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VGIHVVVGANGATGTVLCRELLAAGHTVRAVSRSGRGAPSGVDEIAADATDAVRITEICAGATSLYHCAL PPMGSWLPTYVDLTRSLITAAGNVGARLVYADDTWMYGKVNGPMREDSPVRPVAYKGALRALAAEMIASA YARGQTESVVGRAAELYGPRVESLLGAGVFAAGITGRKAIWPGDPDLPMTATFIGDFGKALADLGQHPAV VGQVFHVPVAPAITGRQFIELIASQAGTVPKVGRLTPPMVALLKVVAPIVREGAELLYQFEQPFLVDDSR FRALTGRTATTWRAGIEQTITWYRADPERIKYRLLPGKSR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4711 | - | - | 100% (320) | hypothetical protein MAB_4711 |
| M. abscessus ATCC 19977 | MAB_3697 | - | 6e-05 | 26.57% (207) | putative epimerase/dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2073c | - | 8e-06 | 40.00% (65) | hypothetical protein Mb2073c |
| M. gilvum PYR-GCK | Mflv_1108 | - | 2e-06 | 26.04% (192) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv2047c | - | 8e-06 | 40.00% (65) | hypothetical protein Rv2047c |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_2451 | - | 3e-06 | 26.20% (187) | hypothetical protein MAV_2451 |
| M. smegmatis MC2 155 | MSMEG_5504 | - | 1e-05 | 37.14% (70) | hypothetical protein MSMEG_5504 |
| M. thermoresistible (build 8) | TH_0078 | - | 6e-07 | 29.11% (158) | POSSIBLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_5705 | - | 8e-05 | 30.53% (95) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2073c|M.bovis_AF2122/97 ---MRIAVTGASGVLGRGLTARLLSQGHEVVGIARHRPDSWPS---SADF
Rv2047c|M.tuberculosis_H37Rv ---MRIAVTGASGVLGRGLTARLLSQGHEVVGIARHRPDSWPS---SADF
MAV_2451|M.avium_104 ---MRIAVTGASGVLGRGLAARLLSKGHDVVGIARHRPDSWSS---AADF
Mflv_1108|M.gilvum_PYR-GCK -MSAPVLVIGANGYLGSHVTRKLVAAGNDVRVMVRDGANTVGIDDLAVTR
Mvan_5705|M.vanbaalenii_PYR-1 -MTA--LVIGANGYLGSHVTRRLVADGQDVRVMVREGANTIGIDDLTVTR
TH_0078|M.thermoresistible__bu VTARPKLVIGANGFLGSHVTRQLVADGHQVRAMVRPGANTVGIDDLALHR
MSMEG_5504|M.smegmatis_MC2_155 -MPRSVLVTGATGTLGHHVVPEATQAGHAVRALSRRPRVGYTG----VHW
MAB_4711|M.abscessus_ATCC_1997 --MGIHVVVGANGATGTVLCRELLAAGHTVRAVSRSGRGAPSG----VDE
* **.* * : . *: * : *
Mb2073c|M.bovis_AF2122/97 IAADIRDATAVESAMTGADVVAHCAWVRGRND----HINIDGTANVLKAM
Rv2047c|M.tuberculosis_H37Rv IAADIRDATAVESAMTGADVVAHCAWVRGRND----HINIDGTANVLKAM
MAV_2451|M.avium_104 IEADIRDAAAVNRAVTSADVVAHFAWTHDTQERTGSQVNIAGTANVLAAM
Mflv_1108|M.gilvum_PYR-GCK YVGDIWNTDVLREAMTGCEVVYYCVVDTRG--------------------
Mvan_5705|M.vanbaalenii_PYR-1 FVGDIWDDDVLREAMTGCDVVYYCVVDTRG--------------------
TH_0078|M.thermoresistible__bu FHGDVFDTETLRAAMDGVDDVYYCVVDTRG--------------------
MSMEG_5504|M.smegmatis_MC2_155 QQGDLSDAGTLDAALDGIDTVVHCATQPTGDK------------------
MAB_4711|M.abscessus_ATCC_1997 IAADATDAVRITEICAGATSLYHCALPPMG--------------------
.* : : . : : .
Mb2073c|M.bovis_AF2122/97 AETGTGRIVFTSS----G--------------------HQPRVEQMLADC
Rv2047c|M.tuberculosis_H37Rv AETGTGRIVFTSS----G--------------------HQPRVEQMLADC
MAV_2451|M.avium_104 AETSARRIVFPSSPHVYGGGDTPRSEAEAPAPSAADAVQQARVEEMLVAS
Mflv_1108|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5705|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0078|M.thermoresistible__bu --------------------------------------------------
MSMEG_5504|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4711|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 GLEWVAVRCALIFGRNVDNWVQRLFALPVLPAGYADRVVQVVHSDDAQRL
Rv2047c|M.tuberculosis_H37Rv GLEWVAVRCALIFGRNVDNWVQRLFALPVLPAGYADRVVQVVHSDDAQRL
MAV_2451|M.avium_104 GLESVTIRCALVVGRNVDNWVRRVLALPAFPGGTVDRPIQLVHLDDALRL
Mflv_1108|M.gilvum_PYR-GCK -------------------WLR----------------------------
Mvan_5705|M.vanbaalenii_PYR-1 -------------------WLR----------------------------
TH_0078|M.thermoresistible__bu -------------------WLR----------------------------
MSMEG_5504|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4711|M.abscessus_ATCC_1997 ------------------SWLP----------------------------
Mb2073c|M.bovis_AF2122/97 LVRALLDTVIDSGPVNLAAPGELTFRRIAAALGRPMVPIGSPVLRRVTSF
Rv2047c|M.tuberculosis_H37Rv LVRALLDTVIDSGPVNLAAPGELTFRRIAAALGRPMVPIGSPVLRRVTSF
MAV_2451|M.avium_104 LESAVLSHEIPSGTVNLAAPGTTTFRRIAATLRRPVLRLGRPAP------
Mflv_1108|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5705|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0078|M.thermoresistible__bu --------------------------------------------------
MSMEG_5504|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4711|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 AELELLHSAPLMDVTLLRDRWGFQPAWNAEECLEDFTLAVRGRIGLGKRT
Rv2047c|M.tuberculosis_H37Rv AELELLHSAPLMDVTLLRDRWGFQPAWNAEECLEDFTLAVRGRIGLGKRT
MAV_2451|M.avium_104 AELEPVLSAPLMDTALLHERWGFRPAWQCGECVEDMALAVRGRVTVGRRV
Mflv_1108|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5705|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0078|M.thermoresistible__bu --------------------------------------------------
MSMEG_5504|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4711|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 FSLPWRLANIQDLPAVDSPADDGVAPRLAGPEGANGEFDTPIDPRFPTYL
Rv2047c|M.tuberculosis_H37Rv FSLPWRLANIQDLPAVDSPADDGVAPRLAGPEGANGEFDTPIDPRFPTYL
MAV_2451|M.avium_104 VSLPWRLANVADLPAVDAPAQDGVVPVPAGPEGVNGEFDTPIDPRFPTFL
Mflv_1108|M.gilvum_PYR-GCK ---------------------DPAPLFRTNVEGTRNVLDVAVEPGIAATL
Mvan_5705|M.vanbaalenii_PYR-1 ---------------------DPAPLFRTNVEGTRNVLNIAVEPAVAAGL
TH_0078|M.thermoresistible__bu ---------------------DPTPLFQTNVEGTRNVLNVALDVTEKAGL
MSMEG_5504|M.smegmatis_MC2_155 ---------------------DIVAARNLTNAVRRNNVGHLIYVSIVGID
MAB_4711|M.abscessus_ATCC_1997 ------------------TYVDLTRSLITAAGNVGARLVYADDTWMYGKV
* . .
Mb2073c|M.bovis_AF2122/97 ATNLSEALPGPFSPSSASVTVRGLRAGGVGIAERLRPSGVIQREIAMRTV
Rv2047c|M.tuberculosis_H37Rv ATNLSEALPGPFSPSSASVTVRGLRAGGVGIAERLRPSGVIQREIAMRTV
MAV_2451|M.avium_104 ATNLSEALPGPFSPSSASATVRGVRAGGVTIAERLRPGGLVQREIALRTV
Mflv_1108|M.gilvum_PYR-GCK RK---------FVFTSSCVTVGRTRGRVATEAD-----------------
Mvan_5705|M.vanbaalenii_PYR-1 RK---------FVFTSSYVTVGRRRGRVATEAD-----------------
TH_0078|M.thermoresistible__bu RR---------FVYTSSYVTVGRRRGRRATEED-----------------
MSMEG_5504|M.smegmatis_MC2_155 KIP--------LPYYRTKLRVEQLLADSG---------------------
MAB_4711|M.abscessus_ATCC_1997 NGP--------MREDSPVRPVAYKGALRALAAE-----------------
: . * .
Mb2073c|M.bovis_AF2122/97 AVFAHRLYGAITSAHFMAATVPFAKPATIVSNSGFFGPSMASLPIFGAQR
Rv2047c|M.tuberculosis_H37Rv AVFAHRLYGAITSAHFMAATVPFAKPATIVSNSGFFGPSMASLPIFGAQR
MAV_2451|M.avium_104 GVFAHRLYGAITSAHFMAETVPFAKPSMIVSNSGFFGPSMASLPVFGEQR
Mflv_1108|M.gilvum_PYR-GCK ---------VISDPADLKSLTPYVRSRVQAEN------------------
Mvan_5705|M.vanbaalenii_PYR-1 ---------VIAD----RGLTPYVRSRVQAEN------------------
TH_0078|M.thermoresistible__bu ---------QIGN----RRVTPYVKSRVLAEN------------------
MSMEG_5504|M.smegmatis_MC2_155 ----------------VPHTIQRATQFH----------------------
MAB_4711|M.abscessus_ATCC_1997 ---------MIASAYARGQTESVVGRAAELYG------------------
.
Mb2073c|M.bovis_AF2122/97 PPSESSRARRWLRTLRNIGVFGVNLVGLSAGSPRDTDAYVADVDRLERLA
Rv2047c|M.tuberculosis_H37Rv PPSESSRARRWLRTLRNIGVFGVNLVGLSAGSPRDTDAYVADVDRLERLA
MAV_2451|M.avium_104 P-AETGWARRLLRNTRNIGVFGVNLVGLSSGAARDTDDFIADVDRLERLA
Mflv_1108|M.gilvum_PYR-GCK ---------LVMEYARERGLPAVAMCVSTT--------------------
Mvan_5705|M.vanbaalenii_PYR-1 ---------LVLEYARTRGLPAVAMCVSTT--------------------
TH_0078|M.thermoresistible__bu ---------LVLAYARERGLPAVAMCVSTT--------------------
MSMEG_5504|M.smegmatis_MC2_155 ---------ELIKRIFDIQRFSPVLVALRD--------------------
MAB_4711|M.abscessus_ATCC_1997 ---------PRVESLLGAGVFAAGITGRKAIWP-----------------
: . :
Mb2073c|M.bovis_AF2122/97 FDNLATHDDRRLLSLILLARDHVVHGWVLASGSFMLCAAFNVLLRGLCGR
Rv2047c|M.tuberculosis_H37Rv FDNLATHDDRRLLSLILLARDHVVHGWVLASGSFMLCAAFNVLLRGLCGR
MAV_2451|M.avium_104 GD-AAELDERRLLSLIALARDQVVHGWVLASASFMLCAAFNVLLRAVCGR
Mflv_1108|M.gilvum_PYR-GCK ----------------------------YGAGDWGRTPHGAIIAGAAFGK
Mvan_5705|M.vanbaalenii_PYR-1 ----------------------------YGAGDWGRTPHGAIIAGAAFGK
TH_0078|M.thermoresistible__bu ----------------------------HSTG----PDH-----------
MSMEG_5504|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4711|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 DTAPAAGPELVSARSVEAVQRLVAAARRDPVVIRLLAEPGERLDKLAVEA
Rv2047c|M.tuberculosis_H37Rv DTAPAAGPELVSARSVEAVQRLVAAARRDPVVIRLLAEPGERLDKLAVEA
MAV_2451|M.avium_104 DTSAPAGPELVSARSVEAMQRLVVAAQRDPNVARVLTEPGERLDKLAVDA
Mflv_1108|M.gilvum_PYR-GCK LPFVMGGIELEAVGIDDAAQAMLLAARKGRAGERYLISEKMISNADVVRI
Mvan_5705|M.vanbaalenii_PYR-1 LPFVLGGIELEAVGVEDAAHALLLAAEKGRVGERYLISEKMISNADVVRI
TH_0078|M.thermoresistible__bu ---------------DKEFPATVVIAEQESLGN-----------------
MSMEG_5504|M.smegmatis_MC2_155 -------VRFQPIDTRDVASRLVELIDQEPGGR-----------------
MAB_4711|M.abscessus_ATCC_1997 ---GDPDLPMTATFIGDFGKALADLGQHPAVVG-----------------
. :
Mb2073c|M.bovis_AF2122/97 PEFHSAVLAELTLIGHRGPAEVEMAATSYADNPELLVRMVAKTLRAVPAP
Rv2047c|M.tuberculosis_H37Rv PEFHSAVLAELTLIGHRGPAEVEMAATSYADNPELLVRMVAKTLRAVPAP
MAV_2451|M.avium_104 PEFHAAVLAELALIGHRGPAELEMLSTSYADDPELLVRMVAKAMAATAAP
Mflv_1108|M.gilvum_PYR-GCK AAEAAGVPAPTKKIPLVLSYAMAALGSAKSRLKGTDERMSLGSLRLMRAE
Mvan_5705|M.vanbaalenii_PYR-1 AAEAAGVPAPSRTMPLPLSYAMAALGSLKGRLKGTDERLSLDSLRLMRAE
TH_0078|M.thermoresistible__bu ------ITATTSPVDIPRSRRTPASRSAP------AARASRXSRCACRPP
MSMEG_5504|M.smegmatis_MC2_155 -------VTDMGGPEVVEHPDLAQMYLAAHSSRRRVVRFTPPGRIAAGYR
MAB_4711|M.abscessus_ATCC_1997 ------QVFHVPVAPAITGRQFIELIASQAGTVPKVGRLTPPMVALLKVV
*
Mb2073c|M.bovis_AF2122/97 QPPTPVIPLRAKPVALLAARQLRDREVRRDRMVRAIWVLRALLREYGRRL
Rv2047c|M.tuberculosis_H37Rv QPPTPVIPLRAKPVALLAARQLRDREVRRDRMVRAIWVLRALLREYGRRL
MAV_2451|M.avium_104 PPQHPRIPLQAKLIAALTARQLRDREARRDKVVRANWVLRALLREYGRRL
Mflv_1108|M.gilvum_PYR-GCK AP----------VDCSKARRELGWQPRPVEESIREAAKFWVGLKAAKRQR
Mvan_5705|M.vanbaalenii_PYR-1 AP----------VDCGKAKRELGWQPRPVEESIREAAKFWVGLRAAKRAG
TH_0078|M.thermoresistible__bu TA----------AATGAAPRMARSSPRRRSASCRS---------------
MSMEG_5504|M.smegmatis_MC2_155 SG------------AHLTPDNAVGTVTFQQYLASGT--------------
MAB_4711|M.abscessus_ATCC_1997 APIVREG---AELLYQFEQPFLVDDSRFRALTGRTATTWRAGIEQTITWY
Mb2073c|M.bovis_AF2122/97 TEAGVFDTPDDVFYLLVDEIDALPADVSGLVARRRAEQRRLAGIVPPTVF
Rv2047c|M.tuberculosis_H37Rv TEAGVFDTPDDVFYLLVDEIDALPADVSGLVARRRAEQRRLAGIVPPTVF
MAV_2451|M.avium_104 THAGVFGSADDVFYLLVDELDALPADVAAVVARRRAEHRRLAGIAPPTVF
Mflv_1108|M.gilvum_PYR-GCK TA------------------------------------------------
Mvan_5705|M.vanbaalenii_PYR-1 KAAG----------------------------------------------
TH_0078|M.thermoresistible__bu --------------------------------------------------
MSMEG_5504|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4711|M.abscessus_ATCC_1997 RAD-----PERIKYRLLPGKSR----------------------------
Mb2073c|M.bovis_AF2122/97 SGSWEPSPSSAAALAAGDTLRGVGVCGGRVRGRVRIVRPETIDDLQPGEI
Rv2047c|M.tuberculosis_H37Rv SGSWEPSPSSAAALAAGDTLRGVGVCGGRVRGRVRIVRPETIDDLQPGEI
MAV_2451|M.avium_104 SGSWQPTATSVPALAGGGTLRGVGVCGGRVRGRVRIVRPETIDDLQPGEI
Mflv_1108|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5705|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0078|M.thermoresistible__bu --------------------------------------------------
MSMEG_5504|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4711|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 LVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVDAQGAT
Rv2047c|M.tuberculosis_H37Rv LVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVDAQGAT
MAV_2451|M.avium_104 LVAEATDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVDVQGAT
Mflv_1108|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5705|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0078|M.thermoresistible__bu --------------------------------------------------
MSMEG_5504|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4711|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 RFLPPGALVEVDGATGEIHVVELASEDGPALPGSDLSR
Rv2047c|M.tuberculosis_H37Rv RFLPPGALVEVDGATGEIHVVELASEDGPALPGSDLSR
MAV_2451|M.avium_104 KSLPPGALVEVDGATGEIRVLELASE--PATGGG----
Mflv_1108|M.gilvum_PYR-GCK --------------------------------------
Mvan_5705|M.vanbaalenii_PYR-1 --------------------------------------
TH_0078|M.thermoresistible__bu --------------------------------------
MSMEG_5504|M.smegmatis_MC2_155 --------------------------------------
MAB_4711|M.abscessus_ATCC_1997 --------------------------------------