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RGSKISKLRAAALAAVGALAVSACTPPGLDSLPLPAPNMGSQSYKLTARFANALNLPAKAKVRLGGADVG EVESMDAVDYVAVVQLRIREGVRLPVGTTAQLRTATPLGDVFVAVTPPATPSGQLLKDGGTLDLDNTSSA ATVEGVLASAAVLVNGGVIRNLTHVVNGLGKSSGGNGSNGIVFGDIVKQSDQLMGTLNGRSAQIQNSLDK TSQLASTLSAREKTINDLLESGAPALKAIDPHQVTDLADTAGHISDQLAKFPSIQGTDSRSMITDFNTVA RAFNDVTVSPDTSLVALNRLLPILIKANAGSALAVDVNMAKLALGNWPDAGYKGDPTFHGPKQADWGYLV GSFKYSLYRLQERVVGQGPNPPAPAPAPQPEPAPAPEPGPGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4595c | - | - | 100% (393) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_4564c | - | e-117 | 57.11% (387) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_4512c | - | e-104 | 50.88% (397) | putative Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 7e-21 | 24.00% (375) | MCE-family lipoprotein LprK |
| M. gilvum PYR-GCK | Mflv_0006 | - | 1e-108 | 51.53% (392) | hypothetical protein Mflv_0006 |
| M. tuberculosis H37Rv | Rv0593 | lprL | 2e-21 | 24.61% (386) | MCE-family lipoprotein LprL |
| M. leprae Br4923 | MLBr_02593 | lprK | 5e-23 | 28.25% (223) | putative lipoprotein |
| M. marinum M | MMAR_3868 | mce5E | 1e-102 | 49.37% (397) | Mce family protein, Mce5E |
| M. avium 104 | MAV_0106 | - | 1e-104 | 50.49% (410) | mce related protein |
| M. smegmatis MC2 155 | MSMEG_1147 | - | 1e-109 | 50.49% (408) | mce related protein |
| M. thermoresistible (build 8) | TH_4097 | - | 1e-108 | 51.54% (390) | PUTATIVE mce related protein |
| M. ulcerans Agy99 | MUL_3800 | mce5E | 1e-102 | 49.37% (397) | Mce family protein, Mce5E |
| M. vanbaalenii PYR-1 | Mvan_0963 | - | 1e-105 | 48.72% (392) | hypothetical protein Mvan_0963 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0006|M.gilvum_PYR-GCK -----------------------MMTRRAATALAVAMTTCLSVTSCATEG
Mvan_0963|M.vanbaalenii_PYR-1 ------------------------MAIRAKGLMALLVTTSLSVSACATEG
MSMEG_1147|M.smegmatis_MC2_155 ------------------MMAASPKRLRKVRLVAAFAMT-VIVSGCATNG
TH_4097|M.thermoresistible__bu ---------------------MSVLRLR--RLVPALVTVGCLVSGCATNG
MMAR_3868|M.marinum_M -------------------------MSGFGKAAAAIAMTTLLSSGCAANG
MUL_3800|M.ulcerans_Agy99 -------------------------MSGFGKAAAAIAVTTLLSSGCAANG
MAV_0106|M.avium_104 ------------------------MKAGKRKALAVACSAVMASSGCATNG
MAB_4595c|M.abscessus_ATCC_199 ---------------------MRGSKISKLRAAALAAVGALAVSACTPPG
Mb0179|M.bovis_AF2122/97 ---MMSVLAR--------MRVMRHRAWQG----LVLLVLALLLSSCGWRG
MLBr_02593|M.leprae_Br4923 MRRAMSVVHT--------SRVR-HQTWRG----LVMLVAALLLSSCGWRG
Rv0593|M.tuberculosis_H37Rv MRCGVSAGSANGKPNRWTLRCGVSAGHRGSVFLLAVLLAPVVLTSCTWRG
:.* *
Mflv_0006|M.gilvum_PYR-GCK LSSLPLP-APGGGSGGYTLTAVFSNALNLPAMAKVKLAGADIGQLESMQA
Mvan_0963|M.vanbaalenii_PYR-1 LASLPLP-APSGGSGGYTLTAVFSNALNVPMMAKVKLAGADVGELESMQA
MSMEG_1147|M.smegmatis_MC2_155 LADLPLP-APGVGSGGYRITAIFSNALNLPANAKVKLAGADIGEMDSMVA
TH_4097|M.thermoresistible__bu LADLPLP-APGVGSGGYRLTAEFTNALNLPANAKVKLAGADVGEVESMVA
MMAR_3868|M.marinum_M LDSLPLP-APTLGSGGYTLTAVFADALNLPMNAKVKLAGADVGQVESMVA
MUL_3800|M.ulcerans_Agy99 LDSLPLP-APTLGSGGYTLTAVFADALNLPMNAKVKLAGADVGQVESMVA
MAV_0106|M.avium_104 LASLPLP-APGIGSGGYLLNAVFSNALNLPAHAKVKLAGADVGQLESMVA
MAB_4595c|M.abscessus_ATCC_199 LDSLPLP-APNMGSQSYKLTARFANALNLPAKAKVRLGGADVGEVESMDA
Mb0179|M.bovis_AF2122/97 ISNVAIPGGPGTGPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKL
MLBr_02593|M.leprae_Br4923 ISNVSIPGGPGSGKGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINL
Rv0593|M.tuberculosis_H37Rv IANVPLPVGRGMGPDRMTIYVQMPDTLALNTNSRVRVADVWVGTVRDISL
: .:.:* . * : . ..::* : ::* :... :* : :
Mflv_0006|M.gilvum_PYR-GCK RDYTAVTTLRIREGVLLPVGSTAELRSATPLGDVFVSIKPPPSAGQGTPL
Mvan_0963|M.vanbaalenii_PYR-1 RDYTAVTTLRIREGVQLPKGSTAELRSATPLGDVFIAIKPPPSVQPGAAL
MSMEG_1147|M.smegmatis_MC2_155 RNYTAVTTLRIMEGVRLPEGSTAELRSATPLGDVFIAIKPPAPVEPGTPL
TH_4097|M.thermoresistible__bu RDYLAVTTLRIMDGVRLPRGSTAELRSATPLGDVFVAIKPPIDVPPDTPM
MMAR_3868|M.marinum_M RNYTAVTRLRITDDVRLPRGSTAELRTATPLGDVFVALRPPAGAGTEAAM
MUL_3800|M.ulcerans_Agy99 RNYTAVTRLRITDDVRLPRGSTAELRTATPLGDVFVALRPPAGAGTEAAM
MAV_0106|M.avium_104 RNYTAVTTLRIMDGVRVPVGSTAELRSATPLGDVFVAIKPPVPADPSAPL
MAB_4595c|M.abscessus_ATCC_199 VDYVAVVQLRIREGVRLPVGTTAQLRTATPLGDVFVAVTPP--ATPSGQL
Mb0179|M.bovis_AF2122/97 KNWVATLTLSLKKDVTLPKNATAKIGQTSLLGSQHVELAAP--PDPSPVP
MLBr_02593|M.leprae_Br4923 KNWVATLTLGLNKDVQLPKNTTAKIGQTSLLGSQHVELAAP--ANPSLEL
Rv0593|M.tuberculosis_H37Rv RNWIATLTLELEPTVRLPANATAKIGQTSLLGTQHVELAAP--PIPSPQP
:: *. * : * :* .:**:: :: ** .: : .*
Mflv_0006|M.gilvum_PYR-GCK LTDGDTIGLESTTAAATVESVLSSAAILVNGGAVRNFTNIINGLGKATGD
Mvan_0963|M.vanbaalenii_PYR-1 LRDGDTIGLESTTAAATVESVLSSAAILVNGGAVRNFTNIINGLGKATGD
MSMEG_1147|M.smegmatis_MC2_155 LKDGDTIDLDATAAAATVESVLSSAAILVNGGAVRNFTNLINGMGKATGD
TH_4097|M.thermoresistible__bu LRDGDTIGKDSTKAAATVESVLASAAILVNGGAVRNFTNIINGLGKATGD
MMAR_3868|M.marinum_M LKDGDTIGLDSTTAAATVESVLSSAAILVNGGAIRNFTNMINGFGNATGD
MUL_3800|M.ulcerans_Agy99 LKDGDTIGLDSTTAAATVESVLSSAAILVNGGAIRNFTNMINGFGNATGD
MAV_0106|M.avium_104 LKAGDTIGLPATRAAATVESVLSSAALLVNGGAVRNFTNIVNGAGKATGD
MAB_4595c|M.abscessus_ATCC_199 LKDGGTLDLDNTSSAATVEGVLASAAVLVNGGVIRNLTHVVNGLGKSSGG
Mb0179|M.bovis_AF2122/97 LKDGDTIPLKRSSAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTG
MLBr_02593|M.leprae_Br4923 LKNGDTIPLKNSSVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHG
Rv0593|M.tuberculosis_H37Rv LKSGDTIGLKNSSAYPTVERTLASVALILTGGGIVNLDVIQTEILNILDG
* *.*: : .*.* .*:* : :: ** : *: : .
Mflv_0006|M.gilvum_PYR-GCK QGQ---AFGELIRKTNHTLGTLNGRSEEIKTALTETSQLAAQLEAKNQSL
Mvan_0963|M.vanbaalenii_PYR-1 QGR---AFGDLIRKTNSTLGTMNARSGEISTAITETSRLAAQMEAKNAAL
MSMEG_1147|M.smegmatis_MC2_155 QGQ---AFGNLIRKTNNTLATLTARSEEISTAMTETSRLAQQISAKNQAL
TH_4097|M.thermoresistible__bu EGQ---AFGNLVRKTNATLAKLNARSAEISTAMTETSRLASEIAAKNQVL
MMAR_3868|M.marinum_M QGQ---AFGNLIRKSNRLLATLDSRSEQISTGLSELASLAEQLDAKNQAV
MUL_3800|M.ulcerans_Agy99 QGQ---AFGNLIRKSNRLLATLDSRSEQISTGLSELASLAEQLDAKNQAV
MAV_0106|M.avium_104 QGR---AFGDLINRTNSLLTKLNARSDQIDAAVTETAALADRLDAKNQAI
MAB_4595c|M.abscessus_ATCC_199 NGSNGIVFGDIVKQSDQLMGTLNGRSAQIQNSLDKTSQLASTLSAREKTI
Mb0179|M.bovis_AF2122/97 RAD---QIRAFLGKLDTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVL
MLBr_02593|M.leprae_Br4923 RAD---QIHAFLTKLDTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVL
Rv0593|M.tuberculosis_H37Rv HAG---QIREFLERLATFTAELNNQRGDLTRAIDSTNQLLTIIANRNDTL
.. : :: : : : :: .: . * : :. :
Mflv_0006|M.gilvum_PYR-GCK AEVMDAAAPATSTLAAQTNGIADLVLTVGATTEQLRKFPSIAGTDTSGRS
Mvan_0963|M.vanbaalenii_PYR-1 GEVMDAAGPAADTLAAHTDEIADLVQQVGATAELLRRFPSIAGSDTSGRS
MSMEG_1147|M.smegmatis_MC2_155 SDVMAQARPATDTLAAHTTQIADLVTQIGDVSDQLRKFPSIAGADTSGRS
TH_4097|M.thermoresistible__bu SEVMAEARPATDTLAGHATEIADLVERFGGISDQAHRFPSIAGTDTSGRS
MMAR_3868|M.marinum_M TELMAAAEPAADALAANTGELSNLVVQVGDTTRLLARFPALGGTDTSGRS
MUL_3800|M.ulcerans_Agy99 TELMAAAEPAADALAANTGELSNLVVQVGDTTRLLARFPALGGTDTSGRS
MAV_0106|M.avium_104 TDVLRAVGPATDVLSGNADDIADVVDELGATTRQLSKFPSIAGTDKTGRS
MAB_4595c|M.abscessus_ATCC_199 NDLLESGAPALKAIDPH--QVTDLADTAGHISDQLAKFPSIQGTDS--RS
Mb0179|M.bovis_AF2122/97 NRVLTDLPPLIKHFADKQELLINASDAVGRLSQSADQYLSAA-----RGD
MLBr_02593|M.leprae_Br4923 DQILTDIPPLIKHFADTKNLLINAVGSVGQLSQAVDQYLSEA-----RGP
Rv0593|M.tuberculosis_H37Rv DRVLTDVPPLIEHFADTGQLFADATESLGRFSEVANRALAAT-----RPN
:: * . : . : * : : :
Mflv_0006|M.gilvum_PYR-GCK VIADASRIAGAWNDVVLAPGADLYSLNRLMPPFIKSTTSNAIAVRASIDR
Mvan_0963|M.vanbaalenii_PYR-1 VIADANQIAGAWNDVVLAPGADLYSLNKLMPPFIKSTTSNAIAVNASIDR
MSMEG_1147|M.smegmatis_MC2_155 VIADANTVAGAWNDVALAPDATLYALNRLLPPFIKSMSSGAISLDASVDR
TH_4097|M.thermoresistible__bu VIADANTIANAWNDVALAPGATLYALNRLMPPFIKTMSGGSVALDASVDR
MMAR_3868|M.marinum_M MIRDLNTIAGAANDIAVSPDTSWLALNRMIPPMVKSTAGGALSVRASVDR
MUL_3800|M.ulcerans_Agy99 MIRDLNTIAGAANDIAVSPDTSWLALNRMIPPMVKSTARGALSVRASVDR
MAV_0106|M.avium_104 VIKDANAIAAAWNDVVLSPDTSLAGLNRLIPPFVKATPSQAISVRGSFDR
MAB_4595c|M.abscessus_ATCC_199 MITDFNTVARAFNDVTVSPDTSLVALNRLLPILIKANAGSALAVDVNMAK
Mb0179|M.bovis_AF2122/97 LHQDLQALQCPLKELRRAAPYLVGALKLILTQPFDVD---------TVPQ
MLBr_02593|M.leprae_Br4923 LHTDLQALACPLRELGRGAPYFIGAMKLILTQPYDVD---------TVPK
Rv0593|M.tuberculosis_H37Rv LHQTLQSLQRPLRQLERASPYVVGALKLGLTAPFNID---------EVPN
: . : . .:: .. .:: :. . . .
Mflv_0006|M.gilvum_PYR-GCK LVLGSIPDIG-----FAGDPGLHGPKRYNWHQLVGSLRYTLLRLQERVVG
Mvan_0963|M.vanbaalenii_PYR-1 LVLGSIPDIG-----FAGDSGLHGPKRYNWHQLVGSLQYTLYRLQERIVG
MSMEG_1147|M.smegmatis_MC2_155 LILGSTPDIG-----FAGDQGLHGPKRHDWHQLVGTLKYTLLRLQERVVG
TH_4097|M.thermoresistible__bu LVWGHHPDIG-----FAGDPGLHGPKWSDWHQLVGTLQYTLFRLQERVVG
MMAR_3868|M.marinum_M LVLGSIPDIG-----FPGDIGLHGPHRYNWNQFIGSLKYTLWRLQERVVG
MUL_3800|M.ulcerans_Agy99 LVLGSIPDIG-----FPGDVGLHGPHRYNWNQFIGSLKYTLWRLQERVVG
MAV_0106|M.avium_104 LVLGSRPGTGAETGGFKGDPAFHGPMRRDWNYLIGSIKYVLWRLQERVVG
MAB_4595c|M.abscessus_ATCC_199 LALGNWPDAG-----YKGDPTFHGPKQADWGYLVGSFKYSLYRLQERVVG
Mb0179|M.bovis_AF2122/97 LVRGDYMNLS-----LTLDLTYS---AIDNAFLTGTGFSGALRALEQSFG
MLBr_02593|M.leprae_Br4923 IMRGDYQNVS-----LTLDVTYS---AMDNAVLTGTGLSGALRALEQSFG
Rv0593|M.tuberculosis_H37Rv VIRGDYVNVS-----ATFDVTLS---ALDNALLSGTGISGMLRALEQAWG
: * . . * : : *: * *: *
Mflv_0006|M.gilvum_PYR-GCK KGP--GVPQMPVIPSPTEPGQWAPAPPPGPVPPGPAP-----------AV
Mvan_0963|M.vanbaalenii_PYR-1 KGP--GVPQVPVMPHPTEPGLIVPVPAPAP-PPG--------------AP
MSMEG_1147|M.smegmatis_MC2_155 QGP--GVPQVPVIPSPTEPGEIIVEPGAAAPPEDAPAPEPAPAAQAPAPL
TH_4097|M.thermoresistible__bu KGP--DVPQLPVIPSPTEPGEIIPAPGPAAG-----------------AA
MMAR_3868|M.marinum_M RGP--GSPQLPVMPDPEVPGEIQIAPPLSP------------------QP
MUL_3800|M.ulcerans_Agy99 RGP--GSPQLPVMPDPEVPDEIQIAPPLSP------------------QP
MAV_0106|M.avium_104 RGP--QTPMGQSPWTPSGP-PLPPAPAGQAPPD---------------PM
MAB_4595c|M.abscessus_ATCC_199 QGP--NPP----APAPAPQPEPAPAPEPGPGR------------------
Mb0179|M.bovis_AF2122/97 RDPETMIPDIRYTPNPNDAPGGPLVERGNRQC------------------
MLBr_02593|M.leprae_Br4923 RDPETMIPDVRYTTNPNDAPGGPLVERADRRC------------------
Rv0593|M.tuberculosis_H37Rv RDPDTMIPDVRYTPNPNDAPGGPLVERAE---------------------
:.* * *
Mflv_0006|M.gilvum_PYR-GCK APPAPGVP
Mvan_0963|M.vanbaalenii_PYR-1 APEAPR--
MSMEG_1147|M.smegmatis_MC2_155 PAEAPR--
TH_4097|M.thermoresistible__bu PEEAPR--
MMAR_3868|M.marinum_M PGPPP---
MUL_3800|M.ulcerans_Agy99 PGPPP---
MAV_0106|M.avium_104 VPEPPR--
MAB_4595c|M.abscessus_ATCC_199 --------
Mb0179|M.bovis_AF2122/97 --------
MLBr_02593|M.leprae_Br4923 --------
Rv0593|M.tuberculosis_H37Rv --------