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YVEAVRWQRSAASRDVLADYDEQAVTVAPRKREAAGVRAVMVSLQRGMQQMGALRTAAALARLNQRNGFD CPGCAWPEEPGGRKLAEFCENGAKAVAEEATKRTVTAEFFARHSVAELSAKPEYWLSQQGRLAHPMVLRP GDDHYRPISWDAAYQLIAEQLNGLDSPDRAVFYTSGRTSNEAAFCYQLLVRSFGTNNLPDCSNMCHESSG AALTDSIGIGKGSVTIGDVEHADLIVIAGQNPGTNHPRMLSVLGKAKANGAKIIAVNPLPEAGLIRFKDP QKVNGVVGHGIPIADEFVQIRLGGDMALFAGLGRLLLEAEERVPGSVVDRSFVDNHCAGFDGYRRRTLQV GLDTVMDATGIELAQLQRVAAMLMASQRTVICWAMGLTQHAHAVATIGEVTNVLLLRGMIGKPGAGVCPV RGHSNVQGDRTMGIWEKMPEQFLAALDREFGITSPRAHGFDTVAAIRAMRDGRVSVFMGMGGNFASATPD TAVTEAALRRCALTVQVSTKLNRSHLVHGATALILPTLGRTDRDTRNGRKQLVSVEDSMSMVHLSRGSLH PPSDQVRSEVQIICQLARALFGPGHPVPWERFADDYDTIRDAIAAVVPGCDDYNHKVRVPDGFQLPHPPR DAREFRTSTGKANFAVNPLQWVPVPPGRLVLQTLRSHDQYNTTIYGLDDRYRGVKGGRRVVFINPADIET FGLTAGDRVDLVSEWTDGQGGLQERRAKDFLVVAYSTPVGNAAAYYPETNPLVPLDHTAAQSNTPVSKAI IVRLEPTA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2900c | fdhF | - | 100% (779) | POSSIBLE FORMATE DEHYDROGENASE H FDHF (FORMATE-HYDROGEN-LYASE-LINKED, SELENOCYSTEINE-CONTAINING POLYPEPTIDE) (FORMATE DEHYDROGENASE-H ALPHA SUBUNIT) (FDH-H) |
| M. tuberculosis H37Rv | Rv0197 | - | 5e-09 | 23.59% (301) | oxidoreductase |
| M. tuberculosis H37Rv | Rv1442 | bisC | 6e-09 | 24.40% (336) | biotin sulfoxide reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2924c | fdhF | 0.0 | 100.00% (779) | formate dehydrogenase H |
| M. gilvum PYR-GCK | Mflv_2594 | - | 0.0 | 79.87% (765) | oxidoreductase alpha (molybdopterin) subunit |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1593c | - | 0.0 | 78.75% (753) | formate dehydrogenase, A chain |
| M. marinum M | MMAR_0121 | - | 0.0 | 85.40% (774) | formate dehydrogenase H |
| M. avium 104 | MAV_2075 | - | 6e-29 | 28.03% (396) | FdhF protein |
| M. smegmatis MC2 155 | MSMEG_4668 | - | 0.0 | 78.49% (767) | oxidoreductase alpha (molybdopterin) subunit |
| M. thermoresistible (build 8) | TH_1166 | fdhF | 0.0 | 80.03% (766) | POSSIBLE FORMATE DEHYDROGENASE H FDHF |
| M. ulcerans Agy99 | MUL_1474 | fdhF | 3e-25 | 28.74% (334) | formate dehydrogenase H FdhF |
| M. vanbaalenii PYR-1 | Mvan_4032 | - | 0.0 | 80.83% (767) | oxidoreductase alpha (molybdopterin) subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2900c|M.tuberculosis_H37Rv ----------------------------MYVEAVRWQRSAASRDVL----
Mb2924c|M.bovis_AF2122/97 ----------------------------MYVEAVRWQRSAASRDVL----
MMAR_0121|M.marinum_M ---------------------------------MAFQRSAASGDVP----
Mflv_2594|M.gilvum_PYR-GCK -----------------------------------MTTARNARDVD----
Mvan_4032|M.vanbaalenii_PYR-1 --------------------------------------MALSKDVD----
TH_1166|M.thermoresistible__bu ------------------------MGIRFPSVRGGGRGHRTPRDPDHLAE
MSMEG_4668|M.smegmatis_MC2_155 -----------------------------------MTRASDVRDYD----
MAB_1593c|M.abscessus_ATCC_199 ------------------------------MTGHRIPTAHHDGQAE----
MAV_2075|M.avium_104 -------MNTMCAYCGVGCGMVLQITTDPQTGRRHVAKSVGNKEHPANFG
MUL_1474|M.ulcerans_Agy99 MAPNKDAVKTVCAYCGVGCGIVLQTTTDPQTGKRRVAKSTGDKSHPANLG
.
Rv2900c|M.tuberculosis_H37Rv ----ADYDEQAVTVAPRKREAAGVRA------------------------
Mb2924c|M.bovis_AF2122/97 ----ADYDEQAVTVAPRKREAAGVRA------------------------
MMAR_0121|M.marinum_M ----AEYDEDSITVTSPKREAAGVRA------------------------
Mflv_2594|M.gilvum_PYR-GCK ----ADYSERDVEVGPAKDEAAGVKA------------------------
Mvan_4032|M.vanbaalenii_PYR-1 ----ADYSELDVEVSGAKAQAAGVKA------------------------
TH_1166|M.thermoresistible__bu SDHPADYDEHAVRVTGAKGEAAGVRA------------------------
MSMEG_4668|M.smegmatis_MC2_155 ----ADYDDHDVITSGPKHEAAGVKA------------------------
MAB_1593c|M.abscessus_ATCC_199 ---PSGDAEADIAVTGAKSVAAGLTA------------------------
MAV_2075|M.avium_104 RLCTKGATTADLLAAPGRMDSAHARAGRGEPLEPIGTDQAITRCAKQLRA
MUL_1474|M.ulcerans_Agy99 RLCTKGTTTADLLAAPGRMESAHLRAHRAGHLESIPIDDAITQCAMRLRA
: . : :* *
Rv2900c|M.tuberculosis_H37Rv ------------------------VMVSLQRGMQQMGALRTAAALARLNQ
Mb2924c|M.bovis_AF2122/97 ------------------------VMVSLQRGMQQMGALRTAAALARLNQ
MMAR_0121|M.marinum_M ------------------------VLVSLQRGLEQMGAFRTAAALARLNQ
Mflv_2594|M.gilvum_PYR-GCK ------------------------VMVSLQRAVEQMGPVRTVAALSKLNQ
Mvan_4032|M.vanbaalenii_PYR-1 ------------------------VMVSMRRALQQMGPVRTVAALVRLNQ
TH_1166|M.thermoresistible__bu ------------------------VLVSMQRALTSMGPVRTAASLFRLNQ
MSMEG_4668|M.smegmatis_MC2_155 ------------------------VMVSMQRGLTQMGPVRTTAALTRLNQ
MAB_1593c|M.abscessus_ATCC_199 ------------------------VGVSLQRGIEQMGPLRTAATLTKLNQ
MAV_2075|M.avium_104 IIDEHGPDAFAMYVSGQMSLEAQYLANKLTKGFIGTNQIESNSRLCMASA
MUL_1474|M.ulcerans_Agy99 IIDEHGPDAVGVYVSGQMSIEAQYLANKLTKGFIGTKQIESNSRLCMAGA
: .: :.. ..: : * .
Rv2900c|M.tuberculosis_H37Rv RN------GFDCPGCAWPEEPGGRKLAEFCENGAKAVAEEATKRTVTAEF
Mb2924c|M.bovis_AF2122/97 RN------GFDCPGCAWPEEPGGRKLAEFCENGAKAVAEEATKRTVTAEF
MMAR_0121|M.marinum_M RN------GFDCPGCAWPEEPGGRKLAEFCENGAKAVAEEATRRTVTPEF
Mflv_2594|M.gilvum_PYR-GCK RH------GFDCPGCAWPEEHGGRKLAEFCENGAKAVAEEATKRVVTPEF
Mvan_4032|M.vanbaalenii_PYR-1 RH------GFDCPGCAWPEEPGGRKFAEFCENGAKAVAEEATKRVVTPEF
TH_1166|M.thermoresistible__bu RH------GFDCPGCAWPEEPGGRKFAEFCENGAKAVAEEATTRLVTPEF
MSMEG_4668|M.smegmatis_MC2_155 RH------GFDCPGCAWPEEHGGRKIAEFCENGAKAVAEEATKRRVTPEF
MAB_1593c|M.abscessus_ATCC_199 RH------GFDCPGCAWPETPGHRKLAEFCENGAKAVAEEATTRTVTPAF
MAV_2075|M.avium_104 GSGYKLSLGADGPPGSYQDFEHADVFFVIGANMADCHPILFLRMMDRVKA
MUL_1474|M.ulcerans_Agy99 SSGYKLSLGADGPPGSYQDFDHADVFLVIGANMADCHPILFLRMMERVKS
* * * :: : : : * *.. .
Rv2900c|M.tuberculosis_H37Rv FARHSVAELS-------------AKPEYWLSQQGRLAHPMVLRPGDDHYR
Mb2924c|M.bovis_AF2122/97 FARHSVAELS-------------AKPEYWLSQQGRLAHPMVLRPGDDHYR
MMAR_0121|M.marinum_M FARHSVTELL-------------AKPEYWLSQQGRLSHPMVLRPGDDHYR
Mflv_2594|M.gilvum_PYR-GCK FARHTIAELE-------------ARPEYWLSQQGRLTHPMVLRPGDDHYR
Mvan_4032|M.vanbaalenii_PYR-1 FARHTVAELD-------------AKPEYWLSQQGRLTHPVVLRPGDDHYR
TH_1166|M.thermoresistible__bu FARHSVAELS-------------ERPEYWLSQQGRLTHPMVLRPGDDHYR
MSMEG_4668|M.smegmatis_MC2_155 FARHSVAELQ-------------NKPEYWLSQQGRLTHPMVLHEGDTHYR
MAB_1593c|M.abscessus_ATCC_199 FAEHSVEELR-------------QAPEYWLSQQGRLTHPMVLRPGEAHYR
MAV_2075|M.avium_104 GAKLIVVDPRRTATAEKADLFLQIAPGTDLALLNGLLHLIVENGHTDGEF
MUL_1474|M.ulcerans_Agy99 GAKLIVVDPRRTATADKADLFLQIAPGTDLALLNGLLHLIVENEQTDPQF
*. : : * *: . * * :* .
Rv2900c|M.tuberculosis_H37Rv PISWDAAYQLIAEQLNGLD-------------SPDRAVFYTSGRTSNEAA
Mb2924c|M.bovis_AF2122/97 PISWDAAYQLIAEQLNGLD-------------SPDRAVFYTSGRTSNEAA
MMAR_0121|M.marinum_M PIGWDEAYRLIAEHLKALG-------------SPDEALFYTSGRTSNEAA
Mflv_2594|M.gilvum_PYR-GCK PIEWDDAYRLIADELRALD-------------DPNRAVFYTSGRTSNEAA
Mvan_4032|M.vanbaalenii_PYR-1 PIGWDEAYRLIADELNALD-------------DPDQAVFYTSGRTSNEAA
TH_1166|M.thermoresistible__bu PIDWDDAYRLIADELRALP-------------DPDQAVFYTSGRTSNEAA
MSMEG_4668|M.smegmatis_MC2_155 PIAWDDAYRLIADELNALD-------------SPDEACFYTSGRTSNEAA
MAB_1593c|M.abscessus_ATCC_199 PIDWDDAYALIADEIRAAD-------------DPDRLVFYTSGRTSNEAA
MAV_2075|M.avium_104 IAEFTEGWEVMPSFLEQYTPDRVSEITGIPEQDIRAAAQLIGEADNFMSC
MUL_1474|M.ulcerans_Agy99 ISEFTEGWEVMPSFLEQFTPDRVSEITGIPSEDIRTAARWIGTAANWMSC
: .: ::.. :. . . . :.
Rv2900c|M.tuberculosis_H37Rv FCYQLLVRSFGTNNLPDCS-------NMCHESSG----AALTDSIGIGKG
Mb2924c|M.bovis_AF2122/97 FCYQLLVRSFGTNNLPDCS-------NMCHESSG----AALTDSIGIGKG
MMAR_0121|M.marinum_M FCYQLLVRSFGTNNLPDCS-------NMCHESSG----SALSESIGIGKG
Mflv_2594|M.gilvum_PYR-GCK FLYQLLVRSFGTNNLPDCS-------NMCHESSG----TALIDAIGIGKG
Mvan_4032|M.vanbaalenii_PYR-1 FLYQLLVRSFGTNNLPDCS-------NMCHESSG----TALIDAIGIGKG
TH_1166|M.thermoresistible__bu FLYQLLVRSFGTNNLPDCS-------NMCHESSG----TALIDAIGVGKG
MSMEG_4668|M.smegmatis_MC2_155 FLYQLLVRSYGTNNLPDCS-------NMCHESSG----TALTESIGIGKG
MAB_1593c|M.abscessus_ATCC_199 FCYQLLVRSLGTNNLPDCS-------NMCHESSG----TALTDSIGIGKG
MAV_2075|M.avium_104 WTMGLNQSTHGTWNTNAICNLHLATGAICKPGSGPFSLTGQPNAMGGREM
MUL_1474|M.ulcerans_Agy99 WTMGLNQSTHGTWNTNALCNLHLATGAICRPGSGPFSLTGQPNAMGGREM
: * : ** * . :*: .** :. :::* :
Rv2900c|M.tuberculosis_H37Rv SVTIGDVEHADLIVIAGQ-----------------NPGTNHPRMLSVLGK
Mb2924c|M.bovis_AF2122/97 SVTIGDVEHADLIVIAGQ-----------------NPGTNHPRMLSVLGK
MMAR_0121|M.marinum_M SVTVEDVEHADLIIIAGQ-----------------NPGTNHPRMLTVLEK
Mflv_2594|M.gilvum_PYR-GCK SVTVEDLVQSDLILIAGQ-----------------NPGTNHPRMLSILEK
Mvan_4032|M.vanbaalenii_PYR-1 SVTVDDLVRADLILIAGQ-----------------NPGTNHPRMLSVLEK
TH_1166|M.thermoresistible__bu SVTVEDLVAADLIVIAGQ-----------------NPGTNHPRMLSVLEK
MSMEG_4668|M.smegmatis_MC2_155 SVTVDDLIHADVIVIAGQ-----------------NPGTNHPRMLSILEK
MAB_1593c|M.abscessus_ATCC_199 SVSVPDVEHADVILIAGQ-----------------NPGTNHPRMLSVLEK
MAV_2075|M.avium_104 GYMGPGLPGQRSVASAADREFVEDVWGVPRGRLRTEVGTGTIDMFSRMAD
MUL_1474|M.ulcerans_Agy99 GYMGPGLPGQRSVLSAPDREFVEEQWGLPGGALRTDVSGGVIDMFSRMAD
. .: : * : : . . *:: : .
Rv2900c|M.tuberculosis_H37Rv AKANGAKIIAVNPLPEAG-----LIRFKDPQKVNGVVGHGIPIADEFVQI
Mb2924c|M.bovis_AF2122/97 AKANGAKIIAVNPLPEAG-----LIRFKDPQKVNGVVGHGIPIADEFVQI
MMAR_0121|M.marinum_M AKANGAKIIAINPLPEAG-----LIRFKDPQKMNGVVGHGVPIADEFVQI
Mflv_2594|M.gilvum_PYR-GCK AKANGAKIVAINPLPEAG-----LIRFKDPQKVHGVVGDGVPIADEFVQI
Mvan_4032|M.vanbaalenii_PYR-1 AKANGAKIIAVNPLPEAG-----LIRFKDPQKLHGVLGDGVPIADEFVQI
TH_1166|M.thermoresistible__bu AKANGAEIIAVNPLREAG-----LLRFKDPQKVRGVLGDGVAIADEYVQI
MSMEG_4668|M.smegmatis_MC2_155 AKANGAKVIAINPLPEAG-----LIRFKDPQKVHGVVGHGVPIADEFVQI
MAB_1593c|M.abscessus_ATCC_199 AKANGAKIIAVNPLPEAG-----LLRFKDPQKVHGVVGHGVAIADEFVQI
MAV_2075|M.avium_104 GQIKACWIICTNPVASVANRKTVLAGLERAELVIAQDAYLGTETSEYADV
MUL_1474|M.ulcerans_Agy99 GEIKACWIICSNPVATVANRKTVLAGLEKAELVISQDAFFETETNEYANV
.: :.. ::. **: .. * :: .: : . . . :.*:.::
Rv2900c|M.tuberculosis_H37Rv RLGGDMALFAG-----------LGRLLLEAEERVPG--SVVDRSFVDN--
Mb2924c|M.bovis_AF2122/97 RLGGDMALFAG-----------LGRLLLEAEERVPG--SVVDRSFVDN--
MMAR_0121|M.marinum_M RIGGDMALFAG-----------LGRLLLEAEERAPG--TVVDQAFVDQ--
Mflv_2594|M.gilvum_PYR-GCK RIGGDMALFAG-----------LGRLLLEAQDEAGPGAKIVDRDFVDR--
Mvan_4032|M.vanbaalenii_PYR-1 RLGGDMALFAG-----------LGRLLLEAQDKAGPGVQIVDRDFVDG--
TH_1166|M.thermoresistible__bu RIGGDMALFAG-----------LGRLLLEADDRAPG--SVVDRRFIAD--
MSMEG_4668|M.smegmatis_MC2_155 RIGGDMALFAG-----------LGKLLLEAEDKAPG--TVVDHEFVAA--
MAB_1593c|M.abscessus_ATCC_199 RLGGDMALFAG-----------LGRLLLEAEDASPG--RIVDRRFIEK--
MAV_2075|M.avium_104 LLPAALWAETEGVMVNSERNITLSQPAVAAPGGAMPDWQIIARIACEMGF
MUL_1474|M.ulcerans_Agy99 LLPAALWTESDGVMVNCERNMSLFPKAVDPVGDALPDWQIIARIACEMGF
: . : : * : . :: :
Rv2900c|M.tuberculosis_H37Rv -----HCAGFDGYRRRTLQVGLDTVMDATGIELAQLQRVAAMLMA-----
Mb2924c|M.bovis_AF2122/97 -----HCAGFDGYRRRTLQVGLDTVMDATGIELAQLQRVAAMLMA-----
MMAR_0121|M.marinum_M -----HCAGFDEYRRRTLQIEMDTVLAATGVGAPQLERIAAMVMA-----
Mflv_2594|M.gilvum_PYR-GCK -----YTAGFTEYETRTRGIDLDTVLAATGIGRDQLERLAAMMAD-----
Mvan_4032|M.vanbaalenii_PYR-1 -----HTAGFAEYETRTRAVDLDTVLEATGIDRAQLDRVAAMMAT-----
TH_1166|M.thermoresistible__bu -----HCANFAAYEARTRAVDLDTVCEATGVCRAQLERVAAKMAA-----
MSMEG_4668|M.smegmatis_MC2_155 -----HCAGFDEYAAQTRAVDLDTVVEASGIDRTQLQRVADMLIG-----
MAB_1593c|M.abscessus_ATCC_199 -----HCAGYEEWAERTRAVDWETVTRATGIDMDQLRTVADMLAN-----
MAV_2075|M.avium_104 SEAFSYSCAEEVFEEIKRFWNPTTGYDLRGVSYERLRRQPLQWPCPPQST
MUL_1474|M.ulcerans_Agy99 SESFSYSSAAEVFEEIKRFSNPATGYDLRGISHDRLRETPLQWPCPPDGA
: . : . * *: :* .
Rv2900c|M.tuberculosis_H37Rv SQRTVICWAMGLTQHAHAVATIGEVTNVLLLRG-----MIGKP-------
Mb2924c|M.bovis_AF2122/97 SQRTVICWAMGLTQHAHAVATIGEVTNVLLLRG-----MIGKP-------
MMAR_0121|M.marinum_M SQRTIICWAMGLTQHSHAVATIGEATNLLFLRG-----MIGKP-------
Mflv_2594|M.gilvum_PYR-GCK SQRTIVCWAMGLTQHKHAVPSITEISNLLLMRG-----MIGKP-------
Mvan_4032|M.vanbaalenii_PYR-1 SQRIVVCWAMGLTQHKHAVPSISEISNVLLMRG-----MIGKP-------
TH_1166|M.thermoresistible__bu AQRIVVCWAMGLTQHRHAVPTIAEITNVLLMRG-----MIGKP-------
MSMEG_4668|M.smegmatis_MC2_155 SERTVLCWAMGLTQQHHAVATIGEATNLLLMRG-----MIGKP-------
MAB_1593c|M.abscessus_ATCC_199 SQRTIFCWAMGLTQHRHAVATIGEATNLLLMRG-----MIGKP-------
MAV_2075|M.avium_104 ADRNPIRYLNDGVSQTQLVREDGTVPRLAFPTPSGRAVFFARPHLQPEEM
MUL_1474|M.ulcerans_Agy99 SNRSPIRYLNDGVSQLQFVRADGTVPRLAFPTATGRAVFFARPHLVPDEM
::* . : . ..: : * ..: : ::.:*
Rv2900c|M.tuberculosis_H37Rv ---------GAGVCPVRGHSNVQGDRTMGIWEKMPEQFLAALDREFG---
Mb2924c|M.bovis_AF2122/97 ---------GAGVCPVRGHSNVQGDRTMGIWEKMPEQFLAALDREFG---
MMAR_0121|M.marinum_M ---------GAGVCPVRGHSNVQGDRTMGIWEQMPEQFLAALDREFG---
Mflv_2594|M.gilvum_PYR-GCK ---------GAGLCPVRGHSNVQGDRTMGIWEKMPERFLANLDDRFG---
Mvan_4032|M.vanbaalenii_PYR-1 ---------GAGLCPVRGHSNVQGDRTMGIWEKMPEQFLAALDARFG---
TH_1166|M.thermoresistible__bu ---------GAGVCPVRGHSNVQGDRTMGIWEKMPESFLAALDDRFG---
MSMEG_4668|M.smegmatis_MC2_155 ---------GAGVCPVRGHSNVQGDRTMGIWEKAPDAFLDALDAHFG---
MAB_1593c|M.abscessus_ATCC_199 ---------GAGVCPVRGHSNVQGDRTMGIWEKMPESFLAALDSEFG---
MAV_2075|M.avium_104 PDDDYPFLLNTGRLPHQWHTMTKTGKVAKLNKLNPGPFVEIHPDDAARLG
MUL_1474|M.ulcerans_Agy99 PDGDYPFLLNTGRLAHQWHTLTKTGKIAKLNKLNPGPFVEVHPDDAADMQ
.:* . : *: .: .: : : * *: .
Rv2900c|M.tuberculosis_H37Rv --------ITSPRAHGFDTVAAIRAMRDGRVSVFMGMGGNFASATPDTAV
Mb2924c|M.bovis_AF2122/97 --------ITSPRAHGFDTVAAIRAMRDGRVSVFMGMGGNFASATPDTAV
MMAR_0121|M.marinum_M --------IDSPRKHGYDTVAAIRAMRDGQAAVFMAMGGNFASATPDTAV
Mflv_2594|M.gilvum_PYR-GCK --------IHSPREHGLDTVGAIRAMRDGHATVFMAMGGNFASATPDTPV
Mvan_4032|M.vanbaalenii_PYR-1 --------IASPRDHGYDTVDAIRAMRDGKATVFMAMGGNFVSATPDTAV
TH_1166|M.thermoresistible__bu --------ITSPRTPGHDTVAAIRAMRDGQAKVFMAMGGNFASATPDTEV
MSMEG_4668|M.smegmatis_MC2_155 --------ITSPRKHGYDAVDSIRAMRDGKAKVFMAMGGNFVSASPDTEV
MAB_1593c|M.abscessus_ATCC_199 --------ISTPRKHGFDTVDAIRAMRDGKVGVFIGMGGNFASATPDTAV
MAV_2075|M.avium_104 IGEHDRVEIASRRGRAVLPAVVSDRVRPGNCFAPFHWNDAFGEYLSINAV
MUL_1474|M.ulcerans_Agy99 ICEGDHIEIASRRGRAVLPVVITDRVRPGNCFAPFHWNDAFGEYLSINAV
* : * . .. :* *. . : .. * . . . *
Rv2900c|M.tuberculosis_H37Rv TEAALR---------RCALTVQVS--------------------------
Mb2924c|M.bovis_AF2122/97 TEAALR---------RCALTVQVS--------------------------
MMAR_0121|M.marinum_M TEAALR---------SCALTVQIS--------------------------
Mflv_2594|M.gilvum_PYR-GCK TEAALR---------NCSLTVQVS--------------------------
Mvan_4032|M.vanbaalenii_PYR-1 TESALR---------NCSLTVQVS--------------------------
TH_1166|M.thermoresistible__bu TEAALR---------TCSLTVQVS--------------------------
MSMEG_4668|M.smegmatis_MC2_155 TEAALR---------SCNLTVQVS--------------------------
MAB_1593c|M.abscessus_ATCC_199 TEAALR---------NCSLTVQIS--------------------------
MAV_2075|M.avium_104 TNDAVDPISNQPEFKACAVTLTKVAVSHPDSAIG-TGPSAGHDTPESAPT
MUL_1474|M.ulcerans_Agy99 TNDAVDPISRQPEYKACAVTLTKVARPQLQPEPGEPADACADATAPKLLA
*: *: * :*:
Rv2900c|M.tuberculosis_H37Rv -------TKLNRSHLVHGATALILPTLGRTDRDTRNGRKQLVSVEDSMSM
Mb2924c|M.bovis_AF2122/97 -------TKLNRSHLVHGATALILPTLGRTDRDTRNGRKQLVSVEDSMSM
MMAR_0121|M.marinum_M -------TKLNRSHLVHGSTALILPTLGRTDRDLRDGRKQVVSVEDSMSM
Mflv_2594|M.gilvum_PYR-GCK -------TKLNRSHLVHGRTALILPSLGRTDRDVQAGGKQLVSVEDSMSM
Mvan_4032|M.vanbaalenii_PYR-1 -------TKLNRSHLVHGRTALILPSLGRTDRDIQAGGKQLVSVEDSMSM
TH_1166|M.thermoresistible__bu -------TKLNRSHLVHGRTALILPSLGRTDRDIRNGVRQVVSVEDSMSM
MSMEG_4668|M.smegmatis_MC2_155 -------TKLNRSHFVPGRKALILPTLGRTDRDIVDGRKQLVSVEDSMSM
MAB_1593c|M.abscessus_ATCC_199 -------TKLNRSHLVNGRTALILPTLGRTDKDIQKSGKQLVSVEDSMSM
MAV_2075|M.avium_104 EVREISVSQVDALGELLGVATSFKPEFNELGRSYLAGMLTGLRSDVGRRA
MUL_1474|M.ulcerans_Agy99 DTAQFSVTQVDALAELLGVGNEPTPQFGPSARSYLAGLIAGLRSETGRRM
:::: : * * :. :. . : : .
Rv2900c|M.tuberculosis_H37Rv VHLSRGSLHPPSDQ---VRSEVQIICQLARALFGPGHPVP----------
Mb2924c|M.bovis_AF2122/97 VHLSRGSLHPPSDQ---VRSEVQIICQLARALFGPGHPVP----------
MMAR_0121|M.marinum_M VHLSRGSLHPPSDQ---VRSEVQIVCQLARTLLGAQHPVP----------
Mflv_2594|M.gilvum_PYR-GCK VHLSRGSLRPPSDQ---VRSEVAIVCQLARAVLGPEHRVP----------
Mvan_4032|M.vanbaalenii_PYR-1 VHLSRGSLHPPGDQ---VRSEVAIVCQLARTVLGPDHPVP----------
TH_1166|M.thermoresistible__bu VHLSRGSLTPPSDQ---VRSEVAIVCELARELLGPDHPVP----------
MSMEG_4668|M.smegmatis_MC2_155 VHLSRGSLKPPSAE---LRSEVAIVCQLARTLLGPDHPVP----------
MAB_1593c|M.abscessus_ATCC_199 VHLSRGSLHPPSTL---LRSEVAIVCELARTILGPAHPVP----------
MAV_2075|M.avium_104 GGVPTLPPSAPFDSRTRLWVDGLLAGLFSRADASQQAALPEPPQPAAQQP
MUL_1474|M.ulcerans_Agy99 AGVSTLPISSPFDTGTRLWLDGLLAGMFARAETPPALPFPQTPGAAAQSD
:. . .* : : : ::* .*
Rv2900c|M.tuberculosis_H37Rv -------------------WERFADDYDTIRDAIAAVVPGCDDYNHKVRV
Mb2924c|M.bovis_AF2122/97 -------------------WERFADDYDTIRDAIAAVVPGCDDYNHKVRV
MMAR_0121|M.marinum_M -------------------WERFASDYDTIRDAIASVVPGCADYNLRVRQ
Mflv_2594|M.gilvum_PYR-GCK -------------------WETFNADYDTIRDAIAAVVPGCDDYNRRVRE
Mvan_4032|M.vanbaalenii_PYR-1 -------------------WETFNADYDTIRDAIAAVVPGCEDYNRKVRA
TH_1166|M.thermoresistible__bu -------------------WETFADDYDTIRDAIADVVPGCEDYNTRVRR
MSMEG_4668|M.smegmatis_MC2_155 -------------------WETFASDYDTIRDAIAAVVPGCTDYNTRVRR
MAB_1593c|M.abscessus_ATCC_199 -------------------WERFADDYDTIRDAISRVVPGCADYNAKVRR
MAV_2075|M.avium_104 PAAPAGATPAPERAPVVVLWASQTGNAEELAADVAAQLA-AAELPVALHS
MUL_1474|M.ulcerans_Agy99 NAAEA----AVEQPPIVVLWASQTGTAEELAASVAAQLS-AAELPVVLHG
* : : :: :. . : ::
Rv2900c|M.tuberculosis_H37Rv PDGFQLPHPPRDAREFRTSTGKAN--------------------------
Mb2924c|M.bovis_AF2122/97 PDGFQLPHPPRDAREFRTSTGKAN--------------------------
MMAR_0121|M.marinum_M PDGFQLPHPPRDAREFPTSTGKAN--------------------------
Mflv_2594|M.gilvum_PYR-GCK PDGFQLPHPPRDSREFHTATGKAN--------------------------
Mvan_4032|M.vanbaalenii_PYR-1 PDGFQLPHPPRDSREFHTTTGKAN--------------------------
TH_1166|M.thermoresistible__bu PDGFQLPHPPRDSREFPTATGRAN--------------------------
MSMEG_4668|M.smegmatis_MC2_155 SDGFQLPHPPRDSREFPTHTGKAN--------------------------
MAB_1593c|M.abscessus_ATCC_199 PDGFALPHPPRDDRQFPTHTGKAN--------------------------
MAV_2075|M.avium_104 MDDFPAAELAATRELLLITSTTGDGDAPDNGSGLWRALTGDAAPRLGNTR
MUL_1474|M.ulcerans_Agy99 MDEFAVADLVSTQRLLLVTSTTGDGEPPDNGAAFWRELCAPTAPSLAGTR
* * .. . : : .:
Rv2900c|M.tuberculosis_H37Rv ------------------------------------------FAVNPLQW
Mb2924c|M.bovis_AF2122/97 ------------------------------------------FAVNPLQW
MMAR_0121|M.marinum_M ------------------------------------------FSVSPLQW
Mflv_2594|M.gilvum_PYR-GCK ------------------------------------------FEAYPLEW
Mvan_4032|M.vanbaalenii_PYR-1 ------------------------------------------FAAYPLEW
TH_1166|M.thermoresistible__bu ------------------------------------------FEVYPLEW
MSMEG_4668|M.smegmatis_MC2_155 ------------------------------------------FSVYPLEW
MAB_1593c|M.abscessus_ATCC_199 ------------------------------------------FSAAPLEW
MAV_2075|M.avium_104 YAVLALGDSNYDDFCGHGRKLDARLAELGATRIAERVDCEPDYEQAAAKW
MUL_1474|M.ulcerans_Agy99 YSVLALGDSNYADFCGHGRALDHRLAELGASRITDRVDCEPDYEESAARW
: . .*
Rv2900c|M.tuberculosis_H37Rv VP------------------------------------------------
Mb2924c|M.bovis_AF2122/97 VP------------------------------------------------
MMAR_0121|M.marinum_M VP------------------------------------------------
Mflv_2594|M.gilvum_PYR-GCK VD------------------------------------------------
Mvan_4032|M.vanbaalenii_PYR-1 VP------------------------------------------------
TH_1166|M.thermoresistible__bu VP------------------------------------------------
MSMEG_4668|M.smegmatis_MC2_155 VP------------------------------------------------
MAB_1593c|M.abscessus_ATCC_199 VP------------------------------------------------
MAV_2075|M.avium_104 VADVIEALTRTPTAVGGDGGATVSARTSPVAAPSRPNTPAPHTYSKKHPL
MUL_1474|M.ulcerans_Agy99 LQEVLDGLRRTAPPV---------ITAEPVRAASIASR--PQGYTKKRPL
:
Rv2900c|M.tuberculosis_H37Rv -------------------------VPPGRLVLQTLRSHDQYNTTIYGLD
Mb2924c|M.bovis_AF2122/97 -------------------------VPPGRLVLQTLRSHDQYNTTIYGLD
MMAR_0121|M.marinum_M -------------------------VPPGRLILQTLRSHDQYNTTVYGLD
Mflv_2594|M.gilvum_PYR-GCK -------------------------VPEGRLVLQTLRSHDQYNTTIYGLD
Mvan_4032|M.vanbaalenii_PYR-1 -------------------------VPEGRLVLQTLRSHDQYNTTIYGLD
TH_1166|M.thermoresistible__bu -------------------------VPDGRLVLQTLRSHDQYNTTIYGLD
MSMEG_4668|M.smegmatis_MC2_155 -------------------------VPEGRLVLQTLRSHDQYNTTIYGLD
MAB_1593c|M.abscessus_ATCC_199 -------------------------VPEGRLVLQTLRSHDQYNTTIYGLD
MAV_2075|M.avium_104 ITDMVRNTTLNGPKSTKDVRHLVFNLPEDAVSYEAGDALGVWPRNSDELV
MUL_1474|M.ulcerans_Agy99 LTSVMRNTTLSRPRSAKDVRQLVFRVPEQTVSYEAGDALGVWPRNAHQLV
:* : :: : . : . *
Rv2900c|M.tuberculosis_H37Rv DRYRGVK--GGRRVVFINPADIETFGLTAGDRVDLVSEWTDGQGGLQERR
Mb2924c|M.bovis_AF2122/97 DRYRGVK--GGRRVVFINPADIETFGLTAGDRVDLVSEWTDGQGGLQERR
MMAR_0121|M.marinum_M DRYRGVK--GGRRVVFMHPSDIEALGLTAGERVDLVSEYHDAGGNLQERR
Mflv_2594|M.gilvum_PYR-GCK DRYRGVK--GGRRVVFVNPADLATFGLSDGDRVDLVSEFTDADGRLQERR
Mvan_4032|M.vanbaalenii_PYR-1 DRYRGVK--GGRRVVFVNPADLTRFGLSDGDRVDLISEFTDTDGQLQERC
TH_1166|M.thermoresistible__bu DRYRGVS--GGRRVVFVNPADIASLGLRDGDRVDLVSEFTGADGRLQERR
MSMEG_4668|M.smegmatis_MC2_155 DRYRGVK--GGRRVVFVNPTDIARLGLKPDDRVDLISEFEG-----QERW
MAB_1593c|M.abscessus_ATCC_199 DRYRGVK--GGRRVVFVNPEDLTAFGLSEGSRVDLVSEYPGSDGTLEERR
MAV_2075|M.avium_104 DEWLAVTGLDGQTPVEVGEHGLMSLRSALTERIEIAHISRDLVRFVQERT
MUL_1474|M.ulcerans_Agy99 DEWLGVTRLDGHTEVEVAGHGTMSLRAALTDRFEIAHLSPDLLRFVAQRT
*.: .*. .*: * : . : .*.:: . :*
Rv2900c|M.tuberculosis_H37Rv AKD---------------------------FLVVAYSTPVGNAAAYYPET
Mb2924c|M.bovis_AF2122/97 AKD---------------------------FLVVAYSTPVGNAAAYYPET
MMAR_0121|M.marinum_M AKD---------------------------FLVIGYSTPVGNAAAYYPET
Mflv_2594|M.gilvum_PYR-GCK AQD---------------------------FAVVAYSTPVGNAAAYYPET
Mvan_4032|M.vanbaalenii_PYR-1 AKD---------------------------FRVVAYPTPEGNAAAYYPET
TH_1166|M.thermoresistible__bu AED---------------------------FRVVAYSTPVGNAAAYYPET
MSMEG_4668|M.smegmatis_MC2_155 AKD---------------------------FLVVPYSTPEGNAAAYYPET
MAB_1593c|M.abscessus_ATCC_199 AED---------------------------FLVVPYSTPRGNAAAYYPET
MAV_2075|M.avium_104 GDA----KLAELLKPENKRALADWTWGRQSIDLLAQLPVSASAHEWLRVL
MUL_1474|M.ulcerans_Agy99 LDSNTANQLAELMRPENKAALADWTWGRQSVDLLAQSPVRASVDEWMSVL
. . :: . ... :
Rv2900c|M.tuberculosis_H37Rv NPLVPLDHTAAQSNTPVSKAIIVRLEPTA---------------------
Mb2924c|M.bovis_AF2122/97 NPLVPLDHTAAQSNTPVSKAIIVRLEPTA---------------------
MMAR_0121|M.marinum_M NPLVPLDHTAEKSNTPVSKAIVVRVEPASGGDDRR---------------
Mflv_2594|M.gilvum_PYR-GCK NPLVPLDHTAAKSNTPVSKAVVIRLERR----------------------
Mvan_4032|M.vanbaalenii_PYR-1 NPLVPLDHTAAKSNTPVSKAIVIRLERS----------------------
TH_1166|M.thermoresistible__bu NPLVPLDHVAIKSNTPASKAVVIRLEKTWAG-------------------
MSMEG_4668|M.smegmatis_MC2_155 NPLVPLDHTAKKSNTPVSKAVVVRLQRREGSAS-----------------
MAB_1593c|M.abscessus_ATCC_199 NPLVPLDHVAERSNTPVSKAVVIRLVARG---------------------
MAV_2075|M.avium_104 KRLQPRLYSISSSPKACPGEVHLTVSPVRYNFQGVPRRGVCSTYLAARSP
MUL_1474|M.ulcerans_Agy99 KPIQPRLYSISSSPKEHPGEVHLTVSPVRYNFQGVPRRGVCSTYLADRSP
: : * : * . . : : :
Rv2900c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2924c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0121|M.marinum_M --------------------------------------------------
Mflv_2594|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4032|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1166|M.thermoresistible__bu --------------------------------------------------
MSMEG_4668|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1593c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2075|M.avium_104 GDRVAVYLQPSSNFRPPSDPDTPMIMIGPGTGIAPFRGFLQERRALGHRG
MUL_1474|M.ulcerans_Agy99 SDQIAIYVRKSSNFRPPSDPRTPMIMIGPGTGIAPFRGFLQERRALGHTG
Rv2900c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2924c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0121|M.marinum_M --------------------------------------------------
Mflv_2594|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4032|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1166|M.thermoresistible__bu --------------------------------------------------
MSMEG_4668|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1593c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2075|M.avium_104 PNWLFFGEQHAATDFYYRDELEQMREDGFLTELDLAFSRDQQHKVYVQHL
MUL_1474|M.ulcerans_Agy99 PNWLFFGEQHAATDFYYRDEIQAMHRDGLLTNLDLAFSRDQRDKVYVQHL
Rv2900c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2924c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0121|M.marinum_M --------------------------------------------------
Mflv_2594|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4032|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1166|M.thermoresistible__bu --------------------------------------------------
MSMEG_4668|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1593c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2075|M.avium_104 MRNRGKQLWSWLQDGAQLYVCGTADPMAKDVDRALCDIAAEFGNLDPDAA
MUL_1474|M.ulcerans_Agy99 MQQRGAQLWQWLQDGAQVYVCGTADPMAKDVDRMLCQIVAEHGGLDPESA
Rv2900c|M.tuberculosis_H37Rv ------------------
Mb2924c|M.bovis_AF2122/97 ------------------
MMAR_0121|M.marinum_M ------------------
Mflv_2594|M.gilvum_PYR-GCK ------------------
Mvan_4032|M.vanbaalenii_PYR-1 ------------------
TH_1166|M.thermoresistible__bu ------------------
MSMEG_4668|M.smegmatis_MC2_155 ------------------
MAB_1593c|M.abscessus_ATCC_199 ------------------
MAV_2075|M.avium_104 KAYVQSLSADKRYHRDVY
MUL_1474|M.ulcerans_Agy99 TAFVHALSADKRYHRDVY