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VRGPLIGLSLFMAIAIAVTWMVYATLRRDVAGPTTPYAAMFTDVYGLRVGDDVRMAGVRVGRVEKVELAG KLAKVSFIVENDQRLYGNTVASVTYQNIIGQRYLGLSLGETGSRTTLSAGSVIPVQQTDPSFDVGKLLNG FEPLFTLLNPKDADDLTKGVLQSLQGDQASIPLLVEQTSTITKTLSARDQSLGDLISSLTRVTDTVARQN DDLDQALNQTRDAVANFDDRRAALQDDVGSIARVTRRLSAIADDVDPSLNELITREPGFSKHLVGIEPQL AFTGDNLPLLLKGFARAVSEGSYGNAYACDLNATGFFPGLNDITTFIVNAATPGNAYPITTKNLGWHTPR CRNMANG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0103 | - | - | 100% (357) | virulence factor Mce family protein |
| M. avium 104 | MAV_2387 | - | e-128 | 61.24% (356) | virulence factor Mce family protein |
| M. avium 104 | MAV_5014 | - | 8e-41 | 30.48% (315) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0605 | mce2B | 2e-37 | 30.31% (353) | MCE-family protein MCE2B |
| M. gilvum PYR-GCK | Mflv_0009 | - | 1e-134 | 66.01% (356) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv0170 | mce1B | 2e-34 | 26.25% (320) | MCE-family protein MCE1B |
| M. leprae Br4923 | MLBr_02590 | mce1B | 4e-42 | 30.96% (323) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_1009c | - | 1e-139 | 68.07% (357) | putative MCE family protein |
| M. marinum M | MMAR_3865 | mce5B | 1e-134 | 64.61% (356) | Mce family protein, Mce5B |
| M. smegmatis MC2 155 | MSMEG_1144 | - | 1e-132 | 63.31% (357) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3156 | - | 1e-132 | 64.04% (356) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3797 | mce5B | 1e-133 | 64.33% (356) | Mce family protein, Mce5B |
| M. vanbaalenii PYR-1 | Mvan_0960 | - | 1e-135 | 66.57% (356) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0103|M.avium_104 --MRGPLIGLSLFMAIAIAVTWMVYATLRRDVAGPTTPYAAMFTDVYGLR
MAB_1009c|M.abscessus_ATCC_199 MKFRGPLIALTVFMAVALALTWLVYATLRRDVAGGTTSYSAIFTDVYGLR
Mflv_0009|M.gilvum_PYR-GCK MKYRGPLIGLSLFMIVAITLTWLVYVTLRRDVAGEKVPYSAMFTDVFGLR
Mvan_0960|M.vanbaalenii_PYR-1 MKYRGALVGLSLFMVVAVTLTWLVYVTLRRDVAGSTAPYAAVFTDVFGLR
MSMEG_1144|M.smegmatis_MC2_155 MKIRGALIGLSLFMVVALTLTWMVYVTLRRDVAGRTVPYTAVFTDVFGLR
TH_3156|M.thermoresistible__bu MRSRGALIGLSLFMAVAVVLTWLVYVTLRRDVAGSTVPYSAVFTDVFGLR
MMAR_3865|M.marinum_M MKFRGPLIGLSLFMVVAVALTWMVYVSLRREVAGKTVAYAAVFTDVYGLR
MUL_3797|M.ulcerans_Agy99 MKFRGPLIGLSLFMVVAVALTWMVYVSLRREVAGKTVAYAAVFTDVYGLR
Rv0170|M.tuberculosis_H37Rv MKITGTVVKLGIVSVVLLFFTVMIIVIFGQMRFDRTNGYTAEFSNVSGLR
MLBr_02590|M.leprae_Br4923 MKLTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFGRTNGYTAEFTNISGLR
Mb0605|M.bovis_AF2122/97 MKTTGTTIKLGIVWLVLSVFTVMIIVVFGQVRFHHTTGYSAVFTHVSGLR
*. : * :. : .* :: . : : . *:* *:.: ***
MAV_0103|M.avium_104 VGDDVRMAGVRVGRVEKVELAG--KLAKVSFIVENDQRLYGNTVASVTYQ
MAB_1009c|M.abscessus_ATCC_199 DGDDVRMAGVRVGRVEKIELVNN-KQAKVDFVVQNDQKLYGNTLASVTYQ
Mflv_0009|M.gilvum_PYR-GCK EGDDVRMAGVRVGRVEKIELDG--KLAKVSFVVQGDQQVLGTTVASVTYQ
Mvan_0960|M.vanbaalenii_PYR-1 EGDDVRMAGVRVGRVEKIELQG--DLAKVSFVVQNDQQVLGTTVASVTYQ
MSMEG_1144|M.smegmatis_MC2_155 EGDDVRMAGVRVGRVEKIELDG--KHAKVSFVVQADQQVFGNTVASVTYQ
TH_3156|M.thermoresistible__bu EGDDVRMAGVRVGRVERIELDG--KYAKVSFVVQSDQQVLGNTVASVTYQ
MMAR_3865|M.marinum_M EGDDVRMAGVRVGRVEKIDLEG--KLAKVRFVVQNEQRLFGNTVASVTYQ
MUL_3797|M.ulcerans_Agy99 EGDGVRMAGVRVGRVEKIDLEG--KLAKVRFVVQNEQRLFGNTVASVTYQ
Rv0170|M.tuberculosis_H37Rv QGQFVRASGVEIGKVKALHLVDGGRRVRVEFNIDRSVPLYQSTTAQIRYS
MLBr_02590|M.leprae_Br4923 TGQFVRASGVEVGKVNSVALINGGTRVRVKFNVDRSVPLYQSTTAQIRYL
Mb0605|M.bovis_AF2122/97 AGQFVRAAGVEVGKVAKVTLIDGDKQVLVDFTVDRSLSLDQATTASIRYL
*: ** :**.:*:* : * . . * * :: . : * *.: *
MAV_0103|M.avium_104 NIIGQRYLGLSLGE-TGSRTTLSAGSVIPVQQTDPSFDVGKLLNGFEPLF
MAB_1009c|M.abscessus_ATCC_199 NIVGQRYLGLSLGK-TGDTNVLAGGSTIPVERTDPSFDVTTLLNGYEPLF
Mflv_0009|M.gilvum_PYR-GCK NIVGQRYLGLTLGS-QGEPVPLPAGSVLPLERSDPSFDVTTLLNGYEPLF
Mvan_0960|M.vanbaalenii_PYR-1 NIVGQRYLGLSLGN-TGDPRPLPAGSVIPLERSEASFDVTTLLNGYEPLF
MSMEG_1144|M.smegmatis_MC2_155 NIVGQRYLGLSLGK-EGDPTLLAAGSVIPLERTDPSFDVGTLLNGYEPLF
TH_3156|M.thermoresistible__bu NIVGQRYLGLSLGN-LGDPHPLPPGATIPVEQTDPSFDVGALLNGYEPLF
MMAR_3865|M.marinum_M NIVGQRYLGLSLGK-KGSPDQLAPGSVIPVQRTEPSFDVTALLNGYEPLF
MUL_3797|M.ulcerans_Agy99 NIVGQRYLGLSLGK-KGSPDQLAPGSVIPVQRTEPSFDVTALLNGYEPLF
Rv0170|M.tuberculosis_H37Rv DLIGNRYVELKRGEGKGANDLLPPGGLIPLSRTSPALDLDALIGGFKPVF
MLBr_02590|M.leprae_Br4923 DLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTSPALDLDALIGGFKPLF
Mb0605|M.bovis_AF2122/97 NLIGDRYLELGRG---HSGQRLAPGATIPLEHTHPALDLDALLGGFRPLF
:::*:**: * * :. *. :*:.:: .::*: *:.*:.*:*
MAV_0103|M.avium_104 TLLNPKDADDLTKGVLQSLQGDQASIPLLVEQTSTITKTLSARDQSLGDL
MAB_1009c|M.abscessus_ATCC_199 STLSPEQADNLTKGVIQSLQGDQASITSLVDQTSTLTKTFAGRDQVLGNV
Mflv_0009|M.gilvum_PYR-GCK SLLDPQAADDLTQGVIQSLQGDEASLVALVDQTSQLTESFAGHDEELGAV
Mvan_0960|M.vanbaalenii_PYR-1 SLLNPRDADNLTQGVIQSLQGDEASIVGLVDQTSQLTESLAGRDEELGTV
MSMEG_1144|M.smegmatis_MC2_155 SVLDPKYANNLTEGVIQSLQGDQGSITALIDQTAQLTEAFAGREEELGSV
TH_3156|M.thermoresistible__bu SVLDPKHADNLTKGVIESLQGDEASITALVDQTAQLTEAFAGRDEELGAV
MMAR_3865|M.marinum_M SLLNPRDADNLTKGIIESLQGDTASLATLVSQTSTLTETFAGRDQALGDV
MUL_3797|M.ulcerans_Agy99 SLLNPRDADNLTKGIIESLQGDTASLATLVSQTSTLTETFAGRDQALGDV
Rv0170|M.tuberculosis_H37Rv RALDPAKVNNIANALITVFQGQGGTINDILDQTAQLTSQIAERDQAIGEV
MLBr_02590|M.leprae_Br4923 RALDPDKINTIASAIVAAFQGQGGTINDILDQTAQLTTAIGERDQAIGEV
Mb0605|M.bovis_AF2122/97 QTLDPDKVNSIASSIITVFQGQGATINDILDQTASLTATLADRDHAIGEV
*.* : ::..:: :**: .:: ::.**: :* :. ::. :* :
MAV_0103|M.avium_104 ISSLTRVTDTVARQNDDLDQALNQTRDAVANFDDRRAALQDDVGSIARVT
MAB_1009c|M.abscessus_ATCC_199 ITSLSTVTGNLAQQNDSLDKAITNTRKVVADFDSRRPELVNSVGSLAQTM
Mflv_0009|M.gilvum_PYR-GCK ITDLNTVMSNLAKHNDSMDQVLTETQAAVSIFDAQRQELVDSTGSISRVV
Mvan_0960|M.vanbaalenii_PYR-1 ITDLNAVMGNLARHNDSLDQVLTQVQSAVTTFDGQRQELVDSTGSMARVV
MSMEG_1144|M.smegmatis_MC2_155 ITDLNAVAANLARHNDDLDHIVSEAQSVVATFEARRPELVESMGSIAKVV
TH_3156|M.thermoresistible__bu ITDLNTVVANLARHNDDLDHVIGEARSVVSTFDDRRDQLIDSMGSAAKVI
MMAR_3865|M.marinum_M ITNLNKVIYNLAQQNDNLDGVITDTREVVSTLDQRRPELVSSIGSLARVL
MUL_3797|M.ulcerans_Agy99 ITNLNKVIYNLAQQNDNLDGVITDTREVVSTLDQRRPELVSSIGSLARVL
Rv0170|M.tuberculosis_H37Rv VKNLNIVLDTTVKHRKEFDETVNNLENLITGLRNHSDQLAGGLAHISNGA
MLBr_02590|M.leprae_Br4923 VKNLNVVLDTTVRHRKEFDQTVNNLEILITGLKDHGDQLAGSFAHISNAA
Mb0605|M.bovis_AF2122/97 VNNLNTVLATTVKHQTEFDRTVDKLEVLITGLKNRADPLAAAAAHISSAA
:..*. * . .::. .:* : . . :: : : * . :
MAV_0103|M.avium_104 RRLSAIADDVDPSLNELITREPGFSKHLVGIEPQLAFTGDNLPLLLKGFA
MAB_1009c|M.abscessus_ATCC_199 RRLSKITDEVYPSLDELITRQPGFAKHMVQIEPKLAFLGGNLPLLLKGLA
Mflv_0009|M.gilvum_PYR-GCK SRLSTVSDDVYPSLNELIEREPGFAQHLVSIEPQLAFTGANLPLLLKGFA
Mvan_0960|M.vanbaalenii_PYR-1 RQLSTISDEVYPSLNELITREPGFTQHMVSIEPQLAFTGANLPLLLKGFA
MSMEG_1144|M.smegmatis_MC2_155 RQLSTISDEVYPSLSEMVQRQPGFAAHMLGIEPQLAFVGANLPLMLKGFA
TH_3156|M.thermoresistible__bu RQLSAISDEVYQPLNEMVQREPGFAKHMLGIEPQLAFVGANLPLMLKGFA
MMAR_3865|M.marinum_M ERLSASANDVYPQLREFIDRQPGATRHILSVEPQVAFFGDNIPLLLKGLT
MUL_3797|M.ulcerans_Agy99 ERLSASANDVYPQLREFIDRQPGATRHILSVEPQVAFFGDNIPLLLKGLT
Rv0170|M.tuberculosis_H37Rv GTVADLLAENRTLVRKAVSYLDAIQQPVIDQRVELDDLLHKTPTALTALG
MLBr_02590|M.leprae_Br4923 GTVANLLAEDHALLHKSINYLDGIQQPLIDQRLQLEDYLHKLPTVLNQIG
Mb0605|M.bovis_AF2122/97 GTLADLLGADRPLLHSSFGHLEGIQQPLIDELAELDHVLGKLPDAYRIIG
:: : . . . :: :: : * :
MAV_0103|M.avium_104 RAV-SEGSYGNAYACDLNATGFFPGLNDITTFIVNAATPGNAYPITTKNL
MAB_1009c|M.abscessus_ATCC_199 RIT-GDGAYGNAYICDLNITGFFPGLNDVVPIIVNAATPG--------NV
Mflv_0009|M.gilvum_PYR-GCK RIT-SEGAYANAYACDLNATGFFPGLNDVTPIIVDAATPG--------ND
Mvan_0960|M.vanbaalenii_PYR-1 RIT-GEGAYANAYACDLNIQGFFPGLNDVVPIIVDAATPG--------ND
MSMEG_1144|M.smegmatis_MC2_155 RIT-QEGTYANAYLCDLNATAFFPGLNDVTPIIVDAATPG--------NK
TH_3156|M.thermoresistible__bu RVT-GEGTYANAYACNLDGTAFFPGLNDITPIIVAAATPG--------NK
MMAR_3865|M.marinum_M RVG-NRGAYGNAYVCDINAFGFFPGLNDVMPIIVNAATPG--------NQ
MUL_3797|M.ulcerans_Agy99 RVG-NRGAYGNAYVCDINAFGFFPGLNDVMPIIVNAATPG--------NQ
Rv0170|M.tuberculosis_H37Rv RANGTYGDFQNFYLCDLQIKWNGFQAGGPVRTVKLFSQPT----------
MLBr_02590|M.leprae_Br4923 RTIGSYGDFVNFYSCDITLKINGLQPGGPVRTVRLFQQPT----------
Mb0605|M.bovis_AF2122/97 RAGGIYGDFFNFYLCDISLKVNGLQPGGPVRTVKLFGQPT----------
* * : * * *:: .. : *
MAV_0103|M.avium_104 GWHTPRCRNMANG
MAB_1009c|M.abscessus_ATCC_199 AQHTPRCRNLANG
Mflv_0009|M.gilvum_PYR-GCK AQYSPKCRNMANG
Mvan_0960|M.vanbaalenii_PYR-1 ARYTPKCRNMANG
MSMEG_1144|M.smegmatis_MC2_155 AQHTPKCRSMANG
TH_3156|M.thermoresistible__bu ARYTPKCRNLANG
MMAR_3865|M.marinum_M ARHTPRCRSMADG
MUL_3797|M.ulcerans_Agy99 ARHTPRCRSMADG
Rv0170|M.tuberculosis_H37Rv GRCTPQ-------
MLBr_02590|M.leprae_Br4923 GRCTPQ-------
Mb0605|M.bovis_AF2122/97 GRCTPQ-------
. :*: