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TQPDTDWDAAYRQAAPPPWSIGRPQPELERLIDEGKFRSDVLDSGCGHAALSLRLAALGHTVVGLDASAT AIAEATAAAAAQGLTTATFARADVTDFADYPPGSEGRFATIVDSGLFHALPPQRRQDYLRSIFRAAAPGA ALYILAFAAGALAPAHPDRPGPQGFTETELREAVSVLWHIDDLRAARVYGNDDSAGAPDSPLAHLERDGE GHFMAPGFLVSAHKRD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0313 | - | - | 100% (227) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. avium 104 | MAV_0404 | - | 4e-59 | 55.80% (224) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. avium 104 | MAV_0119 | - | 7e-47 | 45.42% (240) | thiopurine S-methyltransferase (tpmt) superfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3725 | - | 9e-59 | 52.14% (234) | hypothetical protein Mb3725 |
| M. gilvum PYR-GCK | Mflv_1324 | - | 2e-53 | 52.00% (225) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv3699 | - | 9e-59 | 52.14% (234) | hypothetical protein Rv3699 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0961c | - | 5e-56 | 53.07% (228) | hypothetical protein MAB_0961c |
| M. marinum M | MMAR_5210 | - | 2e-59 | 51.71% (234) | hypothetical protein MMAR_5210 |
| M. smegmatis MC2 155 | MSMEG_6235 | - | 7e-53 | 49.57% (230) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. thermoresistible (build 8) | TH_3824 | - | 2e-66 | 56.83% (227) | PUTATIVE thiopurine S-methyltransferase (tpmt) superfamily |
| M. ulcerans Agy99 | MUL_0662 | - | 8e-50 | 53.97% (189) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_5471 | - | 6e-53 | 52.89% (225) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0313|M.avium_104 ---MTQPDTDWDAAYRQAAP-------PPWSIGRPQPELERLIDE-----
TH_3824|M.thermoresistible__bu --------MEWDDMYRRGVP-------PPWSIGAPQPELAALLDAGPAQC
Mb3725|M.bovis_AF2122/97 ---MTDEVMDWDSAYREQGA-FEG--PPPWNIGEPQPELATLIAA-----
Rv3699|M.tuberculosis_H37Rv ---MTDEVMDWDSAYREQGA-FEG--PPPWNIGEPQPELATLIAA-----
MMAR_5210|M.marinum_M ---MTSPVMDWDDAYQQQGA-FEG--PPPWNIGEPQPELAALIAA-----
MSMEG_6235|M.smegmatis_MC2_155 MGVMTSHVLDWDGAYRGDTG-FQG--PPPWNIGEPQPELAALHRA-----
Mflv_1324|M.gilvum_PYR-GCK ----MAEVMDWDSAYRGEGE-FEG--EPPWNIGEPQPELAALWRD-----
Mvan_5471|M.vanbaalenii_PYR-1 -MAHMTDVMDWDSAYRGEGD-FEG--EPPWNIGEPQPELAALWRD-----
MAB_0961c|M.abscessus_ATCC_199 --MTSNELPDWDATYQGKGELFQG--EPPWNIGEPQPELAALIDA-----
MUL_0662|M.ulcerans_Agy99 --MTESLDLQFATAYRGESAEFGAGIRPPWSLGEPQPELATLIEQ-----
:: *: ***.:* ***** *
MAV_0313|M.avium_104 ---GKFRSDVLDSGCGHAALSLRLAALGHTVVGLDASATAIAEATAAAAA
TH_3824|M.thermoresistible__bu PVQGTVRGEVLDAGCGEAALSLELAARGHTVVGLDCSAAAVAAATATAAE
Mb3725|M.bovis_AF2122/97 ---GKVRSDVLDAGCGYAELSLALAADGYTVVGIDLTPTAVAAATKAAEE
Rv3699|M.tuberculosis_H37Rv ---GKVRSDVLDAGCGYAELSLALAADGYTVVGIDLTPTAVAAATKAAEE
MMAR_5210|M.marinum_M ---GKIHSDVLDAGCGYAELSLALAAEGYTVVGIDITPTAIAAATKAAAE
MSMEG_6235|M.smegmatis_MC2_155 ---GRFRSDVLDAGCGHAELSLALAADGYTVVGMDLSPSAIAAANRAAQE
Mflv_1324|M.gilvum_PYR-GCK ---GRFRSEVLDAGCGHAELSLALAADGYTVTGVDISPTAMAAASAAAAE
Mvan_5471|M.vanbaalenii_PYR-1 ---GKFRSEVLDAGCGHAELSLALAADGYTVTGVDLSPTAVAAATAASAE
MAB_0961c|M.abscessus_ATCC_199 ---GKFHGTVLDVGCGHAETSLRLAALGHTTVGLDLSPTAIEAARAAAAE
MUL_0662|M.ulcerans_Agy99 ---GKVHGEVLDAGCGEAALAMALAGRGHPVVGLDISPTAVELAGREAAR
* .:. *** *** * :: **. *:...*:* :.:*: * :
MAV_0313|M.avium_104 QGLTT-ATFARADVTDFADYPPGSEGRFATIVDSGLFHALPPQRRQDYLR
TH_3824|M.thermoresistible__bu RGLTT-ATFAQADLTEFGGY----DGRFSTIIDSGLLHALPVDRRQAYLR
Mb3725|M.bovis_AF2122/97 RGLTT-ASFVQADITEFAAYPAGSAGRFSTVIDSTLFHSLPVDSRDRYLS
Rv3699|M.tuberculosis_H37Rv RGLTT-ASFVQADITEFAAYPAGSAGRFSTVIDSTLFHSLPVDSRDRYLS
MMAR_5210|M.marinum_M RGLGN-TSFMQADITDFNAYPAGSAGRFATVIDSTLFHSLPVSGRDDYLK
MSMEG_6235|M.smegmatis_MC2_155 RNLAT-ASFVQGDITSFTGY----DGRFSTVIDSTLFHSLPVEGREGYLQ
Mflv_1324|M.gilvum_PYR-GCK RGLSEKASFVAADITALSGF----DGRFSTVVDSTLFHSLPVESRAGYLE
Mvan_5471|M.vanbaalenii_PYR-1 RGLSERTSFVAADITTLTGF----DGRFATVVDSTLFHSLPVESRDGYLQ
MAB_0961c|M.abscessus_ATCC_199 RGLTN-ATFEVADITDFSGY----DGRFNTIVDSTLFHSIPVEAREAYLQ
MUL_0662|M.ulcerans_Agy99 PGLTN-ASFAVADITDFASYPPESAGRFNTIMDSTLFHSMPVELREGCQR
.* ::* .*:* : : *** *::** *:*::* . *
MAV_0313|M.avium_104 SIFRAAAPGAALYILAFAAGALAPAHPDRPGPQGFTETELREAVSVLWHI
TH_3824|M.thermoresistible__bu AIHRAAAPNARLFILTFAERPFGDGH----GPDGFTAEELRDTVGVLWTV
Mb3725|M.bovis_AF2122/97 SVHRAAAPGASYYVLVFAKGAFPAELEV--KPNEVDEDELRAAVSKYWKI
Rv3699|M.tuberculosis_H37Rv SVHRAAAPGASYYVLVFAKGAFPAELEV--KPNEVDEDELRAAVSKYWKI
MMAR_5210|M.marinum_M SVHRAAAPGASYFVLVFAKGAFPAALET--KPNEVDEDELRAAVGKYWEI
MSMEG_6235|M.smegmatis_MC2_155 SIHRASAPGARYFVLVFAKGAFPADLEV--KPNEVTEEELRTTVGKYWVV
Mflv_1324|M.gilvum_PYR-GCK SVHRAARPGAGFFVLVFAKGAFPADTEQ--GPNEVSEIELREAVSPYWTI
Mvan_5471|M.vanbaalenii_PYR-1 SVHRAAAPGAGYFVLVFAKGAFPAEMEG--GPNEVTELELREAVSRYWII
MAB_0961c|M.abscessus_ATCC_199 SISRAAAPDASYFVLVFAVGAFPPGIG----PNAVTEDELRAAVEPYWAI
MUL_0662|M.ulcerans_Agy99 SIVRAAAPGASYFVLVFDKAALSGDGPI----NGVTEEELRDAVSKHWVI
:: **: *.* ::*.* .: : . *** :* * :
MAV_0313|M.avium_104 DDLRAARVYGNDDSAG----APDSPLAHLERDGEGHFM----------AP
TH_3824|M.thermoresistible__bu DEIRPAKLYVNDFTGD----LLDGPPTAYERAADGKLM----------FP
Mb3725|M.bovis_AF2122/97 DEIRPAFIHVNPVTIPPQLAGAPVEFPPYDHDEKGRVK----------FP
Rv3699|M.tuberculosis_H37Rv DEIRPAFIHVNPVTIPPQLAGAPVEFPPYDHDEKGRVK----------FP
MMAR_5210|M.marinum_M DEIRPAFIHANVPVIPPLPAGSPIEFPPHQRDEKGRMK----------FP
MSMEG_6235|M.smegmatis_MC2_155 DDIRPAFIHANAVVFP-----DAPELPPHGYDDKGRIM----------FP
Mflv_1324|M.gilvum_PYR-GCK DDIRPALIHTNVPKLP-----GMPPPPLDMLDDRGHLR----------MQ
Mvan_5471|M.vanbaalenii_PYR-1 DDIRPALIDTNVPKLP-----GMPPPPLDMLDDRGRLR----------MQ
MAB_0961c|M.abscessus_ATCC_199 DELSSAYIHSNIPEVIP---GANFEMPVFHKDEKGRNK----------QP
MUL_0662|M.ulcerans_Agy99 DEIRPARIHANLPPEVPG--CPPSTLATNPRAASPSVRGCSQPIWADGTP
*:: .* : * .
MAV_0313|M.avium_104 GFLVSAHKRD
TH_3824|M.thermoresistible__bu GFLVSAHKD-
Mb3725|M.bovis_AF2122/97 AYLLTAHKAG
Rv3699|M.tuberculosis_H37Rv AYLLTAHKAG
MMAR_5210|M.marinum_M AYLLTAHKA-
MSMEG_6235|M.smegmatis_MC2_155 AFLLEAHRD-
Mflv_1324|M.gilvum_PYR-GCK AFLLSAHKEP
Mvan_5471|M.vanbaalenii_PYR-1 AFLLQAHKES
MAB_0961c|M.abscessus_ATCC_199 AFLLQAHKR-
MUL_0662|M.ulcerans_Agy99 HAVYSPANEG
: . .