGQMTLEAQYLANKLAKGYIRTTHIESNSRLCMA
MUL_1474|M.ulcerans_Agy99 RAIIDEHGPDAVGVYVSGQMSIEAQYLANKLTKGFIGTKQIESNSRLCMA
Mb2924c|M.bovis_AF2122/97 --------------------------------------------------
Rv2900c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155 --------------------------------------------------
TH_1885|M.thermoresistible__bu KVYVKDG-------IITWETQETDYPSVGPDRPEYEPRGCPRGAAFSWYT
MAV_0422|M.avium_104 ---------------------MANADCIVIQGSNMAECHPVGFQWVEEAR
MMAR_5195|M.marinum_M ------------------------------MGSNMAEAHPVGFQWVIEAK
Mflv_3016|M.gilvum_PYR-GCK SAGTGYKQSLGSDGPPGSYTDFDCTNLFFVIGSNMADCHPILYLRMADRL
Mvan_3491|M.vanbaalenii_PYR-1 SAGTGFKQSLGADGPPGSYTDFDCTDLFFVIGSNMADCHPILYLRMADRL
MAB_2438|M.abscessus_ATCC_1997 SAGTGYAQSLGADGPPGSYSDIEHSDLFFVIGANMADCHPILFLRMADRL
MUL_1474|M.ulcerans_Agy99 GASSGYKLSLGADGPPGSYQDFDHADVFLVIGANMADCHPILFLRMMERV
Mb2924c|M.bovis_AF2122/97 -------------------------------MYVEAVRWQRSAASRDVLA
Rv2900c|M.tuberculosis_H37Rv -------------------------------MYVEAVRWQRSAASRDVLA
MSMEG_2837|M.smegmatis_MC2_155 --------------------------------MARTDRISDPWGSRTPYA
TH_1885|M.thermoresistible__bu YSPTRVRYPYARGVLVEMYREAKARLTDPVLAWADIQADPQRRRRYQQAR
MAV_0422|M.avium_104 ARGARVIHVDPRFTRTSAVSDRHIPIRAGSDVVLLGALINHVLTNDLWFS
MMAR_5195|M.marinum_M TRGAQVIHIDPRFTRTSAVADRHVPLRAGSDIAFLGGVINYILSNDLDFR
Mflv_3016|M.gilvum_PYR-GCK KAGARLIVVDPRRTATADKADLYLPIRPGTDLALLNGILRVLVQDGAIDE
Mvan_3491|M.vanbaalenii_PYR-1 KAGAKLIVVDPRRTATADKADLYLPIRPGTDLALLNGILHLLVENGAVDQ
MAB_2438|M.abscessus_ATCC_1997 SSGARLIVVDPRRTATADRADLFLQITPGTDLALLNGLLHLLVENGAVDA
MUL_1474|M.ulcerans_Agy99 KSGAKLIVVDPRRTATADKADLFLQIAPGTDLALLNGLLHLIVENEQTDP
Mb2924c|M.bovis_AF2122/97 DYDEQAVTVAPRKREAAGVRAVMVSLQRG--MQQMGALRTAAALAR----
Rv2900c|M.tuberculosis_H37Rv DYDEQAVTVAPRKREAAGVRAVMVSLQRG--MQQMGALRTAAALAR----
MSMEG_2837|M.smegmatis_MC2_155 AGEPWPQRVDRYLTPGLTDDDVDRWVQSAAVLHSNGDGLDIAVKDGRIVG
TH_1885|M.thermoresistible__bu GKGGLVRISWAEATEMIAAAHVHTIKTHGPDRVAGFSPIPAMSMVSFAAG
.
MAV_0422|M.avium_104 EYVVAYTN-----AATVINENFRDTEDLGGLFSGFDPETGQYDTSS----
MMAR_5195|M.marinum_M EYVTAYTN-----APFLVGEDYCDAEDLDGLFSGYDHASASYDPTT----
Mflv_3016|M.gilvum_PYR-GCK AFIAEHTEGWEAMPAFLADYPPSRVAEITGLAEADIRSAAAMIAEAGDWI
Mvan_3491|M.vanbaalenii_PYR-1 EFIAEHTQGWESMPEFLAGYPPDRVAAITGLSEADIRAAADMIAEAGDWL
MAB_2438|M.abscessus_ATCC_1997 EFIAQHTEGWDGMPEFLAGYAPAVVAAITGLAEEDIRTAARWIGEAREWM
MUL_1474|M.ulcerans_Agy99 QFISEFTEGWEVMPSFLEQFTPDRVSEITGIPSEDIRTAARWIGTAANWM
Mb2924c|M.bovis_AF2122/97 ----------------LNQRNGFDCPGCAWPEEPGGRKLAEFCENG----
Rv2900c|M.tuberculosis_H37Rv ----------------LNQRNGFDCPGCAWPEEPGGRKLAEFCENG----
MSMEG_2837|M.smegmatis_MC2_155 VRGRADDR---------VNHGRLDPKDLFGWQANHARDRLRTPLIR----
TH_1885|M.thermoresistible__bu SRFIELLGG-------VMTSFYDWYADLPVASPQVFGDQTDVPESGDWWD
MAV_0422|M.avium_104 --WAYEEEDDGRSGGEIESPGGGHTHGATATHSAAGDEHGSGGPPLAHAR
MMAR_5195|M.marinum_M --WRYQPGD-----------------------------------------
Mflv_3016|M.gilvum_PYR-GCK SCWTMGLNQSTHGTWNTNAICNLHLATGAICRPGAGPMSLTGQPNAMGGR
Mvan_3491|M.vanbaalenii_PYR-1 SCWTMGLNQSTHGTWNTNAICNLHLATGAICRPGSGPMSLTGQPNAMGGR
MAB_2438|M.abscessus_ATCC_1997 TLWTMGLNQSTHGTWNTNAICNLHLATGAICRPGSGPFSLTGQPNAMGGR
MUL_1474|M.ulcerans_Agy99 SCWTMGLNQSTHGTWNTNALCNLHLATGAICRPGSGPFSLTGQPNAMGGR
Mb2924c|M.bovis_AF2122/97 --------------------------------------------------
Rv2900c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155 --------------------------------------------------
TH_1885|M.thermoresistible__bu AAYLMMWGSNVPVTRTPDAHWMAEVRYRGTKVVAVSPDYADNTKFADEWM
MAV_0422|M.avium_104 --VRRDETLQHPRTVFQILKRHYARYTPEMVKD-----------------
MMAR_5195|M.marinum_M ---HADPTLQHPRCVYQILKRHYARYTPEMVER-----------------
Mflv_3016|M.gilvum_PYR-GCK EMGYMGPGLPGQRAVLSAEDRSFVETQWDLEPGTVRTEVGPGTVEMFRRI
Mvan_3491|M.vanbaalenii_PYR-1 EMGYMGPGLPGQRSVASAADRAFVEEQWDLEPGTIRADIGPGTVEMFRQM
MAB_2438|M.abscessus_ATCC_1997 EMGYMGPGLPGQRSVKSPADRDFVEKRWQLPPGSIRAEFGTGTVDMFAQM
MUL_1474|M.ulcerans_Agy99 EMGYMGPGLPGQRSVLSAPDREFVEEQWGLPGGALRTDVSGGVIDMFSRM
Mb2924c|M.bovis_AF2122/97 -----AKAVAEEATKRTVTAEFFARHSVAELSA-----------------
Rv2900c|M.tuberculosis_H37Rv -----AKAVAEEATKRTVTAEFFARHSVAELSA-----------------
MSMEG_2837|M.smegmatis_MC2_155 -----QDGVLVESDWDTAMDRIVARSRQLLDER-----------------
TH_1885|M.thermoresistible__bu PCAAGTDGAMAMAMGHVILSEFFVRKQVPFFTDYVRRYTDLPFLVKLEER
. ..
MAV_0422|M.avium_104 -------------------------VCGISREDFDYLARSIVENSGRERT
MMAR_5195|M.marinum_M -------------------------VCGVPAQSFLQVARAWTENSGRERT
Mflv_3016|M.gilvum_PYR-GCK AGGDIKAVWIICTNPVASVANRDTVITGLQSAELVITQDAYVDTATNRYA
Mvan_3491|M.vanbaalenii_PYR-1 GSGDIKAAWIICTNPVASVANRDAVVAGLSTAELVITQDVYADTATNRYA
MAB_2438|M.abscessus_ATCC_1997 AAGNIKACWIICTNPVASVANRKNVVDGLRRAELVIAQDAFLATATNEYA
MUL_1474|M.ulcerans_Agy99 ADGEIKACWIICSNPVATVANRKTVLAGLEKAELVISQDAFFETETNEYA
Mb2924c|M.bovis_AF2122/97 -----------------------------KPEYWLSQQGRLAHPMVLRPG
Rv2900c|M.tuberculosis_H37Rv -----------------------------KPEYWLSQQGRLAHPMVLRPG
MSMEG_2837|M.smegmatis_MC2_155 ---------------------------GPNSIGFYTSGQLFLEEYYTQCV
TH_1885|M.thermoresistible__bu DGALVPG----------KMLTVADLGEVFGQHENAAFKPMLLDEATDTVT
MAV_0422|M.avium_104 TCFAYAVGWTQHT-LGAQFIRTATILQLLMGNVGRPGSGIMALRGHATIQ
MMAR_5195|M.marinum_M TALVYSVGWTQHS-MGAQFIRAGSIIQLLLGNIGRPGGGIFALRGHASIQ
Mflv_3016|M.gilvum_PYR-GCK DIMLPATLWAEADAVMVNSGRTLTLLAQSVPAAGDARPDWELICGVARHL
Mvan_3491|M.vanbaalenii_PYR-1 DIVLPATLWAETDAVMVNSDRNLTLLQQSVPPVGDARPDWELICGVARHL
MAB_2438|M.abscessus_ATCC_1997 DILLPAALWAESDGVSINSERTATLTNRAVEAPGDARPDWQLICDIATAM
MUL_1474|M.ulcerans_Agy99 NVLLPAALWTESDGVMVNCERNMSLFPKAVDPVGDALPDWQIIARIACEM
Mb2924c|M.bovis_AF2122/97 DDHYRPISWDAAYQLIAEQLNGLDSPDRAVFYTSGRTSNEAAFCYQLLVR
Rv2900c|M.tuberculosis_H37Rv DDHYRPISWDAAYQLIAEQLNGLDSPDRAVFYTSGRTSNEAAFCYQLLVR
MSMEG_2837|M.smegmatis_MC2_155 IAHGAIGTNHVDGNTRLCTATAAEALKESFGCDGQPGS-YTDVDHADVIA
TH_1885|M.thermoresistible__bu VPHGSLGFRYGTDGAGKWNLDLGPVVPALTVRTGDGPVTEVRLPCFDSVD
. .
MAV_0422|M.avium_104 GSTDIPTLFNLLPGYLPMPKAGVHDTLADYLDAVGSKK---------QKG
MMAR_5195|M.marinum_M GSTDVPTLFNLLPGYLDMPHAG-QATLSDYLDNIKSRN---------QKG
Mflv_3016|M.gilvum_PYR-GCK GFGDAFDHKSSEEIFDEIRRFHNPRTGYDLRGVTYERL---------RAT
Mvan_3491|M.vanbaalenii_PYR-1 GFGDAFDYKSSEQIFDEIRRFHNPGTGYDLRGITYERL---------RDT
MAB_2438|M.abscessus_ATCC_1997 GFGDAFGYSSSEEIFEEIRAFWNPRTGYDMRGMSYARL---------RQG
MUL_1474|M.ulcerans_Agy99 GFSESFSYSSAAEVFEEIKRFSNPATGYDLRGISHDRL---------RET
Mb2924c|M.bovis_AF2122/97 SFG-----TNNLPDCSNMCHESSGAALTDSIGIGKGSV---------TIG
Rv2900c|M.tuberculosis_H37Rv SFG-----TNNLPDCSNMCHESSGAALTDSIGIGKGSV---------TIG
MSMEG_2837|M.smegmatis_MC2_155 LYGHNVAETQTVLWMRMLDRLAGPNPPAIVCIDPRPTP---------VAR
TH_1885|M.thermoresistible__bu GHGTTVTRGVPVRHVGDHRVCTVFDLMLAQYGVSRPGLPGDWPTGYDDAT
MAV_0422|M.avium_104 --FWANADAYTVSLLKAWWGEAATADNDWAYD--YLPRLTGPHGTYQTVM
MMAR_5195|M.marinum_M --FWHNADAYMVSLLKEYWGEHATADNDYCFD--YLPRINGDHSTYRTVM
Mflv_3016|M.gilvum_PYR-GCK PVQWPCPSEDAPDRNPIRYLNDGVSQDLHIDDDGHIPRLAFATPSRRAVF
Mvan_3491|M.vanbaalenii_PYR-1 PVQWPCASAEQSDRNPIRYLNDGVSQDQYVGPDGHRPRLAFPTPSRRAVF
MAB_2438|M.abscessus_ATCC_1997 PVQWPCPPESEVDRNPIRYLNDGISQHPHVDENGVVPRLAFPTPSRRAVF
MUL_1474|M.ulcerans_Agy99 PLQWPCPPDGASNRSPIRYLNDGVSQLQFVRADGTVPRLAFPTATGRAVF
Mb2924c|M.bovis_AF2122/97 -------DVEHADLIVIAGQNPGTNHP------RMLSVLGKAKANGAKII
Rv2900c|M.tuberculosis_H37Rv -------DVEHADLIVIAGQNPGTNHP------RMLSVLGKAKANGAKII
MSMEG_2837|M.smegmatis_MC2_155 HATVHLAPLPGTNVALMNGLLHEILDHDWMDHDYIEAHTVGFHELRKRVA
TH_1885|M.thermoresistible__bu RPYTPAWQEPITGVSAAQVIRIATEFARNAEESGGRSMIIMGAGICQWFH
. . .
MAV_0422|M.avium_104 GMLADEVEGYFLLGQNPAVGSAHGRMQRLGMSHLKWLVVRDFNLIESATW
MMAR_5195|M.marinum_M DMIDGKVFGYFLLGQNPAVGSAHGRMQRLGMANLDWLVVRDLVMIESATF
Mflv_3016|M.gilvum_PYR-GCK HPRPHLDAAELPDDDYPFILNTG-RLQHQWHTMTKTGRVAKLTKLNPAPF
Mvan_3491|M.vanbaalenii_PYR-1 HPRPHMDAAELPDDDYPLVLNTG-RLQHQWHTMTKTGKVAKLNKLNPGPF
MAB_2438|M.abscessus_ATCC_1997 HARAHRDPAELPGEGYPVVLNTG-RLQHHWHTLTKTGRIKTLDRLHPSPF
MUL_1474|M.ulcerans_Agy99 FARPHLVPDEMPDGDYPFLLNTG-RLAHQWHTLTKTGKIAKLNKLNPGPF
Mb2924c|M.bovis_AF2122/97 AVNPLPEAGLIRFKDPQKVNGVVGHGIPIADEFVQIRLGGDMALFAG---
Rv2900c|M.tuberculosis_H37Rv AVNPLPEAGLIRFKDPQKVNGVVGHGIPIADEFVQIRLGGDMALFAG---
MSMEG_2837|M.smegmatis_MC2_155 EFPPERVADICG-VDPDDVRRAGELIGTAERLLSTVLQGFYQSHQATAAA
TH_1885|M.thermoresistible__bu GDATYRAVLALLLLTGSMGRNGGGWAHYVGQEKCRPVTGWATMAMATDWS
MAV_0422|M.avium_104 WKDGPE-------IASGELKTEEIETEVFFLPAATHVEKAG---------
MMAR_5195|M.marinum_M WKEAPE-------VETGEISPQTCRTEVFFFPAASHVEKAG---------
Mflv_3016|M.gilvum_PYR-GCK VEIHPSDAAALGITDGQDLELRTRRGRAVLPAVLTERVRPGNTWAPFHWN
Mvan_3491|M.vanbaalenii_PYR-1 VEIHPDDAAALGISGGHDVELVTRRGRAVLPAVLTDRVQPGNTWVPFHWN
MAB_2438|M.abscessus_ATCC_1997 VEIHPHDATTLGISDGDIVEIASRRGTAELPALVSDRVKRGSCFAPFHWN
MUL_1474|M.ulcerans_Agy99 VEVHPDDAADMQICEGDHIEIASRRGRAVLPVVITDRVRPGNCFAPFHWN
Mb2924c|M.bovis_AF2122/97 -------------LGRLLLEAEERVPGSVVDRSFVDNHCAG---------
Rv2900c|M.tuberculosis_H37Rv -------------LGRLLLEAEERVPGSVVDRSFVDNHCAG---------
MSMEG_2837|M.smegmatis_MC2_155 VQVN----------NIHLVRGMLGRPGCGLLQMNGQPTAEN--------T
TH_1885|M.thermoresistible__bu RPPRQMPGTSYWYVHTDQWNYDGYRADALASPIGRGRFRGKHTMDVLASA
MAV_0422|M.avium_104 -SFTQTQRLVQWRHQAVEP-------------------------------
MMAR_5195|M.marinum_M -TFTQTQRMLQWREKAVDP-------------------------------
Mflv_3016|M.gilvum_PYR-GCK DEHGENLTINALTNDAVDPDSLQPEFKVCAVRLTPVPAADG---------
Mvan_3491|M.vanbaalenii_PYR-1 DEHGDHLTVNALTNDAVDPDSLQPEFKVCAVRLAPVPAAG----------
MAB_2438|M.abscessus_ATCC_1997 DAHGPGLTINAVTNDAVDPDSLQPEFKVSAVALRPT--------------
MUL_1474|M.ulcerans_Agy99 DAFGEYLSINAVTNDAVDPISRQPEYKACAVTLTKVARPQLQPEPGEPAD
Mb2924c|M.bovis_AF2122/97 --------FDGYRRRTLQVG------------------------------
Rv2900c|M.tuberculosis_H37Rv --------FDGYRRRTLQVG------------------------------
MSMEG_2837|M.smegmatis_MC2_155 RECGADGDLAGFRNWANDS-------------------------------
TH_1885|M.thermoresistible__bu TAMGWSPFYPQFDRSSLDIADEARAAGKEIGAYVCEQLASG---------
. : :
MAV_0422|M.avium_104 --------------------------------------------------
MMAR_5195|M.marinum_M --------------------------------------------------
Mflv_3016|M.gilvum_PYR-GCK -----------------------------------APDLTDDEKLYIAGF
Mvan_3491|M.vanbaalenii_PYR-1 -----------------------------------APEFTETEKLYLAGF
MAB_2438|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_1474|M.ulcerans_Agy99 ACADATAPKLLADTAQFSVTQVDALAELLGVGNEPTPQFGPSARSYLAGL
Mb2924c|M.bovis_AF2122/97 --------------------------------------------------
Rv2900c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155 --------------------------------------------------
TH_1885|M.thermoresistible__bu --------------------------------------------------
MAV_0422|M.avium_104 --------------------------------------------------
MMAR_5195|M.marinum_M --------------------------------------------------
Mflv_3016|M.gilvum_PYR-GCK LAGVDEGR----PGVPVLPAGAPVGARARLWVDGLLAGRYSRLETA----
Mvan_3491|M.vanbaalenii_PYR-1 FAGIEEGL----PGVPVLPASAPVGPRARLWVDGLLAGRYSRSDTV----
MAB_2438|M.abscessus_ATCC_1997 -------------------------------------GRTKADSMP----
MUL_1474|M.ulcerans_Agy99 IAGLRSETGRRMAGVSTLPISSPFDTGTRLWLDGLLAGMFARAETPPALP
Mb2924c|M.bovis_AF2122/97 --------------------------------------------------
Rv2900c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155 --------------------------------------------------
TH_1885|M.thermoresistible__bu --------------GLKLAVTDPDDPRNWPRVLSVWRSNLLGSSSK----
MAV_0422|M.avium_104 ----------------PGQCQSELQFFYELGKRIRQRLAGSTDERDR---
MMAR_5195|M.marinum_M ----------------PGDARSELWFFYHLGRKLREKLSGSTDERDR---
Mflv_3016|M.gilvum_PYR-GCK --------------APSASPRGGPLVLWASQTGTAEEFAGSLGERLA---
Mvan_3491|M.vanbaalenii_PYR-1 --------------AETPATEG-PLVLWASQTGNAEEFAGRLGERLN---
MAB_2438|M.abscessus_ATCC_1997 --------------EKQKEALGDVAILWTSQTGNAETAAVSVHRLLHTAG
MUL_1474|M.ulcerans_Agy99 FPQTPGAAAQSDNAAEAAVEQPPIVVLWASQTGTAEELAASVAAQLSAAE
Mb2924c|M.bovis_AF2122/97 --------------------LDTVMDATGIELAQLQRVAAMLMASQRTVI
Rv2900c|M.tuberculosis_H37Rv --------------------LDTVMDATGIELAQLQRVAAMLMASQRTVI
MSMEG_2837|M.smegmatis_MC2_155 -------------------HIEELATLWNLDVTAIPHYAPPTHAMQMFR-
TH_1885|M.thermoresistible__bu -----------GNEYFLRHLLGTDSNLRATRTPEALRPNDVRSPDEIPEG
MAV_0422|M.avium_104 -PLLDLTWDYPTDEHGDPDGEAVLAEINGYRVGEPADPLASYTELRADGS
MMAR_5195|M.marinum_M -PLLQLAWDYATEGD-EPSGEDVLRHMNGIDLGT-GRTIDGYPSLKADGS
Mflv_3016|M.gilvum_PYR-GCK -GARLRAMDDTDLSELSDAGEVVIVTSTFGDGGPPDNGTAFWERLESADA
Mvan_3491|M.vanbaalenii_PYR-1 -GARLRAMDDVELDDLSEAGEVVIVTSTFGDGGPPDNGAGFWERLESPHA
MAB_2438|M.abscessus_ATCC_1997 ISATITAMDECDPADLVGVNTAVVIASSFGEGGPPDNGARFWAALSGDTK
MUL_1474|M.ulcerans_Agy99 LPVVLHGMDEFAVADLVSTQRLLLVTSTTGDGEPPDNGAAFWRELCAPTA
Mb2924c|M.bovis_AF2122/97 CWAMGLTQHAHAVATIGEVTNVLLLRGMIGKPGAGVCPVRGHSNVQGDRT
Rv2900c|M.tuberculosis_H37Rv CWAMGLTQHAHAVATIGEVTNVLLLRGMIGKPGAGVCPVRGHSNVQGDRT
MSMEG_2837|M.smegmatis_MC2_155 -----YAEEGSLRMLWVSATNPAVSLPELGRIRRILSQDRLFLVVQDLFL
TH_1885|M.thermoresistible__bu KLDLLMSIDFRMTSTTLLSDIVLPAATWYEKHDLSSTDMHPYVHAFSPAI
.
MAV_0422|M.avium_104 TAAGCWIYTGVYANAVN------------------QAARRVPNGGASPSQ
MMAR_5195|M.marinum_M TACGCWIYSGVYADEVN------------------QAARRKPRDEQRPYE
Mflv_3016|M.gilvum_PYR-GCK PALDGVRYTVLGIGDRSYDNFCGHAKSLDTRLADLGATRMLDRADCEAYD
Mvan_3491|M.vanbaalenii_PYR-1 PSLDGVRYTVLGIGDRSYDNFCGHARSLDARLADLGATRMLDRVECEAYD
MAB_2438|M.abscessus_ATCC_1997 P-LNHMRYAVLGFGDRAYADFCGHAKALDARLHELGASPLLGRVDGEATD
MUL_1474|M.ulcerans_Agy99 PSLAGTRYSVLALGDSNYADFCGHGRALDHRLAELGASRITDRVDCEPDY
Mb2924c|M.bovis_AF2122/97 MGIWEKMPEQFLAALDR------------------EFGITSPRAHGFDTV
Rv2900c|M.tuberculosis_H37Rv MGIWEKMPEQFLAALDR------------------EFGITSPRAHGFDTV
MSMEG_2837|M.smegmatis_MC2_155 TETAQLADVVLPAAAWA------------------EKTGTFTNADRTVHI
TH_1885|M.thermoresistible__bu DPPWETRSDYDAFGAIARAFSALARKHLGTRTDVVLGALQHDTPGAMAYA
MAV_0422|M.avium_104 SEWGWAWPADRRVLYNR---------------ASADPDGKPWSERKRYIW
MMAR_5195|M.marinum_M NEWGWTWPLNRRVLYNR---------------ASADPQGRPWSERKKLVW
Mflv_3016|M.gilvum_PYR-GCK EQPMAAWADSVVGLMSTPVTPAPT-------QPAVPAAPAPFTRGNPAQA
Mvan_3491|M.vanbaalenii_PYR-1 AQPLARWADSVVELVAAPGTPP----------AAPAQEPTLFTRAEPVAA
MAB_2438|M.abscessus_ATCC_1997 RTLVASWTADLLDAIGDGATAIVETVRKLRSEGLRVAAPERFTRDAPILA
MUL_1474|M.ulcerans_Agy99 EESAARWLQEVLDGLRRTAPPVITAEPVR--AASIASRPQGYTKKRPLLT
Mb2924c|M.bovis_AF2122/97 AAIRAMRDGRVSVFMGMGG-------------NFASATPDTAVTEAALRR
Rv2900c|M.tuberculosis_H37Rv AAIRAMRDGRVSVFMGMGG-------------NFASATPDTAVTEAALRR
MSMEG_2837|M.smegmatis_MC2_155 SDKAVDPPGQARSDFDIFL-------------DYARRMDFRDRDGRPLPA
TH_1885|M.thermoresistible__bu GGTERDWRVTGEVPVPGKTIGP---------LAVVERDYTAIADKWAALG
MAV_0422|M.avium_104 WDPDQRRWVGYDVPDFVVDRAPGARPDPELGGPDALAGDDPFIMQADGKG
MMAR_5195|M.marinum_M WDAELGEWTGHDVPDFEKHKAPDYRPPAGAVGVEALRGDDAFVMQADGKG
Mflv_3016|M.gilvum_PYR-GCK PLCRNVRLTPDGAGKDVRQFGFDISGQDLAYSVGDSLGVWVVNSDAVVES
Mvan_3491|M.vanbaalenii_PYR-1 PLCRNTRLTPQGAAKEVRQIGFDISAHDVTYSVGDSLGVCVVNSDFVVEN
MAB_2438|M.abscessus_ATCC_1997 ALSHNELLSAPNSGKEVRRIEFDLTGHDVSYSAGDALGIYPTNREEDVQR
MUL_1474|M.ulcerans_Agy99 SVMRNTTLSRPRSAKDVRQLVFRVPEQTVSYEAGDALGVWPRNAHQLVDE
Mb2924c|M.bovis_AF2122/97 CALTVQVSTKLNRSHLVHGATALILPTLGRTDRDTRNGRKQLVSVEDSMS
Rv2900c|M.tuberculosis_H37Rv CALTVQVSTKLNRSHLVHGATALILPTLGRTDRDTRNGRKQLVSVEDSMS
MSMEG_2837|M.smegmatis_MC2_155 WNTPDEAFEAWKRCSAGRPCDYTGLSYEKLRGSGGIQWPCNAEHPDGVER
TH_1885|M.thermoresistible__bu PLVEELGVTTKGVTTWPVQEVAELAKAFGVMDSGPAAGRPAITTAARMAE
MAV_0422|M.avium_104 WLFAPKGVVDGPLPTHYE---PQESPVANALYPQQRNPARITFARKDNLS
MMAR_5195|M.marinum_M WLFAPSGLADGPLPTHYE---PHESPVRNALYAQQGNPTRIVFGRKDNPS
Mflv_3016|M.gilvum_PYR-GCK WLSATGFHGAEAVIVDGR-QISLREALTRHYDVCKVTSNLVTFVAEHCPD
Mvan_3491|M.vanbaalenii_PYR-1 WLAATDLRGDEAVVVDGV-QQALRDALTAHYDVCKVTSNLVKFVAEHCRD
MAB_2438|M.abscessus_ATCC_1997 WLTTTGFDAQLPVTIDGG-ELPLATALANHYDICRVTEDLLRFIAERRRD
MUL_1474|M.ulcerans_Agy99 WLGVTRLDGHTEVEVAGHGTMSLRAALTDRFEIAHLSPDLLRFVAQRTLD
Mb2924c|M.bovis_AF2122/97 MVHLSRGSLHPPSDQVRS-EVQIICQLARALFGPGHPVPWERFADDYDTI
Rv2900c|M.tuberculosis_H37Rv MVHLSRGSLHPPSDQVRS-EVQIICQLARALFGPGHPVPWERFADDYDTI
MSMEG_2837|M.smegmatis_MC2_155 LYAGGEFFAAPDYCEAYGKDLITGAPLEPTEYRAMNPFGKAIIKAAEYVP
TH_1885|M.thermoresistible__bu VILALSGTSNGRLAVEGFRELEKRTGQRLAQLAEGSEERRITFADTQARP
:
MAV_0422|M.avium_104 APSA-----------GEPGSDVYPYVFTTYRLTEHHTAGGMSRWLPYLSE
MMAR_5195|M.marinum_M NPSP-----------PEAHGEVFPFVFTAARLTEHHTAGGMSRQLPYLTE
Mflv_3016|M.gilvum_PYR-GCK AATA----KRLRN-DRGALDTWLVDRNGLDLVREFGIRADPALWQEVLVR
Mvan_3491|M.vanbaalenii_PYR-1 AATA----KRLRN-DRGELDRWLVNRNGLDLVREFSVRADPQLWQEVLVR
MAB_2438|M.abscessus_ATCC_1997 KHSA----KLLQGRDTQAREVWLRGRNALDVIREFPIRAAIEEWQQVLIR
MUL_1474|M.ulcerans_Agy99 SNTANQLAELMRPENKAALADWTWGRQSVDLLAQSPVRASVDEWMSVLKP
Mb2924c|M.bovis_AF2122/97 RDAI-----------AAVVPGCDDYNHKVRVPDGFQLPHPPRDAREFRTS
Rv2900c|M.tuberculosis_H37Rv RDAI-----------AAVVPGCDDYNHKVRVPDGFQLPHPPRDAREFRTS
MSMEG_2837|M.smegmatis_MC2_155 PHER-------------PSAEYPCVLITGRTVYHFHTRTKTGRTPQLQAA
TH_1885|M.thermoresistible__bu VPVITSPEWSGSETAGRRYAPFTVNIEHLKPFHTLTGRMHFYLDHDWLEE
MAV_0422|M.avium_104 LQPEMFCEVSPELAA-------------------ERGLQPYGWATIISPR
MMAR_5195|M.marinum_M LQPALFMEVSPELAR-------------------MRGLTHMDWAHVITSR
Mflv_3016|M.gilvum_PYR-GCK LTPRQYSISSSPLVSPHEVQLTVSVVRYRGADGTPRGGVASTYLADLPDC
Mvan_3491|M.vanbaalenii_PYR-1 LTPRQYSISSSPLVSPNEVQLTVSVVRYRGADGGPRGGVASTYLADLPDG
MAB_2438|M.abscessus_ATCC_1997 LTPRQYSISSSPLVSPQAISLTVSIVRYQGPDGSPRGGVGSTFLADRAQH
MUL_1474|M.ulcerans_Agy99 IQPRLYSISSSPKEHPGEVHLTVSPVRYN-FQGVPRRGVCSTYLADRSPS
Mb2924c|M.bovis_AF2122/97 TGKANFAVNPLQWVP---------------------VPPGRLVLQTLRSH
Rv2900c|M.tuberculosis_H37Rv TGKANFAVNPLQWVP---------------------VPPGRLVLQTLRSH
MSMEG_2837|M.smegmatis_MC2_155 APEVWVELARADALR---------------------AGIVEGDLVEIRTV
TH_1885|M.thermoresistible__bu LGEQLPVYRPPLDMAR---------------------LFGAQQIGHSDGV
MAV_0422|M.avium_104 AAIEARVLVTKRVAPLVINGHTVHQIGLPY--------------------
MMAR_5195|M.marinum_M TAVDARVFVTDRMRPLRIEDHVVQQVWMPY--------------------
Mflv_3016|M.gilvum_PYR-GCK TPVPVFLQRSPHFRPPEDPHTPMIMVGPGTGIAPFRGFLQERRALGHRGA
Mvan_3491|M.vanbaalenii_PYR-1 TAVPVFLQRSPHFRPPQDSHTPMIMVGPGTGIAPFRGFLQERRALGHRGP
MAB_2438|M.abscessus_ATCC_1997 LPVPIFLQRSPHFRPPRTSDTPMIMIGPGTGIAPFRGFLQERRALGHTGA
MUL_1474|M.ulcerans_Agy99 DQIAIYVRKSSNFRPPSDPRTPMIMIGPGTGIAPFRGFLQERRALGHTGP
Mb2924c|M.bovis_AF2122/97 DQYNTTIYGLDDRYRGVKGGRRVVFINPAD--------------------
Rv2900c|M.tuberculosis_H37Rv DQYNTTIYGLDDRYRGVKGGRRVVFINPAD--------------------
MSMEG_2837|M.smegmatis_MC2_155 RGCVTAAARLTDLRR-----------------------------------
TH_1885|M.thermoresistible__bu GLTVRYLTPHSKWSIHSEYQDNLLMLSLSRG-----------------GP
MAV_0422|M.avium_104 HWGVGGDAVVSGDAAN--DLLGVTLDP-----NVQIQESKAGSCDIRPGR
MMAR_5195|M.marinum_M HWGYTG--LVEGDVVN--DLLGVVLDP-----NVFIQESKVATCDVQPGR
Mflv_3016|M.gilvum_PYR-GCK NWLFFGDQHREQNFYYRDDLLDMVDDGFLNRLDLAFSRDQRQRIYVQHKM
Mvan_3491|M.vanbaalenii_PYR-1 NWLFFGDQHRAQNFYYRDDLQDMVDDGFLNRLDLAFSRDQARRVYVQHKM
MAB_2438|M.abscessus_ATCC_1997 NWLFFGDQHRTEHFYYRDELDGFLRDGSLRRLDLAFSRDQAKRIYVQHRM
MUL_1474|M.ulcerans_Agy99 NWLFFGEQHAATDFYYRDEIQAMHRDGLLTNLDLAFSRDQRDKVYVQHLM
Mb2924c|M.bovis_AF2122/97 ------IETFGLTAGDRVDLVSEWTDG-----QGGLQERRAKDFLVVAYS
Rv2900c|M.tuberculosis_H37Rv ------IETFGLTAGDRVDLVSEWTDG-----QGGLQERRAKDFLVVAYS
MSMEG_2837|M.smegmatis_MC2_155 -----GVVFLPFHYGYWDTGDDGGKDG---------HHRAANELTLTDWD
TH_1885|M.thermoresistible__bu TMWMSPADAAKIGVADNDWVEAVNPNGVLVCRAIVSHRMPEGVVYVYHVQ
: . :
MAV_0422|M.avium_104 RPRGEELLRLIAD--YQSRSGVTAETG---NVRVDDAVWERGS-------
MMAR_5195|M.marinum_M RPRGPALLDYIAE--YRRRAGITTETGTHLDTTRDDGIAHPDPEESP---
Mflv_3016|M.gilvum_PYR-GCK LDYGADVWRWLDDGAHFYVCGDATRMAKDVDDALTEILRTHARMSSDAAR
Mvan_3491|M.vanbaalenii_PYR-1 LDYGADVWRWLDDGAHFYVCGDATRMAGDVDDALTEIIRTHGGMSADAAR
MAB_2438|M.abscessus_ATCC_1997 MEQGAQLWRWLNEGAHLYVCGDASRMAKDVDGALLTIAQKHGKLSGEQAL
MUL_1474|M.ulcerans_Agy99 QQRGAQLWQWLQDGAQVYVCGTADPMAKDVDRMLCQIVAEHGGLDPESAT
Mb2924c|M.bovis_AF2122/97 TPVGNAAAYYPETNPLVPLDHTAAQSNTPVSKAIIVRLEPTA--------
Rv2900c|M.tuberculosis_H37Rv TPVGNAAAYYPETNPLVPLDHTAAQSNTPVSKAIIVRLEPTA--------
MSMEG_2837|M.smegmatis_MC2_155 PVSKQPIFKTAAASVRRIGAGMAATPEPVAHAVADEHL------------
TH_1885|M.thermoresistible__bu ERTIDVPIAETTGKRGGIHNSLTRLLIKPSHLAGGYAQNAFAFNYLGPTG
:
MAV_0422|M.avium_104 ------------------
MMAR_5195|M.marinum_M ------------------
Mflv_3016|M.gilvum_PYR-GCK EYKREMVAEKRYVRDVY-
Mvan_3491|M.vanbaalenii_PYR-1 DYKREMVAEKRYVRDVY-
MAB_2438|M.abscessus_ATCC_1997 EFRKELVAEKRYVRDVY-
MUL_1474|M.ulcerans_Agy99 AFVHALSADKRYHRDVY-
Mb2924c|M.bovis_AF2122/97 ------------------
Rv2900c|M.tuberculosis_H37Rv ------------------
MSMEG_2837|M.smegmatis_MC2_155 ------------------
TH_1885|M.thermoresistible__bu NQRDEVTVVRRRSQRVVF